WILLIAM GEORGE NELSON

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylation
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 1650 Orleans Street, CRB 116, Baltimore, MD 21231, USA
    Nucleic Acids Res 34:e19. 2006
  2. doi request reprint The diet as a cause of human prostate cancer
    William G Nelson
    Departments of Oncology, Pathology, and Urology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Weinberg Bldg 1100, 1650 Orleans Street, Baltimore, MD, 21231, USA
    Cancer Treat Res 159:51-68. 2014
  3. doi request reprint USP2a activation of MYC in prostate cancer
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Cancer Discov 2:206-7. 2012
  4. pmc The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men
    Andy Menke
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    BMC Public Health 8:72. 2008
  5. pmc Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Genomics 12:313. 2011
  6. pmc Epigenetic alterations in human prostate cancers
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Endocrinology 150:3991-4002. 2009
  7. ncbi request reprint Agents in development for prostate cancer prevention
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, UK
    Expert Opin Investig Drugs 13:1541-54. 2004
  8. ncbi request reprint The role of inflammation in the pathogenesis of prostate cancer
    William G Nelson
    Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Urol 172:S6-11; discussion S11-2. 2004
  9. ncbi request reprint Prostate cancer
    William G Nelson
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 349:366-81. 2003
  10. ncbi request reprint Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies
    W G Nelson
    Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 46:S67-72. 2000

Research Grants

  1. Molecular Targets for Cancer Detection and Treatment
    William Nelson; Fiscal Year: 2007
  2. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2004
  3. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2009
  4. SPORE IN PROSTATE CANCER
    William Nelson; Fiscal Year: 2006
  5. MBD2 as a Target for Cancer Prevention and Treatment
    William Nelson; Fiscal Year: 2007
  6. SPORE IN PROSTATE CANCER
    William Nelson; Fiscal Year: 2007
  7. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2007
  8. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2006
  9. AUA/SBUR Res. Conf.-"Inflammation in Prostate Diseases"
    William Nelson; Fiscal Year: 2005
  10. MBD2 as a Target for Cancer Prevention and Treatment
    William Nelson; Fiscal Year: 2005

Detail Information

Publications74

  1. pmc Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylation
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 1650 Orleans Street, CRB 116, Baltimore, MD 21231, USA
    Nucleic Acids Res 34:e19. 2006
    ..This novel technology could significantly improve our ability to detect CGI hypermethylation...
  2. doi request reprint The diet as a cause of human prostate cancer
    William G Nelson
    Departments of Oncology, Pathology, and Urology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Weinberg Bldg 1100, 1650 Orleans Street, Baltimore, MD, 21231, USA
    Cancer Treat Res 159:51-68. 2014
    ..Specifically, nutritional agents might prevent PIA lesions or reduce the propensity of PIA lesions to suffer "catastrophic" epigenome corruption. ..
  3. doi request reprint USP2a activation of MYC in prostate cancer
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Cancer Discov 2:206-7. 2012
    ..Ubiquitin-specific protease 2a, a deubiquitinating enzyme, elevates MYC levels in prostate cancer cells via its stabilization of MDM2, undermining p53 regulation of microRNAs that target MYC mRNA...
  4. pmc The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men
    Andy Menke
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    BMC Public Health 8:72. 2008
    ..Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small...
  5. pmc Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Genomics 12:313. 2011
    ..This MBD-chip approach was used to characterize DNA methylation patterns across all non-repetitive sequences of human chromosomes 21 and 22 at high-resolution in normal and malignant prostate cells...
  6. pmc Epigenetic alterations in human prostate cancers
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Endocrinology 150:3991-4002. 2009
    ..Finally, a growing portfolio of epigenetic drugs, capable of reversing the phenotypic consequences of somatic epigenetic defects, has entered clinical trials for prostate cancer in the search for a new rational therapy for the disease...
  7. ncbi request reprint Agents in development for prostate cancer prevention
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, UK
    Expert Opin Investig Drugs 13:1541-54. 2004
    ..This review will consider the rational development of these and other new agents and approaches for prostate cancer prevention in the context of recent research progress in ascertaining the aetiology of prostate cancer...
  8. ncbi request reprint The role of inflammation in the pathogenesis of prostate cancer
    William G Nelson
    Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Urol 172:S6-11; discussion S11-2. 2004
    ..A new hypothesis for the etiology of prostate cancer is that chronic or recurrent prostate inflammation may initiate and promote prostate cancer development...
  9. ncbi request reprint Prostate cancer
    William G Nelson
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 349:366-81. 2003
  10. ncbi request reprint Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies
    W G Nelson
    Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 46:S67-72. 2000
    ....
  11. ncbi request reprint Prostate cancer prevention
    William G Nelson
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA
    J Nutr 134:3211S-3212S. 2004
  12. ncbi request reprint Beefing up prostate cancer therapy with performance-enhancing (anti-) steroids
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Cancer Cell 20:7-9. 2011
    ..report that the inhibition of androgen synthesis by abiraterone acetate prolonged the survival of men with prostate cancer previously treated by androgen suppression...
  13. ncbi request reprint Abnormal DNA methylation, epigenetics, and prostate cancer
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Brady Urological Institute, Baltimore, MD 21231, USA
    Front Biosci 12:4254-66. 2007
    ..If sufficiently safe strategies for chromatin modulation can be discovered and developed, epigenetic alterations may become rational targets for both prostate cancer prevention and prostate cancer treatment...
  14. ncbi request reprint Prostate cancer prevention
    William G Nelson
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Urol 17:157-67. 2007
    ..This review focuses on prostate cancer prevention in the context of new mechanistic insights into human prostatic carcinogenesis...
  15. ncbi request reprint Preneoplastic prostate lesions: an opportunity for prostate cancer prevention
    W G Nelson
    The Johns Hopkins Comprehensive Cancer Center, Baltimore, Maryland 21231 1000, USA
    Ann N Y Acad Sci 952:135-44. 2001
    ....
  16. pmc Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targets
    Bora Gurel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Adv Anat Pathol 15:319-31. 2008
    ..In addition, recent studies in which new molecular diagnostic approaches have been applied in the clinic will be discussed...
  17. ncbi request reprint The diet, prostate inflammation, and the development of prostate cancer
    William G Nelson
    The Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Cancer Metastasis Rev 21:3-16. 2002
    ..The model predicts that the critical prostate carcinogens will be those that are substrates for GSTP1 detoxification and are associated with high prostate cancer risk diet and lifestyle habits...
  18. ncbi request reprint Detection of GSTP1 methylation in prostatic secretions using combinatorial MSP analysis
    Mark L Gonzalgo
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 63:414-8. 2004
    ..To evaluate the utility of methylation-specific polymerase chain reaction analysis of the pi-class glutathione-S-transferase (GSTP1) gene promoter in prostatic secretions for cancer detection and prognostication...
  19. ncbi request reprint Prostate cancer detection by GSTP1 methylation analysis of postbiopsy urine specimens
    Mark L Gonzalgo
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Clin Cancer Res 9:2673-7. 2003
    ..We assess the feasibility of a urinary test for prostate cancer detection in a high-risk patient cohort based on methylation-specific PCR analysis of the pi class glutathione S-transferase (GSTP1) gene promoter...
  20. ncbi request reprint Hypermethylation of CpG islands in primary and metastatic human prostate cancer
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    Cancer Res 64:1975-86. 2004
    ..Furthermore, CpG island hypermethylation patterns in prostate cancer metastases were very similar to the primary prostate cancers and tended to show greater differences between cases than between anatomical sites of metastasis...
  21. ncbi request reprint Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells
    Xiaohui Lin
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 63:498-504. 2003
    ..These findings implicate MBD2 in GSTP1 silencing associated with somatic GSTP1 CpG island hypermethylation in breast cancer cells...
  22. pmc Phase II, randomized, placebo-controlled trial of neoadjuvant celecoxib in men with clinically localized prostate cancer: evaluation of drug-specific biomarkers
    Emmanuel S Antonarakis
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Clin Oncol 27:4986-93. 2009
    ..We conducted a randomized, double-blind trial to examine the effect of celecoxib on drug-specific biomarkers from prostate tissue obtained at prostatectomy...
  23. pmc MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells
    Tsuyoshi Iwata
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9427. 2010
    ..We also identified a novel histopathologically identifiable intermediate step prior to invasion that should facilitate studies of molecular pathway alterations occurring during early progression of prostatic adenocarcinomas...
  24. ncbi request reprint GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer
    Masashi Nakayama
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Cell Biochem 91:540-52. 2004
    ..GSTP1 CpG island hypermethylation, a somatic epigenetic alteration, appears poised to serve as a molecular biomarker useful for prostate cancer screening, detection, and diagnosis...
  25. ncbi request reprint Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy
    Patrick J Bastian
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 11:4037-43. 2005
    ..We evaluated circulating cell-free DNA GSTP1 CpG island hypermethylation as a prognostic biomarker in the serum of men with prostate cancer...
  26. pmc Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture micr
    Masashi Nakayama
    Department of Pathology, The Johns Hopkins Medical Institutions, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
    Am J Pathol 163:923-33. 2003
    ..Because these atrophic lesions are so prevalent and extensive, even though only a small subset contains this somatic DNA alteration, the clinical impact may be substantial...
  27. pmc DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 68:8954-67. 2008
    ....
  28. pmc Inflammation in prostate carcinogenesis
    Angelo M De Marzo
    Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA
    Nat Rev Cancer 7:256-69. 2007
    ....
  29. ncbi request reprint Inflammation, atrophy, and prostate carcinogenesis
    Angelo M De Marzo
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
    Urol Oncol 25:398-400. 2007
    ..Additional epidemiological, molecular pathological, and animal model work needs to be done to determine whether inflammation and atrophy are "driving" prostate carcinogenesis...
  30. ncbi request reprint High concordance of gene methylation in post-digital rectal examination and post-biopsy urine samples for prostate cancer detection
    Craig G Rogers
    The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 176:2280-4. 2006
    ....
  31. ncbi request reprint Systemic therapeutic strategies for prostate cancer
    William G Nelson
    Johns Hopkins Medical Institute, Baltimore, MD 21205, USA
    Clin Adv Hematol Oncol 3:619-21. 2005
  32. ncbi request reprint Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis
    Mark L Gonzalgo
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 10:7276-83. 2004
    ..We determine the utility of molecular profiling based on quantitative methylation analysis for characterization of sporadic renal cell carcinoma...
  33. ncbi request reprint Human prostate cancer precursors and pathobiology
    Angelo M De Marzo
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Urology 62:55-62. 2003
    ..Additional results show that AMACR may be an important new marker of prostate cancer, and its use in combination with p63 staining may provide the basis for an improved method for identification of prostate cancer...
  34. ncbi request reprint Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors
    Spencer J Collis
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 63:1550-4. 2003
    ..Together, these data provide strong evidence for the potential use of siRNA as a novel radiation/chemotherapy-sensitizing agent...
  35. ncbi request reprint Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatment
    Angelo M De Marzo
    Department of Oncology, The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231 1000, USA
    J Cell Biochem 91:459-77. 2004
    ..We also present the implications of these changes for prostate cancer diagnosis, detection, prevention, and treatment...
  36. pmc Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
    Michael C Haffner
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:668-75. 2010
    ..These findings implicate androgen-induced TOP2B-mediated DSBs in generating TMPRSS2-ERG rearrangements...
  37. doi request reprint Prostate cancer: New answers prompt new questions regarding cell of origin
    Angelo M De Marzo
    The Brady Urological Research Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nat Rev Urol 7:650-2. 2010
    ..However, these results are not mutually exclusive: there are potential solutions, and alternative views on the initiating cell derivation of prostate tumors also exist...
  38. ncbi request reprint Focus on prostate cancer
    William Isaacs
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Cell 2:113-6. 2002
  39. ncbi request reprint The design of a randomized, placebo-controlled trial of celecoxib in preprostatectomy men with clinically localized adenocarcinoma of the prostate
    Elisabeth I Heath
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Clin Prostate Cancer 1:182-7. 2002
  40. ncbi request reprint Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase protein
    Craig G Rogers
    James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Urol 172:1501-3. 2004
    ..We assessed the feasibility of a novel urinary test for prostate cancer based on the presence of alpha methylacyl coenzyme A racemase (AMACR) protein in voided urine specimens obtained after prostate biopsy...
  41. ncbi request reprint Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells
    Jila Bakker
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    J Biol Chem 277:22573-80. 2002
    ..These findings implicate MBD2 in the repression of GSTP1 expression associated with GSTP1 CpG island hypermethylation in HCC cells...
  42. pmc Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen
    Charles G Drake
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Cell 7:239-49. 2005
    ..These results suggest that immunotherapy for prostate cancer may be most efficacious when administered after androgen ablation...
  43. ncbi request reprint Prostate carcinogenesis and inflammation: emerging insights
    Ganesh S Palapattu
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Carcinogenesis 26:1170-81. 2005
    ..These emerging insights into chronic inflammation in the etiology of prostate carcinogenesis hold the promise of spawning new diagnostic and therapeutic modalities for men with prostate cancer...
  44. pmc Procainamide is a specific inhibitor of DNA methyltransferase 1
    Byron H Lee
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 280:40749-56. 2005
    ..Because many reports have strongly linked DNMT1 with epigenetic alterations in carcinogenesis, procainamide may be a useful drug in the prevention of cancer...
  45. ncbi request reprint Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles
    Antony R Parker
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 278:47937-45. 2003
    ..Finally, using antibody-isolated MutY protein, we show that MutY can be directly phosphorylated by PKC that directly increases the level of MutY catalyzed A.8-oxoG repair...
  46. ncbi request reprint Molecular biomarker in prostate cancer: the role of CpG island hypermethylation
    Patrick J Bastian
    The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Eur Urol 46:698-708. 2004
    ..CpG island hypermethylation may serve as a useful molecular biomarker for the detection and diagnosis of patients with prostate cancer...
  47. pmc CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer
    Patrick J Bastian
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 179:529-34; discussion 534-5. 2008
    ..In this study we investigated the hypermethylation profile of several genes in the serum of men with localized and hormone refractory prostate cancer...
  48. pmc Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells
    Qun Zhou
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, CRB Room 144, Baltimore, MD 21231, USA
    Mol Cancer Res 6:873-83. 2008
    ..Our studies suggest a new role for HDAC1 and identify a novel mechanism of action for the HDAC inhibitors as down-regulators of DNMT1...
  49. pmc Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation
    Christopher J Gamper
    Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    J Immunol 183:2267-76. 2009
    ....
  50. pmc Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors
    Georges J Netto
    Department of Pathology, Division of Genitourinary Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Mod Pathol 21:1337-44. 2008
    ..That is, IGCNU cells and seminoma cells remain unmethylated, whereas all other histological types appear to arise after de novo methylation...
  51. ncbi request reprint Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy
    Patrick J Bastian
    The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 13:5361-7. 2007
    ..We evaluated the association of preoperative serum cell-free circulating DNA concentration in men with clinically localized prostate cancer who underwent radical prostatectomy with prostate-specific antigen (PSA) recurrence...
  52. ncbi request reprint Pathological and molecular aspects of prostate cancer
    Angelo M DeMarzo
    Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Lancet 361:955-64. 2003
    ..Changed gene expression (eg, proliferation-related genes, changes in the androgen receptor, apoptosis and stress-response genes) have potential as biomarkers and therapeutic targets in prostate cancer...
  53. ncbi request reprint Prostate-specific antigen as a marker of disease activity in prostate cancer
    Alan W Partin
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Oncology (Williston Park) 16:1218-24; discussion 1224, 1227-8 passim. 2002
    ..Part 2 of this two-part article, which began in the August issue, discusses the role of PSA in hormonal and drug therapies and in primary and secondary chemoprevention...
  54. ncbi request reprint Inadequate "caretaker" gene function and human cancer development
    Theodore L DeWeese
    John Hopkins Oncology Center, Baltimore, MD, USA
    Methods Mol Biol 222:249-68. 2003
  55. ncbi request reprint MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine
    Gloria L David
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Cancer Biol Ther 3:540-8. 2004
    ..In this state, MDR1 expression was markedly sensitive to treatment with the histone deacetylase inhibitor trichostatin A...
  56. ncbi request reprint Prostate-specific antigen as a marker of disease activity in prostate cancer
    Alan W Partin
    Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
    Oncology (Williston Park) 16:1024-38, 1042; discussion 1042, 1047-8, 1051. 2002
    ..Part 1 of this two-part article, which concludes in the September issue, focuses on the physiology of PSA, its measurement and use in clinical practice, and its predictive value following radical prostatectomy and radiation therapy...
  57. ncbi request reprint Evasion of early cellular response mechanisms following low level radiation-induced DNA damage
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 279:49624-32. 2004
    ....
  58. ncbi request reprint Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer
    Agoston T Agoston
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231 1000, USA
    J Biol Chem 280:18302-10. 2005
    ..The regulation of DNMT1 destruction via this domain may be dysfunctional in cancer cells leading to subsequent cytosine hypermethylation in the genome...
  59. ncbi request reprint Sexually transmitted infections and prostatic inflammation/cell damage as measured by serum prostate specific antigen concentration
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Urol 175:1937-42. 2006
    ..We indirectly investigated this question by measuring serum PSA, a possible marker of prostatic inflammation and cell damage, in men with documented STIs...
  60. doi request reprint Sex steroid hormone concentrations and risk of death in US men
    Andy Menke
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 171:583-92. 2010
    ..Future studies should be conducted to fully characterize the association of low free and bioavailable testosterone concentrations and mortality in men and to describe the mechanism underlying the association...
  61. ncbi request reprint Epithelial architectural destruction is necessary for bone marrow derived cell contribution to regenerating prostate epithelium
    Ganesh S Palapattu
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Urol 176:813-8. 2006
    ....
  62. ncbi request reprint Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Diabetes Care 30:234-8. 2007
    ..The objective of this study is to test the hypothesis that low normal levels of total, free, and bioavailable testosterone are associated with prevalent diabetes in men...
  63. ncbi request reprint Cyclooxygenases in cancer: progress and perspective
    Shan Zha
    Brady Urological Institute, The Johns Hopkins University, Baltimore, MD, USA
    Cancer Lett 215:1-20. 2004
    ..Here we review the fundamental features of COX enzymes, especially as related to carcinogenesis, their expression and function in both animal tumor models and clinical cancers and the proposed mechanisms behind their roles in cancer...
  64. ncbi request reprint Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines
    Lan Yan
    Sidney Kimmel Comprehensive Cancer at Johns Hopkins University Medical School, Baltimore, Maryland USA
    Cancer Biol Ther 2:552-6. 2003
    ..Our results suggest that specific inhibition of DNMT1 expression alone is sufficient to re-express ERa in human breast cancer cell lines...
  65. ncbi request reprint Identification of potential prostate cancer preventive agents through induction of quinone reductase in vitro
    James D Brooks
    Department of Urology, Stanford University School of Medicine, USA
    Cancer Epidemiol Biomarkers Prev 11:868-75. 2002
    ..Our data suggest that measurement of QR induction in prostate cancer cell lines may help identify potential cancer chemopreventive agents effective in the prostate...
  66. ncbi request reprint Loss-of-function of Nkx3.1 promotes increased oxidative damage in prostate carcinogenesis
    Xuesong Ouyang
    Center for Advanced Biotechnology and Medicine, The Cancer Institute of New Jersey, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5638, USA
    Cancer Res 65:6773-9. 2005
    ..Thus, our findings provide a molecular link between a gene whose inactivation is known to be involved in prostate carcinogenesis, namely Nkx3.1, and oxidative damage of the prostatic epithelium...
  67. ncbi request reprint Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward
    Gary J Kelloff
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Clin Cancer Res 12:3661-97. 2006
    ....
  68. ncbi request reprint Transmission/disequilibrium tests of androgen receptor and glutathione S-transferase pi variants in prostate cancer families
    Gloria Y F Ho
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cancer 98:938-42. 2002
    ..Our findings do not support the hypothesis that familial clustering of prostate cancer in high-risk families is attributable to these genetic variants...
  69. ncbi request reprint The dietary charred meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine acts as both a tumor initiator and promoter in the rat ventral prostate
    Yasutomo Nakai
    Department of Urology, Osaka University, Osaka, Japan
    Cancer Res 67:1378-84. 2007
    ..quot; The prostate lobe-specific infiltration of mast cells and macrophages in response to PhIP suggests a potential new mechanism by which this dietary compound can increase cancer risk-by prompting inflammation...
  70. ncbi request reprint Fourth International Conference on Innovations and Challenges in Prostate Cancer: Prevention, Detection and Treatment
    Peter R Carroll
    Department of Urology, University of California School of Medicine, San Francisco 94115 1711, USA
    J Urol 172:S3-5. 2004
  71. pmc The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics)
    Richard L Schilsky
    University of Chicago, Chicago, Illinois, USA
    Clin Cancer Res 14:5685-91. 2008
    ..This article presents the Agents Developmental Pathway and discusses key challenges associated with the processes described...
  72. ncbi request reprint Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naïve prostate cancer
    Jonathan W Simons
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 12:3394-401. 2006
    ....
  73. ncbi request reprint Granulocyte macrophage colony-stimulating factor--secreting allogeneic cellular immunotherapy for hormone-refractory prostate cancer
    Eric J Small
    University of California, San Francisco, Comprehensive Cancer Center, San Francisco, California 94115, USA
    Clin Cancer Res 13:3883-91. 2007
    ..The immunotherapy, based on the GVAX platform, is a combination of two prostate carcinoma cell lines modified with the granulocyte macrophage colony-stimulating factor (GM-CSF) gene...
  74. ncbi request reprint Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development
    Joyce A O'Shaughnessy
    Baylor Sammons Cancer Center, US Oncology, Collins 5, 3535 Worth Street, Dallas, TX 75246, USA
    Clin Cancer Res 8:314-46. 2002
    ..The IEN Task Force proposes several clinical trial designs that provide practical and feasible approaches to the rapid development of new agents to treat and prevent precancer...

Research Grants20

  1. Molecular Targets for Cancer Detection and Treatment
    William Nelson; Fiscal Year: 2007
    ..Mentors monitor the trainee's research progress while continuously emphasizing ethical and responsible conduct of research. ..
  2. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2004
    ..abstract_text> ..
  3. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2009
    ..This proposal is focused on ascertaining the cause of the disease, providing the basis for its prevention. ..
  4. SPORE IN PROSTATE CANCER
    William Nelson; Fiscal Year: 2006
    ..The Research Projects are supported by Core Resources for Administration, for a Tissue Archive, for Biomarker Development, and for Biostatistics. ..
  5. MBD2 as a Target for Cancer Prevention and Treatment
    William Nelson; Fiscal Year: 2007
    ..abstract_text> ..
  6. SPORE IN PROSTATE CANCER
    William Nelson; Fiscal Year: 2007
    ..The Research Projects are supported by Core Resources for Administration, for a Tissue Archive, for Biomarker Development, and for Biostatistics. ..
  7. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2007
    ..abstract_text> ..
  8. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2006
    ..abstract_text> ..
  9. AUA/SBUR Res. Conf.-"Inflammation in Prostate Diseases"
    William Nelson; Fiscal Year: 2005
    ..Support for this meeting will encourage the future development of urology research by providing mentoring for new investigators as well as education on this emerging research area. ..
  10. MBD2 as a Target for Cancer Prevention and Treatment
    William Nelson; Fiscal Year: 2005
    ..abstract_text> ..
  11. GSTPI PROMOTOR HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2002
    ....
  12. GSTPI PROMOTOR HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2001
    ....
  13. GSTPI PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2000
    ....
  14. MBD2 as a Target for Cancer Prevention and Treatment
    William Nelson; Fiscal Year: 2006
    ..abstract_text> ..
  15. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    William Nelson; Fiscal Year: 2005
    ..abstract_text> ..
  16. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    WILLIAM GEORGE NELSON; Fiscal Year: 2010
    ..This proposal is focused on ascertaining the cause of the disease, providing the basis for its prevention. ..