Research Topics
Species | K J MurphySummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Percutaneous vertebroplasty in benign and malignant diseaseK J Murphy
Department of Radiology and Radiological Sciences, The John Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Neuroimaging Clin N Am 10:535-45. 2000..The few complications reported have been related to excessive PMMA injection, underlining the need for excellent imaging conditions to control the cement injection...- Multilevel vertebroplasty via a single pedicular approach using a curved 13-gauge needle: technical noteKieran J Murphy
Division of Interventional Neuroradiology, Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 600 North Wolfe St, Baltimore, MD 21287
Can Assoc Radiol J 53:293-5. 2002 
CT fluoroscopy-guided postmyelographic transthecal radiofrequency ablation of a posterior vertebral body osteoid osteomaKieran Murphy
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Radiology B 100, Baltimore, MD 21287 2182, USA
J Vasc Interv Radiol 19:291-3. 2008..After computed tomographic (CT) myelography, CT fluoroscopy was used to guide the transthecal approach of the RF ablation procedure...- Development of a research agenda for skeletal intervention: proceedings from a multidisciplinary consensus panelKieran J Murphy
Department of Radiology, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
J Vasc Interv Radiol 19:631-8. 2008 - CT fluoroscopy: novel application for the treatment of ventricular pathologiesKieran Murphy
Interventional Neuroradiology, Johns Hopkins Hospital, Baltimore, MD, USA
Neuroradiology 49:373-8. 2007.... 
Detection of FLT3 internal tandem duplication and D835 mutations by a multiplex polymerase chain reaction and capillary electrophoresis assayKathleen M Murphy
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
J Mol Diagn 5:96-102. 2003..Here we describe the performance characteristics of the assay, assay validation, and our clinical experience using this assay to analyze 147 clinical specimens...- Vertebroplasty: a simple solution to a difficult problemK J Murphy
Intervention Neuroradiology, Department of Radiology and Radiologic Science, Johns Hopkins Medical Institution, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Clin Densitom 4:189-97. 2001..It is a safe and simple outpatient procedure. We discuss patient selection, the techniques, and the results based on our experience and that of our radiology colleagues... - Sequencing of genomic DNA by combined amplification and cycle sequencing reactionKathleen M Murphy
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Clin Chem 51:35-9. 2005..Our aim was to develop a method to routinely combine PCR amplification and cycle sequencing into one single reaction, enabling direct sequencing of genomic DNA... - ISAT and ISUIA: the impact on informed consentKieran Murphy
Department of Radiology and Neurosurgery, Johns Hopkins Medical Institution, Baltimore, MD 21287, USA
Tech Vasc Interv Radiol 8:106-7. 2005..The investigators used the term "clinical equipoise" to describe this balance. This study more than any other has set the playing field for the future of interventional radiology/endovascular neurosurgery politics... - Mechanical detachable platinum coil: report of the European phase II clinical trial in 60 patientsK J Murphy
Div of Diagnostic and Interventional Radiology, Geneva Univ Hospital, Switzerland
Radiology 219:541-4. 2001..To determine the safety and reliability of the mechanical detachment system of a platinum coil (Detach-18) when used for neurovascular embolization... - Role of the distal balloon protection technique in the prevention of cerebral embolic events during carotid stent placementJ B Martin
Department of Radiology, Geneva University Hospital, Geneva, Switzerland
Stroke 32:479-84. 2001..We sought to quantitatively and qualitatively evaluate the release of atheromatous plaque debris induced by carotid stenting procedures... - FLT3 mutations in myeloid sarcomaM Ali Ansari-Lari
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Br J Haematol 126:785-91. 2004.... - Molecular diagnosis of oligodendroglioma in paraffin sectionsKimmo J Hatanpaa
Division of Neuropathology, The Johns Hopkins University, Baltimore, Maryland, USA
Lab Invest 83:419-28. 2003..Because only a paraffin section is required, the pathologist can perform both the traditional histopathologic evaluation and this supporting molecular assay from the material at hand... - Anatomic relationship between arachnoid granulations in the transverse sinus and the termination of the vein of Labbé: an angiographic studyP Gailloud
Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 600 North Wolfe Street Baltimore, MD 21287, USA
Neuroradiology 43:139-43. 2001..The constant character of this relationship suggests a developmental role of afferent veins in the formation of arachnoid granulations... - Complex rearrangement of chromosomes 1, 7, 21, 22 in Ewing sarcomaNatini Jinawath
Institute of Genetic Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
Cancer Genet Cytogenet 201:42-7. 2010..This case adds to the spectrum of genetic rearrangements identified in ES tumors... - Pooling of echographic contrast agents during transcranial Doppler sonography: a sign in favor of slow-flowing giant saccular aneurysmsP Gailloud
Division of Diagnostic and Interventional Radiology, Geneva University Hospital, Switzerland
Neuroradiology 44:21-4. 2002..Knowledge of atypical or contrast-specific lesion appearances will become important if contrast-enhanced TCD is to be used routinely in the diagnosis of intracranial aneurysms... - Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sézary syndrome: search for recurrent chromosome abnormalitiesDenise A S Batista
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Genes Chromosomes Cancer 45:383-91. 2006..2;p11.2). Two patients with SS reported in the literature seem to have a similar translocation. If confirmed, a psu dic(17;8) could be the first recurring translocation detected in at least three patients with MF/SS... - Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesionsElizabeth Montgomery
Johns Hopkins University School of Medicine, Baltimore, Maryland 21230, USA
Appl Immunohistochem Mol Morphol 14:24-30. 2006..The findings suggest that alterations in Claudin proteins are an early event in tumorigenesis and may provide targets for diagnosis and directed therapy for esophageal adenocarcinoma and its precursors... - Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: diagnostic and clinical implicationsAthanasios C Tsiatis
The Johns Hopkins Medical Institutions, Department of Pathology, 600 N Wolfe Street, Park SB202, Baltimore, MD 21287, USA
J Mol Diagn 12:425-32. 2010..1% false positives and 6.1% false negatives. In our hands, the limit of detection for Sanger sequencing, pyrosequencing, and melting curve analysis was approximately 15 to 20%, 5%, and 10% mutant alleles, respectively... - Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapyJonathan R Brody
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cancer Res 66:9369-73. 2006..The data suggest that TS copy number in a patient's tumor may be a dominating variable affecting 5FU responsiveness... - Molecular genotyping of hydatidiform moles: analytic validation of a multiplex short tandem repeat assayKathleen M Murphy
Department of Pathology, Johns Hopkins Medical Institutions, Park Bldg Room SB202, 600 North Wolfe St, Baltimore, MD 21287, USA
J Mol Diagn 11:598-605. 2009..To avoid these pitfalls, we have developed an algorithm with quantitative guidelines for the interpretation of short tandem repeat genotyping data... - Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q lossConstance A Griffin
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Neuropathol Exp Neurol 65:988-94. 2006..Subsequent loss of the der(1;19)(p10;q10) then results in the simultaneous 1p and 19q loss observed in oligodendroglioma with retention of the der(1;19)(q10;p10) seen in these cases... - Use of T-cell antibodies for donor dosaging in a canine model of in utero hematopoietic stem cell transplantationScott M Petersen
Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Fetal Diagn Ther 22:175-9. 2007..Microchimerism following canine in utero hematopoietic stem cell transplantation (IUHSCT) development of T-cell dosing regimens... - Complete hydatidiform mole with retained maternal chromosomes 6 and 11Thomas G McConnell
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Am J Surg Pathol 33:1409-15. 2009..Genome-wide analysis has the potential to assist in localizing imprinted genes critical for determining the morphologic and behavioral phenotypes of hydatidiform moles... - Constitutional duplication of a region of chromosome Yp encoding AMELY, PRKY, and TBL1Y: implications for sex chromosome analysis and bone marrow engraftment analysisKathleen M Murphy
Department of Pathology, John Hopkins Medical Institutions, Baltimore, MD, USA
J Mol Diagn 9:408-13. 2007..Although this and other genetic variants involving AMELY are uncommon, one should use caution when using amelogenin for sex chromosome analysis and bone marrow engraftment analysis... - BCR/ABL rearrangement in two cases of Philadelphia chromosome negative chronic myeloid leukemia: deletion on the derivative chromosome 9 may or not be presentDenise A S Batista
Department of Pathology, Division of Molecular Pathology, Johns Hopkins University, 600 North Wolfe Street, Park SB 202, Baltimore, MD 21287, USA
Cancer Genet Cytogenet 163:164-7. 2005..Some authors reported that patients with the chimeric gene located on the derivative 9 have a poor clinical course. We suggest that deletion rather than location of the chimeric gene alone is more likely to be associated with prognosis... - Mutation and single nucleotide polymorphism detection using temperature gradient capillary electrophoresisKathleen M Murphy
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Expert Rev Mol Diagn 3:811-8. 2003..The utility of temperature gradient capillary electrophoresis for the detection of known sequence alterations and as a tool for mutation discovery is reviewed... - A single nucleotide primer extension assay to detect the APC I1307K gene variantKathleen M Murphy
Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Mol Diagn 5:222-6. 2003..The single nucleotide extension assay provides a highly sensitive and specific assay to identify individuals with the APC I1307K gene variant who may benefit from increased colorectal screening... - Internal tandem duplications of the FLT3 gene are present in leukemia stem cellsMark Levis
Blood 106:673-80. 2005..Taken together, these experiments establish that the FLT3/ITD mutations are present in leukemia stem cells, and that FLT3 inhibitors may have activity against these cells... - Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemiaB Douglas Smith
Departments of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Blood 103:3669-76. 2004..Our results show that FLT3 inhibition is associated with clinical activity in AML patients harboring FLT3-activating mutations and indicate that CEP-701 holds promise as a novel, molecularly targeted therapy for this disease... - In vitro evaluation of the effectiveness of distal protection in the prevention of cerebral thromboembolism during carotid stent placementJ B Martin
Department of Radiology, University Hospital of Geneva, Switzerland
Acad Radiol 8:623-8. 2001..CONCLUSION: In vitro evaluation of the distal flow protection technique indicates that it should reduce stroke risk during carotid stent placement... - A molecular fraction collecting tool for the ABI 310 automated sequencerMing Tseh Lin
The Sol Goldman Pancreatic Cancer Research Center, Departments of Pathology and Oncology, Johns Hopkins School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
J Mol Diagn 9:598-603. 2007..In addition, we successfully isolated bands that were only three bases apart that comigrated on polyacrylamide gel electrophoresis. DNA sequencing was used to confirm that the correct peaks were recovered at sufficient purity... - Molecular diagnosis of metastasizing oligodendroglioma: a case reportMin Wang
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Mol Diagn 6:52-7. 2004..This analysis revealed evidence of LOH at all eight of the microsatellite loci tested. The combination of cytologic and molecular findings defined the extracranial tumor to be metastatic oligodendroglioma... - Diagnosis and subclassification of hydatidiform moles using p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approachThomas G McConnell
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 33:805-17. 2009.... - A rare e14a3 (b3a3) BCR-ABL fusion transcript in chronic myeloid leukemia: diagnostic challenges in clinical laboratory practiceNatini Jinawath
Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Mol Diagn 11:359-63. 2009.... - FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AMLKeith W Pratz
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
Blood 115:1425-32. 2010..These results have important implications for the potential therapeutic use of FLT3 inhibitors in that patients with newly diagnosed FLT3-mutant AML might be less likely to respond clinically to highly selective FLT3 inhibition... - Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomasVikki Rand
Department of Neurosurgery, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 102:14344-9. 2005..Our results demonstrate the utility of applying DNA sequencing technology to systematically assess the coding sequence of genes within cancer genomes... - Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancersPaula M Hempen
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Cancer Res 63:994-9. 2003..This evidence is compatible with a high degree of selection for inactivation of the ACVR2 gene in tumorigenesis, supporting ACVR2 as a candidate tumor suppressor gene in gastrointestinal cancers... - Abnormal villous morphology associated with triple trisomy of paternal originAlexis Norris-Kirby
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Mol Diagn 12:525-9. 2010..The three trisomies may have originated from paternal meiosis II errors, or from mitotic nondisjunction. We believe this to be the first report of triple trisomy in a SAB confirmed to be of paternal origin... - Bone marrow engraftment analysis after granulocyte transfusionSharon L Swierczynski
Department of Pathology, Johns Hopkins Medical Institutions, Park Building, Room SB202, 600 North Wolfe St, Baltimore, MD 21287, USA
J Mol Diagn 7:422-6. 2005..This case illustrates that white cell transfusion can lead to erroneous bone marrow engraftment results, particularly if only one microsatellite locus is used to monitor engraftment... - Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancersKathleen M Murphy
Department of Pathology, Johns Hopkins University School of Medicine, USA
J Mol Diagn 8:305-11. 2006..Our results suggest that the MSI Analysis System is generally superior and may help resolve cases of MSI-low into either MSI-high or MSS... - Capillary electrophoresis artifact due to eosin: implications for the interpretation of molecular diagnostic assaysKathleen M Murphy
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Mol Diagn 7:143-8. 2005..Histological dyes may fluoresce, and artifacts from them should be considered when primary peaks contain additional underlying peaks of other colors... - Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tagsDengfeng Cao
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Cancer Biol Ther 3:1081-9; discussion 1090-1. 2004.... - Cook detachable coil embolization of a symptomatic, isolated orbital arteriovenous fistula via a superior ophthalmic vein approachP S Subramanian
Department of Ophthalmology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
Neuroradiology 47:62-5. 2005..We describe the clinical presentation and treatment of a spontaneous arteriovenous fistula of the right posterior orbit via a superior ophthalmic vein approach for embolization using platinum detachable coils... - Vascular compression by a ventricular shunt catheter: clinical value of volume-rendered CT angiographyP Gailloud
Neuroradiology Division, Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
AJNR Am J Neuroradiol 22:1570-1. 2001.... - Interstitial microduplication of Xp22.31: Causative of intellectual disability or benign copy number variant?Feng Li
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA
Eur J Med Genet 53:93-9. 2010..To date, this report is the largest compilation of clinical and array data regarding the microduplication of Xp22.31 and will serve to broaden the knowledge of regions involving copy number variation (CNV)... - RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumorsAnkita S Patel
Department of Pathology, Johns Hopkins University, Park SB 202, 600 N Wolfe Street, Baltimore MD 21287, USA
Cancer Genet Cytogenet 176:107-14. 2007.... - Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%Kathleen M Murphy
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Cancer Res 62:3789-93. 2002..These findings confirm the increased risk of pancreatic cancer in individuals with BRCA2 mutations and identify germ-line BRCA2 mutations as the most common inherited genetic alteration yet identified in familial pancreatic cancer... - Simultaneous sequencing of multiple polymerase chain reaction products and combined polymerase chain reaction with cycle sequencing in single reactionsKathleen M Murphy
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Pathol 161:27-33. 2002..We anticipate that these methods will have utility in research and clinical settings where panels of mutations or large numbers of samples are be analyzed and/or when turnaround time is critical... - Identification of immunohistochemical biomarkers for papillary thyroid carcinoma using gene expression profilingKathleen M Murphy
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Hum Pathol 39:420-6. 2008..These results validate our approach for PTC biomarker discovery and identify several candidate biomarkers for further development... - High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporterTaylor A Sohn
Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Carcinogenesis 23:949-57. 2002.... - Application of traditional clinical pathology quality control techniques to molecular pathologyShu Ling Liang
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Mol Diagn 10:142-6. 2008..By incorporating these tools into an overall quality assurance program, a laboratory can identify systematic errors and perform corrective actions before actual assay failure, thereby improving the quality of patient care... - Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRsYansong Bian
Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Cancer Biol Ther 5:1392-9. 2006.... - Evaluation of the Cepheid GeneXpert BCR-ABL assayZsolt Jobbagy
Molecular Diagnostics Laboratory, Department of Pathology, Johns Hopkins Medical Institutions, 600 N Wolfe St, Park SB 202, Baltimore, MD 21287, USA
J Mol Diagn 9:220-7. 2007.... - Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcomaHassan Nayer
Leuk Lymphoma 47:2651-4. 2006 - Immunodetecting members of the Bcl-2 family of proteinsRichard B Lock
Children's Cancer Institute Australia for Medical Research, South Australia, Sydney
Methods Mol Med 111:83-96. 2005..In addition, the methodology describes how conformational changes can be observed by immunofluorescence and immunoprecipitation, and how subcellular redistribution of Bcl-2 homologs can be followed...