Jean B Nachega

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults
    Jean B Nachega
    Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 43:78-84. 2006
  2. doi request reprint Severe mental illness at ART initiation is associated with worse retention in care among HIV-infected Ugandan adults
    Jean B Nachega
    Department of Medicine and Centre for Infectious Diseases, Stellenbosch University, Cape Town, South Africa
    Trop Med Int Health 18:53-7. 2013
  3. doi request reprint Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis
    Jean B Nachega
    Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins University Bloomberg School of Public Health, 615N Wolfe Street, Suite W5031, Baltimore, MD21205, USA
    AIDS 26:2039-52. 2012
  4. ncbi request reprint Antiretroviral therapy adherence and drug-drug interactions in the aging HIV population
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS 26:S39-53. 2012
  5. pmc Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    J Int AIDS Soc 14:52. 2011
  6. pmc Antifungal treatment for invasive Candida infections: a mixed treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
    Ann Clin Microbiol Antimicrob 8:23. 2009
  7. ncbi request reprint Management of adult active tuberculosis disease in era of HIV pandemic, current practices and future perspectives
    Jean B Nachega
    Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Infect Disord Drug Targets 11:134-43. 2011
  8. ncbi request reprint HIV treatment adherence, drug resistance, virologic failure: evolving concepts
    Jean B Nachega
    Departments of International Health and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Infect Disord Drug Targets 11:167-74. 2011
  9. ncbi request reprint Impact of metabolic complications on antiretroviral treatment adherence: clinical and public health implications
    Jean B Nachega
    Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Suite W5031, Baltimore, MD 21205, USA
    Curr HIV/AIDS Rep 6:121-9. 2009
  10. pmc Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern Africa
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 51:65-71. 2009

Research Grants

Detail Information

Publications40

  1. ncbi request reprint Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults
    Jean B Nachega
    Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 43:78-84. 2006
    ..42-7.72, for CD4+ T-cell count<or=50 cells/microL vs >200 cells/microL). Pharmacy-based records may be a simple and effective population-level tool for monitoring adherence as HAART programs in Africa are scaled up...
  2. doi request reprint Severe mental illness at ART initiation is associated with worse retention in care among HIV-infected Ugandan adults
    Jean B Nachega
    Department of Medicine and Centre for Infectious Diseases, Stellenbosch University, Cape Town, South Africa
    Trop Med Int Health 18:53-7. 2013
    ..We aimed to measure the association between SMI at antiretroviral therapy (ART) initiation and subsequent retention in care in HIV-infected Ugandan adults...
  3. doi request reprint Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis
    Jean B Nachega
    Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins University Bloomberg School of Public Health, 615N Wolfe Street, Suite W5031, Baltimore, MD21205, USA
    AIDS 26:2039-52. 2012
    ..To estimate antiretroviral therapy (ART) adherence rates during pregnancy and postpartum in high-income, middle-income, and low-income countries...
  4. ncbi request reprint Antiretroviral therapy adherence and drug-drug interactions in the aging HIV population
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS 26:S39-53. 2012
    ..Well designed ART adherence interventions and DDI studies are needed in the elderly HIV population...
  5. pmc Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    J Int AIDS Soc 14:52. 2011
    ....
  6. pmc Antifungal treatment for invasive Candida infections: a mixed treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
    Ann Clin Microbiol Antimicrob 8:23. 2009
    ..Treatment guidelines vary on optimal treatment strategies. We aimed to determine the effects of different antifungal therapies on global response rates, mortality and safety...
  7. ncbi request reprint Management of adult active tuberculosis disease in era of HIV pandemic, current practices and future perspectives
    Jean B Nachega
    Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Infect Disord Drug Targets 11:134-43. 2011
    ....
  8. ncbi request reprint HIV treatment adherence, drug resistance, virologic failure: evolving concepts
    Jean B Nachega
    Departments of International Health and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Infect Disord Drug Targets 11:167-74. 2011
    ....
  9. ncbi request reprint Impact of metabolic complications on antiretroviral treatment adherence: clinical and public health implications
    Jean B Nachega
    Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Suite W5031, Baltimore, MD 21205, USA
    Curr HIV/AIDS Rep 6:121-9. 2009
    ..In this article, we review the effects of these metabolic complications on ART adherence and approaches to prevent or reverse them...
  10. pmc Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern Africa
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 51:65-71. 2009
    ..To determine adherence to and effectiveness of antiretroviral therapy (ART) in adolescents vs. adults in southern Africa...
  11. ncbi request reprint Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa
    J B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 20:1053-6. 2004
    ..Strategies to maximize adherence in this setting should emphasize ready access to affordable and simple ART regimens, as well as HIV education programs to help increase awareness and decrease disease stigmatization...
  12. ncbi request reprint HIV/AIDS and antiretroviral treatment knowledge, attitudes, beliefs, and practices in HIV-infected adults in Soweto, South Africa
    Jean B Nachega
    Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 38:196-201. 2005
    ..The low rate of HIV serostatus disclosure to sexual partners calls for multidimensional interventions to reduce HIV-related stigma...
  13. ncbi request reprint Travel-acquired scrub typhus: emphasis on the differential diagnosis, treatment, and prevention strategies
    Jean B Nachega
    Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA, and Department of Internal Medicine, St Luc University Hospital, Brussels, Belgium
    J Travel Med 14:352-5. 2007
    ..The differential diagnosis includes malaria, typhoid fever, leptospirosis, and arboviroses. Doxycycline 100 mg twice daily for 7 days should be initiated as soon as the disease is suspected...
  14. ncbi request reprint Successful treatment of Acanthamoeba rhinosinusitis in a patient with AIDS
    J B Nachega
    Department of Internal Medicine, Universite Catholique de Louvain UCL, Saint Luc University Hospital, Brussels, Belgium
    AIDS Patient Care STDS 19:621-5. 2005
    ..In the era of the HIV/AIDS pandemic, the present report underscores the need for early identification and prompt aggressive treatment to ensure successful management of this rare but potentially fatal opportunistic infection...
  15. ncbi request reprint Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomes
    Jean B Nachega
    Johns Hopkins Bloomberg School of Public Health and Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Ann Intern Med 146:564-73. 2007
    ..Adherence of 95% or more to unboosted protease regimens is required for optimal virologic suppression in HIV-1-infected patients. Whether the same is true for nonnucleoside reverse transcriptase inhibitor (NNRTI)-based therapy is unclear...
  16. ncbi request reprint Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults. A qualitative study
    Jean B Nachega
    Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21215, USA
    J Acquir Immune Defic Syndr 43:S127-33. 2006
    ..In addition, our results suggest that interventions tailored to treatment supporter characteristics and relationship factors may be effective in influencing patients' antiretroviral therapy adherence...
  17. pmc Efavirenz versus nevirapine-based initial treatment of HIV infection: clinical and virological outcomes in Southern African adults
    Jean B Nachega
    Department of Internal Medicine and Center for Infectious Disease, Stellenbosch University, Cape Town, South Africa
    AIDS 22:2117-25. 2008
    ..To determine the effectiveness of efavirenz versus nevirapine in initial antiretroviral therapy regimens for adults in sub-Saharan Africa...
  18. pmc Patient-nominated, community-based HIV treatment supporters: patient perspectives, feasibility, challenges, and factors for success in HIV-infected South African adults
    Monique M Duwell
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    AIDS Patient Care STDS 27:96-102. 2013
    ....
  19. pmc Evaluation of paradoxical TB-associated IRIS with the use of standardized case definitions for resource-limited settings
    Ingrid Eshun-Wilson
    Division of Infectious Diseases, Department of Internal Medicine, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa
    J Int Assoc Physicians AIDS Care (Chic) 9:104-8. 2010
    ..We evaluated paradoxical tuberculosis (TB)-associated IRIS in a large cohort from a TB endemic setting with the use of these case definitions...
  20. pmc Randomized controlled trial of trained patient-nominated treatment supporters providing partial directly observed antiretroviral therapy
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    AIDS 24:1273-80. 2010
    ..Directly observed therapy (DOT) for antiretroviral therapy (ART) may improve adherence, but there are limited data on its clinical effectiveness...
  21. doi request reprint Depression, alcohol use and adherence to antiretroviral therapy in sub-Saharan Africa: a systematic review
    Etheldreda Nakimuli-Mpungu
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624N Broadway, Hampton House, Baltimore, MD, 21205, USA
    AIDS Behav 16:2101-18. 2012
    ..45 (95% CI 0.31-0.66, Tau(2) = 0.20, P value = 0.000). Interventions to improve mental health of HIV-positive individuals and to support adherence are desperately needed in sub-Saharan Africa...
  22. doi request reprint Association of antiretroviral therapy adherence and health care costs
    Jean B Nachega
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Ann Intern Med 152:18-25. 2010
    ..Antiretroviral therapy (ART) adherence predicts HIV disease progression and survival, but its effect on direct health care costs is unclear...
  23. doi request reprint HIV-related stigma, isolation, discrimination, and serostatus disclosure: a global survey of 2035 HIV-infected adults
    Jean B Nachega
    1Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Int Assoc Physicians AIDS Care (Chic) 11:172-8. 2012
    ..Little is known globally about the perspectives of people living with HIV/AIDS (PLWHA) on perceived HIV-related stigma and its consequences...
  24. doi request reprint Progression and persistence of low-grade cervical squamous intraepithelial lesions in women living with human immunodeficiency virus
    Michèle Desiré Zeier
    Department of Medicine, Stellenbosch University, Cape Town, South Africa
    J Low Genit Tract Dis 16:243-50. 2012
    ..This study aimed to investigate the progression and persistence of low-grade squamous intraepithelial lesions (SILs) in human immunodeficiency virus (HIV)-infected women...
  25. pmc Impact of immune reconstitution inflammatory syndrome on antiretroviral therapy adherence
    Jean B Nachega
    University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa Johns Hopkins University, Bloomberg School of Public Health, Departments of International Health and Epidemiology, Baltimore, Maryland, USA Johns Hopkins University, Center for Tuberculosis Research, Baltimore, Maryland, USA
    Patient Prefer Adherence 6:887-91. 2012
    ..We determined the impact of immune reconstitution inflammatory syndrome (IRIS) on antiretroviral therapy (ART) adherence in a cohort of 274 human immunodeficiency virus (HIV)-infected South African adults initiating ART...
  26. pmc Current status and future prospects of epidemiology and public health training and research in the WHO African region
    Jean B Nachega
    Department of Medicine and Centre for Infectious Diseases, Stellenbosch University, Cape Town, South Africa
    Int J Epidemiol 41:1829-46. 2012
    ..To date little has been published about epidemiology and public health capacity (training, research, funding, human resources) in WHO/AFRO to help guide future planning by various stakeholders...
  27. doi request reprint HIV treatment adherence, patient health literacy, and health care provider-patient communication: results from the 2010 AIDS Treatment for Life International Survey
    Jean B Nachega
    1Department of Medicine and Centre for Infectious Diseases CID, Stellenbosch University, Faculty of Health Sciences, Cape Town, South Africa
    J Int Assoc Physicians AIDS Care (Chic) 11:128-33. 2012
    ..Little is known about patients' health literacy regarding antiretroviral therapy (ART) adherence and drug resistance and patient-provider communication about these topics. Design and..
  28. ncbi request reprint Update on diagnostic and treatment of uncomplicated and complicated malaria in adults and selected vulnerable populations
    Philip Botha
    Stellenbosch University, Faculty of Medicine and Health Sciences, Van Zyl Drive Cape Town, South Africa
    Infect Disord Drug Targets 13:278-91. 2013
    ..The full amplitude of mutual interactions between these conditions is only beginning to be elucidated while the complex, multi-directional and pharmacokinetic interactions between antimalarial agents and HIV drugs continue to emerge. ..
  29. ncbi request reprint Targeting HIV: past, present and future
    Michele D Zeier
    Department of Internal Medicine Infectious Diseases, University of Stellenbosch and Tygerberg Hospital, Parow 7505, Cape Town, South Africa
    Infect Disord Drug Targets 11:98-114. 2011
    ..We shortly revisit the older and perhaps lesser used as well as the more recently approved drugs and mention some of the compounds still under investigation...
  30. doi request reprint Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trials
    Nathan Ford
    Medecins Sans Frontieres, Cape Town, Western Cape, South Africa
    Lancet 374:2064-71. 2009
    ..We did a systematic review and meta-analysis of randomised trials of directly observed versus self-administered antiretroviral treatment...
  31. pmc Twice-daily versus once-daily antiretroviral therapy and coformulation strategies in HIV-infected adults: benefits, risks, or burden?
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Patient Prefer Adherence 5:645-51. 2011
    ..Comprehensive cost-benefit analysis of regimen simplification could help facilitate evidence-based decisions regarding antiretroviral regimen choices...
  32. ncbi request reprint Tuberculosis drug resistance: a global threat
    Jean B Nachega
    Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Clin Infect Dis 36:S24-30. 2003
    ..An understanding of the molecular basis of drug resistance may contribute to the development of new drugs. Management of MDR-TB relies on prompt recognition and treatment with at least 3 drugs to which an isolate is susceptible...
  33. pmc Treatment simplification in HIV-infected adults as a strategy to prevent toxicity, improve adherence, quality of life and decrease healthcare costs
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Patient Prefer Adherence 5:357-67. 2011
    ....
  34. pmc Cross-cultural adaptation and validation of the self-reporting questionnaire among HIV+ individuals in a rural ART program in southern Uganda
    Etheldreda Nakimuli-Mpungu
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    HIV AIDS (Auckl) 4:51-60. 2012
    ..HIV treatment programs are in need of brief, valid instruments to identify common mental disorders such as depression...
  35. ncbi request reprint Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial
    Anne Spinewine
    Center for Clinical Pharmacy, School of Pharmacy, Universite Catholique de Louvain, Brussels, Belgium
    J Am Geriatr Soc 55:658-65. 2007
    ..To evaluate the effect of pharmaceutical care provided in addition to acute Geriatric Evaluation and Management (GEM) care on the appropriateness of prescribing...
  36. ncbi request reprint A wake-up call for global access to salvage HIV drug regimens
    Edward J Mills
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    Lancet 370:1885-7. 2007
  37. ncbi request reprint Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    JAMA 296:679-90. 2006
    ..Concerns about incomplete adherence among patients living in poverty have been an important consideration in expanding the access to antiretroviral therapy in sub-Saharan Africa...
  38. pmc Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults on antiretroviral therapy
    Gregory P Bisson
    Department of Medicine, Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Med 5:e109. 2008
    ....
  39. ncbi request reprint HIV infection as a weapon of war
    Edward J Mills
    Lancet Infect Dis 6:752-3. 2006
  40. pmc Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    PLoS Med 3:e438. 2006
    ..We systematically reviewed the literature to determine patient-reported barriers and facilitators to adhering to antiretroviral therapy...

Research Grants2

  1. DOT-HARRT for HIV-Infected South African Adults
    Jean Nachega; Fiscal Year: 2007
    ..My career plan and research proposal are consistent with my long-term goals of becoming an effective independent investigator, and optimizing treatment outcomes in HIV-infected in sub-Saharan Africa. ..