Research Topics
Species | G NestadtSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Agoraphobia in adults: incidence and longitudinal relationship with panicO Joseph Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 101, Baltimore, MD 21287, USA
Br J Psychiatry 188:432-8. 2006..Theories regarding how spontaneous panic and agoraphobia relate are based mostly on cross-sectional and/or clinic data...
Concordance between personality disorder assessment methodsG Nestadt
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Psychol Med 42:657-67. 2012..Studies have criticized the low level of agreement between the various methods of personality disorder (PD) assessment. This is an important issue for research and clinical purposes...
Obsessive-compulsive disorder: subclassification based on co-morbidityG Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Psychol Med 39:1491-501. 2009..Many patients manifest other psychiatric syndromes. This study investigated the relationship between OCD and co-morbid conditions to identify subtypes...- Homeobox genes in obsessive-compulsive disorderG Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 159:53-60. 2012..The OCD Collaborative Genetics Study (OCGS) has identified several OCD susceptibility loci through linkage analysis... - The stability of DSM personality disorders over twelve to eighteen yearsGerald Nestadt
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Meyer 113, Baltimore, Maryland 21287, USA
J Psychiatr Res 44:1-7. 2010..The aim of this study is to investigate the stability of DSM-III personality disorders in a community sample of eastern Baltimore residents unselected for treatment... - The relationship between the five-factor model and latent Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition personality disorder dimensionsGerald Nestadt
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Compr Psychiatry 49:98-105. 2008..Whether additional maladaptive traits would better define the domain of PDs remains an important objective for future research... - Genetics of obsessive-compulsive disorderGerald Nestadt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Meyer 113, 600 North Wolfe Street, Baltimore, MD 21287, USA
Psychiatr Clin North Am 33:141-58. 2010..The condition probably has a complex pattern of inheritance. Molecular studies have identified several potentially relevant genes, but much additional research is needed to establish definitive causes of the condition... - Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspectiveO J Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Psychol Med 42:1-13. 2012..The current study uses co-morbidity and familiality data to inform these issues... - A screen of SLC1A1 for OCD-related allelesY Wang
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
Am J Med Genet B Neuropsychiatr Genet 153:675-9. 2010..Further investigation of this variant is necessary to determine whether and how it is related to OCD. There was no other evidence of significant accumulation of deleterious coding mutations in SLC1A1 in the OCD cases... - Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics studyO J Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 150:710-20. 2009..We conclude that Sapap3 is a promising functional candidate gene for human GDs, though further work is necessary to confirm this preliminary evidence of association... - Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sexG Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
Am J Hum Genet 67:1611-6. 2000.... - A family study of obsessive-compulsive disorderG Nestadt
Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Arch Gen Psychiatry 57:358-63. 2000..Evidence of familial aggregation is one approach for investigating the role of genetics in the etiology of this condition. The current study was conducted to determine ifOCD is familial and to investigate possible familial subtypes... - A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 familiesY Y Shugart
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21044, USA
Am J Med Genet B Neuropsychiatr Genet 150:886-92. 2009..5 kb away from the boundary of the SLC1A1 gene. However, this potential finding needs to be validated biologically. Further functional studies in this region are planned by this research group... - Normal personality traits and comorbidity among phobic, panic and major depressive disordersO J Bienvenu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University JHU, Baltimore, MD 21287, USA
Psychiatry Res 102:73-85. 2001..Therefore, neuroticism and introversion are associated with increased comorbidity due to relationships in common with the prevalence of the different disorders. In contrast, extraversion is associated with increased comorbidity per se... - Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder familiesY Wang
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Am J Med Genet B Neuropsychiatr Genet 150:33-40. 2009..No SNP showed significant association with the OCD phenotype only in the families with a female proband. The results suggest a possible gender effect in the etiology of OCD... - The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family studyM A Grados
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA
Biol Psychiatry 50:559-65. 2001..CONCLUSIONS: Tic disorders constitute an alternate expression of the familial OCD phenotype... - Phobic, panic, and major depressive disorders and the five-factor model of personalityO J Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
J Nerv Ment Dis 189:154-61. 2001..This study emphasizes the utility of lower-order personality assessments and underscores the need for further research on personality/psychopathology etiologic relationships... - Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6qY Y Shugart
Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21287, USA
Mol Psychiatry 11:763-70. 2006..Given probable etiologic heterogeneity in OCD, mapping gene(s) involved in the disorder may be enhanced by replication studies, large-scale family-based linkage studies, and the application of novel statistical methods... - The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family StudyG Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
Psychol Med 31:481-7. 2001..CONCLUSION: GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome... - The identification of OCD-related subgroups based on comorbidityGerald Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
Biol Psychiatry 53:914-20. 2003..This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups... - The OCD collaborative genetics study: methods and sample descriptionJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-7228, USA
Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006.... - Hoarding in obsessive compulsive disorder: results from a case-control studyJ Samuels
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore 21287, USA
Behav Res Ther 40:517-28. 2002..Hoarding appears to be transmitted in some OCD families and may differentiate a clinical subgroup of OCD... - Familiality of novel factorial dimensions of schizophreniaJohn A McGrath
Department of Psychiatry, The Johns Hopkins University School of Medicine, 1820 Lancaster St, Ste 300, Baltimore, MD 21231, USA
Arch Gen Psychiatry 66:591-600. 2009..Examination of familiality of factor scores can demonstrate whether they are likely to be of use in genetic research... - Adult antisocial personality traits are associated with experiences of low parental care and maternal overprotectionI M Reti
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Acta Psychiatr Scand 106:126-33. 2002..CONCLUSION: Adult antisocial personality traits are associated with experiences of low parental care and maternal overprotection... - An epidemiological study of histrionic personality disorderG Nestadt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Psychol Med 20:413-22. 1990..The diagnosis is associated with clear evidence of disturbance in the emotional, behavioural, and social realms. Individuals with this disorder tend to use health care facilities more frequently than others... - Epidemiology of personality disordersN Sater
Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287-7481, USA
Curr Psychiatry Rep 3:41-5. 2001..This paper reviews and discusses empiric advances made over the past 2 years in the epidemiologic study of personality disorders... - Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypesA E Pulver
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Mol Psychiatry 5:650-3. 2000..008). The identification of multiple susceptibility loci for schizophrenia may be enhanced by stratification of families using psychiatric diagnoses of the non-schizophrenic relatives... - Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics StudyJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
Behav Res Ther 45:673-86. 2007..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families... - Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics StudyJack Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
Am J Psychiatry 164:493-9. 2007..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder... - Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Depress Anxiety 25:218-24. 2008..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner... - An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophreniaAnn E Pulver
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
Am J Med Genet B Neuropsychiatr Genet 124:6-9. 2004..The failure to support the paternal age hypothesis may be a function of heterogeneous samples, but calls for further research in the context of family studies... - Personality disorder traits as predictors of subsequent first-onset panic disorder or agoraphobiaO Joseph Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Compr Psychiatry 50:209-14. 2009..These results suggest that avoidant and dependent personality traits are predisposing factors, or at least markers of risk, for panic disorder and agoraphobia-not simply epiphenomena... - Influences of parenting on normal personality traitsIrving M Reti
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 600 N Wolfe St, Meyer 3 181, Baltimore, MD 21205, USA
Psychiatry Res 111:55-64. 2002.... - Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoardingKung Yee Liang
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 147:1000-2. 2008.... - Sex-specific clinical correlates of hoarding in obsessive-compulsive disorderJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
Behav Res Ther 46:1040-6. 2008..These findings indicate that specific clinical correlates of hoarding in OCD are different in men and women and may reflect sex-specific differences in the course, expression, and/or etiology of hoarding behavior in OCD... - Social and communication difficulties and obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Psychopathology 41:194-200. 2008..In this study we sought to establish if there is any association between the presence of abnormal pragmatic behaviors and OCD and whether this association delineates a familial subtype of OCD... - Utility of the Leyton Obsessional Inventory to distinguish OCD and OCPDDavid Wellen
Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Depress Anxiety 24:301-6. 2007..These findings may contribute to effective diagnosis and treatment by allowing the LOI to screen for OCD and OCPD in a population exhibiting obsessional symptoms and traits... - Prevalence and correlates of hoarding behavior in a community-based sampleJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 109, Baltimore, MD 21287 7228, USA
Behav Res Ther 46:836-44. 2008..These findings suggest that hoarding may be relatively prevalent and that alcohol dependence, personality disorder traits, and specific childhood adversities are associated with hoarding in the community... - Factor analysis of the Yale-Brown Obsessive Compulsive Scale in a family study of obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Depress Anxiety 24:130-8. 2007..There were specific clinical correlates for these factors, and significant intrafamilial sib-sib correlations were found for the Symmetry/Order and Hoarding factors... - Anxiety and depressive disorders and the five-factor model of personality: a higher- and lower-order personality trait investigation in a community sampleO Joseph Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Depress Anxiety 20:92-7. 2004..Neuroticism in particular was related to acuity of disorder. Longitudinal study is necessary to differentiate state versus pathoplastic effects... - Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuseIrving M Reti
The School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Compr Psychiatry 52:188-94. 2011..The 30-base pair variable number tandem repeat in the MAOA promoter regulates MAOA levels, but its effects on ASP in humans are unclear... - The association between parental bonding and obsessive compulsive disorder in offspring at high familial riskHolly C Wilcox
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7228, USA
J Affect Disord 111:31-9. 2008..The aim of the current study is to estimate the association between parenting factors derived from the Parental Bonding Instrument (PBI) and a lifetime DSM-IV diagnosis of OCD... - Personality disorders and traits as predictors of incident cardiovascular disease: findings from the 23-year follow-up of the Baltimore ECA studyHochang Benjamin Lee
The Johns Hopkins University School of Medicine, 4th Floor, 5300 Alpha Commons Drive, Baltimore, MD 21224, USA
Psychosomatics 51:289-96. 2010..Over the past several decades, the relationship between personality traits and heart disease has interested clinicians and researchers alike... - Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorderVirginia L Willour
Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
Am J Hum Genet 75:508-13. 2004..046 and .02, respectively) for association... - Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22M Daniele Fallin
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21231, USA
Am J Hum Genet 73:601-11. 2003..2 Mb for the location of the trait locus (D10S1677 to D10S1753). We find these results encouraging for the study of schizophrenia among Ashkenazi families and suggest further linkage and association studies in this chromosome 10q region... - Obsessive-compulsive disorder: defining the phenotypeGerald Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
J Clin Psychiatry 63:5-7. 2002..This article describes a family-study approach for identifying the spectrum of conditions related to OCD and subtyping OCD cases into homogeneous subtypes... - Five latent factors underlying schizophrenia: analysis and relationship to illnesses in relativesJohn A McGrath
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Schizophr Bull 30:855-73. 2004..Increased early onset/developmental signs in the proband were also associated with increased risk for depression in relatives. These findings suggest a possible endophenotypic role for the factor scores in future studies... - Prevalence and correlates of personality disorders in a community sampleJack Samuels
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Br J Psychiatry 180:536-42. 2002..CONCLUSIONS: Approximately 9% of this community sample has a DSM-IV personality disorder. Personality disorders are over-represented in certain demographic subgroups of the community... - Population-based study of first onset and chronicity in major depressive disorderWilliam W Eaton
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Arch Gen Psychiatry 65:513-20. 2008..There are no studies of the natural history of major depressive disorder that lack prevalence and clinic biases... - Relationship between cortisol responses to stress and personalityLynn M Oswald
Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuropsychopharmacology 31:1583-91. 2006..These findings suggest that personality traits that have been traditionally associated with greater psychopathology were also associated with blunted HPA axis responses to stress... - Personality dimensions and criminal arrestJack Samuels
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Compr Psychiatry 45:275-80. 2004..The results suggest that specific dimensions of normal personality are related to criminal arrest in the community... - Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish familiesM Daniele Fallin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am J Hum Genet 75:204-19. 2004.... - Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent triosM Daniele Fallin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
Am J Hum Genet 77:918-36. 2005..They provide further support for shared genetic susceptibility between these two disorders that involve glutamate-signaling pathways... - Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophreniaPei Lung Chen
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Hum Genet 84:21-34. 2009..These biological properties together with our linkage and association results strongly support NRG3 as a gene involved in SZ... - Latent structure of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition personality disorder criteriaGerald Nestadt
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Compr Psychiatry 47:54-62. 2006.... - Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish womenYaping Liu
Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Psychiatr Genet 20:184-6. 2010..Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype--phenotype correlations... - Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B geneDimitrios Avramopoulos
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
Genet Med 9:745-51. 2007..This study is a second stage follow-up focusing on regions that showed positive linkage scores in our previous scan but were not fine-mapped at that time... - Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-respondersMona A Mohamed
The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States
Psychiatry Res 156:175-9. 2007..Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor... - The longitudinal relationship between personality disorder dimensions and global functioning in a community-residing populationJin Pyo Hong
Department of Psychiatry, Asian Medical Center, School of Medicine, Ulsan University, Seoul, Korea
Psychol Med 35:891-5. 2005..This suggests that the functional effect of the other personality disorder traits may be mediated through their relationship with Axis I disorders. Future research is needed using more specific and sensitive outcome measures... - Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sampleEmil F Coccaro
Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, University of Chicago, IL 60637, USA
J Clin Psychiatry 65:820-4. 2004..To determine the lifetime and 1-month prevalence of intermittent explosive disorder (IED) by both DSM-IV and research criteria in a community sample... - No major schizophrenia locus detected on chromosome 1q in a large multicenter sampleDouglas F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 296:739-41. 2002..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small... - Clinical correlates of recurrent major depression in obsessive-compulsive disorderJin Pyo Hong
Department of Psychiatry, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
Depress Anxiety 20:86-91. 2004..In a multiple logistic regression model, only early age of OCD diagnosis was significantly associated with RDD. Early age at onset of OCD increases the risk of depressive disorder in individuals with OCD... - Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics StudyGregor Hasler
Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Biol Psychiatry 61:617-25. 2007..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions... - Practice guideline for the treatment of patients with obsessive-compulsive disorderLorrin M Koran
Am J Psychiatry 164:5-53. 2007 - Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categoriesAnthony Pinto
Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
Psychiatry Res 160:83-93. 2008..The results support investigation of this multidimensional model in OCD genetic linkage studies... - Serotonin-norepinephrine reuptake inhibitors in the treatment of obsessive-compulsive disorder: A critical reviewGerald Nestadt
Department of Psychiatry, Compulsive, Impulsive and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Psychiatry 67:600-10. 2006..Double-blind, placebo-controlled studies are, however, needed to confirm the positive findings reported by several studies with venlafaxine... - Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: SchizophreniaCathryn M Lewis
Division of Genetics and Development, Guy's, King's and St Thomas' School of Medicine, London, UK
Am J Hum Genet 73:34-48. 2003..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
Research Grants
- Collaborative OCD Genetics StudyGerald Nestadt; Fiscal Year: 2005..abstract_text> ..
- EPIDEMIOLOGY OF PERSONALITY DISORDERSGerald Nestadt; Fiscal Year: 2007..Building on our previous contributions, this proposal applies innovative constructs of disordered personality and rigorous analytic strategies. ..
- OCD Collaborative Genetics Association StudyGerald Nestadt; Fiscal Year: 2007..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..
- FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDERGerald Nestadt; Fiscal Year: 1999..Families with multiple affected members with OCD will be identified to possible future genetic linkage study. ..
- EPIDEMIOLOGY OF PERSONALITY DISORDERSGerald Nestadt; Fiscal Year: 2000..It provides an unusual opportunity to develop insights into personality disorders; their diagnosis, population rates and distribution, and course and consequences. ..
- OCD Collaborative Genetics Association StudyGerald Nestadt; Fiscal Year: 2010..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..