Research Topics
| Jean B NachegaSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
Research Grants
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Detail Information
Publications
Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adultsJean B Nachega
Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 43:78-84. 2006..42-7.72, for CD4+ T-cell count<or=50 cells/microL vs >200 cells/microL). Pharmacy-based records may be a simple and effective population-level tool for monitoring adherence as HAART programs in Africa are scaled up...
Severe mental illness at ART initiation is associated with worse retention in care among HIV-infected Ugandan adultsJean B Nachega
Department of Medicine and Centre for Infectious Diseases, Stellenbosch University, Cape Town, South Africa
Trop Med Int Health 18:53-7. 2013..We aimed to measure the association between SMI at antiretroviral therapy (ART) initiation and subsequent retention in care in HIV-infected Ugandan adults...- Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysisJean B Nachega
Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins University Bloomberg School of Public Health, 615N Wolfe Street, Suite W5031, Baltimore, MD21205, USA
AIDS 26:2039-52. 2012..To estimate antiretroviral therapy (ART) adherence rates during pregnancy and postpartum in high-income, middle-income, and low-income countries... - Antiretroviral therapy adherence and drug-drug interactions in the aging HIV populationJean B Nachega
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
AIDS 26:S39-53. 2012..Well designed ART adherence interventions and DDI studies are needed in the elderly HIV population... 
Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in UgandaEdward J Mills
Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
J Int AIDS Soc 14:52. 2011....- Antifungal treatment for invasive Candida infections: a mixed treatment comparison meta-analysisEdward J Mills
Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
Ann Clin Microbiol Antimicrob 8:23. 2009..Treatment guidelines vary on optimal treatment strategies. We aimed to determine the effects of different antifungal therapies on global response rates, mortality and safety... - Impact of metabolic complications on antiretroviral treatment adherence: clinical and public health implicationsJean B Nachega
Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Suite W5031, Baltimore, MD 21205, USA
Curr HIV/AIDS Rep 6:121-9. 2009..In this article, we review the effects of these metabolic complications on ART adherence and approaches to prevent or reverse them... - Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern AfricaJean B Nachega
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 51:65-71. 2009..To determine adherence to and effectiveness of antiretroviral therapy (ART) in adolescents vs. adults in southern Africa... - Travel-acquired scrub typhus: emphasis on the differential diagnosis, treatment, and prevention strategiesJean B Nachega
Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA, and Department of Internal Medicine, St Luc University Hospital, Brussels, Belgium
J Travel Med 14:352-5. 2007..The differential diagnosis includes malaria, typhoid fever, leptospirosis, and arboviroses. Doxycycline 100 mg twice daily for 7 days should be initiated as soon as the disease is suspected... - Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomesJean B Nachega
Johns Hopkins Bloomberg School of Public Health and Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Ann Intern Med 146:564-73. 2007..Adherence of 95% or more to unboosted protease regimens is required for optimal virologic suppression in HIV-1-infected patients. Whether the same is true for nonnucleoside reverse transcriptase inhibitor (NNRTI)-based therapy is unclear... - Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults. A qualitative studyJean B Nachega
Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21215, USA
J Acquir Immune Defic Syndr 43:S127-33. 2006..In addition, our results suggest that interventions tailored to treatment supporter characteristics and relationship factors may be effective in influencing patients' antiretroviral therapy adherence... - Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South AfricaJ B Nachega
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
AIDS Res Hum Retroviruses 20:1053-6. 2004..Strategies to maximize adherence in this setting should emphasize ready access to affordable and simple ART regimens, as well as HIV education programs to help increase awareness and decrease disease stigmatization... - HIV/AIDS and antiretroviral treatment knowledge, attitudes, beliefs, and practices in HIV-infected adults in Soweto, South AfricaJean B Nachega
Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 38:196-201. 2005..The low rate of HIV serostatus disclosure to sexual partners calls for multidimensional interventions to reduce HIV-related stigma... - Successful treatment of Acanthamoeba rhinosinusitis in a patient with AIDSJ B Nachega
Department of Internal Medicine, Universite Catholique de Louvain UCL, Saint Luc University Hospital, Brussels, Belgium
AIDS Patient Care STDS 19:621-5. 2005..In the era of the HIV/AIDS pandemic, the present report underscores the need for early identification and prompt aggressive treatment to ensure successful management of this rare but potentially fatal opportunistic infection... - Management of adult active tuberculosis disease in era of HIV pandemic, current practices and future perspectivesJean B Nachega
Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Infect Disord Drug Targets 11:134-43. 2011.... - HIV treatment adherence, drug resistance, virologic failure: evolving conceptsJean B Nachega
Departments of International Health and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Infect Disord Drug Targets 11:167-74. 2011.... - Efavirenz versus nevirapine-based initial treatment of HIV infection: clinical and virological outcomes in Southern African adultsJean B Nachega
Department of Internal Medicine and Center for Infectious Disease, Stellenbosch University, Cape Town, South Africa
AIDS 22:2117-25. 2008..To determine the effectiveness of efavirenz versus nevirapine in initial antiretroviral therapy regimens for adults in sub-Saharan Africa... - Randomized controlled trial of trained patient-nominated treatment supporters providing partial directly observed antiretroviral therapyJean B Nachega
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
AIDS 24:1273-80. 2010..Directly observed therapy (DOT) for antiretroviral therapy (ART) may improve adherence, but there are limited data on its clinical effectiveness... - Evaluation of paradoxical TB-associated IRIS with the use of standardized case definitions for resource-limited settingsIngrid Eshun-Wilson
Division of Infectious Diseases, Department of Internal Medicine, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa
J Int Assoc Physicians AIDS Care (Chic) 9:104-8. 2010..We evaluated paradoxical tuberculosis (TB)-associated IRIS in a large cohort from a TB endemic setting with the use of these case definitions... - Association of antiretroviral therapy adherence and health care costsJean B Nachega
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Ann Intern Med 152:18-25. 2010..Antiretroviral therapy (ART) adherence predicts HIV disease progression and survival, but its effect on direct health care costs is unclear... - Depression, alcohol use and adherence to antiretroviral therapy in sub-Saharan Africa: a systematic reviewEtheldreda Nakimuli-Mpungu
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624N Broadway, Hampton House, Baltimore, MD, 21205, USA
AIDS Behav 16:2101-18. 2012..45 (95% CI 0.31-0.66, Tau(2) = 0.20, P value = 0.000). Interventions to improve mental health of HIV-positive individuals and to support adherence are desperately needed in sub-Saharan Africa... - Progression and persistence of low-grade cervical squamous intraepithelial lesions in women living with human immunodeficiency virusMichèle Desiré Zeier
Department of Medicine, Stellenbosch University, Cape Town, South Africa
J Low Genit Tract Dis 16:243-50. 2012..This study aimed to investigate the progression and persistence of low-grade squamous intraepithelial lesions (SILs) in human immunodeficiency virus (HIV)-infected women... - HIV-Related Stigma, Isolation, Discrimination, and Serostatus Disclosure: A Global Survey of 2035 HIV-Infected AdultsJean B Nachega
1Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Int Assoc Physicians AIDS Care (Chic) 11:172-8. 2012..38); and nondisclosure of HIV status (OR: 1.75; 95% CI 1.28-2.41). CONCLUSION: Thirty years into the HIV pandemic, perceived HIV stigma, isolation, and discrimination persist and are associated with loneliness and depression among PLWHA... - Impact of immune reconstitution inflammatory syndrome on antiretroviral therapy adherenceJean B Nachega
University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa Johns Hopkins University, Bloomberg School of Public Health, Departments of International Health and Epidemiology, Baltimore, Maryland, USA Johns Hopkins University, Center for Tuberculosis Research, Baltimore, Maryland, USA
Patient Prefer Adherence 6:887-91. 2012..We determined the impact of immune reconstitution inflammatory syndrome (IRIS) on antiretroviral therapy (ART) adherence in a cohort of 274 human immunodeficiency virus (HIV)-infected South African adults initiating ART... - Current status and future prospects of epidemiology and public health training and research in the WHO African regionJean B Nachega
Department of Medicine and Centre for Infectious Diseases, Stellenbosch University, Cape Town, South Africa
Int J Epidemiol 41:1829-46. 2012..To date little has been published about epidemiology and public health capacity (training, research, funding, human resources) in WHO/AFRO to help guide future planning by various stakeholders... - Targeting HIV: past, present and futureMichele D Zeier
Department of Internal Medicine Infectious Diseases, University of Stellenbosch and Tygerberg Hospital, Parow 7505, Cape Town, South Africa
Infect Disord Drug Targets 11:98-114. 2011..We shortly revisit the older and perhaps lesser used as well as the more recently approved drugs and mention some of the compounds still under investigation... - Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trialsNathan Ford
Medecins Sans Frontieres, Cape Town, Western Cape, South Africa
Lancet 374:2064-71. 2009..We did a systematic review and meta-analysis of randomised trials of directly observed versus self-administered antiretroviral treatment... - Twice-daily versus once-daily antiretroviral therapy and coformulation strategies in HIV-infected adults: benefits, risks, or burden?Jean B Nachega
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Patient Prefer Adherence 5:645-51. 2011..Comprehensive cost-benefit analysis of regimen simplification could help facilitate evidence-based decisions regarding antiretroviral regimen choices... - Tuberculosis drug resistance: a global threatJean B Nachega
Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland 21231, USA
Clin Infect Dis 36:S24-30. 2003..An understanding of the molecular basis of drug resistance may contribute to the development of new drugs. Management of MDR-TB relies on prompt recognition and treatment with at least 3 drugs to which an isolate is susceptible... - HIV Treatment Adherence, Patient Health Literacy, and Health Care Provider-Patient Communication: Results from the 2010 AIDS Treatment for Life International SurveyJean B Nachega
1Department of Medicine and Centre for Infectious Diseases CID, Stellenbosch University, Faculty of Health Sciences, Cape Town, South Africa
J Int Assoc Physicians AIDS Care (Chic) 11:128-33. 2012..Conclusions: Optimal ART adherence remains a challenge globally. There is a critical need to improve patient-provider communication about the importance of ART adherence and its benefits for patient's health... - Treatment simplification in HIV-infected adults as a strategy to prevent toxicity, improve adherence, quality of life and decrease healthcare costsJean B Nachega
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Patient Prefer Adherence 5:357-67. 2011.... - Cross-cultural adaptation and validation of the self-reporting questionnaire among HIV+ individuals in a rural ART program in southern UgandaEtheldreda Nakimuli-Mpungu
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
HIV AIDS (Auckl) 4:51-60. 2012..HIV treatment programs are in need of brief, valid instruments to identify common mental disorders such as depression... - Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trialAnne Spinewine
Center for Clinical Pharmacy, School of Pharmacy, Universite Catholique de Louvain, Brussels, Belgium
J Am Geriatr Soc 55:658-65. 2007..To evaluate the effect of pharmaceutical care provided in addition to acute Geriatric Evaluation and Management (GEM) care on the appropriateness of prescribing... - Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults on antiretroviral therapyGregory P Bisson
Department of Medicine, Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS Med 5:e109. 2008.... - Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysisEdward J Mills
Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
JAMA 296:679-90. 2006..Concerns about incomplete adherence among patients living in poverty have been an important consideration in expanding the access to antiretroviral therapy in sub-Saharan Africa... - A wake-up call for global access to salvage HIV drug regimensEdward J Mills
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada
Lancet 370:1885-7. 2007 - HIV infection as a weapon of warEdward J Mills
Lancet Infect Dis 6:752-3. 2006 
Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitatorsEdward J Mills
Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
PLoS Med 3:e438. 2006..We systematically reviewed the literature to determine patient-reported barriers and facilitators to adhering to antiretroviral therapy...
Research Grants
- DOT-HARRT for HIV-Infected South African AdultsJean Nachega; Fiscal Year: 2007..My career plan and research proposal are consistent with my long-term goals of becoming an effective independent investigator, and optimizing treatment outcomes in HIV-infected in sub-Saharan Africa. ..