Research Topics
| Saman NazarianSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Clinical predictors of conduction disease progression in type I myotonic muscular dystrophySaman Nazarian
Department of Medicine, Johns Hopkins University School of Medicine and the Kennedy Krieger Institute, Baltimore, Maryland 21287, USA
Pacing Clin Electrophysiol 34:171-6. 2011..We sought to characterize the trends and predictors of time-dependent electrocardiographic (ECG) variations in patients with DM1...
QRS prolongation in myotonic muscular dystrophy and diffuse fibrosis on cardiac magnetic resonanceSaman Nazarian
Department of Medicine Cardiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Magn Reson Med 64:107-14. 2010..The SNRV of the left ventricle is associated with QRS prolongation, likely due to late depolarization of tissue within islands of patchy fibrosis. The association of SNRV with future clinical events warrants further study...
New technologies and therapies for cardiac arrhythmiasS Nazarian
Johns Hopkins University, Baltimore, MD 21287, USA
Minerva Cardioangiol 58:731-40. 2010..This review focuses on improved imaging modalities used in the modern electrophysiology laboratory...
Feasibility of endoscopic guidance for nonsurgical transthoracic atrial and ventricular epicardial ablationSaman Nazarian
Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Heart Rhythm 5:1115-9. 2008..The safety, efficacy, and applicability of epicardial catheter ablation likely will improve with direct visualization of the pericardial space...
Persistent left ventricular dilatation in tachycardia-induced cardiomyopathy patients after appropriate treatment and normalization of ejection fractionGopi Dandamudi
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Heart Rhythm 5:1111-4. 2008..Tachycardia-induced cardiomyopathy (TIC) seems to be a form of reversible cardiomyopathy. With recurrence, TIC can be more severe and may increase the risk for sudden cardiac death...
Feasibility of real-time magnetic resonance imaging for catheter guidance in electrophysiology studiesSaman Nazarian
Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Carnegie 592C, 600 N Wolfe St, Baltimore, MD 21287, USA
Circulation 118:223-9. 2008..In this study, we sought to test the feasibility of performing electrophysiology studies with real-time MRI guidance...
A prospective evaluation of a protocol for magnetic resonance imaging of patients with implanted cardiac devicesSaman Nazarian
Johns Hopkins University, Baltimore, Maryland 21287, USA
Ann Intern Med 155:415-24. 2011..Magnetic resonance imaging (MRI) is avoided in most patients with implanted cardiac devices because of safety concerns...
Conventional pulmonary vein isolation compared with the "box isolation" method: a randomized clinical trialKaruna Chilukuri
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Interv Card Electrophysiol 32:137-46. 2011..This study compares the acute and long-term efficacy of the box isolation method with conventional circumferential pulmonary vein isolation (PVI) for catheter ablation of AF...
Incidence and predictors of left atrial thrombus prior to catheter ablation of atrial fibrillationDaniel Scherr
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Cardiovasc Electrophysiol 20:379-84. 2009..However, the incidence and predictors of LA thrombus detected with TEE have not been systematically examined in this setting...
Incidence and predictors of periprocedural cerebrovascular accident in patients undergoing catheter ablation of atrial fibrillationDaniel Scherr
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 20:1357-63. 2009..Cerebrovascular accident (CVA) is a serious complication of catheter ablation of atrial fibrillation (AF). The incidence and clinical predictors of periprocedural CVA in patients undergoing AF ablation are not fully understood...
Outcomes in patients requiring cardioversion following catheter ablation of atrial fibrillationKaruna Chilukuri
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 21:27-32. 2010..This study reports the outcomes of patients who underwent cardioversion for persistent AF or atrial flutter following an AF ablation procedure...
Association of transseptal punctures with isolated migraine aura in patients undergoing catheter ablation of cardiac arrhythmiasKaruna Chilukuri
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0409, USA
J Cardiovasc Electrophysiol 20:1227-30. 2009..TSC causes a transient iatrogenic atrial septal defect that can predispose patients to migraine episodes. However, isolated migraine aura episodes in patients undergoing TSC have not been described...
Long- and short-term temporal stability of complex fractionated atrial electrograms in human left atrium during atrial fibrillationDaniel Scherr
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 20:13-21. 2009..Complex fractionated atrial electrograms (CFAEs) have been reported as targets for catheter ablation of atrial fibrillation (AF). However, the temporal stability of CFAE sites remains poorly defined...
Impact of heart rhythm status on registration accuracy of the left atrium for catheter ablation of atrial fibrillationJun Dong
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 18:1269-76. 2007..However, the impact of the heart rhythm change on the accuracy of left atrium (LA) registration has not been studied...
Transoesophageal echocardiography predictors of periprocedural cerebrovascular accident in patients undergoing catheter ablation of atrial fibrillationKaruna Chilukuri
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, A 1 East, Baltimore, MD 21224, USA
Europace 12:1543-9. 2010....
Dual antiplatelet therapy and heparin "bridging" significantly increase the risk of bleeding complications after pacemaker or implantable cardioverter-defibrillator device implantationChristine Tompkins
Johns Hopkins Hospital, Baltimore, Maryland, USA
J Am Coll Cardiol 55:2376-82. 2010..This study was designed to assess the risk of significant bleeding complications in patients receiving antiplatelet or anticoagulation medications at the time of implantable cardioverter-defibrillator (ICD) device implantation...
Long-term single procedure efficacy of catheter ablation of atrial fibrillationAamir Cheema
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Interv Card Electrophysiol 15:145-55. 2006..In order to be able to compare outcomes of various techniques in differing patient populations, we urge investigators to report long-term single procedure outcomes...
Incidence and outcomes of protamine reactions in patients undergoing catheter ablation of atrial fibrillationKaruna Chilukuri
Department of Medicine, Division of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Interv Card Electrophysiol 25:175-81. 2009..The purpose of this study is to describe the incidence and outcome of protamine reactions and analyze the risk factors in patients undergoing catheter ablation of AF...
Myocardial structural associations with local electrograms: a study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mappingTakeshi Sasaki
Department of Medicine Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Circ Arrhythm Electrophysiol 5:1081-90. 2012..We aimed to quantify these associations to gain insights regarding LGE-CMR image characteristics of tissues and critical sites that support postinfarct ventricular tachycardia (VT)...
Predictive value of obstructive sleep apnoea assessed by the Berlin Questionnaire for outcomes after the catheter ablation of atrial fibrillationKaruna Chilukuri
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Europace 11:896-901. 2009..The purpose of this study is to determine whether OSA assessed by the simple tool, the Berlin Questionnaire (BQ), is useful in predicting the efficacy of catheter ablation of AF...
Clinical utility and safety of a protocol for noncardiac and cardiac magnetic resonance imaging of patients with permanent pacemakers and implantable-cardioverter defibrillators at 1.5 teslaSaman Nazarian
Department of Cardiology, Johns Hopkins Hospital, Carnegie 568, 600 N Wolfe St, Baltimore, MD 21287, USA
Circulation 114:1277-84. 2006..We sought to evaluate the diagnostic utility and safety of noncardiac and cardiac MRI at 1.5T using a protocol that incorporates device selection and programming and limits the estimated specific absorption rate of MRI sequences...
Continuation of warfarin during pacemaker or implantable cardioverter-defibrillator implantation: a randomized clinical trialAlan Cheng
Section of Cardiac Electrophysiology, Division of Cardiology, Johns Hopkins Medical Institutes, Baltimore, Maryland, USA
Heart Rhythm 8:536-40. 2011..Prior studies demonstrate that continuation of warfarin may be safer when compared with strategies requiring interruption and/or heparin bridging. Limited data from randomized trials exist...
Effects of surgical and endoscopic electrocautery on modern-day permanent pacemaker and implantable cardioverter-defibrillator systemsAlan Cheng
Section for Cardiac Electrophysiology, Division of Cardiovascular Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Pacing Clin Electrophysiol 31:344-50. 2008..The ability of newer devices to withstand system malfunction or failure during surgery/endoscopy remains unknown...
Circumferential ablation with pulmonary vein isolation in permanent atrial fibrillationAamir Cheema
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 99:1425-8. 2007..In conclusion, study results suggest that circumferential ablation with PV isolation has moderate efficacy in patients with permanent AF. Efficacy is limited in those in continuous AF for >12 months...
Characterization of acute and subacute radiofrequency ablation lesions with nonenhanced magnetic resonance imagingTimm Dickfeld
Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21201, USA
Heart Rhythm 4:208-14. 2007..However, MRI patterns after RF ablation have not been well investigated...
Demographic profile of patients undergoing catheter ablation of atrial fibrillationHana Hoyt
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 22:994-8. 2011..Catheter ablation is a widely accepted treatment for drug refractory atrial fibrillation (AF). The purpose of our study was to examine secular trends in the demographic profile of patients undergoing AF ablation...
Complications arising from catheter ablation of atrial fibrillation: temporal trends and predictorsHana Hoyt
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Heart Rhythm 8:1869-74. 2011..The reported complication rate of catheter ablation of atrial fibrillation (AF) varies...
The critical isthmus sites of ischemic ventricular tachycardia are in zones of tissue heterogeneity, visualized by magnetic resonance imagingHeidi L Estner
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 20215, USA
Heart Rhythm 8:1942-9. 2011..A need exists to develop alternative approaches to VT ablation that provide an improved delineation of the arrhythmogenic substrate...
Quantitative assessment of artifacts on cardiac magnetic resonance imaging of patients with pacemakers and implantable cardioverter-defibrillatorsTakeshi Sasaki
Department of Medicine Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circ Cardiovasc Imaging 4:662-70. 2011..This study aims to evaluate the extent of artifacts on cardiac magnetic resonance (CMR) in patients with PM and ICD (PM/ICD)...
Incidence and time course of early recovery of pulmonary vein conduction after catheter ablation of atrial fibrillationAamir Cheema
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0409, USA
J Cardiovasc Electrophysiol 18:387-91. 2007..Although it is well recognized that recovery of pulmonary vein (PV) conduction is common among patients who fail atrial fibrillation (AF) ablation, little is known about the precise time course of recurrence...
Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathySaman Nazarian
Department of Medicine Cardiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Circulation 112:2821-5. 2005..However, the substrate for ventricular arrhythmia in patients with nonischemic cardiomyopathy remains poorly understood. We hypothesized that the distribution of scar identified by MRI is predictive of inducible ventricular tachycardia...
Direct imaging of transvenous radiofrequency cardiac ablation using a steerable fiberoptic infrared endoscopeBradley P Knight
Division of Cardiology, Department of Internal Medicine, University of Chicago, Chicago, Illinois, USA
Heart Rhythm 2:1116-21. 2005..Direct imaging through blood has been achieved in vivo using fiberoptics and infrared wavelength technology...
A prospective study evaluating the role of obesity and obstructive sleep apnea for outcomes after catheter ablation of atrial fibrillationKaruna Chilukuri
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 21:521-5. 2010..The purpose of this study was to prospectively determine the effects of obesity, assessed by the body mass index (BMI) and OSA on the efficacy of catheter ablation of AF...
Predictors of high defibrillation threshold in the modern eraEdward F Lin
Johns Hopkins University, Baltimore, Maryland, USA
Pacing Clin Electrophysiol 36:231-7. 2013..Identification of the predictors of elevated DFT may allow selective application of DFT testing. However, the clinical characteristics of patients with high DFT in the modern era have not been well-defined...
High prevalence of catecholamine-facilitated focal ventricular tachycardia in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathyBinu Philips
Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Circ Arrhythm Electrophysiol 6:160-6. 2013..We hypothesized that VT in arrhythmogenic right ventricular dysplasia/cardiomyopathy shows a high degree of association with the PVC at baseline...
Novel electrode design for potentially painless internal defibrillation also allows for successful external defibrillationVenku Jayanti
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0409, USA
J Cardiovasc Electrophysiol 18:1095-100. 2007....
Association of QRS duration with left ventricular structure and function and risk of heart failure in middle-aged and older adults: the Multi-Ethnic Study of Atherosclerosis (MESA)Leonard Ilkhanoff
Department of Medicine, Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Eur J Heart Fail 14:1285-92. 2012..We sought to determine whether QRSd is associated with incident HF and measures of cardiac structure and function by cardiac MRI...
Outcomes of catheter ablation of ventricular tachycardia in arrhythmogenic right ventricular dysplasia/cardiomyopathyBinu Philips
Division of Cardiology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
Circ Arrhythm Electrophysiol 5:499-505. 2012..The overall objective of the present study was to assess the efficacy of radiofrequency catheter ablation (RFA) of VT in ARVD/C, with particular focus on newer ablation strategies, including epicardial catheter ablation...
The value of defibrillator far-field electrograms for ablation of idiopathic ventricular fibrillationBinu Philips
Division of Cardiology Cardiac Arrhythmia, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
Europace 14:607-8. 2012..We report a case of idiopathic ventricular fibrillation treated by catheter ablation of the monomorphic initiating premature beat. The initiating focus was identified using intacardiac defibrillator electrograms (EGMs)...
Evaluation of cardiac arrhythmia among athletesJames Walker
Department of Biology, Johns Hopkins University, Baltimore, MD 21287, USA
Am J Med 123:1075-81. 2010..This article surveys recent research and expert opinion addressing benign and pathogenic cardiac changes underlying arrhythmias in athletes...
Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablationHiroshi Ashikaga
Division of Cardiology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Traylor 903, Baltimore, MD 20215, USA
Circ Res 101:939-47. 2007..Magnetic resonance-based visualization of scar morphology would potentially contribute to preprocedural planning for catheter ablation of scar-related, unmappable VT...
Profound hypotension due to slow atrioventricular nodal pathway conduction during atrial tachycardiaSaman Nazarian
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Pacing Clin Electrophysiol 32:278-80. 2009..This case illustrates the potential importance of AV timing in determining the hemodynamic effect of SVT...
Initial experience with magnetic resonance imaging of atrial scar and co-registration with electroanatomic voltage mapping during atrial fibrillation: success and limitationsDavid D Spragg
Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland, USA
Heart Rhythm 9:2003-9. 2012..Early studies have suggested that delayed enhancement magnetic resonance imaging (DE-MRI) of the left atrium (LA) can assist in performing repeat ablation procedures...
Computed tomography image-guided catheter ablation of a focal atrial tachycardia from the noncoronary sinus of ValsalvaJoseph E Marine
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0409, USA
Heart Rhythm 4:1582. 2007
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scarAlbert C Lardo
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Circulation 113:394-404. 2006....
Long-term safety and efficacy of circumferential ablation with pulmonary vein isolationAamir Cheema
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0409, USA
J Cardiovasc Electrophysiol 17:1080-5. 2006..Repeat procedures involving re-isolation of the PVs result in a significant improvement in outcomes. Complete electrical isolation of the PVs has a significant impact on the long-term efficacy of the procedure...
Direct visualization of coronary sinus ostium and branches with a flexible steerable fiberoptic infrared endoscopeSaman Nazarian
Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Heart Rhythm 2:844-8. 2005..This study reports our experience with navigation into and within the coronary sinus in a closed-chest animal preparation, using a flexible steerable fiberoptic infrared endoscope that allows visualization through flowing blood...
Impact of scar, viable myocardium, and epicardial fat on substrate identification of ventricular tachycardia in a case with nonischemic cardiomyopathyTakeshi Sasaki
Medicine Cardiology Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Pacing Clin Electrophysiol 35:e345-8. 2012..This case provides a unique opportunity to explore the reliability of electrical surrogates of scar in nonischemic cardiomyopathy...
Assessment of cardiac involvement in myotonic muscular dystrophy by T1 mapping on magnetic resonance imagingEvrim B Turkbey
Radiology and Imaging Sciences, Clinical Center, and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
Heart Rhythm 9:1691-7. 2012..Patients with myotonic muscular dystrophy (DM) are at risk for atrioventricular block and left ventricular (LV) dysfunction. Noninvasive detection of diffuse myocardial fibrosis may improve disease management in this population...
Impact of implantable cardioverter defibrillators on survival and recurrent hospitalization in advanced heart failureSaman Nazarian
Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Am Heart J 150:955-60. 2005..The aim of this study was to assess the impact of QRS duration and disease etiology on survival and rehospitalization in advanced heart failure patients with ICDs...
Fatal outcome of a calcified amorphous tumor of the heart (cardiac CAT)Marc Lewin
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Cardiovasc Pathol 15:299-302. 2006..Magnetic resonance imaging, echocardiography, angiography, and histologic descriptions of the lesion are described...
Migraine headache and ischemic stroke risk: an updated meta-analysisJune T Spector
Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Am J Med 123:612-24. 2010..We performed an updated meta-analysis to quantitatively summarize the strength of association between migraine and ischemic stroke risk...
