C P O'Donnell

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Leptin, obesity, and respiratory function
    C P O'Donnell
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD, USA
    Respir Physiol 119:163-70. 2000
  2. ncbi Leptin prevents respiratory depression in obesity
    C P O'Donnell
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 159:1477-84. 1999
  3. ncbi Female gender exacerbates respiratory depression in leptin-deficient obesity
    V Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 164:1470-5. 2001
  4. ncbi Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5
    H Schneider
    Johns Hopkins Sleep Disorder, Division of Pulmonary and Critical Care Medicine, John Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Appl Physiol 95:11-9. 2003
  5. ncbi Leptin is essential in maintaining normal vascular compliance independent of body weight
    G Sikka
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Obes (Lond) 34:203-6. 2010
  6. ncbi The impact of insulin-dependent diabetes on ventilatory control in the mouse
    V Y Polotsky
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 163:624-32. 2001

Collaborators

Detail Information

Publications6

  1. ncbi Leptin, obesity, and respiratory function
    C P O'Donnell
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD, USA
    Respir Physiol 119:163-70. 2000
    ..Thus, the possibility exists that a relative deficiency in leptin, or a leptin resistance, may play a role in obesity-related breathing disorders such as obesity hypoventilation syndrome (OHS) or obstructive sleep apnea (OSA)...
  2. ncbi Leptin prevents respiratory depression in obesity
    C P O'Donnell
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 159:1477-84. 1999
    ..O'Donnell CP, Schaub CD, Haines AS, Berkowitz DE, Tankersley CG, Schwartz AR, Smith PL. Leptin prevents respiratory depression in obesity...
  3. ncbi Female gender exacerbates respiratory depression in leptin-deficient obesity
    V Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 164:1470-5. 2001
    ..Thus, leptin deficiency in female obesity is even more detrimental to hypercapnic ventilatory control during wakefulness and NREM sleep than in obese, leptin-deficient males...
  4. ncbi Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5
    H Schneider
    Johns Hopkins Sleep Disorder, Division of Pulmonary and Critical Care Medicine, John Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Appl Physiol 95:11-9. 2003
    ....
  5. ncbi Leptin is essential in maintaining normal vascular compliance independent of body weight
    G Sikka
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Obes (Lond) 34:203-6. 2010
    ..Interestingly, treating WT mice with a leptin antagonist increases aortic stiffness with no change in weight. Thus, we conclude that leptin is essential for maintaining normal aortic compliance independent of body weight...
  6. ncbi The impact of insulin-dependent diabetes on ventilatory control in the mouse
    V Y Polotsky
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 163:624-32. 2001
    ..These results suggest that: (1) depression of the HCVR in IDDM is associated with hyperglycemia and glycosylation of the diaphragm; and (2) the hyperventilation of DKA is leptin dependent...