G Nestadt

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Agoraphobia in adults: incidence and longitudinal relationship with panic
    O Joseph Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 101, Baltimore, MD 21287, USA
    Br J Psychiatry 188:432-8. 2006
  2. pmc Concordance between personality disorder assessment methods
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:657-67. 2012
  3. pmc Genetics of obsessive-compulsive disorder
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Meyer 113, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Psychiatr Clin North Am 33:141-58. 2010
  4. pmc The relationship between the five-factor model and latent Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition personality disorder dimensions
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Compr Psychiatry 49:98-105. 2008
  5. pmc The stability of DSM personality disorders over twelve to eighteen years
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Meyer 113, Baltimore, Maryland 21287, USA
    J Psychiatr Res 44:1-7. 2010
  6. pmc Obsessive-compulsive disorder: subclassification based on co-morbidity
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Psychol Med 39:1491-501. 2009
  7. pmc Homeobox genes in obsessive-compulsive disorder
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 159:53-60. 2012
  8. doi request reprint Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:1-13. 2012
  9. doi request reprint A screen of SLC1A1 for OCD-related alleles
    Y Wang
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Am J Med Genet B Neuropsychiatr Genet 153:675-9. 2010
  10. doi request reprint Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:710-20. 2009

Research Grants

  1. Collaborative OCD Genetics Study
    Gerald Nestadt; Fiscal Year: 2005
  2. EPIDEMIOLOGY OF PERSONALITY DISORDERS
    Gerald Nestadt; Fiscal Year: 2007
  3. OCD Collaborative Genetics Association Study
    Gerald Nestadt; Fiscal Year: 2007
  4. FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDER
    Gerald Nestadt; Fiscal Year: 1999
  5. EPIDEMIOLOGY OF PERSONALITY DISORDERS
    Gerald Nestadt; Fiscal Year: 2000
  6. OCD Collaborative Genetics Association Study
    Gerald Nestadt; Fiscal Year: 2010

Detail Information

Publications68

  1. ncbi request reprint Agoraphobia in adults: incidence and longitudinal relationship with panic
    O Joseph Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 101, Baltimore, MD 21287, USA
    Br J Psychiatry 188:432-8. 2006
    ..Theories regarding how spontaneous panic and agoraphobia relate are based mostly on cross-sectional and/or clinic data...
  2. pmc Concordance between personality disorder assessment methods
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:657-67. 2012
    ..Studies have criticized the low level of agreement between the various methods of personality disorder (PD) assessment. This is an important issue for research and clinical purposes...
  3. pmc Genetics of obsessive-compulsive disorder
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Meyer 113, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Psychiatr Clin North Am 33:141-58. 2010
    ..The condition probably has a complex pattern of inheritance. Molecular studies have identified several potentially relevant genes, but much additional research is needed to establish definitive causes of the condition...
  4. pmc The relationship between the five-factor model and latent Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition personality disorder dimensions
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Compr Psychiatry 49:98-105. 2008
    ..Whether additional maladaptive traits would better define the domain of PDs remains an important objective for future research...
  5. pmc The stability of DSM personality disorders over twelve to eighteen years
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Meyer 113, Baltimore, Maryland 21287, USA
    J Psychiatr Res 44:1-7. 2010
    ..The aim of this study is to investigate the stability of DSM-III personality disorders in a community sample of eastern Baltimore residents unselected for treatment...
  6. pmc Obsessive-compulsive disorder: subclassification based on co-morbidity
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Psychol Med 39:1491-501. 2009
    ..Many patients manifest other psychiatric syndromes. This study investigated the relationship between OCD and co-morbid conditions to identify subtypes...
  7. pmc Homeobox genes in obsessive-compulsive disorder
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 159:53-60. 2012
    ..The OCD Collaborative Genetics Study (OCGS) has identified several OCD susceptibility loci through linkage analysis...
  8. doi request reprint Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:1-13. 2012
    ..The current study uses co-morbidity and familiality data to inform these issues...
  9. doi request reprint A screen of SLC1A1 for OCD-related alleles
    Y Wang
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Am J Med Genet B Neuropsychiatr Genet 153:675-9. 2010
    ..Further investigation of this variant is necessary to determine whether and how it is related to OCD. There was no other evidence of significant accumulation of deleterious coding mutations in SLC1A1 in the OCD cases...
  10. doi request reprint Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:710-20. 2009
    ..We conclude that Sapap3 is a promising functional candidate gene for human GDs, though further work is necessary to confirm this preliminary evidence of association...
  11. pmc Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Hum Genet 67:1611-6. 2000
    ....
  12. ncbi request reprint A family study of obsessive-compulsive disorder
    G Nestadt
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 57:358-63. 2000
    ..Evidence of familial aggregation is one approach for investigating the role of genetics in the etiology of this condition. The current study was conducted to determine ifOCD is familial and to investigate possible familial subtypes...
  13. doi request reprint A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families
    Y Y Shugart
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21044, USA
    Am J Med Genet B Neuropsychiatr Genet 150:886-92. 2009
    ..5 kb away from the boundary of the SLC1A1 gene. However, this potential finding needs to be validated biologically. Further functional studies in this region are planned by this research group...
  14. doi request reprint Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder families
    Y Wang
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:33-40. 2009
    ..No SNP showed significant association with the OCD phenotype only in the families with a female proband. The results suggest a possible gender effect in the etiology of OCD...
  15. ncbi request reprint Normal personality traits and comorbidity among phobic, panic and major depressive disorders
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University JHU, Baltimore, MD 21287, USA
    Psychiatry Res 102:73-85. 2001
    ..Therefore, neuroticism and introversion are associated with increased comorbidity due to relationships in common with the prevalence of the different disorders. In contrast, extraversion is associated with increased comorbidity per se...
  16. ncbi request reprint The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study
    M A Grados
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA
    Biol Psychiatry 50:559-65. 2001
    ..CONCLUSIONS: Tic disorders constitute an alternate expression of the familial OCD phenotype...
  17. ncbi request reprint Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q
    Y Y Shugart
    Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Mol Psychiatry 11:763-70. 2006
    ..Given probable etiologic heterogeneity in OCD, mapping gene(s) involved in the disorder may be enhanced by replication studies, large-scale family-based linkage studies, and the application of novel statistical methods...
  18. ncbi request reprint Phobic, panic, and major depressive disorders and the five-factor model of personality
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
    J Nerv Ment Dis 189:154-61. 2001
    ..This study emphasizes the utility of lower-order personality assessments and underscores the need for further research on personality/psychopathology etiologic relationships...
  19. ncbi request reprint The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Psychol Med 31:481-7. 2001
    ..CONCLUSION: GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome...
  20. ncbi request reprint The identification of OCD-related subgroups based on comorbidity
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    Biol Psychiatry 53:914-20. 2003
    ..This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups...
  21. pmc The OCD collaborative genetics study: methods and sample description
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7228, USA
    Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006
    ....
  22. ncbi request reprint Hoarding in obsessive compulsive disorder: results from a case-control study
    J Samuels
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore 21287, USA
    Behav Res Ther 40:517-28. 2002
    ..Hoarding appears to be transmitted in some OCD families and may differentiate a clinical subgroup of OCD...
  23. doi request reprint Familiality of novel factorial dimensions of schizophrenia
    John A McGrath
    Department of Psychiatry, The Johns Hopkins University School of Medicine, 1820 Lancaster St, Ste 300, Baltimore, MD 21231, USA
    Arch Gen Psychiatry 66:591-600. 2009
    ..Examination of familiality of factor scores can demonstrate whether they are likely to be of use in genetic research...
  24. ncbi request reprint Adult antisocial personality traits are associated with experiences of low parental care and maternal overprotection
    I M Reti
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Acta Psychiatr Scand 106:126-33. 2002
    ..To investigate the role of parenting in the development of adult antisocial personality traits...
  25. ncbi request reprint An epidemiological study of histrionic personality disorder
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Psychol Med 20:413-22. 1990
    ..The diagnosis is associated with clear evidence of disturbance in the emotional, behavioural, and social realms. Individuals with this disorder tend to use health care facilities more frequently than others...
  26. ncbi request reprint Epidemiology of personality disorders
    N Sater
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287-7481, USA
    Curr Psychiatry Rep 3:41-5. 2001
    ..This paper reviews and discusses empiric advances made over the past 2 years in the epidemiologic study of personality disorders...
  27. pmc Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients
    A Hatzimanolis
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transl Psychiatry 3:e264. 2013
    ..On the basis of this, we propose a general model of pathway heterogeneity in SZ, which, in part, may explain its phenotypic variability and genetic complexity...
  28. ncbi request reprint Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes
    A E Pulver
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Mol Psychiatry 5:650-3. 2000
    ..008). The identification of multiple susceptibility loci for schizophrenia may be enhanced by stratification of families using psychiatric diagnoses of the non-schizophrenic relatives...
  29. pmc Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder
    Virginia L Willour
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Hum Genet 75:508-13. 2004
    ..046 and .02, respectively) for association...
  30. doi request reprint Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoarding
    Kung Yee Liang
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1000-2. 2008
    ....
  31. doi request reprint The association between parental bonding and obsessive compulsive disorder in offspring at high familial risk
    Holly C Wilcox
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7228, USA
    J Affect Disord 111:31-9. 2008
    ..The aim of the current study is to estimate the association between parenting factors derived from the Parental Bonding Instrument (PBI) and a lifetime DSM-IV diagnosis of OCD...
  32. doi request reprint Social and communication difficulties and obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Psychopathology 41:194-200. 2008
    ..In this study we sought to establish if there is any association between the presence of abnormal pragmatic behaviors and OCD and whether this association delineates a familial subtype of OCD...
  33. doi request reprint Personality disorders and traits as predictors of incident cardiovascular disease: findings from the 23-year follow-up of the Baltimore ECA study
    Hochang Benjamin Lee
    The Johns Hopkins University School of Medicine, 4th Floor, 5300 Alpha Commons Drive, Baltimore, MD 21224, USA
    Psychosomatics 51:289-96. 2010
    ..Over the past several decades, the relationship between personality traits and heart disease has interested clinicians and researchers alike...
  34. pmc Prevalence and correlates of hoarding behavior in a community-based sample
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 109, Baltimore, MD 21287 7228, USA
    Behav Res Ther 46:836-44. 2008
    ..These findings suggest that hoarding may be relatively prevalent and that alcohol dependence, personality disorder traits, and specific childhood adversities are associated with hoarding in the community...
  35. ncbi request reprint An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia
    Ann E Pulver
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Am J Med Genet B Neuropsychiatr Genet 124:6-9. 2004
    ..The failure to support the paternal age hypothesis may be a function of heterogeneous samples, but calls for further research in the context of family studies...
  36. pmc Personality disorder traits as predictors of subsequent first-onset panic disorder or agoraphobia
    O Joseph Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Compr Psychiatry 50:209-14. 2009
    ..These results suggest that avoidant and dependent personality traits are predisposing factors, or at least markers of risk, for panic disorder and agoraphobia-not simply epiphenomena...
  37. pmc Sex-specific clinical correlates of hoarding in obsessive-compulsive disorder
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Behav Res Ther 46:1040-6. 2008
    ..These findings indicate that specific clinical correlates of hoarding in OCD are different in men and women and may reflect sex-specific differences in the course, expression, and/or etiology of hoarding behavior in OCD...
  38. ncbi request reprint Influences of parenting on normal personality traits
    Irving M Reti
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 600 N Wolfe St, Meyer 3 181, Baltimore, MD 21205, USA
    Psychiatry Res 111:55-64. 2002
    ....
  39. pmc Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse
    Irving M Reti
    The School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Compr Psychiatry 52:188-94. 2011
    ..The 30-base pair variable number tandem repeat in the MAOA promoter regulates MAOA levels, but its effects on ASP in humans are unclear...
  40. ncbi request reprint Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 25:218-24. 2008
    ..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner...
  41. ncbi request reprint Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Am J Psychiatry 164:493-9. 2007
    ..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder...
  42. ncbi request reprint Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Behav Res Ther 45:673-86. 2007
    ..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families...
  43. ncbi request reprint Anxiety and depressive disorders and the five-factor model of personality: a higher- and lower-order personality trait investigation in a community sample
    O Joseph Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 20:92-7. 2004
    ..Neuroticism in particular was related to acuity of disorder. Longitudinal study is necessary to differentiate state versus pathoplastic effects...
  44. ncbi request reprint Factor analysis of the Yale-Brown Obsessive Compulsive Scale in a family study of obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Depress Anxiety 24:130-8. 2007
    ..There were specific clinical correlates for these factors, and significant intrafamilial sib-sib correlations were found for the Symmetry/Order and Hoarding factors...
  45. ncbi request reprint Utility of the Leyton Obsessional Inventory to distinguish OCD and OCPD
    David Wellen
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Depress Anxiety 24:301-6. 2007
    ..These findings may contribute to effective diagnosis and treatment by allowing the LOI to screen for OCD and OCPD in a population exhibiting obsessional symptoms and traits...
  46. ncbi request reprint Five latent factors underlying schizophrenia: analysis and relationship to illnesses in relatives
    John A McGrath
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Schizophr Bull 30:855-73. 2004
    ..Increased early onset/developmental signs in the proband were also associated with increased risk for depression in relatives. These findings suggest a possible endophenotypic role for the factor scores in future studies...
  47. ncbi request reprint Relationship between cortisol responses to stress and personality
    Lynn M Oswald
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:1583-91. 2006
    ..These findings suggest that personality traits that have been traditionally associated with greater psychopathology were also associated with blunted HPA axis responses to stress...
  48. pmc Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21231, USA
    Am J Hum Genet 73:601-11. 2003
    ..2 Mb for the location of the trait locus (D10S1677 to D10S1753). We find these results encouraging for the study of schizophrenia among Ashkenazi families and suggest further linkage and association studies in this chromosome 10q region...
  49. ncbi request reprint Prevalence and correlates of personality disorders in a community sample
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Br J Psychiatry 180:536-42. 2002
    ..Knowledge of the prevalence and correlates of personality disorders in the community is important for identifying treatment needs and for provision of psychiatric services...
  50. ncbi request reprint Personality dimensions and criminal arrest
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Compr Psychiatry 45:275-80. 2004
    ..The results suggest that specific dimensions of normal personality are related to criminal arrest in the community...
  51. ncbi request reprint Obsessive-compulsive disorder: defining the phenotype
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    J Clin Psychiatry 63:5-7. 2002
    ..This article describes a family-study approach for identifying the spectrum of conditions related to OCD and subtyping OCD cases into homogeneous subtypes...
  52. pmc Population-based study of first onset and chronicity in major depressive disorder
    William W Eaton
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:513-20. 2008
    ..There are no studies of the natural history of major depressive disorder that lack prevalence and clinic biases...
  53. ncbi request reprint Latent structure of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition personality disorder criteria
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Compr Psychiatry 47:54-62. 2006
    ..The relationship between the obtained personality disorder dimensions and measures of functioning and disability was examined...
  54. pmc Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    Am J Hum Genet 77:918-36. 2005
    ..They provide further support for shared genetic susceptibility between these two disorders that involve glutamate-signaling pathways...
  55. pmc Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Hum Genet 75:204-19. 2004
    ....
  56. pmc Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia
    Pei Lung Chen
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 84:21-34. 2009
    ..These biological properties together with our linkage and association results strongly support NRG3 as a gene involved in SZ...
  57. pmc Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women
    Yaping Liu
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychiatr Genet 20:184-6. 2010
    ..Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype--phenotype correlations...
  58. ncbi request reprint Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders
    Mona A Mohamed
    The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States
    Psychiatry Res 156:175-9. 2007
    ..Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor...
  59. ncbi request reprint Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene
    Dimitrios Avramopoulos
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Genet Med 9:745-51. 2007
    ..This study is a second stage follow-up focusing on regions that showed positive linkage scores in our previous scan but were not fine-mapped at that time...
  60. ncbi request reprint Practice guideline for the treatment of patients with obsessive-compulsive disorder
    Lorrin M Koran
    Am J Psychiatry 164:5-53. 2007
  61. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  62. ncbi request reprint Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study
    Gregor Hasler
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Biol Psychiatry 61:617-25. 2007
    ..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
  63. ncbi request reprint The longitudinal relationship between personality disorder dimensions and global functioning in a community-residing population
    Jin Pyo Hong
    Department of Psychiatry, Asian Medical Center, School of Medicine, Ulsan University, Seoul, Korea
    Psychol Med 35:891-5. 2005
    ..The purpose of this study was to investigate, in a community-residing population, the longitudinal relationship between psychiatrist-assessed personality disorder scores and global functioning 13-18 years later...
  64. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  65. ncbi request reprint Clinical correlates of recurrent major depression in obsessive-compulsive disorder
    Jin Pyo Hong
    Department of Psychiatry, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
    Depress Anxiety 20:86-91. 2004
    ..In a multiple logistic regression model, only early age of OCD diagnosis was significantly associated with RDD. Early age at onset of OCD increases the risk of depressive disorder in individuals with OCD...
  66. ncbi request reprint Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, University of Chicago, IL 60637, USA
    J Clin Psychiatry 65:820-4. 2004
    ..To determine the lifetime and 1-month prevalence of intermittent explosive disorder (IED) by both DSM-IV and research criteria in a community sample...
  67. ncbi request reprint Serotonin-norepinephrine reuptake inhibitors in the treatment of obsessive-compulsive disorder: A critical review
    Bernardo Dell'Osso
    Department of Psychiatry, Compulsive, Impulsive and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychiatry 67:600-10. 2006
    ....
  68. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...

Research Grants22

  1. Collaborative OCD Genetics Study
    Gerald Nestadt; Fiscal Year: 2005
    ..abstract_text> ..
  2. EPIDEMIOLOGY OF PERSONALITY DISORDERS
    Gerald Nestadt; Fiscal Year: 2007
    ..Building on our previous contributions, this proposal applies innovative constructs of disordered personality and rigorous analytic strategies. ..
  3. OCD Collaborative Genetics Association Study
    Gerald Nestadt; Fiscal Year: 2007
    ..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..
  4. FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDER
    Gerald Nestadt; Fiscal Year: 1999
    ..Families with multiple affected members with OCD will be identified to possible future genetic linkage study. ..
  5. EPIDEMIOLOGY OF PERSONALITY DISORDERS
    Gerald Nestadt; Fiscal Year: 2000
    ..It provides an unusual opportunity to develop insights into personality disorders; their diagnosis, population rates and distribution, and course and consequences. ..
  6. OCD Collaborative Genetics Association Study
    Gerald Nestadt; Fiscal Year: 2010
    ..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..