Research Topics
| G J NettoSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Emerging critical role of molecular testing in diagnostic genitourinary pathologyGeorge J Netto
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
Arch Pathol Lab Med 136:372-90. 2012..In sharp contrast, molecular biomarkers have been largely excluded from current management algorithms of urologic malignancies...
Theranostic and prognostic biomarkers: genomic applications in urological malignanciesGeorge J Netto
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Pathology 42:384-94. 2010..The following review discusses some of the candidate biomarkers that may soon make their transition into clinically applicable assays in urological oncology patients...
Diagnostic molecular pathology: an increasingly indispensable tool for the practicing pathologistGeorge J Netto
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Arch Pathol Lab Med 130:1339-48. 2006..Familiarity with some of the technologic principles and current, as well as upcoming, molecular diagnostic applications is greatly advantageous for today's practice of pathology...- Interobserver agreement in hepatitis C grading and staging and in the Banff grading schema for acute cellular rejection: the "hepatitis C 3" multi-institutional trial experienceGeorge J Netto
Departments of Pathology, Baylor University Medical Center, Dallas, Tex, USA
Arch Pathol Lab Med 130:1157-62. 2006..Establishing adequate interobserver agreement is crucial not only for standardization of patient care but also to ensure validity of findings in multi-institutional trials... - Radio-frequency ablation of hepatocellular carcinoma before liver transplantation: a histologic and 'TUNEL' studyG J Netto
Department of Pathology, Baylor University Medical Center, Dallas, TX, USA
Liver Int 26:746-51. 2006..The current study evaluates the effectiveness of RFA in this setting based on evaluation of total cell death in explanted native livers... - Molecular diagnostics in urologic malignancies: a work in progressGeorge J Netto
Department of Pathology, Johns Hopkins Medical Institutions, The Harry and Jeanette Weinberg Building, 401 N Broadway, Baltimore, MD 21231 2410, USA
Arch Pathol Lab Med 135:610-21. 2011..Several promising biomarkers for detection, prognosis, and targeted therapeutics are being evaluated... - Molecular biomarkers in urothelial carcinoma of the bladder: are we there yet?George J Netto
Department of Pathology, James Buchanan Brady Urological Institute, Johns Hopkins University, 402 N Broadway Avenue, Weinberg Building suite 2242, Baltimore, MD 21231, USA
Nat Rev Urol 9:41-51. 2012..Robust predictive biomarkers that are able to forecast and stratify responses to emerging targeted therapies are also needed... - Recurrence of hepatitis C in liver transplant recipients treated with mycophenolate mofetilC G Fasola
Transplantation Services, Baylor University Medical Center, 3500 Gaston Avenue, Roberts 4th Floor, Dallas, TX 75246, USA
Transplant Proc 34:1563-4. 2002 - A distinctive subset of PEComas harbors TFE3 gene fusionsPedram Argani
Department of Pathology and Oncology, The Johns Hopkins Medical Intuitions, Baltimore, MD, USA
Am J Surg Pathol 34:1395-406. 2010..Despite significant morphologic and immunohistochemical overlap with other PEComas, PEComas harboring TFE3 gene fusions may represent a distinctive entity... - Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinomaPedram Argani
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 32:1353-9. 2008..Fluorescence in situ hybridization analysis effectively separates these morphologically very similar yet genetically distinctive entities... - Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markersPedram Argani
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 34:1295-303. 2010..Elevated expression of phosphorylated S6 in Xp11 translocation RCC suggests the mTOR pathway as an attractive potential therapeutic target for these neoplasms... - Early prostate cancer antigen expression in predicting presence of prostate cancer in men with histologically negative biopsiesD E Hansel
Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21231, USA
J Urol 177:1736-40. 2007.... - PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tractRoula Albadine
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Am J Surg Pathol 34:965-9. 2010..We investigated the expression pattern of PAX8 in CDC and its utility, in combination with p63, in resolving the differential diagnosis of CDC versus upper tract urothelial carcinoma (UUC)... - Comparison of gene expression profiles in tubulocystic carcinoma and collecting duct carcinoma of the kidneyAdeboye O Osunkoya
Department of Pathology, Emory University School of Medicine, Room H174, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
Am J Surg Pathol 33:1103-6. 2009..Overall, these findings support the view that tubulocystic carcinoma and collecting duct carcinoma should be considered as 2 distinct entities at the molecular level... - Prostatic adenocarcinoma in colorectal biopsy: clinical and pathologic featuresZhaoli Lane
Department of Pathology at the Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Hum Pathol 39:543-9. 2008..Immunohistochemical studies could help establish the diagnosis... - Delay of hepatitis C recurrence in liver transplant recipients: impact of mycophenolate mofetil on transplant recipients with severe acute rejection or with renal dysfunctionC G Fasola
Transplantation Services, Baylor University Medical Center, 3500 Gaston Avenue, Roberts 4th Floor, Dallas, TX 75246, USA
Transplant Proc 34:1561-2. 2002 - PSMA expression in Schwannoma: a potential clinical mimicker of metastatic prostate carcinomaWenle Wang
Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
Urol Oncol 27:525-8. 2009..The current study further evaluates PSMA expression in Schwannomas... - Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissuesAndrew C Goodwin
Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Prostate 68:766-72. 2008.... - Corticosteroid-free immunosuppression with daclizumab in HCV(+) liver transplant recipients: 1-year interim results of the HCV-3 studyGoran B G Klintmalm
Transplantation Services, Baylor University Medical Center, Dallas, TX 75246, USA
Liver Transpl 13:1521-31. 2007..In conclusion, these results suggest that a corticosteroid-free regimen of tacrolimus and MMF following daclizumab induction is safe and effective in HCV(+) liver transplant recipients... - TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomasTamara L Lotan
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Mod Pathol 22:359-65. 2009.... - Distinguishing prostatic from colorectal adenocarcinoma on biopsy samples: the role of morphology and immunohistochemistryChristopher L Owens
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
Arch Pathol Lab Med 131:599-603. 2007..Such determination can affect prognosis and therapy... - Conventional prostatic adenocarcinoma arising in a multilocular prostatic cystadenomaThomas K Lee
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
Pathol Int 60:413-6. 2010..We report the first case of conventional prostatic adenocarcinoma involving a multilocular cystadenoma. Distinction from cystadenocarcinoma is also made... - Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapyRoula Albadine
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
J Urol 182:735-40. 2009.... - Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytologyKazutoshi Fujita
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Hum Pathol 40:924-33. 2009..1, nucleolin, and 4'-6-diamidino-2-phenylindole to detect prostate cancer cells in urine. Further refinements in marker selection and technique may increase sensitivity and applicability for prostate cancer diagnosis... - TMPRSS2-ERG gene fusion status in minute (minimal) prostatic adenocarcinomaRoula Albadine
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Mod Pathol 22:1415-22. 2009..Our finding of comparable rate of TMPRSS2-ERG fusion in minute adenocarcinomas may argue against its value as a marker of aggressive prostate carcinoma phenotype... - Incidence and recurrence of autoimmune/alloimmune hepatitis in liver transplant recipientsErnesto P Molmenti
Transplantation Services, Baylor University Medical Center, Dallas, TX 75246, USA
Liver Transpl 8:519-26. 2002..We cannot establish with certainty whether the observed process represents recurrence of the original autoimmune disease, an alloimmune phenomenon, or allograft dysfunction mimicking AIH... - Fat-predominant mixed epithelial stromal tumor (MEST): report of a unique case mimicking angiomyolipomaAnthony N Sireci
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Int J Surg Pathol 16:73-7. 2008..Melanocytic markers HMB45 and Melan A, typically positive in angiomyolipoma, were nonreactive. This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma... - Colorectal adenocarcinoma involving the prostate: report of 9 casesAdeboye O Osunkoya
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Hum Pathol 38:1836-41. 2007..Immunohistochemical stains for beta-catenin, CDX2, carcinoembryonic antigen, high-molecular-weight cytokeratin, prostate-specific antigen, P501S (prostein), CK20, and CK7 can be helpful in making a definitive diagnosis... - The changing clinical presentation of recurrent primary biliary cirrhosis after liver transplantationEdmund Q Sanchez
Baylor University Medical Center, Transplantation Services, Dallas, TX 75246, USA
Transplantation 76:1583-8. 2003..Controlled randomized studies are necessary to determine differences between tacrolimus and cyclosporine treatment, if any... - Cadaveric orthotopic auxiliary split liver transplantation and kidney transplantation: an alternative for type 1 primary hyperoxaluriaNicholas Onaca
Baylor Regional Transplant Institute, Dallas, TX, USA
Transplantation 80:421-4. 2005..Orthotopic auxiliary LTX is an alternative to whole LTX in PH1. By using a split deceased donor liver, it does not deprive the donor pool and protects the recipient from liver failure in case of graft loss... - Liver and kidney transplantation for polycystic liver and kidney-renal function and outcomeTakehisa Ueno
Baylor Regional Transplant Institute, Dallas, TX. 2 Dallas Transplant Institute, Dallas, TX, USA
Transplantation 82:501-7. 2006..For patients with acceptable renal function at time of transplantation, solitary liver transplantation has an excellent outcome... - Profiling the expression pattern of GPI transamidase complex subunits in human cancerJatin K Nagpal
Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Mod Pathol 21:979-91. 2008..Collectively, our study defines a trend involving the deregulated expression and the functional contribution of the GPIT subunits in various cancers with potential implications in diagnosis, prognosis and therapeutic intervention... - Hematologic aspects of liver transplantation for Budd-Chiari syndrome with special reference to myeloproliferative disordersJason M Melear
Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
Transplantation 74:1090-5. 2002..For those patients with conditions not corrected by OLT or with idiopathic BCS, anticoagulation or other therapy to control the hypercoagulable state should be given... - Pretransplant MELD score as a predictor of outcome after liver transplantation for chronic hepatitis CNicholas N Onaca
Transplantation Services, Baylor University Medical Center, Dallas, TX, USA
Am J Transplant 3:626-30. 2003..Therapeutic modalities to decrease post-transplant graft injury in these patients should be explored... - Widespread high-grade prostatic intraepithelial neoplasia on prostatic needle biopsy: a significant likelihood of subsequently diagnosed adenocarcinomaGeorge J Netto
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 30:1184-8. 2006..In summary, our study reveals a 39% risk of finding PCa on repeat biopsies obtained after an initial diagnosis of widespread HGPIN. Our findings support the need for a repeat biopsy in this subset of patients... - Radiofrequency thermal ablation of hepatocellular carcinoma before liver transplantation--a clinical and histological examinationAdrian P Martin
Baylor Regional Transplant Institute, Dallas, TX, USA
Clin Transplant 20:695-705. 2006..H&E stain tends to under-represent the amount of tumor necrosis on the ablation sites. Survival of RFA patients after LTX is excellent... - Extracellular matrix associated protein CYR61 is linked to prostate cancer developmentKatherine B D'Antonio
The Brady Urological Institute, Baltimore, Maryland 21287, USA
J Urol 183:1604-10. 2010..Depending on cancer type these changes are linked with enhanced or inhibited tumor growth. We characterized Cyr61 in prostate cancer. Cyr61 is an integrin binding matricellular protein with altered expression in many cancer types... - Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer modelSatoshi Wada
Department of Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Cancer Res 69:4309-18. 2009..Taken together, these data clarify the dose, timing, and mechanism of action by which immunomodulatory cyclophosphamide can be translated to a clinical setting in a combinatorial cancer treatment strategy... - Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 casesAdeboye O Osunkoya
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 32:461-7. 2008..Pathologists need to be aware of this rare and unusual phenomenon, which is a potential pitfall in prostate cancer diagnosis...