Research Topics
Genomes and Genes | Ana Navas-AcienSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Publications
Kidney Function and Tobacco Smoke Exposure in US AdolescentsEsther García-Esquinas
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Office W7513D, Baltimore, MD 21205
Pediatrics 131:e1415-23. 2013..Active smoking and secondhand smoke (SHS) are known risk factors for kidney disease in adults. We evaluated the association between exposure to active smoking or SHS and kidney function in US adolescents...- Selenium intake and cardiovascular risk: what is new?Ana Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Curr Opin Lipidol 19:43-9. 2008..This review discusses recent experimental and epidemiologic contributions on the role of selenium for the prevention of atherosclerotic cardiovascular disease... - Arsenic exposure and prevalence of type 2 diabetes in US adultsAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7033B, Baltimore, MD 21205, USA
JAMA 300:814-22. 2008..In contrast, arsenobetaine, an organic arsenic compound derived from seafood intake, is considered nontoxic... - Bone lead levels and blood pressure endpoints: a meta-analysisAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Epidemiology 19:496-504. 2008..We performed a meta-analysis of the association of bone lead levels with systolic blood pressure, diastolic blood pressure, and hypertension using published data... 
Urine arsenic concentrations and species excretion patterns in American Indian communities over a 10-year period: the Strong Heart StudyAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Environ Health Perspect 117:1428-33. 2009..Arsenic exposure in drinking water disproportionately affects small communities in some U.S. regions, including American Indian communities. In U.S. adults with no seafood intake, median total urine arsenic is 3.4 microg/L...- Seafood intake and urine concentrations of total arsenic, dimethylarsinate and arsenobetaine in the US populationAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Environ Res 111:110-8. 2011..Seafood is the main source of organic arsenic exposure (arsenobetaine, arsenosugars and arsenolipids) in the population. Arsenosugars and arsenolipids are metabolized to several species including dimethylarsinate (DMA)... - Arsenic exposure and type 2 diabetes: a systematic review of the experimental and epidemiological evidenceAna Navas-Acien
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205 2223, USA
Environ Health Perspect 114:641-8. 2006.... 
Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidenceAna Navas-Acien
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 2223, USA
Am J Epidemiol 162:1037-49. 2005..In other populations or in occupational settings, the evidence was inconclusive. Because of the high prevalence of arsenic exposure, carefully performed studies of arsenic and cardiovascular outcomes should be a research priority...- Arsenic exposure, diabetes prevalence, and diabetes control in the Strong Heart StudyMatthew O Gribble
Departments of Environmental Health Sciences and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Room W7513D, Baltimore, MD 21205, USA
Am J Epidemiol 176:865-74. 2012..Prospective studies that evaluate the direction of the relation between poor diabetes control and arsenic exposure are needed... - Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium, and renal functionEliseo Guallar
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Am J Epidemiol 163:700-8. 2006..The association of lead and cadmium with PAD risk deserves further investigation... - Determinants of hair nicotine concentrations in nonsmoking women and children: a multicountry study of secondhand smoke exposure in homesSungroul Kim
Institute for Global Tobacco Control, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 18:3407-14. 2009..The association between children's exposure to secondhand tobacco smoke at home and hair nicotine concentration was stronger among younger children and children with longer exposure at home... - Serum selenium and peripheral arterial disease: results from the national health and nutrition examination survey, 2003-2004Joachim Bleys
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Epidemiol 169:996-1003. 2009..The association between serum selenium levels and the prevalence of peripheral arterial disease was not statistically significant, although a U-shaped relation was suggested... - Secondhand tobacco smoke: a source of lead exposure in US children and adolescentsAndria Apostolou
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Public Health 102:714-22. 2012..We evaluated the relationship between secondhand tobacco smoke (SHS) exposure and blood lead levels in US children and adolescents... - Relationship of monocyte count and peripheral arterial disease: results from the National Health and Nutrition Examination Survey 1999-2002Khurram Nasir
Cardiology Division, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287-0409, USA
Arterioscler Thromb Vasc Biol 25:1966-71. 2005..S. population after adjustment for other inflammatory markers. These findings reflect the potential role of circulating monocyte counts as markers of atherosclerosis... - Metals in urine and peripheral arterial diseaseAna Navas-Acien
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 113:164-9. 2005..Other metals in urine were not associated with PAD at the levels found in the general population... - Secondhand tobacco smoke exposure and chronic rhinosinusitis: a population-based case-control studyDouglas D Reh
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Sinus Center, Johns Hopkins Medicine, Baltimore, Maryland 21287, USA
Am J Rhinol Allergy 23:562-7. 2009..To address this evidence gap, we evaluated the association of SHS and CRS risk in a community-based case-control study of adult nonsmokers... - Cadmium and peripheral arterial disease: gender differences in the 1999-2004 US National Health and Nutrition Examination SurveyMaria Tellez-Plaza
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Epidemiol 172:671-81. 2010..These findings add to the concern of increased cadmium exposure as a cardiovascular risk factor in the general population... - Urine arsenic and hypertension in US adults: the 2003-2008 National Health and Nutrition Examination SurveyMiranda R Jones
Department of Epidemiology, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Epidemiology 22:153-61. 2011..We investigated the association of exposure to inorganic arsenic (as measured in urine) with systolic and diastolic blood pressure levels and the prevalence of hypertension in US adults... - Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999-2006Lauren F Loeffler
Johns Hopkins University School of Medicine, 200 North Wolfe St, Room 3055, Baltimore, MD 21287, USA
Hypertension 59:811-7. 2012..Additional prospective studies and clinical trials are needed to determine whether uric acid is merely a marker in a complex metabolic pathway or causal of hypertension and, thus, a potential screening and therapeutic target... - Blood lead level and kidney function in US adolescents: The Third National Health and Nutrition Examination SurveyJeffrey J Fadrowski
Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA
Arch Intern Med 170:75-82. 2010..Therefore, in this study, we investigated the association between lead exposure and kidney function in a representative sample of US adolescents... - Urine arsenic and prevalent albuminuria: evidence from a population-based studyLaura Y Zheng
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Kidney Dis 61:385-94. 2013..Our objective was to evaluate the cross-sectional association between inorganic arsenic exposure and albuminuria in American Indian adults from rural areas of Arizona, Oklahoma, and North and South Dakota... - Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking ratesMaria Tellez-Plaza
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7513D, Baltimore, MD 21205 USA
Environ Health Perspect 120:204-9. 2012..S. adults. However, trends in urine cadmium, a marker of cumulative cadmium exposure, have not been evaluated... - Cadmium exposure and hypertension in the 1999-2004 National Health and Nutrition Examination Survey (NHANES)Maria Tellez-Plaza
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Rm W7033B, Baltimore, MD 21205, USA
Environ Health Perspect 116:51-6. 2008..Cadmium induces hypertension in animal models. Epidemiologic studies of cadmium exposure and hypertension, however, have been inconsistent... - Tobacco sales and promotion in bars, cafes and nightclubs from large cities around the worldShahida Shahrir
Institute for Global Tobacco Control, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Tob Control 20:285-90. 2011..Information on tobacco sales, advertisement and promotion in bars, cafes and nightclubs is needed to develop interventions to reduce smoking initiation and relapse, particularly among youths and young adults... - Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general populationMaria Tellez-Plaza
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Environ Health Perspect 120:1017-22. 2012..Since 1988, cadmium exposure has decreased substantially in the United States. The associations between blood and urine cadmium and cardiovascular disease (CVD) mortality at more recent levels of exposure are unknown... - Associations of blood lead with estimated glomerular filtration rate using MDRD, CKD-EPI and serum cystatin C-based equationsJune T Spector
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Nephrol Dial Transplant 26:2786-92. 2011..However, studies evaluating associations of lead dose with newer, potentially more accurate, estimates of kidney function, in participants with a wide range of glomerular filtration rates (GFRs), are scarce... - Lead exposure and cardiovascular disease--a systematic reviewAna Navas Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 115:472-82. 2007..This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations... - Arsenic exposure and hypertension: a systematic reviewLalita N Abhyankar
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Environ Health Perspect 120:494-500. 2012..Environmental exposure to arsenic has been linked to hypertension in persons living in arsenic-endemic areas... - Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activityDeepti Malhotra
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Respir Crit Care Med 180:1196-207. 2009..Because accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and ER stress-induced apoptosis, Nrf2 may potentially prevent ER stress-mediated apoptosis in COPD... - Secondhand tobacco smoke exposure in selected public places (PM2.5 and air nicotine) and non-smoking employees (hair nicotine) in GhanaWilfred Agbenyikey
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Tob Control 20:107-11. 2011..5 μm (PM(2.5)) and nicotine concentrations and (2) hair nicotine concentrations in non-smoking employees. Quantifying SHS exposure will provide evidence needed to develop tobacco control legislation... - Promoting smoke-free environments in Latin America: a comparison of methods to assess secondhand smoke exposureErika Avila-Tang
Institute for Global Tobacco Control, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Salud Publica Mex 52:S138-48. 2010..Measuring SHS exposure across Latin America has increased our understanding of the magnitude of exposure in this region and results have been used to effectively promote smoke-free legislation... - Secondhand smoke exposure among women and children: evidence from 31 countriesHeather Wipfli
Institute for Global Tobacco Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, W6027, Baltimore, MD 21205, USA
Am J Public Health 98:672-9. 2008.... - Blood cadmium and lead and chronic kidney disease in US adults: a joint analysisAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Epidemiol 170:1156-64. 2009..58, 10.65) for both outcomes. These findings support consideration of cadmium and lead as chronic kidney disease risk factors in the general population and provide novel evidence of risk with environmental exposure to both metals... - Arsenic exposure and cardiovascular disease: an updated systematic reviewKatherine Moon
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W7604, Baltimore, MD 21205, USA
Curr Atheroscler Rep 14:542-55. 2012..Our review strengthens the evidence for a causal association between high-chronic arsenic exposure and clinical cardiovascular endpoints. Additional high quality studies are needed at low-moderate arsenic levels... - Association of markers of chronic viral hepatitis and blood mercury levels in US reproductive-age women from NHANES 2001-2008: a cross-sectional studyMary C Sheehan
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Environ Health 11:62. 2012.... - Heritability and preliminary genome-wide linkage analysis of arsenic metabolites in urineMaria Tellez-Plaza
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 121:345-51. 2013..Arsenic (III) methyltransferase (AS3MT) has been related to urine arsenic metabolites in association studies. Other genes might also play roles in arsenic metabolism and excretion... - Blood cadmium and estimated glomerular filtration rate in Korean adultsYoung Hwangbo
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Environ Health Perspect 119:1800-5. 2011..Cadmium is a nephrotoxicant at high exposure levels. Few studies have evaluated the role of cadmium in kidney function at low-exposure levels... - Allergic rhinitis and secondhand tobacco smoke: a population-based studySandra Y Lin
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Sinus Center, Johns Hopkins Medicine, Baltimore, Maryland 21287, USA
Am J Rhinol Allergy 25:e66-71. 2011..In this study, we evaluated the association of SHS and AR in a community-based study of adult nonsmokers... - Lead, cadmium, smoking, and increased risk of peripheral arterial diseaseAna Navas-Acien
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Circulation 109:3196-201. 2004..Cadmium may partially mediate the effect of smoking on peripheral arterial disease... - Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungsAnju Singh
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 212045, USA
Free Radic Biol Med 46:376-86. 2009..Thus, Srx1, a key Nrf2-regulated gene, contributes to protection against oxidative injury in the lung... - Serum selenium and diabetes in U.S. adultsJoachim Bleys
Department of Epidemiology, The Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland 21205, USA
Diabetes Care 30:829-34. 2007..The purpose of this study was to examine the relationship between serum selenium levels and the prevalence of diabetes among U.S. adults... - Selenium and coronary heart disease: a meta-analysisGemma Flores-Mateo
Departmentsof Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Clin Nutr 84:762-73. 2006..Evidence from large ongoing trials is needed to establish low selenium concentrations as a cardiovascular disease risk factor. Currently, selenium supplements should not be recommended for cardiovascular disease prevention... - Menthol Cigarettes, Race/Ethnicity, and Biomarkers of Tobacco Use in U.S. Adults: The 1999-2010 National Health and Nutrition Examination Survey (NHANES)Miranda R Jones
Corresponding Author Miranda R Jones, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Office W7513, Baltimore, MD 21205
Cancer Epidemiol Biomarkers Prev 22:224-32. 2013..The cooling effects of menthol could facilitate the absorption of tobacco toxicants. We examined levels of biomarkers of tobacco exposure among U.S. smokers of menthol and nonmenthol cigarettes... - Low-level lead exposure and elevations in blood pressure during pregnancyEllen M Wells
Department of Environmental Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Environ Health Perspect 119:664-9. 2011..Lead exposure is associated with elevated blood pressure during pregnancy; however, the magnitude of this relationship at low exposure levels is unclear... - Secondhand tobacco smoke in public places in Latin America, 2002-2003Ana Navas-Acien
Institute for Global Tobacco Control, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
JAMA 291:2741-5. 2004..In 2001, the Pan American Health Organization (PAHO) launched the Smoke-Free Americas Initiative to build capacity to achieve smoke-free environments in Latin America and the Caribbean... - Involuntary tobacco smoke exposure and urinary levels of polycyclic aromatic hydrocarbons in the United States, 1999 to 2002Plernpit Suwan-ampai
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W7503, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 18:884-93. 2009..S. population. Policy and educational efforts must continue to minimize PAH exposure through active and involuntary tobacco smoke exposure... - Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adultsJoachim Bleys
Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Arch Intern Med 168:404-10. 2008..We evaluated the association between selenium levels and all-cause and cause-specific mortality in a representative sample of US adults... - Association of secondhand smoke exposure with nicotine dependence among Black smokersShondelle M Wilson-Frederick
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Addict Behav 36:412-5. 2011..SHS exposure may occur in various settings, including the living space, workplace, and other social environments. This study examines the association between exposure to SHS and nicotine dependence among current smokers... - Environmental monitoring of secondhand smoke exposureBenjamin J Apelberg
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615N Wolfe St, Baltimore, Maryland 21205, USA
Tob Control 22:147-55. 2013..This topic assessment presents a comprehensive summary of SHSe monitoring approaches using environmental markers and discusses the strengths and weaknesses of these methods and approaches... - Second-hand tobacco smoke in public places in urban and rural ChinaFrances Stillman
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Tob Control 16:229-34. 2007..To assess airborne nicotine concentrations as an indicator of second-hand smoke (SHS) exposure in public places in both urban and rural areas of China... - Involving stakeholders to optimize a study protocol on secondhand tobacco smoke and chronic rhinosinusitis in adultsLaili Irani
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Rhinol Allergy 24:39-44. 2010.... - Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1Deepti Malhotra
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7624, 615 North Wolfe St, Baltimore, MD 21205, USA
Am J Respir Crit Care Med 178:592-604. 2008..NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression that inhibits oxidative stress... - Secondhand smoke exposure in public places in Guatemala: comparison with other Latin American countriesJoaquin Barnoya
Department of Pediatrics, Unidad de Cirugia Cardiovascular de Guatemala, Guatemala City 01010, Guatemala
Cancer Epidemiol Biomarkers Prev 16:2730-5. 2007..To measure secondhand smoke levels in workplaces in Guatemala and to compare exposure to levels in other Latin American cities... - Selenium and diabetes: more bad news for supplementsJoachim Bleys
Ann Intern Med 147:271-2. 2007 - [Involuntary exposure to tobacco smoke in public places in Mexico City]Tonatiuh Barrientos-Gutierrez
School of Public Health, University of Texas, TX 77030, USA
Salud Publica Mex 49:S205-12. 2007..The main objective of this study is to quantify airborne nicotine concentrations in public places in Mexico City... - Serum selenium and serum lipids in US adultsJoachim Bleys
Departments of Epidemiology and Medicine, The Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, Madrid, Spain
Am J Clin Nutr 88:416-23. 2008..However, the effects of selenium intake on the lipid profile in selenium-replete populations, such as the United States, are largely unknown...
Research Grants
- Arsenic Exposure, Cardiovascular Disease and Diabetes in Native AmericansAna Navas Acien; Fiscal Year: 2009..abstract_text> ..
- Arsenic Exposure, Cardiovascular Disease and Diabetes in Native AmericansAna Navas Acien; Fiscal Year: 2010..The elucidation of the contribution of arsenic exposure to cardiovascular and diabetes development in this high-quality prospective cohort study can inform and potentially impact current environmental public health recommendations. ..