G J Netto

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Molecular genetics and genomics progress in urothelial bladder cancer
    George J Netto
    Departments of Pathology, Urology and Oncology, Johns Hopkins University, 402 N Broadway Ave, Weinberg Building suite 2242, Baltimore, Maryland 21231 Electronic address
    Semin Diagn Pathol 30:313-20. 2013
  2. doi request reprint Dysregulation of mammalian target of rapamycin pathway in upper tract urothelial carcinoma
    Enrico Munari
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA Electronic address
    Hum Pathol 44:2668-76. 2013
  3. pmc Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer
    Satoshi Wada
    Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231, USA
    J Transl Med 11:89. 2013
  4. doi request reprint Clinical applications of recent molecular advances in urologic malignancies: no longer chasing a "mirage"?
    George J Netto
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
    Adv Anat Pathol 20:175-203. 2013
  5. pmc Emerging critical role of molecular testing in diagnostic genitourinary pathology
    George J Netto
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Arch Pathol Lab Med 136:372-90. 2012
  6. doi request reprint Theranostic and prognostic biomarkers: genomic applications in urological malignancies
    George J Netto
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Pathology 42:384-94. 2010
  7. ncbi request reprint Diagnostic molecular pathology: an increasingly indispensable tool for the practicing pathologist
    George J Netto
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Arch Pathol Lab Med 130:1339-48. 2006
  8. ncbi request reprint Interobserver agreement in hepatitis C grading and staging and in the Banff grading schema for acute cellular rejection: the "hepatitis C 3" multi-institutional trial experience
    George J Netto
    Departments of Pathology, Baylor University Medical Center, Dallas, Tex, USA
    Arch Pathol Lab Med 130:1157-62. 2006
  9. ncbi request reprint Radio-frequency ablation of hepatocellular carcinoma before liver transplantation: a histologic and 'TUNEL' study
    G J Netto
    Department of Pathology, Baylor University Medical Center, Dallas, TX, USA
    Liver Int 26:746-51. 2006
  10. doi request reprint Molecular biomarkers in urothelial carcinoma of the bladder: are we there yet?
    George J Netto
    Department of Pathology, James Buchanan Brady Urological Institute, Johns Hopkins University, 402 N Broadway Avenue, Weinberg Building suite 2242, Baltimore, MD 21231, USA
    Nat Rev Urol 9:41-51. 2012

Collaborators

Detail Information

Publications44

  1. doi request reprint Molecular genetics and genomics progress in urothelial bladder cancer
    George J Netto
    Departments of Pathology, Urology and Oncology, Johns Hopkins University, 402 N Broadway Ave, Weinberg Building suite 2242, Baltimore, Maryland 21231 Electronic address
    Semin Diagn Pathol 30:313-20. 2013
    ..The following is a brief discussion of some promising candidate biomarkers that may soon become a part of clinical management of bladder cancers. ..
  2. doi request reprint Dysregulation of mammalian target of rapamycin pathway in upper tract urothelial carcinoma
    Enrico Munari
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA Electronic address
    Hum Pathol 44:2668-76. 2013
    ..Dysregulation of the mTOR pathway was observed in UTUC compared with normal urothelium, implicating a potential pathogenic role in tumor development. In our cohort, expression of the evaluated biomarkers had no prognostic value. ..
  3. pmc Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer
    Satoshi Wada
    Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231, USA
    J Transl Med 11:89. 2013
    ..As a single agent, ipilimumab is also being clinically evaluated in advanced (metastatic, castrate-resistant) prostate cancer and two randomized, placebo-controlled Phase III studies have recently completed accrual...
  4. doi request reprint Clinical applications of recent molecular advances in urologic malignancies: no longer chasing a "mirage"?
    George J Netto
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
    Adv Anat Pathol 20:175-203. 2013
    ..The current review discusses the recent advances in prostate, bladder, renal, and testicular neoplasms that are pertinent to the anatomic pathologist...
  5. pmc Emerging critical role of molecular testing in diagnostic genitourinary pathology
    George J Netto
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Arch Pathol Lab Med 136:372-90. 2012
    ..In sharp contrast, molecular biomarkers have been largely excluded from current management algorithms of urologic malignancies...
  6. doi request reprint Theranostic and prognostic biomarkers: genomic applications in urological malignancies
    George J Netto
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Pathology 42:384-94. 2010
    ..The following review discusses some of the candidate biomarkers that may soon make their transition into clinically applicable assays in urological oncology patients...
  7. ncbi request reprint Diagnostic molecular pathology: an increasingly indispensable tool for the practicing pathologist
    George J Netto
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Arch Pathol Lab Med 130:1339-48. 2006
    ..Familiarity with some of the technologic principles and current, as well as upcoming, molecular diagnostic applications is greatly advantageous for today's practice of pathology...
  8. ncbi request reprint Interobserver agreement in hepatitis C grading and staging and in the Banff grading schema for acute cellular rejection: the "hepatitis C 3" multi-institutional trial experience
    George J Netto
    Departments of Pathology, Baylor University Medical Center, Dallas, Tex, USA
    Arch Pathol Lab Med 130:1157-62. 2006
    ..Establishing adequate interobserver agreement is crucial not only for standardization of patient care but also to ensure validity of findings in multi-institutional trials...
  9. ncbi request reprint Radio-frequency ablation of hepatocellular carcinoma before liver transplantation: a histologic and 'TUNEL' study
    G J Netto
    Department of Pathology, Baylor University Medical Center, Dallas, TX, USA
    Liver Int 26:746-51. 2006
    ..The current study evaluates the effectiveness of RFA in this setting based on evaluation of total cell death in explanted native livers...
  10. doi request reprint Molecular biomarkers in urothelial carcinoma of the bladder: are we there yet?
    George J Netto
    Department of Pathology, James Buchanan Brady Urological Institute, Johns Hopkins University, 402 N Broadway Avenue, Weinberg Building suite 2242, Baltimore, MD 21231, USA
    Nat Rev Urol 9:41-51. 2012
    ..Robust predictive biomarkers that are able to forecast and stratify responses to emerging targeted therapies are also needed...
  11. doi request reprint Molecular diagnostics in urologic malignancies: a work in progress
    George J Netto
    Department of Pathology, Johns Hopkins Medical Institutions, The Harry and Jeanette Weinberg Building, 401 N Broadway, Baltimore, MD 21231 2410, USA
    Arch Pathol Lab Med 135:610-21. 2011
    ..Several promising biomarkers for detection, prognosis, and targeted therapeutics are being evaluated...
  12. ncbi request reprint Recurrence of hepatitis C in liver transplant recipients treated with mycophenolate mofetil
    C G Fasola
    Transplantation Services, Baylor University Medical Center, 3500 Gaston Avenue, Roberts 4th Floor, Dallas, TX 75246, USA
    Transplant Proc 34:1563-4. 2002
  13. doi request reprint A distinctive subset of PEComas harbors TFE3 gene fusions
    Pedram Argani
    Department of Pathology and Oncology, The Johns Hopkins Medical Intuitions, Baltimore, MD, USA
    Am J Surg Pathol 34:1395-406. 2010
    ..Despite significant morphologic and immunohistochemical overlap with other PEComas, PEComas harboring TFE3 gene fusions may represent a distinctive entity...
  14. doi request reprint Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma
    Pedram Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 32:1353-9. 2008
    ..Fluorescence in situ hybridization analysis effectively separates these morphologically very similar yet genetically distinctive entities...
  15. pmc Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markers
    Pedram Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 34:1295-303. 2010
    ..Elevated expression of phosphorylated S6 in Xp11 translocation RCC suggests the mTOR pathway as an attractive potential therapeutic target for these neoplasms...
  16. ncbi request reprint Early prostate cancer antigen expression in predicting presence of prostate cancer in men with histologically negative biopsies
    D E Hansel
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Urol 177:1736-40. 2007
    ....
  17. pmc PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract
    Roula Albadine
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Am J Surg Pathol 34:965-9. 2010
    ..We investigated the expression pattern of PAX8 in CDC and its utility, in combination with p63, in resolving the differential diagnosis of CDC versus upper tract urothelial carcinoma (UUC)...
  18. doi request reprint Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidney
    Adeboye O Osunkoya
    Department of Pathology, Emory University School of Medicine, Room H174, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
    Am J Surg Pathol 33:1103-6. 2009
    ..Overall, these findings support the view that tubulocystic carcinoma and collecting duct carcinoma should be considered as 2 distinct entities at the molecular level...
  19. doi request reprint Prostatic adenocarcinoma in colorectal biopsy: clinical and pathologic features
    Zhaoli Lane
    Department of Pathology at the Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 39:543-9. 2008
    ..Immunohistochemical studies could help establish the diagnosis...
  20. ncbi request reprint Delay of hepatitis C recurrence in liver transplant recipients: impact of mycophenolate mofetil on transplant recipients with severe acute rejection or with renal dysfunction
    C G Fasola
    Transplantation Services, Baylor University Medical Center, 3500 Gaston Avenue, Roberts 4th Floor, Dallas, TX 75246, USA
    Transplant Proc 34:1561-2. 2002
  21. pmc TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas
    Tamara L Lotan
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Mod Pathol 22:359-65. 2009
    ....
  22. pmc Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues
    Andrew C Goodwin
    Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Prostate 68:766-72. 2008
    ....
  23. doi request reprint PSMA expression in Schwannoma: a potential clinical mimicker of metastatic prostate carcinoma
    Wenle Wang
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
    Urol Oncol 27:525-8. 2009
    ..The current study further evaluates PSMA expression in Schwannomas...
  24. ncbi request reprint Corticosteroid-free immunosuppression with daclizumab in HCV(+) liver transplant recipients: 1-year interim results of the HCV-3 study
    Goran B G Klintmalm
    Transplantation Services, Baylor University Medical Center, Dallas, TX 75246, USA
    Liver Transpl 13:1521-31. 2007
    ..In conclusion, these results suggest that a corticosteroid-free regimen of tacrolimus and MMF following daclizumab induction is safe and effective in HCV(+) liver transplant recipients...
  25. doi request reprint Conventional prostatic adenocarcinoma arising in a multilocular prostatic cystadenoma
    Thomas K Lee
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Pathol Int 60:413-6. 2010
    ..We report the first case of conventional prostatic adenocarcinoma involving a multilocular cystadenoma. Distinction from cystadenocarcinoma is also made...
  26. ncbi request reprint Distinguishing prostatic from colorectal adenocarcinoma on biopsy samples: the role of morphology and immunohistochemistry
    Christopher L Owens
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Arch Pathol Lab Med 131:599-603. 2007
    ..Such determination can affect prognosis and therapy...
  27. pmc DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma
    M Brait
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Br J Cancer 106:414-23. 2012
    ..The purpose of this study was to determine the methylation frequency of several cancer-related genes in different histological types of testicular cancer and normal testis tissues (NT)...
  28. ncbi request reprint The changing clinical presentation of recurrent primary biliary cirrhosis after liver transplantation
    Edmund Q Sanchez
    Baylor University Medical Center, Transplantation Services, Dallas, TX 75246, USA
    Transplantation 76:1583-8. 2003
    ..Recurrent primary biliary cirrhosis (RPBC) is a histologic diagnosis. Clinical data is unreliable in predicting or diagnosing recurrence. RPBC appears to have a changing clinical presentation in recent years...
  29. pmc TMPRSS2-ERG gene fusion status in minute (minimal) prostatic adenocarcinoma
    Roula Albadine
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Mod Pathol 22:1415-22. 2009
    ..Our finding of comparable rate of TMPRSS2-ERG fusion in minute adenocarcinomas may argue against its value as a marker of aggressive prostate carcinoma phenotype...
  30. pmc Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy
    Roula Albadine
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    J Urol 182:735-40. 2009
    ....
  31. ncbi request reprint Cadaveric orthotopic auxiliary split liver transplantation and kidney transplantation: an alternative for type 1 primary hyperoxaluria
    Nicholas Onaca
    Baylor Regional Transplant Institute, Dallas, TX, USA
    Transplantation 80:421-4. 2005
    ..Orthotopic auxiliary LTX is an alternative to whole LTX in PH1. By using a split deceased donor liver, it does not deprive the donor pool and protects the recipient from liver failure in case of graft loss...
  32. ncbi request reprint Liver and kidney transplantation for polycystic liver and kidney-renal function and outcome
    Takehisa Ueno
    Baylor Regional Transplant Institute, Dallas, TX 2 Dallas Transplant Institute, Dallas, TX, USA
    Transplantation 82:501-7. 2006
    ..Because of preservation of hepatic function in these patients, liver transplantation is not routinely utilized. We report a large series of PLD patients and their outcomes following liver and kidney transplantation...
  33. ncbi request reprint Colorectal adenocarcinoma involving the prostate: report of 9 cases
    Adeboye O Osunkoya
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 38:1836-41. 2007
    ..Immunohistochemical stains for beta-catenin, CDX2, carcinoembryonic antigen, high-molecular-weight cytokeratin, prostate-specific antigen, P501S (prostein), CK20, and CK7 can be helpful in making a definitive diagnosis...
  34. doi request reprint Fat-predominant mixed epithelial stromal tumor (MEST): report of a unique case mimicking angiomyolipoma
    Anthony N Sireci
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Surg Pathol 16:73-7. 2008
    ..Melanocytic markers HMB45 and Melan A, typically positive in angiomyolipoma, were nonreactive. This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma...
  35. ncbi request reprint Incidence and recurrence of autoimmune/alloimmune hepatitis in liver transplant recipients
    Ernesto P Molmenti
    Transplantation Services, Baylor University Medical Center, Dallas, TX 75246, USA
    Liver Transpl 8:519-26. 2002
    ..We cannot establish with certainty whether the observed process represents recurrence of the original autoimmune disease, an alloimmune phenomenon, or allograft dysfunction mimicking AIH...
  36. pmc Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytology
    Kazutoshi Fujita
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 40:924-33. 2009
    ..1, nucleolin, and 4'-6-diamidino-2-phenylindole to detect prostate cancer cells in urine. Further refinements in marker selection and technique may increase sensitivity and applicability for prostate cancer diagnosis...
  37. ncbi request reprint Hematologic aspects of liver transplantation for Budd-Chiari syndrome with special reference to myeloproliferative disorders
    Jason M Melear
    Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Transplantation 74:1090-5. 2002
    ..Because a significant proportion of BCS patients are found to have an underlying myeloproliferative disorder (MPD), antiplatelet therapy may be a more rational treatment strategy for this subgroup...
  38. ncbi request reprint Pretransplant MELD score as a predictor of outcome after liver transplantation for chronic hepatitis C
    Nicholas N Onaca
    Transplantation Services, Baylor University Medical Center, Dallas, TX, USA
    Am J Transplant 3:626-30. 2003
    ..Therapeutic modalities to decrease post-transplant graft injury in these patients should be explored...
  39. pmc Extracellular matrix associated protein CYR61 is linked to prostate cancer development
    Katherine B D'Antonio
    The Brady Urological Institute, Baltimore, Maryland 21287, USA
    J Urol 183:1604-10. 2010
    ..Depending on cancer type these changes are linked with enhanced or inhibited tumor growth. We characterized Cyr61 in prostate cancer. Cyr61 is an integrin binding matricellular protein with altered expression in many cancer types...
  40. pmc Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model
    Satoshi Wada
    Department of Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 69:4309-18. 2009
    ..Taken together, these data clarify the dose, timing, and mechanism of action by which immunomodulatory cyclophosphamide can be translated to a clinical setting in a combinatorial cancer treatment strategy...
  41. ncbi request reprint Widespread high-grade prostatic intraepithelial neoplasia on prostatic needle biopsy: a significant likelihood of subsequently diagnosed adenocarcinoma
    George J Netto
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1184-8. 2006
    ..In summary, our study reveals a 39% risk of finding PCa on repeat biopsies obtained after an initial diagnosis of widespread HGPIN. Our findings support the need for a repeat biopsy in this subset of patients...
  42. ncbi request reprint Radiofrequency thermal ablation of hepatocellular carcinoma before liver transplantation--a clinical and histological examination
    Adrian P Martin
    Baylor Regional Transplant Institute, Dallas, TX, USA
    Clin Transplant 20:695-705. 2006
    ..Radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) is an optional treatment for patients awaiting liver transplantation (LTX). The study evaluates the efficacy of RFA in the explanted liver and its effect on patient outcome...
  43. doi request reprint Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 cases
    Adeboye O Osunkoya
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:461-7. 2008
    ..Pathologists need to be aware of this rare and unusual phenomenon, which is a potential pitfall in prostate cancer diagnosis...
  44. pmc Profiling the expression pattern of GPI transamidase complex subunits in human cancer
    Jatin K Nagpal
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 21:979-91. 2008
    ..Collectively, our study defines a trend involving the deregulated expression and the functional contribution of the GPIT subunits in various cancers with potential implications in diagnosis, prognosis and therapeutic intervention...