Research Topics
| WILLIAM GEORGE NELSONSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
USP2a activation of MYC in prostate cancerWilliam G Nelson
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Cancer Discov 2:206-7. 2012..Ubiquitin-specific protease 2a, a deubiquitinating enzyme, elevates MYC levels in prostate cancer cells via its stabilization of MDM2, undermining p53 regulation of microRNAs that target MYC mRNA...
The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult menAndy Menke
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
BMC Public Health 8:72. 2008..Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small...- Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequencesSrinivasan Yegnasubramanian
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
BMC Genomics 12:313. 2011..This MBD-chip approach was used to characterize DNA methylation patterns across all non-repetitive sequences of human chromosomes 21 and 22 at high-resolution in normal and malignant prostate cells... 
Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignanciesW G Nelson
Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
Cancer Chemother Pharmacol 46:S67-72. 2000....- Prostate cancer preventionWilliam G Nelson
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA
J Nutr 134:3211S-3212S. 2004 - The role of inflammation in the pathogenesis of prostate cancerWilliam G Nelson
Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Urol 172:S6-11; discussion S11-2. 2004..A new hypothesis for the etiology of prostate cancer is that chronic or recurrent prostate inflammation may initiate and promote prostate cancer development... - Agents in development for prostate cancer preventionWilliam G Nelson
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, UK
Expert Opin Investig Drugs 13:1541-54. 2004..This review will consider the rational development of these and other new agents and approaches for prostate cancer prevention in the context of recent research progress in ascertaining the aetiology of prostate cancer... - Epigenetic alterations in human prostate cancersWilliam G Nelson
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
Endocrinology 150:3991-4002. 2009..Finally, a growing portfolio of epigenetic drugs, capable of reversing the phenotypic consequences of somatic epigenetic defects, has entered clinical trials for prostate cancer in the search for a new rational therapy for the disease... - Prostate cancer preventionWilliam G Nelson
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Curr Opin Urol 17:157-67. 2007..This review focuses on prostate cancer prevention in the context of new mechanistic insights into human prostatic carcinogenesis... - Abnormal DNA methylation, epigenetics, and prostate cancerWilliam G Nelson
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Brady Urological Institute, Baltimore, MD 21231, USA
Front Biosci 12:4254-66. 2007..If sufficiently safe strategies for chromatin modulation can be discovered and developed, epigenetic alterations may become rational targets for both prostate cancer prevention and prostate cancer treatment... - Beefing up prostate cancer therapy with performance-enhancing (anti-) steroidsWilliam G Nelson
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
Cancer Cell 20:7-9. 2011..report that the inhibition of androgen synthesis by abiraterone acetate prolonged the survival of men with prostate cancer previously treated by androgen suppression... - Preneoplastic prostate lesions: an opportunity for prostate cancer preventionW G Nelson
The Johns Hopkins Comprehensive Cancer Center, Baltimore, Maryland 21231 1000, USA
Ann N Y Acad Sci 952:135-44. 2001.... - Prostate cancerWilliam G Nelson
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, USA
N Engl J Med 349:366-81. 2003 - The diet, prostate inflammation, and the development of prostate cancerWilliam G Nelson
The Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
Cancer Metastasis Rev 21:3-16. 2002..The model predicts that the critical prostate carcinogens will be those that are substrates for GSTP1 detoxification and are associated with high prostate cancer risk diet and lifestyle habits... - Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targetsBora Gurel
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Adv Anat Pathol 15:319-31. 2008..In addition, recent studies in which new molecular diagnostic approaches have been applied in the clinic will be discussed... - Detection of GSTP1 methylation in prostatic secretions using combinatorial MSP analysisMark L Gonzalgo
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Urology 63:414-8. 2004..Assays of GSTP1 promoter methylation in prostatic massage fluid or ejaculate may therefore serve as useful adjuncts to existing methods for prostate cancer screening and prognostication... - Prostate cancer detection by GSTP1 methylation analysis of postbiopsy urine specimensMark L Gonzalgo
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-2101, USA
Clin Cancer Res 9:2673-7. 2003..This molecular assay has potential application for stratification of patients into low- and high-risk groups for surveillance versus repeat biopsy... - Hypermethylation of CpG islands in primary and metastatic human prostate cancerSrinivasan Yegnasubramanian
Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231-1000, USA
Cancer Res 64:1975-86. 2004..Furthermore, CpG island hypermethylation patterns in prostate cancer metastases were very similar to the primary prostate cancers and tended to show greater differences between cases than between anatomical sites of metastasis... 
Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylationSrinivasan Yegnasubramanian
Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 1650 Orleans Street, CRB 116, Baltimore, MD 21231, USA
Nucleic Acids Res 34:e19. 2006..This novel technology could significantly improve our ability to detect CGI hypermethylation...- Phase II, randomized, placebo-controlled trial of neoadjuvant celecoxib in men with clinically localized prostate cancer: evaluation of drug-specific biomarkersEmmanuel S Antonarakis
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
J Clin Oncol 27:4986-93. 2009..We conducted a randomized, double-blind trial to examine the effect of celecoxib on drug-specific biomarkers from prostate tissue obtained at prostatectomy... - Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cellsXiaohui Lin
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Cancer Res 63:498-504. 2003..These findings implicate MBD2 in GSTP1 silencing associated with somatic GSTP1 CpG island hypermethylation in breast cancer cells... - MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cellsTsuyoshi Iwata
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e9427. 2010..We also identified a novel histopathologically identifiable intermediate step prior to invasion that should facilitate studies of molecular pathway alterations occurring during early progression of prostatic adenocarcinomas... - GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancerMasashi Nakayama
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Cell Biochem 91:540-52. 2004..GSTP1 CpG island hypermethylation, a somatic epigenetic alteration, appears poised to serve as a molecular biomarker useful for prostate cancer screening, detection, and diagnosis... - Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture micrMasashi Nakayama
Department of Pathology, The Johns Hopkins Medical Institutions, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
Am J Pathol 163:923-33. 2003..Because these atrophic lesions are so prevalent and extensive, even though only a small subset contains this somatic DNA alteration, the clinical impact may be substantial... - Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomyPatrick J Bastian
The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231-1000, USA
Clin Cancer Res 11:4037-43. 2005..4; 95% confidence interval, 2.2, 8.8; P < 0.001). CONCLUSION: Our study suggests that GSTP1 CpG island hypermethylation may be an important DNA-based prognostic serum biomarker for prostate cancer... - Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigenCharles G Drake
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Cancer Cell 7:239-49. 2005..These results suggest that immunotherapy for prostate cancer may be most efficacious when administered after androgen ablation... - Systemic therapeutic strategies for prostate cancerWilliam G Nelson
Johns Hopkins Medical Institute, Baltimore, MD 21205, USA
Clin Adv Hematol Oncol 3:619-21. 2005 - Prostate cancer: New answers prompt new questions regarding cell of originAngelo M De Marzo
The Brady Urological Research Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Nat Rev Urol 7:650-2. 2010..However, these results are not mutually exclusive: there are potential solutions, and alternative views on the initiating cell derivation of prostate tumors also exist... - Inflammation, atrophy, and prostate carcinogenesisAngelo M De Marzo
Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
Urol Oncol 25:398-400. 2007..Additional epidemiological, molecular pathological, and animal model work needs to be done to determine whether inflammation and atrophy are "driving" prostate carcinogenesis... - High concordance of gene methylation in post-digital rectal examination and post-biopsy urine samples for prostate cancer detectionCraig G Rogers
The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Urol 176:2280-4. 2006.... - Inflammation in prostate carcinogenesisAngelo M De Marzo
Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA
Nat Rev Cancer 7:256-69. 2007.... - Focus on prostate cancerWilliam Isaacs
Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Cell 2:113-6. 2002 - Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangementsMichael C Haffner
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 42:668-75. 2010..These findings implicate androgen-induced TOP2B-mediated DSBs in generating TMPRSS2-ERG rearrangements... - Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cellsJila Bakker
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
J Biol Chem 277:22573-80. 2002..These findings implicate MBD2 in the repression of GSTP1 expression associated with GSTP1 CpG island hypermethylation in HCC cells... - DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneitySrinivasan Yegnasubramanian
Sidney Kimmel Comprehensive Cancer Center, School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Cancer Res 68:8954-67. 2008.... - Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase proteinCraig G Rogers
James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Urol 172:1501-3. 2004..We assessed the feasibility of a novel urinary test for prostate cancer based on the presence of alpha methylacyl coenzyme A racemase (AMACR) protein in voided urine specimens obtained after prostate biopsy... - The design of a randomized, placebo-controlled trial of celecoxib in preprostatectomy men with clinically localized adenocarcinoma of the prostateElisabeth I Heath
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Clin Prostate Cancer 1:182-7. 2002 - Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factorsSpencer J Collis
Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 63:1550-4. 2003..Together, these data provide strong evidence for the potential use of siRNA as a novel radiation/chemotherapy-sensitizing agent... - Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatmentAngelo M De Marzo
Department of Oncology, The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231 1000, USA
J Cell Biochem 91:459-77. 2004..We also present the implications of these changes for prostate cancer diagnosis, detection, prevention, and treatment... - Human prostate cancer precursors and pathobiologyAngelo M De Marzo
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
Urology 62:55-62. 2003..Additional results show that AMACR may be an important new marker of prostate cancer, and its use in combination with p63 staining may provide the basis for an improved method for identification of prostate cancer... - Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysisMark L Gonzalgo
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin Cancer Res 10:7276-83. 2004..We determine the utility of molecular profiling based on quantitative methylation analysis for characterization of sporadic renal cell carcinoma... - Prostate carcinogenesis and inflammation: emerging insightsGanesh S Palapattu
Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Carcinogenesis 26:1170-81. 2005..These emerging insights into chronic inflammation in the etiology of prostate carcinogenesis hold the promise of spawning new diagnostic and therapeutic modalities for men with prostate cancer... - Procainamide is a specific inhibitor of DNA methyltransferase 1Byron H Lee
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Biol Chem 280:40749-56. 2005..Because many reports have strongly linked DNMT1 with epigenetic alterations in carcinogenesis, procainamide may be a useful drug in the prevention of cancer... - Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY allelesAntony R Parker
Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
J Biol Chem 278:47937-45. 2003..Finally, using antibody-isolated MutY protein, we show that MutY can be directly phosphorylated by PKC that directly increases the level of MutY catalyzed A.8-oxoG repair... - CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancerPatrick J Bastian
James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Urol 179:529-34; discussion 534-5. 2008..In this study we investigated the hypermethylation profile of several genes in the serum of men with localized and hormone refractory prostate cancer... - Molecular biomarker in prostate cancer: the role of CpG island hypermethylationPatrick J Bastian
The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
Eur Urol 46:698-708. 2004..CpG island hypermethylation may serve as a useful molecular biomarker for the detection and diagnosis of patients with prostate cancer... - Prostate-specific antigen as a marker of disease activity in prostate cancerAlan W Partin
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Oncology (Williston Park) 16:1218-24; discussion 1224, 1227-8 passim. 2002..Part 2 of this two-part article, which began in the August issue, discusses the role of PSA in hormonal and drug therapies and in primary and secondary chemoprevention... - Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomyPatrick J Bastian
The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Cancer Res 13:5361-7. 2007..We evaluated the association of preoperative serum cell-free circulating DNA concentration in men with clinically localized prostate cancer who underwent radical prostatectomy with prostate-specific antigen (PSA) recurrence... - Prostate-specific antigen as a marker of disease activity in prostate cancerAlan W Partin
Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
Oncology (Williston Park) 16:1024-38, 1042; discussion 1042, 1047-8, 1051. 2002..Part 1 of this two-part article, which concludes in the September issue, focuses on the physiology of PSA, its measurement and use in clinical practice, and its predictive value following radical prostatectomy and radiation therapy... - Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumorsGeorges J Netto
Department of Pathology, Division of Genitourinary Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
Mod Pathol 21:1337-44. 2008..That is, IGCNU cells and seminoma cells remain unmethylated, whereas all other histological types appear to arise after de novo methylation... - MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidineGloria L David
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231-1000, USA
Cancer Biol Ther 3:540-8. 2004..In this state, MDR1 expression was markedly sensitive to treatment with the histone deacetylase inhibitor trichostatin A... - Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiationChristopher J Gamper
Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
J Immunol 183:2267-76. 2009.... - Pathological and molecular aspects of prostate cancerAngelo M DeMarzo
Department of Pathology, Johns Hopkins' University School of Medicine, Johns Hopkins' Hospital, Baltimore, MD 21231, USA
Lancet 361:955-64. 2003..Changed gene expression (eg, proliferation-related genes, changes in the androgen receptor, apoptosis and stress-response genes) have potential as biomarkers and therapeutic targets in prostate cancer... - Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cellsQun Zhou
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, CRB Room 144, Baltimore, MD 21231, USA
Mol Cancer Res 6:873-83. 2008..Our studies suggest a new role for HDAC1 and identify a novel mechanism of action for the HDAC inhibitors as down-regulators of DNMT1... - Inadequate "caretaker" gene function and human cancer developmentTheodore L DeWeese
John Hopkins Oncology Center, Baltimore, MD, USA
Methods Mol Biol 222:249-68. 2003 - Evasion of early cellular response mechanisms following low level radiation-induced DNA damageSpencer J Collis
Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Biol Chem 279:49624-32. 2004.... - Sex steroid hormone concentrations and risk of death in US menAndy Menke
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 171:583-92. 2010..Future studies should be conducted to fully characterize the association of low free and bioavailable testosterone concentrations and mortality in men and to describe the mechanism underlying the association... - Sexually transmitted infections and prostatic inflammation/cell damage as measured by serum prostate specific antigen concentrationSiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Urol 175:1937-42. 2006..Further studies are warranted to replicate study findings and determine host and infection characteristics associated with large PSA increases... - Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancerAgoston T Agoston
Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231 1000, USA
J Biol Chem 280:18302-10. 2005..The regulation of DNMT1 destruction via this domain may be dysfunctional in cancer cells leading to subsequent cytosine hypermethylation in the genome... - Epithelial architectural destruction is necessary for bone marrow derived cell contribution to regenerating prostate epitheliumGanesh S Palapattu
Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Urol 176:813-8. 2006..CONCLUSIONS: These findings are consistent with a requirement for inflammation associated architectural destruction for the bone marrow derived cell contribution to the regeneration of prostate epithelium... - Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)Elizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Diabetes Care 30:234-8. 2007..The objective of this study is to test the hypothesis that low normal levels of total, free, and bioavailable testosterone are associated with prevalent diabetes in men... - Cyclooxygenases in cancer: progress and perspectiveShan Zha
Brady Urological Institute, The Johns Hopkins University, Baltimore, MD, USA
Cancer Lett 215:1-20. 2004..Here we review the fundamental features of COX enzymes, especially as related to carcinogenesis, their expression and function in both animal tumor models and clinical cancers and the proposed mechanisms behind their roles in cancer... - Identification of potential prostate cancer preventive agents through induction of quinone reductase in vitroJames D Brooks
Department of Urology, Stanford University School of Medicine, USA
Cancer Epidemiol Biomarkers Prev 11:868-75. 2002..Our data suggest that measurement of QR induction in prostate cancer cell lines may help identify potential cancer chemopreventive agents effective in the prostate... - Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forwardGary J Kelloff
National Cancer Institute, Bethesda, Maryland 20852, USA
Clin Cancer Res 12:3661-97. 2006.... - The dietary charred meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine acts as both a tumor initiator and promoter in the rat ventral prostateYasutomo Nakai
Department of Urology, Osaka University, Osaka, Japan
Cancer Res 67:1378-84. 2007..quot; The prostate lobe-specific infiltration of mast cells and macrophages in response to PhIP suggests a potential new mechanism by which this dietary compound can increase cancer risk-by prompting inflammation... - Transmission/disequilibrium tests of androgen receptor and glutathione S-transferase pi variants in prostate cancer familiesGloria Y F Ho
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Int J Cancer 98:938-42. 2002..Our findings do not support the hypothesis that familial clustering of prostate cancer in high-risk families is attributable to these genetic variants... - Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell linesLan Yan
Sidney Kimmel Comprehensive Cancer at Johns Hopkins University Medical School, Baltimore, Maryland USA
Cancer Biol Ther 2:552-6. 2003..Our results suggest that specific inhibition of DNMT1 expression alone is sufficient to re-express ERa in human breast cancer cell lines... - Loss-of-function of Nkx3.1 promotes increased oxidative damage in prostate carcinogenesisXuesong Ouyang
Center for Advanced Biotechnology and Medicine, The Cancer Institute of New Jersey, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5638, USA
Cancer Res 65:6773-9. 2005..Thus, our findings provide a molecular link between a gene whose inactivation is known to be involved in prostate carcinogenesis, namely Nkx3.1, and oxidative damage of the prostatic epithelium... - Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent developmentGary J Kelloff
Baylor-Sammons Cancer Center, US Oncology, Collins 5, 3535 Worth Street, Dallas, TX 75246, USA
Clin Cancer Res 8:314-46. 2002..The IEN Task Force proposes several clinical trial designs that provide practical and feasible approaches to the rapid development of new agents to treat and prevent precancer... - Fourth International Conference on Innovations and Challenges in Prostate Cancer: Prevention, Detection and TreatmentPeter R Carroll
Department of Urology, University of California School of Medicine, San Francisco 94115-1711, USA
J Urol 172:S3-5. 2004 - The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics)Richard L Schilsky
University of Chicago, Chicago, Illinois, USA
Clin Cancer Res 14:5685-91. 2008..This article presents the Agents Developmental Pathway and discusses key challenges associated with the processes described... - Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naïve prostate cancerJonathan W Simons
Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Clin Cancer Res 12:3394-401. 2006.... - Granulocyte macrophage colony-stimulating factor--secreting allogeneic cellular immunotherapy for hormone-refractory prostate cancerEric J Small
University of California, San Francisco, Comprehensive Cancer Center, San Francisco, California 94115, USA
Clin Cancer Res 13:3883-91. 2007..The immunotherapy, based on the GVAX platform, is a combination of two prostate carcinoma cell lines modified with the granulocyte macrophage colony-stimulating factor (GM-CSF) gene...
Research Grants
- GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCERWilliam Nelson; Fiscal Year: 2007..abstract_text> ..
- SPORE IN PROSTATE CANCERWilliam Nelson; Fiscal Year: 2007..The Research Projects are supported by Core Resources for Administration, for a Tissue Archive, for Biomarker Development, and for Biostatistics. ..
- MBD2 as a Target for Cancer Prevention and TreatmentWilliam Nelson; Fiscal Year: 2007..abstract_text> ..
- Molecular Targets for Cancer Detection and TreatmentWilliam Nelson; Fiscal Year: 2007..Mentors monitor the trainee's research progress while continuously emphasizing ethical and responsible conduct of research. ..
- GSTPI PROMOTOR HYPERMETHYLATION IN HUMAN PROSTATE CANCERWilliam Nelson; Fiscal Year: 2002....
- AUA/SBUR Res. Conf.-"Inflammation in Prostate Diseases"William Nelson; Fiscal Year: 2005..Support for this meeting will encourage the future development of urology research by providing mentoring for new investigators as well as education on this emerging research area. ..
- GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCERWILLIAM GEORGE NELSON; Fiscal Year: 2010..This proposal is focused on ascertaining the cause of the disease, providing the basis for its prevention. ..