CHRISTOPHER P O'DONNELL

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint The effect of upper airway obstruction and arousal on peripheral arterial tonometry in obstructive sleep apnea
    CHRISTOPHER P O'DONNELL
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 166:965-71. 2002
  2. ncbi request reprint Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains
    Arnon E Rubin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 168:1520-7. 2003
  3. ncbi request reprint Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice
    Matthew J Campen
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, USA
    Physiol Genomics 20:15-20. 2004
  4. ncbi request reprint Structural and functional differences of the carotid body between DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Appl Physiol 94:1536-42. 2003
  5. pmc Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity
    Nao Iiyori
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 175:851-7. 2007
  6. ncbi request reprint Intermittent hypoxia induces hyperlipidemia in lean mice
    Jianguo Li
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circ Res 97:698-706. 2005
  7. ncbi request reprint Genetic background affects cardiovascular responses to obstructive and simulated apnea
    Nao Iiyori
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Physiol Genomics 24:65-72. 2005
  8. ncbi request reprint Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse
    Vsevolod Y Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 7:7-16. 2006
  9. ncbi request reprint Phenotypic differences in the hemodynamic response during REM sleep in six strains of inbred mice
    Matthew J Campen
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Physiol Genomics 11:227-34. 2002
  10. ncbi request reprint Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 99:1643-8. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The effect of upper airway obstruction and arousal on peripheral arterial tonometry in obstructive sleep apnea
    CHRISTOPHER P O'DONNELL
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 166:965-71. 2002
    ..000 +/- 0.007 to 0.923 +/- 0.007 arbitrary units). We conclude that airflow obstruction in patients with OSA causes an acute digital vasoconstriction that is accentuated in the presence of an EEG arousal...
  2. ncbi request reprint Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains
    Arnon E Rubin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 168:1520-7. 2003
    ..Our data imply that individuals with low hypoxic sensitivity may be at a greater risk for hypoxia-related complications of obstructive sleep apnea...
  3. ncbi request reprint Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice
    Matthew J Campen
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, USA
    Physiol Genomics 20:15-20. 2004
    ..These results suggest that genetic background affects the cardiovascular response to hypoxia, but not hypercapnia...
  4. ncbi request reprint Structural and functional differences of the carotid body between DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Appl Physiol 94:1536-42. 2003
    ..These data suggest that genetic determinants account for the strain differences in the structure and function of the carotid body...
  5. pmc Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity
    Nao Iiyori
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 175:851-7. 2007
    ..Furthermore, we assessed the impact of IH on specific metabolic function in liver and muscle. Finally, we examined the potential mechanistic role of the autonomic nervous system (ANS) in mediating insulin resistance in response to IH...
  6. ncbi request reprint Intermittent hypoxia induces hyperlipidemia in lean mice
    Jianguo Li
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circ Res 97:698-706. 2005
    ....
  7. ncbi request reprint Genetic background affects cardiovascular responses to obstructive and simulated apnea
    Nao Iiyori
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Physiol Genomics 24:65-72. 2005
    ..Thus genetic background can affect both the pattern and magnitude of the cardiovascular response to apnea...
  8. ncbi request reprint Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse
    Vsevolod Y Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 7:7-16. 2006
    ..We hypothesized that both intermittent hypoxia (IH) and non-hypoxic arousals of OSA result in significant disruption of non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS)...
  9. ncbi request reprint Phenotypic differences in the hemodynamic response during REM sleep in six strains of inbred mice
    Matthew J Campen
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Physiol Genomics 11:227-34. 2002
    ..8 +/- 2.0 mmHg; P < 0.0125) compared with the other five strains. We conclude that genetic background contributes to the magnitude, variability, and arterial baroreceptor buffering capacity of cardiovascular responses during REM sleep...
  10. ncbi request reprint Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 99:1643-8. 2005
    ..In conclusion, we have shown that CIH may exacerbate preexisting fatty liver of obesity via upregulation of the pathways of lipid biosynthesis in the liver...
  11. ncbi request reprint Impact of interrupted leptin pathways on ventilatory control
    Vsevolod Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 96:991-8. 2004
    ..We conclude that interruption of leptin pathways does not affect hypoxic sensitivity during sleep and wakefulness but that melanocortin 4 blockade is associated with depressed hypercapnic sensitivity in non-rapid eye movement sleep...
  12. ncbi request reprint Modulation of upper airway collapsibility during sleep: influence of respiratory phase and flow regimen
    Hartmut Schneider
    Johns Hopkins Sleep Disorders Center, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Appl Physiol 93:1365-76. 2002
    ....
  13. pmc Chronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice
    Jahan Naghshin
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 107:787-93. 2009
    ....
  14. pmc Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia
    Euhan J Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Eur J Appl Physiol 113:467-78. 2013
    ..We conclude that in lean mice, the marked metabolic dysfunction that occurs with acute exposure to hypoxia is reversed to a greater extent with chronic CH exposure than chronic IH exposure...
  15. pmc Chronic intermittent hypoxia exposure improves left ventricular contractility in transgenic mice with heart failure
    Jahan Naghshin
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 113:791-8. 2012
    ..We conclude that 4 wk of exposure to IH in mice induces adaptive responses that improve cardiac function in not only healthy animals but also in animals with underlying heart failure...
  16. ncbi request reprint The effect of leptin on the ventilatory responseto hyperoxia
    Harald Groeben
    Department of Anesthesiology and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Exp Lung Res 30:559-70. 2004
    ..Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function...
  17. pmc Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity
    Shubha V Y Raju
    Division of Cardiology and Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:4222-7. 2006
    ....
  18. ncbi request reprint A simplified method for measuring critical pressures during sleep in the clinical setting
    Susheel P Patil
    Johns Hopkins Sleep Disorders Center, Asthma and Allergy Building, 5501 Hopkins Bayview Circle, Room 4B 50, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 170:86-93. 2004
    ....
  19. pmc Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice
    Takuya Yokoe
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Physiol 586:899-911. 2008
    ..This model will provide a basis for future mechanistic studies as well as assessing the metabolic impact of common comorbities in OSA, including obesity, insulin resistance and type 2 diabetes...
  20. pmc Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia
    Ronghua Yang
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Heart Circ Physiol 300:H1467-76. 2011
    ..Taken together, these data suggest that restoring normal leptin signaling can reduce vascular stiffness, increase endothelial relaxation, and correct dyslipidemia associated with IH...
  21. ncbi request reprint A physiologic comparison of nasal and oral positive airway pressure
    Philip L Smith
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Chest 123:689-94. 2003
    ..It is currently unclear whether CPAP delivered orally is also capable of raising pressure in the oropharynx above the critical collapse pressure...
  22. pmc Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy
    Khalid M Minhas
    The Johns Hopkins Medical Institutions, Cardiology Division, 720 Rutland Avenue, Ross 1059, Baltimore, MD 21205, USA
    J Physiol 565:463-74. 2005
    ..Taken together, these data reveal a novel link between the leptin signalling pathway and normal cardiac function and suggest a mechanism by which leptin deficiency or resistance may lead to cardiac depression...
  23. ncbi request reprint Genetic influence on carotid body structure in DBA/2J and A/J strains of mice
    Shigeki Yamaguchi
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    Adv Exp Med Biol 580:105-9; discussion 351-9. 2006
  24. ncbi request reprint Metabolic consequences of intermittent hypoxia
    CHRISTOPHER P O'DONNELL
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Adv Exp Med Biol 618:41-9. 2007
    ..We conclude that intermittent hypoxia can cause acute insulin resistance in otherwise lean healthy animals, and the response occurs independent of activation of the autonomic nervous system...
  25. pmc Intermittent hypoxia increases insulin resistance in genetically obese mice
    Vsevolod Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 552:253-64. 2003
    ..001) and worsening glucose tolerance, consistent with an increase in insulin resistance. We conclude that the increase in insulin resistance in response to intermittent hypoxia is dependent on the disruption of leptin pathways...