Sridhar Nimmagadda

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Differential Expression of Chemokine Receptors and their Roles in Cancer Imaging
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University Baltimore, MD, USA
    Front Oncol 2:46. 2012
  2. pmc Imaging Axl expression in pancreatic and prostate cancer xenografts
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, United States Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, United States Electronic address
    Biochem Biophys Res Commun 443:635-40. 2014
  3. pmc The role of DNA synthesis imaging in cancer in the era of targeted therapeutics
    Sridhar Nimmagadda
    Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Metastasis Rev 27:575-87. 2008
  4. pmc Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 70:3935-44. 2010
  5. pmc ⁶⁴Cu-labeled inhibitors of prostate-specific membrane antigen for PET imaging of prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21287, United States
    J Med Chem 57:2657-69. 2014
  6. pmc 68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21231, USA
    J Med Chem 53:5333-41. 2010
  7. pmc Effect of chelators on the pharmacokinetics of (99m)Tc-labeled imaging agents for the prostate-specific membrane antigen (PSMA)
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    J Med Chem 56:6108-21. 2013
  8. pmc 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, Maryland, USA
    Clin Cancer Res 17:7645-53. 2011
  9. pmc Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465
    Ravindra A De Silva
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 52:986-93. 2011
  10. pmc Immunoimaging of CXCR4 expression in brain tumor xenografts using SPECT/CT
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 50:1124-30. 2009

Collaborators

Detail Information

Publications20

  1. pmc Differential Expression of Chemokine Receptors and their Roles in Cancer Imaging
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University Baltimore, MD, USA
    Front Oncol 2:46. 2012
    ..This review provides a survey of chemokine receptor expression in cancer and evaluates the potential of chemokine receptor imaging as a tool for molecular characterization of cancer...
  2. pmc Imaging Axl expression in pancreatic and prostate cancer xenografts
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, United States Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, United States Electronic address
    Biochem Biophys Res Commun 443:635-40. 2014
    ..These data demonstrate the feasibility of imaging Axl expression in pancreatic and prostate tumor xenografts. ..
  3. pmc The role of DNA synthesis imaging in cancer in the era of targeted therapeutics
    Sridhar Nimmagadda
    Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Metastasis Rev 27:575-87. 2008
    ..In these paradoxical times, this review assesses the role of proliferation imaging in monitoring the efficacy of targeted therapeutics...
  4. pmc Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 70:3935-44. 2010
    ..Our findings show the feasibility of imaging CXCR4 by positron emission tomography using a clinically approved agent as a molecular scaffold...
  5. pmc ⁶⁴Cu-labeled inhibitors of prostate-specific membrane antigen for PET imaging of prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21287, United States
    J Med Chem 57:2657-69. 2014
    ..That could be due to the higher stability of [(64)Cu]CB-TE2A as compared with [(64)Cu]NOTA, [(64)Cu]PCTA, [(64)Cu]Oxo-DO3A, and [(64)Cu]DOTA chelates in vivo. ..
  6. pmc 68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21231, USA
    J Med Chem 53:5333-41. 2010
    ..Both compounds delineated tumor clearly by small animal PET. The urea series of imaging agents for PSMA can be radiolabeled with (68)Ga, a cyclotron-free isotope useful for clinical PET studies, with maintenance of target specificity...
  7. pmc Effect of chelators on the pharmacokinetics of (99m)Tc-labeled imaging agents for the prostate-specific membrane antigen (PSMA)
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    J Med Chem 56:6108-21. 2013
    ..These results suggest that choice of chelator is an important pharmacokinetic consideration in the development of (99m)Tc-labeled radiopharmaceuticals targeting PSMA. ..
  8. pmc 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, Maryland, USA
    Clin Cancer Res 17:7645-53. 2011
    ..PSMA is upregulated in prostate cancer epithelia and in the neovasculature of most solid tumors...
  9. pmc Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465
    Ravindra A De Silva
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 52:986-93. 2011
    ..Our results show that (64)Cu-AMD3465 is capable of detecting lesions in a CXCR4-dependent fashion, with high target selectivity, and may offer a scaffold for the synthesis of clinically translatable agents...
  10. pmc Immunoimaging of CXCR4 expression in brain tumor xenografts using SPECT/CT
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 50:1124-30. 2009
    ..Here we report the results of SPECT/CT of CXCR4 expression levels in experimental brain tumors using (125)I-labeled anti-CXCR4 monoclonal antibodies (mAbs)...
  11. ncbi request reprint Bridged cyclams as imaging agents for chemokine receptor 4 (CXCR4)
    Lauren E Woodard
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, 21287
    Nucl Med Biol 41:552-61. 2014
    ..The biodistribution and PET/CT imaging studies with the radiolabeled bridged cyclams demonstrated longer tumor retention and comparable uptake to [(64)Cu]AMD3465, though [(64)Cu]AMD3465 demonstrated superior overall pharmacokinetics. ..
  12. pmc Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21231, USA
    Neoplasia 11:477-84. 2009
    ....
  13. pmc Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    J Med Chem 51:7933-43. 2008
    ..Because of the many radiohalogenated moieties that can be attached via the epsilon amino group, the intermediate Lys-C(O)-Glu is an attractive template upon which to develop new imaging agents for prostate cancer...
  14. pmc A robust approach to enhance tumor-selective accumulation of nanoparticles
    Yuan Qiao
    The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Oncotarget 2:59-68. 2011
    ....
  15. pmc Imaging virus-associated cancer
    De Xue Fu
    Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Curr Pharm Des 14:3048-65. 2008
    ..Under certain conditions, and particularly during pharmacologic stimulation, gammaherpesviruses will express genes that enable imaging and therapy in vivo. The techniques discussed are readily translatable to the clinic...
  16. pmc Metabolic signatures imaged in cancer-induced cachexia
    Marie France Penet
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 71:6948-56. 2011
    ....
  17. pmc Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals
    Stephanie L Davis
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS ONE 4:e6297. 2009
    ..Our goal was to use this reporter and develop non-invasive methods to detect and localize Mycobacterium tuberculosis...
  18. pmc Targeted molecular imaging in oncology: focus on radiation therapy
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD
    Semin Radiat Oncol 18:136-48. 2008
    ..This review focuses on recent advances in molecular imaging strategies and probes that may aid in improving the efficacy of radiotherapy...
  19. pmc Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression
    Amnon Bar-Shir
    Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Chem Soc 135:1617-24. 2013
    ..In light of these findings, this new approach can be generalized for designing specific probes for the in vivo imaging of a variety of proteins and enzymes...
  20. pmc CXCR4-based imaging agents
    Lauren E Woodard
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 52:1665-9. 2011
    ..This review focuses on recent developments in CXCR4-based imaging agents and their potential role in the molecular diagnosis and treatment of cancer...