Research Topics
| DALE MURRAY contact NEEDHAMSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conferenceDale M Needham
OACIS Group, Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 40:502-9. 2012..These intensive care survivors and their families frequently report a wide range of impairments in their health status which may last for months and years after hospital discharge...
One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trialDale M Needham
Outcomes After Critical Illness and Surgery Group, Johns Hopkins University, Baltimore, MD 21205, USA
BMJ 346:f1532. 2013..To evaluate the effect of initial low energy permissive underfeeding ("trophic feeding") versus full energy enteral feeding ("full feeding") on physical function and secondary outcomes in patients with acute lung injury...- Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort studyDale M Needham
Outcomes After Critical Illness and Surgery Group, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
BMJ 344:e2124. 2012..To evaluate the association of volume limited and pressure limited (lung protective) mechanical ventilation with two year survival in patients with acute lung injury... - A knowledge translation collaborative to improve the use of therapeutic hypothermia in post-cardiac arrest patients: protocol for a stepped wedge randomized trialKatie N Dainty
RESCU Research Program, Keenan Research Centre, Li Ka Shing Knowledge Institute, St, Michael s Hospital Toronto, Canada
Implement Sci 6:4. 2011..Despite the strong evidence for its efficacy and the apparent simplicity of this intervention, recent surveys show that therapeutic hypothermia is delivered inconsistently, incompletely, and often with delay... - Mortality in sepsis versus non-sepsis induced acute lung injuryJonathan E Sevransky
Division of Pulmonary and Critical Care, Johns Hopkins University, 5501 Hopkins Bayview Circle Baltimore, MD 21224 USA
Crit Care 13:R150. 2009..Sepsis-induced acute lung injury (ALI) has been reported to have a higher case fatality rate than other causes of ALI. However, differences in the severity of illness in septic vs. non-septic ALI patients might explain this finding... - Bench-to-bedside review: mobilizing patients in the intensive care unit--from pathophysiology to clinical trialsAlex D Truong
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care 13:216. 2009..Further research is required to determine whether early mobility in the ICU can improve patients' short-term and long-term outcomes... - ICU staffing and patient outcomes: more work remainsDavid J Murphy
Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Crit Care 13:101. 2009..Future studies should evaluate other potential mechanisms by which closed ICUs improve patient outcomes. An improved understanding of these mechanisms may yield new targets for improving the quality of medical care for all ICU patients... - Technology to enhance physical rehabilitation of critically ill patientsDale M Needham
Division of Pulmonary and Critical Care Medicine, Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 37:S436-41. 2009..The introduction of physical medicine and rehabilitation-related technology into the intensive care unit may help facilitate delivery of this therapy... 
Patient safety, quality of care, and knowledge translation in the intensive care unitDale M Needham
Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, 1830 East Monument Street, 5th Floor, Baltimore MD 21205, USA
Respir Care 55:922-8. 2010....- Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement projectDale M Needham
Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA
Arch Phys Med Rehabil 91:536-42. 2010..To (1) reduce deep sedation and delirium to permit mobilization, (2) increase the frequency of rehabilitation consultations and treatments to improve patients' functional mobility, and (3) evaluate effects on length of stay... - Improving data quality control in quality improvement projectsDale M Needham
Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD, USA
Int J Qual Health Care 21:145-50. 2009..Our objective was to provide a primer on basic data quality control methods appropriate for QI efforts... - Mobilizing patients in the intensive care unit: improving neuromuscular weakness and physical functionDale M Needham
Division of Pulmonary and Critical Care Medicine, and Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, Maryland 21205, USA
JAMA 300:1685-90. 2008..Emerging research in this field provides preliminary evidence supporting the safety, feasibility, and potential benefits of early mobilization in critical care medicine... - Intensive care unit exposures for long-term outcomes research: development and description of exposures for 150 patients with acute lung injuryDale M Needham
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
J Crit Care 22:275-84. 2007..This report describes the development of a strategy for comprehensively measuring relevant exposures for long-term outcomes research, and presents empiric results from its implementation... - Are intensive care factors associated with depressive symptoms 6 months after acute lung injury?David W Dowdy
School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 37:1702-7. 2009..To evaluate intensive care-related factors as predictors of depressive symptoms 6 months after acute lung injury (ALI)... - A system factors analysis of airway events from the Intensive Care Unit Safety Reporting System (ICUSRS)Dale M Needham
Pulmonary and Critical Care Medicine, and Dana Center for Preventive Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 32:2227-33. 2004..Prevention efforts should focus on critically ill infants and patients with complex medical conditions. Managers should ensure appropriate ICU staffing to limit the impact of airway events when they occur... - Study protocol: The Improving Care of Acute Lung Injury Patients (ICAP) studyDale M Needham
Johns Hopkins University, 5th Floor, 1830 East Monument Street, Baltimore, MD 21205, USA
Crit Care 10:R9. 2006.... - Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injuryDavid W Dowdy
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Crit Care Med 36:2726-33. 2008..To evaluate the association between intensive care unit blood glucose levels and depression after acute lung injury... - Creating high reliability in health care organizationsPeter J Pronovost
Department of Anesthesiology and Critical Care Medicine, Surgery, and Health Policy and Management, The Johns Hopkins University, 1901 Thames Street, 2nd Floor, Baltimore, MD 21231, USA
Health Serv Res 41:1599-617. 2006.... - Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic reviewDimitry S Davydow
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Psychosom Med 70:512-9. 2008.... - Quality of life in adult survivors of critical illness: a systematic review of the literatureDavid W Dowdy
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Intensive Care Med 31:611-20. 2005..This systematic review provides a general understanding of QOL following critical illness and can serve as a standard of comparison for QOL studies in specific ICU subpopulations... - Pulmonary vs nonpulmonary sepsis and mortality in acute lung injuryJonathan E Sevransky
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Chest 134:534-8. 2008..Acute lung injury (ALI) is a frequent complication of sepsis. It is unclear if a pulmonary vs nonpulmonary source of sepsis affects mortality in patients with sepsis-induced ALI... - Translating evidence into practice: a model for large scale knowledge translationPeter J Pronovost
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Quality and Safety Research Group, 1909 Thames Street, Baltimore, MD 21231, USA
BMJ 337:a1714. 2008 - The use of personal protective equipment for control of influenza among critical care clinicians: A survey studyElizabeth L Daugherty
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 37:1210-6. 2009..Although effective PPE use may significantly reduce healthcare-associated influenza transmission, PPE adherence among ICU HCWs for preventing nosocomial influenza infection has not been evaluated... - Studying outcomes of intensive care unit survivors: measuring exposures and outcomesDale M Needham
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Intensive Care Med 31:1153-60. 2005..There is little systematic guidance for measuring these outcomes and exposures within the ICU setting. As a result measurement methods are often variable and non-comparable across studies... - Inter-rater reliability of manual muscle strength testing in ICU survivors and simulated patientsEddy Fan
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
Intensive Care Med 36:1038-43. 2010..DESIGN, SUBJECTS, AND SETTING: The authors report on 19 trainees undergoing quality assurance within a multi-site prospective cohort study... - A framework for diagnosing and classifying intensive care unit-acquired weaknessRobert D Stevens
Division of Neurosciences Critical Care, Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 37:S299-308. 2009..We propose a simple framework for diagnosing and classifying neuromuscular disorders acquired in critical illness... - Barriers to low tidal volume ventilation in acute respiratory distress syndrome: survey development, validation, and resultsCheryl R Dennison
School of Nursing, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 35:2747-54. 2007..To evaluate perceived attitudes, knowledge, and behaviors regarding the use of low tidal volume ventilation in acute respiratory distress syndrome among physicians, nurses, and respiratory therapists in intensive care units... - Human immunodeficiency virus infection and hospital mortality in acute lung injury patientsPedro A Mendez-Tellez
Department of Anesthesiology and Critical Care Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 38:1530-5. 2010..To evaluate the impact of human immunodeficiency virus infection on hospital mortality in patients with acute lung injury and to evaluate predictors of mortality among acute lung injury patients with human immunodeficiency virus... - Monitoring and reducing central line-associated bloodstream infections: a national survey of state hospital associationsDavid J Murphy
Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Am J Med Qual 25:255-60. 2010..A national collaborative to address CLABSIs may reduce these infections while building capacity to improve other aspects of health care quality... - Team care: beyond open and closed intensive care unitsPeter J Pronovost
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21231, USA
Curr Opin Crit Care 12:604-8. 2006..The purpose of this paper is to accelerate patient's exposure to the benefits of intensivists, and introduce team care in the intensive care unit... - Neuromuscular dysfunction acquired in critical illness: a systematic reviewRobert D Stevens
Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 8 140, Baltimore, MD 21287, USA
Intensive Care Med 33:1876-91. 2007..To determine the prevalence, risk factors, and outcomes of critical illness neuromuscular abnormalities (CINMA)... - Improving the quality of quality improvement projectsSean M Berenholtz
Johns Hopkins University School of Medicine, Department of Anesthesiology and Critical Care Medicine, Quality and Safety Research Group, Baltimore, USA
Jt Comm J Qual Patient Saf 36:468-73. 2010..Our patients deserve nothing less... - Evaluation of two intensive care delirium screening tools for non-critically ill hospitalized patientsKarin J Neufeld
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287 5371, USA
Psychosomatics 52:133-40. 2011..While easy-to-use delirium screening tools exist for ventilated patients, their use in non-critically ill, hospitalized patients has not been validated... - The efficacy of sirolimus- and paclitaxel-eluting stents: a meta-analysis of randomized controlled trialsMichelle M Kittleson
Department of Medicine, Division of Cardiology, Epidemiology and Clinical Research, John Hopkins Medical Institute, Baltimore, MD, USA
Can J Cardiol 21:581-7. 2005.... - The impact of obesity on outcomes after critical illness: a meta-analysisCharles W Hogue
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Intensive Care Med 35:1152-70. 2009..To assess whether obesity is associated with mortality or other adverse intensive care unit (ICU) and post-ICU outcomes... - Long-term mortality and quality of life in sepsis: a systematic reviewBradford D Winters
Departments of Anesthesiology and Critical Care Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 38:1276-83. 2010..Whether patients with sepsis have similar long-term mortality and quality-of-life effects is unclear... - A system factors analysis of "line, tube, and drain" incidents in the intensive care unitDale M Needham
Department of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 33:1701-7. 2005..Focusing on these contributing factors and clinician knowledge and skills is important for reducing and preventing these hazardous events... - How to use an article about quality improvementEddy Fan
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, 1830 E Monument St, Fifth Floor, Baltimore, MD 21287, USA
JAMA 304:2279-87. 2010..Given the potential for widespread implementation of QI interventions, there is a need for robust study methods in QI research... - Studying outcomes of intensive care unit survivors: the role of the cohort studyDavid W Dowdy
School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Intensive Care Med 31:914-21. 2005..CONCLUSIONS: We make recommendations for the design of future cohort studies to maximize the impact of this research in improving the long-term outcomes of critically ill patients... - Hospital volume and mortality for mechanical ventilation of medical and surgical patients: a population-based analysis using administrative dataDale M Needham
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Crit Care Med 34:2349-54. 2006..For medical patients, higher mortality may occur in a subgroup of low-volume hospitals that do not routinely transfer their patients to larger-volume facilities. This finding needs further investigation in a larger-sized study... - Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literatureJonathan E Sevransky
Department of Pulmonary Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Crit Care 11:R67. 2007..Patients with sepsis suffer high morbidity and mortality. We sought to conduct a systematic review of the literature to evaluate the association between hemodynamic goals of therapy and patient outcomes... - Systematic review identifies number of strategies important for retaining study participantsKaren A Robinson
Division of Internal Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
J Clin Epidemiol 60:757-65. 2007..We conducted a systematic review of studies with a primary focus on strategies to retain participants in health care research... - A framework for health care organizations to develop and evaluate a safety scorecardPeter J Pronovost
Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
JAMA 298:2063-5. 2007 - Review of a large clinical series: sedation and analgesia usage with airway pressure release and assist-control ventilation for acute lung injuryEddy Fan
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
J Intensive Care Med 23:376-83. 2008..Our objective was to compare sedative and analgesic doses, agents, and sedation status in patients with airway pressure release ventilation (APRV) versus assist-control (AC) ventilation on the first day after acute lung injury diagnosis... - Intensive care unit physician staffing: financial modeling of the Leapfrog standardPeter J Pronovost
Department of Anesthesiology and Critical Care, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 32:1247-53. 2004..Given the magnitude of its clinical and financial impact, hospital leaders should be asking "how to" rather than "whether to" implement The Leapfrog Group's ICU Physician Staffing standard... - A systematic review of the Charlson comorbidity index using Canadian administrative databases: a perspective on risk adjustment in critical care researchDale M Needham
Department of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
J Crit Care 20:12-9. 2005..Future research should focus on updating the Charlson index for recent changes in the prognosis of comorbid diseases and introduction of International Statistical Classification of Diseases, 10th Revision coding of discharge abstracts... - Rehabilitation therapy and outcomes in acute respiratory failure: an observational pilot projectJennifer M Zanni
Department of Physical Medicine and Rehabilitation, Johns Hopkins Hospital, Baltimore, MD 21205, USA
J Crit Care 25:254-62. 2010..The aim of this study was to describe the frequency, physiologic effects, safety, and patient outcomes associated with traditional rehabilitation therapy in patients who require mechanical ventilation... - Quality of life after acute respiratory distress syndrome: a meta-analysisDavid W Dowdy
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Intensive Care Med 32:1115-24. 2006..CONCLUSIONS: ARDS survivors in different clinical settings experience similar decrements in QOL. The precise magnitude of these decrements helps clarify the long-term prognosis for ARDS survivors... - Critical illness neuromyopathy and muscle weakness in patients in the intensive care unitEddy Fan
Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
AACN Adv Crit Care 20:243-53. 2009..Future studies are needed to elucidate the multiple mechanisms by which immobility, CINM, and other aspects of critical illness lead to muscle loss and neuromuscular dysfunction... - Baseline quality of life before intensive care: a comparison of patient versus proxy responsesJeneen M Gifford
Department of Internal Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
Crit Care Med 38:855-60. 2010..To compare acute lung injury patients' self-reported, retrospective baseline quality of life before their intensive care hospitalization with population norms and retrospective proxy estimates... - Rehabilitation quality improvement in an intensive care unit setting: implementation of a quality improvement modelDale M Needham
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Top Stroke Rehabil 17:271-81. 2010..We present a specific model for undertaking quality improvement (QI) projects and a case study focused on QI for early PM&R in the ICU... - Intensive care unit safety incidents for medical versus surgical patients: a prospective multicenter studyDavid J Sinopoli
UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
J Crit Care 22:177-83. 2007..The aim of this study is to determine if patient safety incidents and the system-related factors contributing to them systematically differ for medical versus surgical patients in intensive care units... - Mechanical ventilation in Ontario, 1992-2000: incidence, survival, and hospital bed utilization of noncardiac surgery adult patientsDale M Needham
Department of Critical Care Medicine and Medicine, University of Toronto, Toronto, Canada
Crit Care Med 32:1504-9. 2004..The increase, over time, in risk-adjusted mortality rate of mechanically ventilated patients is concerning and requires further investigation... - An intensivist all day, keeps the bad outcomes awayEddy Fan
Crit Care Med 35:286-7. 2007 - Troponin I and T levels in renal failure patients without acute coronary syndrome: a systematic review of the literatureDale M Needham
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Can J Cardiol 20:1212-8. 2004..Among hemodialysis patients without ACS symptoms, a positive troponin T helps predict all-cause mortality... - Patient and intensive care unit organizational factors associated with low tidal volume ventilation in acute lung injuryNsikak J Umoh
Department of Surgery, Geisinger Medical Center, Danville, PA, USA
Crit Care Med 36:1463-8. 2008..Within the intensive care unit (ICU) setting, low tidal volume ventilation (LTVV) in patients with acute lung injury (ALI) significantly decreases mortality. However, LTVV has not achieved widespread adoption... - The role of future longitudinal studies in ICU survivors: understanding determinants and pathophysiology of weakness and neuromuscular dysfunctionCatherine L Hough
Department of Medicine, University of Washington, Seattle, Washington, USA
Curr Opin Crit Care 13:489-96. 2007..The goals of this review are to discuss the pathophysiology and determinants of muscle weakness and neuromuscular dysfunction after critical illness, and to offer thoughts regarding the role of future longitudinal studies in this area... - Informed consent in the critically ill: a two-step approach incorporating delirium screeningEddy Fan
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
Crit Care Med 36:94-9. 2008..We describe a two-step process for informed consent and evaluate the natural history of patients' competency by repeated application of this process during their hospitalization... - The science of quality improvementEddy Fan
JAMA 300:390-1; author reply 391-2. 2008 - Critically appraise before you believe: the quality of meta-analyses in critical care medicineDale M Needham
Crit Care Med 35:666-7. 2007 - Projected incidence of mechanical ventilation in Ontario to 2026: Preparing for the aging baby boomersDale M Needham
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
Crit Care Med 33:574-9. 2005..Existing evidence-based strategies that improve both the efficiency and efficacy of critical care services should be carefully evaluated for widespread implementation... - Deciding who to admit to a critical care unitEddy Fan
BMJ 335:1103-4. 2007 - Ventilatory management of acute lung injury and acute respiratory distress syndromeEddy Fan
Interdepartmental Division of Critical Care Medicine and Department of Medicine, University of Toronto and University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada
JAMA 294:2889-96. 2005..Further research is needed to identify barriers to widespread adoption of this strategy, as well as the role of alternative ventilation modes and adjunctive therapies... - The importance of understanding the costs of critical care and mechanical ventilationDale M Needham
Crit Care Med 33:1434-5. 2005 - 24-hour intensivist staffing: balancing benefits and costsAdam Sapirstein
Crit Care Med 36:367-8. 2008 - West Nile virus infection in the intensive care unit: a case series and literature reviewEddy Fan
Department of Medicine, University of Toronto
Can Respir J 11:354-8. 2004..As a consequence, end-of-life discussions with families are especially difficult. The prolonged ICU length of stay and growing incidence of this disease may challenge limited critical care resources... - A province-wide study of the association between hospital resource allocation and length of stayDale M Needham
University of Toronto, Toronto, Canada
Health Serv Manage Res 16:155-66. 2003..Future research should focus on exploring the nature of this relationship and the potential interdependencies among hospital services that cause this effect... - How will we know patients are safer? An organization-wide approach to measuring and improving safetyPeter Pronovost
The Johns Hopkins University, Department of Anesthesiology and Critical Care Medicine, USA
Crit Care Med 34:1988-95. 2006.... - Mechanical ventilation and disuse atrophy of the diaphragmEddy Fan
N Engl J Med 359:90-1; author reply 91-2. 2008
Research Grants
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDale Needham; Fiscal Year: 2009..End of Abstract) ..
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDALE MURRAY contact NEEDHAM; Fiscal Year: 2010..End of Abstract) ..
- Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsDale Needham; Fiscal Year: 2009..End of Abstract) ..