G Nestadt

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint A family study of obsessive-compulsive disorder
    G Nestadt
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 57:358-63. 2000
  2. pmc Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Hum Genet 67:1611-6. 2000
  3. pmc Obsessive-compulsive disorder: subclassification based on co-morbidity
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Psychol Med 39:1491-501. 2009
  4. doi request reprint A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families
    Y Y Shugart
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21044, USA
    Am J Med Genet B Neuropsychiatr Genet 150:886-92. 2009
  5. doi request reprint A screen of SLC1A1 for OCD-related alleles
    Y Wang
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Am J Med Genet B Neuropsychiatr Genet 153:675-9. 2010
  6. doi request reprint Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:1-13. 2012
  7. doi request reprint Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:710-20. 2009
  8. ncbi request reprint Normal personality traits and comorbidity among phobic, panic and major depressive disorders
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University JHU, Baltimore, MD 21287, USA
    Psychiatry Res 102:73-85. 2001
  9. doi request reprint Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder families
    Y Wang
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:33-40. 2009
  10. ncbi request reprint The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Psychol Med 31:481-7. 2001

Collaborators

Detail Information

Publications22

  1. ncbi request reprint A family study of obsessive-compulsive disorder
    G Nestadt
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 57:358-63. 2000
    ..Evidence of familial aggregation is one approach for investigating the role of genetics in the etiology of this condition. The current study was conducted to determine ifOCD is familial and to investigate possible familial subtypes...
  2. pmc Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Hum Genet 67:1611-6. 2000
    ....
  3. pmc Obsessive-compulsive disorder: subclassification based on co-morbidity
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Psychol Med 39:1491-501. 2009
    ..Many patients manifest other psychiatric syndromes. This study investigated the relationship between OCD and co-morbid conditions to identify subtypes...
  4. doi request reprint A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families
    Y Y Shugart
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21044, USA
    Am J Med Genet B Neuropsychiatr Genet 150:886-92. 2009
    ..5 kb away from the boundary of the SLC1A1 gene. However, this potential finding needs to be validated biologically. Further functional studies in this region are planned by this research group...
  5. doi request reprint A screen of SLC1A1 for OCD-related alleles
    Y Wang
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Am J Med Genet B Neuropsychiatr Genet 153:675-9. 2010
    ..Further investigation of this variant is necessary to determine whether and how it is related to OCD. There was no other evidence of significant accumulation of deleterious coding mutations in SLC1A1 in the OCD cases...
  6. doi request reprint Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:1-13. 2012
    ..The current study uses co-morbidity and familiality data to inform these issues...
  7. doi request reprint Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:710-20. 2009
    ..We conclude that Sapap3 is a promising functional candidate gene for human GDs, though further work is necessary to confirm this preliminary evidence of association...
  8. ncbi request reprint Normal personality traits and comorbidity among phobic, panic and major depressive disorders
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University JHU, Baltimore, MD 21287, USA
    Psychiatry Res 102:73-85. 2001
    ..Therefore, neuroticism and introversion are associated with increased comorbidity due to relationships in common with the prevalence of the different disorders. In contrast, extraversion is associated with increased comorbidity per se...
  9. doi request reprint Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder families
    Y Wang
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:33-40. 2009
    ..No SNP showed significant association with the OCD phenotype only in the families with a female proband. The results suggest a possible gender effect in the etiology of OCD...
  10. ncbi request reprint The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Psychol Med 31:481-7. 2001
    ..CONCLUSION: GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome...
  11. pmc Homeobox genes in obsessive-compulsive disorder
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 159:53-60. 2012
    ..The OCD Collaborative Genetics Study (OCGS) has identified several OCD susceptibility loci through linkage analysis...
  12. ncbi request reprint The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study
    M A Grados
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA
    Biol Psychiatry 50:559-65. 2001
    ..CONCLUSIONS: Tic disorders constitute an alternate expression of the familial OCD phenotype...
  13. pmc Concordance between personality disorder assessment methods
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:657-67. 2012
    ..Studies have criticized the low level of agreement between the various methods of personality disorder (PD) assessment. This is an important issue for research and clinical purposes...
  14. ncbi request reprint Hoarding in obsessive compulsive disorder: results from a case-control study
    J Samuels
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore 21287, USA
    Behav Res Ther 40:517-28. 2002
    ..Hoarding appears to be transmitted in some OCD families and may differentiate a clinical subgroup of OCD...
  15. ncbi request reprint Phobic, panic, and major depressive disorders and the five-factor model of personality
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
    J Nerv Ment Dis 189:154-61. 2001
    ..This study emphasizes the utility of lower-order personality assessments and underscores the need for further research on personality/psychopathology etiologic relationships...
  16. ncbi request reprint Epidemiology of personality disorders
    N Sater
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287-7481, USA
    Curr Psychiatry Rep 3:41-5. 2001
    ..This paper reviews and discusses empiric advances made over the past 2 years in the epidemiologic study of personality disorders...
  17. ncbi request reprint Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes
    A E Pulver
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Mol Psychiatry 5:650-3. 2000
    ..008). The identification of multiple susceptibility loci for schizophrenia may be enhanced by stratification of families using psychiatric diagnoses of the non-schizophrenic relatives...
  18. pmc Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients
    A Hatzimanolis
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transl Psychiatry 3:e264. 2013
    ..On the basis of this, we propose a general model of pathway heterogeneity in SZ, which, in part, may explain its phenotypic variability and genetic complexity...
  19. ncbi request reprint An epidemiological study of histrionic personality disorder
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Psychol Med 20:413-22. 1990
    ..The diagnosis is associated with clear evidence of disturbance in the emotional, behavioural, and social realms. Individuals with this disorder tend to use health care facilities more frequently than others...
  20. ncbi request reprint Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q
    Y Y Shugart
    Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Mol Psychiatry 11:763-70. 2006
    ..Given probable etiologic heterogeneity in OCD, mapping gene(s) involved in the disorder may be enhanced by replication studies, large-scale family-based linkage studies, and the application of novel statistical methods...
  21. ncbi request reprint Adult antisocial personality traits are associated with experiences of low parental care and maternal overprotection
    I M Reti
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Acta Psychiatr Scand 106:126-33. 2002
    ..To investigate the role of parenting in the development of adult antisocial personality traits...
  22. ncbi request reprint Rare plus common SERT variants in obsessive-compulsive disorder
    M A Grados
    Mol Psychiatry 12:422-3. 2007