J L Musachio

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint [125/123I]IPH: a radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors
    J L Musachio
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Synapse 26:392-9. 1997
  2. ncbi request reprint Radiosynthesis and mouse brain distribution studies of [11C] CP-126,998: a PET ligand for in vivo study of acetylcholinesterase
    John L Musachio
    Johns Hopkins University School of Medicine, Department of Radiology, Division of Nuclear Medicine, Baltimore, MD 21287, USA
    Nucl Med Biol 29:547-52. 2002
  3. ncbi request reprint 5-[I-125/123]lodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors
    J L Musachio
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Life Sci 62:PL 351-7. 1998
  4. ncbi request reprint Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon
    J L Musachio
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nucl Med Biol 26:201-7. 1999
  5. ncbi request reprint (+)-[C-11]-cis-N-benzyl-normetazocine: a selective ligand for sigma receptors in vivo
    J L Musachio
    Division of Nuclear Medicine, Johns Hopkins Medical Institution, Baltimore, MD 21205 2179
    Life Sci 55:PL225-32. 1994
  6. ncbi request reprint [125/123I] 5-Iodo-3-pyridyl ethers. syntheses and binding to neuronal nicotinic acetylcholine receptors
    H Fan
    Johns Hopkins University School of Medicine, Department of Radiology, Division of Nuclear Medicine, Baltimore, MD 21287, USA
    Nucl Med Biol 28:911-21. 2001
  7. ncbi request reprint Autoradiographic and SPECT imaging of cerebral opioid receptors with an iodine-123 labeled analogue of diprenorphine
    J R Lever
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Synapse 29:172-82. 1998
  8. ncbi request reprint [11C]-methyl 4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)-methyl]-1- piperazinecarboxylate ([11C]GR89696): synthesis and in vivo binding to kappa opiate receptors
    H T Ravert
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0750, USA
    Nucl Med Biol 26:737-41. 1999
  9. ncbi request reprint PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor
    B Bencherif
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Synapse 45:1-9. 2002
  10. ncbi request reprint Synthesis and biodistribution of radiolabeled alpha 7 nicotinic acetylcholine receptor ligands
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287 2182, USA
    J Nucl Med 46:326-34. 2005

Collaborators

Detail Information

Publications27

  1. ncbi request reprint [125/123I]IPH: a radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors
    J L Musachio
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Synapse 26:392-9. 1997
    ..123)I]IPH seems well suited for imaging studies of nAChRs and, to our knowledge, is the first SPECT agent that has allowed for the visualization of nAChRs in primate brain...
  2. ncbi request reprint Radiosynthesis and mouse brain distribution studies of [11C] CP-126,998: a PET ligand for in vivo study of acetylcholinesterase
    John L Musachio
    Johns Hopkins University School of Medicine, Department of Radiology, Division of Nuclear Medicine, Baltimore, MD 21287, USA
    Nucl Med Biol 29:547-52. 2002
    ..Competitive blocking studies using a variety of acetylcholinesterase inhibitors (diisopropylfluorophosphate, tacrine, CP-118,954) verified the specificity of the PET radiotracer for brain acetylcholinesterase...
  3. ncbi request reprint 5-[I-125/123]lodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors
    J L Musachio
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Life Sci 62:PL 351-7. 1998
    ....
  4. ncbi request reprint Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon
    J L Musachio
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nucl Med Biol 26:201-7. 1999
    ..Pretreatment with cytisine blocked [123I]-5-IA uptake in all brain regions (78-59% reduction), demonstrating the specificity of the radiotracer...
  5. ncbi request reprint (+)-[C-11]-cis-N-benzyl-normetazocine: a selective ligand for sigma receptors in vivo
    J L Musachio
    Division of Nuclear Medicine, Johns Hopkins Medical Institution, Baltimore, MD 21205 2179
    Life Sci 55:PL225-32. 1994
    ..Thus, [C-11]-(+)-NBnNM binds with high specificity and selectivity to sigma receptors in vivo and offers excellent potential to study sigma receptors in living human brain via positron emission tomography...
  6. ncbi request reprint [125/123I] 5-Iodo-3-pyridyl ethers. syntheses and binding to neuronal nicotinic acetylcholine receptors
    H Fan
    Johns Hopkins University School of Medicine, Department of Radiology, Division of Nuclear Medicine, Baltimore, MD 21287, USA
    Nucl Med Biol 28:911-21. 2001
    ....
  7. ncbi request reprint Autoradiographic and SPECT imaging of cerebral opioid receptors with an iodine-123 labeled analogue of diprenorphine
    J R Lever
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Synapse 29:172-82. 1998
    ..Thus, [123I]-O-IA-DPN should prove useful for SPECT studies within the constraints imposed by a lack of innate selectivity for a single type of brain opioid receptor...
  8. ncbi request reprint [11C]-methyl 4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)-methyl]-1- piperazinecarboxylate ([11C]GR89696): synthesis and in vivo binding to kappa opiate receptors
    H T Ravert
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0750, USA
    Nucl Med Biol 26:737-41. 1999
    ..8, 5.6, and 4.5 for the hypothalamus, olfactory tubercle, and striatum, respectively. The uptake of [11C]GR89696 correlated with known kappa opioid receptor densities and was inhibited by kappa opioid selective drugs...
  9. ncbi request reprint PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor
    B Bencherif
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Synapse 45:1-9. 2002
    ..This new PET radiotracer may potentially be employed in the diagnosis and treatment of patients with disorders of cholinergic neurotransmission, such as Alzheimer's disease...
  10. ncbi request reprint Synthesis and biodistribution of radiolabeled alpha 7 nicotinic acetylcholine receptor ligands
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287 2182, USA
    J Nucl Med 46:326-34. 2005
    ..Our objective was to develop an array of alpha(7)-selective nicotinic cholinergic receptor (nAChR)-based imaging agents for PET and SPECT...
  11. ncbi request reprint Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor
    Shui Yu Lu
    PET Radiopharmaceutical Sciences, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1003, USA
    Lab Chip 4:523-5. 2004
    ....
  12. ncbi request reprint 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase)
    Martin G Pomper
    Division of Neuroradiology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2182, USA
    Mol Imaging 1:96-101. 2002
    ..For PET, distribution volumes (DVs) were 1.38 then 0.87 pre- and postblocker (PMPA). Little metabolism of 11C-MCG occurred in the mouse or baboon. These results suggest that 11C-MCG may be useful for imaging GCP II in the periphery...
  13. ncbi request reprint Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain
    Masao Imaizumi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
    Synapse 61:595-605. 2007
    ..A critical factor for human use will be whether the tracer has adequately fast wash out from brain relative to the half-life of the radionuclide to obtain stable values of distribution volume...
  14. ncbi request reprint [(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers
    Hayden T Ravert
    Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins Medical Institutions, Nelson Building Room B1 151B, 600 North Wolfe Street, Baltimore, MD 21287 0750, USA
    Nucl Med Biol 29:47-53. 2002
    ..The [(11)C]-labeled S enantiomer showed low affinity and region to cerebellar ratios of 1 for all brain regions. The [(11)C]-labeled GR103545 exhibited a selective and saturable binding for the kappa opioid receptor...
  15. ncbi request reprint Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography
    David C Perry
    Department of Pharmacology, George Washington University Medical Center, Washington, DC 20037, USA
    J Neurochem 82:468-81. 2002
    ....
  16. ncbi request reprint PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat
    Masao Imaizumi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neurosci Lett 411:200-5. 2007
    ..In this first study to demonstrate neuroinflammation in vivo with small animal PET, [11C]PBR28 had adequate sensitivity to localize and quantify the associated increase in PBRs...
  17. ncbi request reprint Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY
    Jeih San Liow
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:96-105. 2007
    ..The effects of CsA in rats are mediated by both P-gp blockade and displacement of the radiotracer from plasma proteins. Studies with wild type and knockout mice showed that CsA affected only P-gp in this species...
  18. ncbi request reprint Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I
    H Umesha Shetty
    PET Radiopharmaceutical Sciences, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C351, MSC 1003, 10 Center Drive, Bethesda, MD 20892 1003, USA
    Eur J Nucl Med Mol Imaging 34:667-78. 2007
    ..We aimed to determine the composition of radioactivity in rat brain after intravenous administration of the dopamine transporter radioligand, [(11)C]PE2I...
  19. ncbi request reprint Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors
    John L Musachio
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346, 10 Center Drive, Bethesda, MD 20892 1003, USA
    Bioorg Med Chem Lett 16:3101-4. 2006
    ..Contrary to our expectations, both of these ligands provided brain images that were more typical of those shown by agents binding to the DAT...
  20. ncbi request reprint PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements
    Sami S Zoghbi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:520-7. 2006
    ....
  21. ncbi request reprint Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans
    Vanessa L Cropley
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:100-4. 2006
    ....
  22. ncbi request reprint Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 26:1201-10. 2005
    ..Phosphodiesterase 4 (PDE4) catabolizes the second messenger 3', 5'-cyclic adenosine monophosphate and may play a critical role in brain diseases. Our aim was to quantify PDE4 in rats with positron emission tomography (PET)...
  23. ncbi request reprint PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease
    Hiroshi Toyama
    Department of Radiology, Fujita Health University, 1 98, Dengakugakubo, Kutsukake, Toyoake, 470 1192, Aichi, Japan
    Eur J Nucl Med Mol Imaging 32:593-600. 2005
    ..The purpose of this study was to evaluate the capacity of [11C]6-OH-BTA-1 and positron emission tomography (PET) to quantify beta-amyloid (Abeta) plaques in the Tg2576 mouse model of Alzheimer's disease (AD)...
  24. ncbi request reprint Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits
    Zhi Liang Wei
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    J Med Chem 48:1721-4. 2005
    ..Our data indicate that the extracellular domains of the nAChRs are sufficiently different to allow for the design of novel ligands with high affinity and selectivity for the nAChR subtypes...
  25. ncbi request reprint 5-Iodo-A-85380 binds to alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors (nAChRs) as well as alpha4beta2* subtypes
    Jennifer M Kulak
    The Parkinson s Institute, Sunnyvale, California 94089 1605, USA
    J Neurochem 81:403-6. 2002
    ..These data are important for identifying alterations in nicotinic receptor subtypes in Parkinson's disease and other basal ganglia disorders both in in vitro and in in vivo imaging studies...
  26. ncbi request reprint Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors
    Michael Kassiou
    Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown NSW 2050 Australia
    Synapse 45:95-104. 2002
    ..These preliminary results suggest that [(76)Br]BrPH has the potential to be a useful radioligand for studying the pharmacology of nicotinic acetylcholine receptors in preclinical experiments...
  27. ncbi request reprint Chronic nicotine administration does not increase nicotinic receptors labeled by [125I]epibatidine in adrenal gland, superior cervical ganglia, pineal or retina
    Martha I Davila-Garcia
    Department of Pharmacology, Howard University College of Medicine, Washington DC, USA
    J Neurochem 85:1237-46. 2003
    ....