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Genomes and Genes | Susumu MoriSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Diffusion tensor imaging of the developing mouse brainS Mori
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
Magn Reson Med 46:18-23. 2001..This ability to detect changes in the organization of the brain during development will greatly enhance morphological studies of transgenic and knockout models of cortical dysfunction. Magn Reson Med 46:18-23, 2001...
White matter atlases based on diffusion tensor imagingSusumu Mori
Division of NMR Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Curr Opin Neurol 22:362-9. 2009..This review will provide an overview of the recent advancements in DTI-based studies and new image analysis tools...- Fiber tract-based atlas of human white matter anatomySetsu Wakana
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 217 Traylor Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
Radiology 230:77-87. 2004..which anatomic structures can be identified on diffusion tensor images and (b). where these anatomic units are located at each section level and orientation. The atlas may prove useful for educational and clinical purposes... - Principles of diffusion tensor imaging and its applications to basic neuroscience researchSusumu Mori
Department of Radiology, Division of NMR, Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Neuron 51:527-39. 2006..The strengths and limitations of DTI and key areas for future research and development are also discussed... - Brain white matter anatomy of tumor patients evaluated with diffusion tensor imagingSusumu Mori
Department of Radiology, Johns Hopkins University School of Medicine, F M Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Ann Neurol 51:377-80. 2002..DTI provides new information regarding the detailed relationship between tumor growth and nearby white matter tracts, which may be useful for preoperative planning... - Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal trackingSusumu Mori
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 47:215-23. 2002..As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated... - Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM templateSusumu Mori
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 40:570-82. 2008..The atlases are freely available and believed to be a useful resource as a target template and for automated parcellation methods... - Fiber tracking: principles and strategies - a technical reviewSusumu Mori
Johns Hopkins University School of Medicine, Department of Radiology and Radiological Science, Baltimore, MD 21205, USA
NMR Biomed 15:468-80. 2002..Special attention is paid to situations where complications may arise, and possible solutions are reviewed. Validation issues and potential future directions and improvements are also discussed... - Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantificationKegang Hua
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 39:336-47. 2008..Excellent correlation was found between the automated and the individual tractography-based results. This tool allows efficient initial screening of the status of multiple white matter tracts... - Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participantsKenichi Oishi
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 46:486-99. 2009..81 (controls) and 0.82 (patients), suggesting "almost perfect" agreement. A power analysis suggested that the proposed method is suitable for detecting FA and size abnormalities of the white matter in clinical studies... - Landmark-referenced voxel-based analysis of diffusion tensor images of the brainstem white matter tracts: application in patients with middle cerebral artery strokeWeihong Zhang
FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Neuroimage 44:906-13. 2009..We believe that this tool is useful for regional brain normalization of patients with severe anatomical alterations, such as stroke, brain tumor, and lobectomy, for whom standard automated normalization tools may not work properly... - Atlas-based analysis of neurodevelopment from infancy to adulthood using diffusion tensor imaging and applications for automated abnormality detectionAndreia V Faria
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuroimage 52:415-28. 2010..As a demonstration of future application studies, the brainstem anatomy of cerebral palsy patients was evaluated and the altered anatomy was delineated... - Mapping of functional areas in the human cortex based on connectivity through association fibersKegang Hua
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cereb Cortex 19:1889-95. 2009..The proposed approach can potentially be used for quantitative assessment of the effect of white matter abnormalities on associated cortical regions... - Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's diseaseMichelle M Mielke
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Alzheimers Dement 8:105-13. 2012.... - DTI tractography based parcellation of white matter: application to the mid-sagittal morphology of corpus callosumHao Huang
Johns Hopkins University School of Medicine, Department of Radiology, Division of MRI Research, Baltimore, MD 21205, USA
Neuroimage 26:195-205. 2005..This approach provides a new tool to investigate callosal morphology and functional relationships... - Diffusion tensor imaging to assess axonal regeneration in peripheral nervesHelmar C Lehmann
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Exp Neurol 223:238-44. 2010..These studies suggest that DTI is a sensitive measure of axon regeneration in mouse models and provide basis for further development of imaging technology for application to living animals and humans... - Unique patterns of diffusion directionality in rat brain tumors revealed by high-resolution diffusion tensor MRIJiangyang Zhang
Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 58:454-62. 2007..High-resolution ex vivo imaging and histology confirmed the in vivo findings. These distinct patterns, undetectable with conventional MRI, may reflect tumor organization and growth patterns at the cellular level... - Mapping postnatal mouse brain development with diffusion tensor microimagingJiangyang Zhang
Johns Hopkins University, School of Medicine, Department of Radiology, Division of NMR Research, 720 Rutland Avenue, Baltimore, MD 21205, USA
Neuroimage 26:1042-51. 2005..The results demonstrate the use of these techniques to three-dimensionally and quantitatively characterize brain growth... - Diffusion tensor-based imaging reveals occult abnormalities in adrenomyeloneuropathyPrachi Dubey
Department of Neurogenetics and Functional Magnetic Resonance Imaging Kirby Center, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Ann Neurol 58:758-66. 2005..Accompanying abnormalities in genu of corpus callosum indicate that the disease pathology in pure AMN may not be limited to spinal cord long tracts alone, although the involvement of the latter is most prominent and severe... - Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomyYajing Zhang
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 52:1289-301. 2010..Probabilistic maps of the 59 tract trajectories were created from the normal subjects and were incorporated into our image analysis tool for automated tract-specific quantification... - Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasisJiangyang Zhang
Department of Radiology, Division of Nuclear Magnetic Resonance Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 25:1881-8. 2005..Thus, this technique serves as a powerful tool to efficiently localize temporal and spatial manifestation of morphological phenotype... - Effects of signal-to-noise ratio on the accuracy and reproducibility of diffusion tensor imaging-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5 TJonathan A D Farrell
F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
J Magn Reson Imaging 26:756-67. 2007.... - Characterization of mouse brain and its development using diffusion tensor imaging and computational techniquesJiangyang Zhang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD21205, USA
Conf Proc IEEE Eng Med Biol Soc 1:2252-5. 2006..To characterize the spatial and temporal patterns of mouse brain development, we applied landmark based computational techniques to analyze the database... - Reproducibility of quantitative tractography methods applied to cerebral white matterSetsu Wakana
F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore, MD 21205, USA
Neuroimage 36:630-44. 2007..Hemispheric asymmetry was observed for the size of white matter tracts projecting to the temporal lobe. This protocol provides guidelines for reproducible DTI-based tract-specific quantification... - White and gray matter development in human fetal, newborn and pediatric brainsHao Huang
Department of Radiology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Neuroimage 33:27-38. 2006..The resultant DTMRI-based 3D human brain data will be a valuable resource for human brain developmental study and will provide reference standards for diagnostic radiology of premature newborns... - Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imagingCan Ceritoglu
The Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21205, USA
Neuroimage 47:618-27. 2009..To improve the accuracy level, cascading and multi-contrast approaches were developed. The accuracy level for the white matter was 1.88+/-0.55 and 2.19+/-0.84 mm for the measured locations in the controls and patients, respectively... - Delayed neural network degeneration after neonatal hypoxia-ischemiaBrian S Stone
Department of Pediatrics, Eudowood Neonatal Pulmonary Division, Neonatal Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Neurol 64:535-46. 2008.... - Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imagingHao Huang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 29:4263-73. 2009..The developing fetal brain DTI database presented can be used for education, as an anatomical research reference, and for data registration... - Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomyJiangyang Zhang
Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 29:3160-71. 2009..These data suggest that there is an early imaging signature associated with axon transections that could be used in a variety of neurological disease processes... - Depressive symptoms in prodromal Huntington's Disease correlate with Stroop-interference related functional connectivity in the ventromedial prefrontal cortexPaul G Unschuld
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychiatry Res 203:166-74. 2012..These findings suggest that depressive symptoms in prodromal HD subjects may reflect altered functional brain network activity in the context of early HD-related brain alterations... - Multiparametric magnetic resonance imaging analysis of the corticospinal tract in multiple sclerosisDaniel S Reich
Department of Neurology, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
Neuroimage 38:271-9. 2007..To do so, we develop an intuitive method for creating and displaying spatially normalized tract-specific imaging data... - Diffusion tensor magnetic resonance imaging and tract-tracing analysis of Probst bundle structure in Netrin1- and DCC-deficient miceTianbo Ren
Department of Anatomy and Neurobiology and The Program in Neuroscience, The University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 27:10345-9. 2007..In these regions, a higher-resolution approach such as tract tracing is required. We conclude that in DCC and Netrin1 mutant mice, guidance mechanisms remain in the dorsal part of the tract but are lost ventrally... - Correction of B0 susceptibility induced distortion in diffusion-weighted images using large-deformation diffeomorphic metric mappingHao Huang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Magn Reson Imaging 26:1294-302. 2008..This postprocessing method is especially useful for correcting existent DTI data without phase maps... - A framework for callosal fiber distribution analysisDongrong Xu
Center for Biomedical Image Computing, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Neuroimage 17:1131-43. 2002..The proposed approach combines methodologies for fiber tracking and spatial normalization and is applied on diffusion tensor images and standard magnetic resonance images... - Spatiotemporal maturation patterns of murine brain quantified by diffusion tensor MRI and deformation-based morphometryRagini Verma
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, 3600 Market Street, Suite 380, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:6978-83. 2005..This analysis provides a framework for quantifying normative maturation patterns against which phenotypes of mice of different genetic and environmental backgrounds can be contrasted... - Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imagingManisha Aggarwal
Division of NMR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 60:2086-95. 2012..The findings of this report can be used for future testing and comparison of potential therapeutics in mouse models of HD... - Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matterKenichi Oishi
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 43:447-57. 2008..We anticipate that this atlas will be useful resource for atlas-based white matter anatomical studies... - Diffusion tensor MR imaging of the brain and white matter tractographyElias R Melhem
Department of Radiology and Radiological Sciences, The Johns Hopkins Medical Institutions, 600 N. Wolfe St, Baltimore, MD 21287-2182, USA
AJR Am J Roentgenol 178:3-16. 2002 - Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imagingJiangyang Zhang
Department of Radiology, Division of NMR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 51:452-7. 2004..It enabled us to study the distribution of plaques in the entire brain in 3D. The results of this study suggest that this method may be useful for assessing treatment efficacy in mouse models of Alzheimer's disease (AD)... - Spatial normalization of diffusion tensor fieldsDongrong Xu
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 50:175-82. 2003..Simulated experiments using this methodology are also described... - Atlas-based analysis of resting-state functional connectivity: evaluation for reproducibility and multi-modal anatomy-function correlation studiesAndreia V Faria
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 61:613-21. 2012..As an example of the cross-modality analysis, correlation with anatomical connectivity is also examined... - DTI analyses and clinical applications in Alzheimer's diseaseKenichi Oishi
The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
J Alzheimers Dis 26:287-96. 2011..Application of these findings in clinical practice remains to be demonstrated... - Automated fiber tracking of human brain white matter using diffusion tensor imagingWeihong Zhang
The Russell H Morgan Department of Radiology and Radiological Science, Division of MRI Research, Neurosection, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 42:771-7. 2008..8) and remained high up to 4-5 mm of the linear transformation errors. As a first example, the automated approach was applied to brain tumor patients and strategies to cope with severe anatomical abnormalities are discussed... - Macroscopic orientation component analysis of brain white matter and thalamus based on diffusion tensor imagingSetsu Wakana
Johns Hopkins University School of Medicine, Department of Radiology and Radiological Science, 720 Rutland Avenue, Baltimore, MD 21205, USA
Magn Reson Med 53:649-57. 2005..Based on the results from these preliminary data sets, this new analysis technique is expected to be an effective tool for macroscopic white matter characterization... - An MRI-based atlas and database of the developing mouse brainNelson Chuang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 54:80-9. 2011..The atlas and database enhance our ability to examine the neuroanatomy in normal or genetically engineered mouse strains and mouse models of neurological diseases... - Superficially located white matter structures commonly seen in the human and the macaque brain with diffusion tensor imagingKenichi Oishi
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Brain Connect 1:37-47. 2011..The delineation of these species-conserved white matter structures may provide new options for understanding brain anatomy and function... - Quantitative analysis of gray and white matter in Williams syndromeAndreia Vasconcellos Faria
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuroreport 23:283-9. 2012..These findings may be linked to the uneven cognitive profile evident in Williams syndrome... - Quantification of brain maturation and growth patterns in C57BL/6J mice via computational neuroanatomy of diffusion tensor imagesSajjad Baloch
Department of Radiology, University of Pennsylvania, PA 19104, USA
Cereb Cortex 19:675-87. 2009..Fiber maturation reaches steady state in about 10 days for the cortex, to 30-40 days for the corpus callosum, the hippocampus, and the internal and external capsules... - Magnetic resonance imaging of mouse skeletal muscle to measure denervation atrophyJiangyang Zhang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Neurol 212:448-57. 2008..We propose that MRI of skeletal muscle is a sensitive surrogate outcome measure of denervation atrophy in animal models of neuromuscular disorders, with potential applicability in preclinical therapeutic screening studies in rodents... - Quantitative analysis of brain pathology based on MRI and brain atlases--applications for cerebral palsyAndreia V Faria
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 54:1854-61. 2011..We illustrate some potential applications for individual characterization and group comparison. This technique also provides a framework for determining the impact of various neuroanatomic features on brain functions... - Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer's diseaseKenichi Oishi
Department of Radiology, Johns Hopkins University Baltimore, MD, USA
Front Neurol 2:54. 2011..Conclusion: The multi-modal approach has the potential to increase the value of MRI in predicting conversion from aMCI to AD... - Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse modelYong Cheng
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neuroimage 56:1027-34. 2011..Our present studies provide the first evidence that longitudinal structural MRI measures can detect the therapeutic effect in HD mice, suggesting that such measures in brain could be valuable biomarkers in HD clinical trials... - Image contrast using the secondary and tertiary eigenvectors in diffusion tensor imagingJiangyang Zhang
Division of NMR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 55:439-49. 2006..Our results suggest that when these contrasts are combined with a priori anatomical knowledge, they reveal neuroanatomical information that is useful for tissue segmentation and diagnosis of white matter lesions... - Analysis of noise effects on DTI-based tractography using the brute-force and multi-ROI approachHao Huang
Department of Radiology, Division of MRI Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Magn Reson Med 52:559-65. 2004..The results confirmed the hypothesis that one can increase the validity of DTI-based tractography by adopting the BF and multi-ROI approach, with respect to the simple one-ROI approach... - Imaging, anatomical, and molecular analysis of callosal formation in the developing human fetal brainTianbo Ren
Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland, USA
Anat Rec A Discov Mol Cell Evol Biol 288:191-204. 2006..Thus, the mouse is an excellent model system for studying normal and pathological commissural formation in human brain development... - High-resolution diffusion tensor imaging of the brain stem at 3 TLidia M Nagae-Poetscher
Russell H. Morgan Department of Radiology and Radiological Science and the Kennedy Krieger Institute, F. M. Kirby Research Center for Functional Brain Imaging, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
AJNR Am J Neuroradiol 25:1325-30. 2004..Various structures in the brain stem, such as the inferior olivary nuclei, deep cerebellar nuclei, some cranial nerves, and white matter tracts were identified, which have been difficult to appreciate by conventional MR techniques... - Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labelingYanshu Wang
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 26:355-64. 2006..This work demonstrates the usefulness of muDTI and genetically directed neuronal labeling for the analysis of nervous system defects in the mouse... - Sensorimotor function and axonal integrity in adrenomyeloneuropathyKathleen M Zackowski
Kennedy Krieger Institute, The Johns Hopkins University; Baltimore, MD 21205, USA
Arch Neurol 63:74-80. 2006..Tract-specific magnetic resonance imaging metrics, such as fractional anisotropy (used herein to evaluate structure-function relationships), significantly reflect disease severity in AMN... - Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtinElaine Waldron-Roby
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurosci 32:183-93. 2012.... - Proton MR spectroscopic and diffusion tensor brain MR imaging in X-linked adrenoleukodystrophy: initial experienceFlorian S Eichler
F. M. Kirby Research Center for Functional Brain Imaging, Johns Hopkins University, Baltimore, MD, USA
Radiology 225:245-52. 2002.... - Effects of diffusion weighting schemes on the reproducibility of DTI-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5TBennett A Landman
Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 36:1123-38. 2007..This result suggests that typical clinical studies, which use similar protocols but different well-balanced DW schemes, are readily comparable within the experimental precision... - DtiStudio: resource program for diffusion tensor computation and fiber bundle trackingHangyi Jiang
Department of Radiology, Johns Hopkins University, School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Comput Methods Programs Biomed 81:106-16. 2006..The program is developed using C++ and OpenGL on a Windows platform... - Evidence of slow maturation of the superior longitudinal fasciculus in early childhood by diffusion tensor imagingJiangyang Zhang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA, and Diagnostic Radiology Unit, Saint Luc University Hospital, Brussels, Belgium
Neuroimage 38:239-47. 2007..The result is attributed to slow axonal and/or myelin maturation of this tract, which is believed to be involved in language functions... - Automated vs. conventional tractography in multiple sclerosis: variability and correlation with disabilityDaniel S Reich
Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
Neuroimage 49:3047-56. 2010..In the optic tract, the automated method failed. With judicious application, therefore, the automated method may be useful for studies that investigate the relationship between imaging findings and clinical outcomes in disease... - Three-dimensional diffusion tensor magnetic resonance microimaging of adult mouse brain and hippocampusJiangyang Zhang
Department of Radiology, Division of MRI Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuroimage 15:892-901. 2002..Identification of these structures allowed reconstruction of their 3-D volume. Thus, high-resolution DTI has excellent potential as a tool for 3-D characterization of murine brains... - Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance imagesJiangyang Zhang
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroimage 49:2340-51. 2010..This is the first report of longitudinal characterization of brain atrophy in a mouse model of Huntington's disease by using automatic morphological analysis... - Passive immunization with anti-ganglioside antibodies directly inhibits axon regeneration in an animal modelHelmar C Lehmann
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Neurosci 27:27-34. 2007.... - Diffusion tensor imaging at low SNR: nonmonotonic behaviors of tensor contrastsBennett A Landman
Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Magn Reson Imaging 26:790-800. 2008..Comparative results are shown in both graphical and tabular forms, so that decisions about suitable acquisition protocols and processing methods can be made on a case-by-case basis without exhaustive experimentation... - Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimagingJiangyang Zhang
Johns Hopkins University School of Medicine, Department of Radiology, Division of NMR Research, 720 Rutland Ave, Baltimore, MD 21205, USA
Neuroimage 20:1639-48. 2003..The technique was applied to the study of the Netrin-1 mutant, allowing verification of its anatomical phenotype... - High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cordCynthia A Deboy
Department of Neurology, Johns Hopkins University, School of Medicine, USA
Brain 130:2199-210. 2007..These data suggest that high resolution DTI may be a more sensitive method than conventional imaging for detecting axonal damage at sites distant from inflammation... - Multi-contrast human neonatal brain atlas: application to normal neonate development analysisKenichi Oishi
Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuroimage 56:8-20. 2011.... - High-resolution isotropic 3D diffusion tensor imaging of the human brainXavier Golay
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 47:837-43. 2002..g., brain pulsations) with respect to cardiac-gated multislice acquisition are demonstrated. The advantages and weaknesses of this approach are discussed... 
Magnetic resonance imaging-based mouse brain atlas and its applicationsManisha Aggarwal
The Russell H Morgan Department of Radiology and Radiological Science, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Methods Mol Biol 711:251-70. 2011..The chapter then demonstrates several applications of MRI-based mouse brain atlases in anatomical phenotyping and guiding stereotaxic operations...- Sensorimotor function and sensorimotor tracts after hemispherectomyJulia T Choi
The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
Neuropsychologia 48:1192-9. 2010..Age at surgery predicted anatomical status of brainstem sensorimotor tracts. In sum, we found that age at surgery influences anatomical changes in brainstem motor pathways, and may also relate to sensorimotor recovery patterns... - Three-dimensional diffusion tensor microimaging for anatomical characterization of the mouse brainManisha Aggarwal
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 64:249-61. 2010.... - Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipidsPeter C M van Zijl
Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 49:440-9. 2003.... - Reduced fractional anisotropy in early-stage cerebellar variant of multiple system atrophyKenichi Oishi
Division of Neurology, Kobe University Hospital, Kobe, Japan
J Neuroimaging 19:127-31. 2009..The sensitivity of detecting early-stage MSA-C and the time course of the FA reduction are also unknown. The purpose was to address these issues to determine the diagnostic value of FA for early diagnosis... - Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differencesDavid Bonekamp
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Neuroimage 34:733-42. 2007..Our results show that the evaluated DTI protocol is suitable for clinical application in pediatric population... - Holoprosencephaly in children: diffusion tensor MR imaging of white matter tracts of the brainstem--initial experienceSait Albayram
Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Radiology 223:645-51. 2002..01) over and above the effect of age. CONCLUSION: In vivo identification of brainstem white matter tract abnormalities in patients with holoprosencephaly can be achieved by performing diffusion tensor MR imaging... - Magnetic resonance microscopy of mouse brain developmentSusumu Mori
Russell H. Morgan Department of Radiology and Radiological Science, Kennedy Krieger Institute, Baltimore, MD, USA
Methods Mol Med 124:129-47. 2006..In this article, the future potential of magnetic resonance (MR) microimaging is discussed, with special emphasis on diffusion tensor microimaging as an effective contrast mechanism for the developing central nervous system... - Origin and minimization of residual motion-related artifacts in navigator-corrected segmented diffusion-weighted EPI of the human brainHangyi Jiang
Department of Radiology, Division of MRI Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 47:818-22. 2002..In addition it is shown that the effects of involuntary motion can be removed by swapping k-space data between redundant datasets... - Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recoveryShozo Goto
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Schools of Medicine, Baltimore, MD 21287, USA
Stroke 33:1101-6. 2002..CONCLUSIONS: PARP-1 deficiency provides both early and prolonged protection from experimental focal stroke. The mechanism is not linked to preservation of ADC and mitigation of secondary energy depletion during early reperfusion... - Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging studySarah A J Reading
Division of Psychiatric Neuroimaging, Department of Psychiatry, The Johns Hopkins University, Phipps 313, Baltimore, MD 21287, USA
Psychiatry Res 140:55-62. 2005..Our results indicate that, before the onset of manifest HD, there are regional decreases in fractional anisotropy, indicating early white matter disorganization... - Pediatric diffusion tensor imaging: normal database and observation of the white matter maturation in early childhoodLaurent Hermoye
Diagnostic Radiology Unit, Saint-Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
Neuroimage 29:493-504. 2006..The database is available online and is expected to foster the use of this promising technique in the diagnosis of pediatric pathologies... - Diffusion tensor MRI and fiber tractography of cerebellar atrophy in phenytoin usersSeung Koo Lee
Department of Radiology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
Epilepsia 44:1536-40. 2003..The purpose of this study was to investigate the afferent fiber system to the cerebellum in patients with phenytoin (PHT)-induced cerebellar atrophy in comparison with cerebellar atrophy of other etiologies by using DT-MRI... - Tractography for arteriovenous malformations near the sensorimotor corticesKei Yamada
Department of Radiology Kyoto Prefectural University of Medicine, Kyoto, Japan
AJNR Am J Neuroradiol 26:598-602. 2005..The relationship between the sensorimotor tracts and the AVM was well demonstrated in all patients. Tractography was also helpful in identifying the location of the motor cortex in some of the cases... - Diffusion tensor MR imaging visualizes the altered hemispheric fiber connection in callosal dysgenesisSeung-Koo Lee
Department of Diagnostic Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea
AJNR Am J Neuroradiol 25:25-8. 2004..The thickness of the anterior commissure was enlarged or smaller than normal brain, and other white matter tracts were not markedly different from normal brain tissue... - Functional activation using apparent diffusion coefficient-dependent contrast allows better spatial localization to the neuronal activity: evidence using diffusion tensor imaging and fiber trackingAllen W Song
Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA
Neuroimage 20:955-61. 2003..This observation provides converging evidence that the activated areas using ADC contrast are more closely coupled to the neuronal activity than those using BOLD contrast... - Fiber-tracking method reveals sensorimotor pathway involvement in stroke patientsKei Yamada
Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Stroke 34:E159-62. 2003..We tested the feasibility of a new MRI technique that provides visualization of the sensorimotor tracts in vivo in a group of stroke victims... - Fiber density index correlates with reduced fractional anisotropy in white matter of patients with glioblastomaTim P L Roberts
Department of Medical Imaging, University of Toronto, Toronto, Canada
AJNR Am J Neuroradiol 26:2183-6. 2005..In this report, FDi is computed in 10 patients with glioblastoma multiforme, in white matter that is peritumoral and contralateral. FDi is shown to correlate significantly with fractional anisotropy... - Diffusion tensor brain imaging and tractographyRyuta Ito
Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, Japan
Neuroimaging Clin N Am 12:1-19. 2002.... - Robo1 regulates the development of major axon tracts and interneuron migration in the forebrainWilliam Andrews
Department of Anatomy and Developmental Biology, University College London, UK
Development 133:2243-52. 2006.... - In vivo mapping of functional domains and axonal connectivity in cat visual cortex using magnetic resonance imagingDae Shik Kim
Center for Magnetic Resonance Research, Radiology, University of Minnesota Medical School, Minneapolis, MN, USA
Magn Reson Imaging 21:1131-40. 2003..The methods developed in this study will lay the foundation for in vivo neuroanatomy and the ability for noninvasive longitudinal studies of brain development... - Quantitative cortical mapping of fractional anisotropy in developing rat brainsHao Huang
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 28:1427-33. 2008..This method may provide a means to delineate specific cortical areas and a quantitative method to detect abnormalities in cortical development in rodent pathological models... - Diffusion tensor MRI visualizes decreased subcortical fiber connectivity in focal cortical dysplasiaSeung-Koo Lee
Department of Radiology, Yonsei University College of Medicine, 134 Shinchondong, Seodaemungu, Seoul 120-752, South Korea
Neuroimage 22:1826-9. 2004..DTI has high potential to be applied to localize the FCD and to provide a better understanding of the pathological changes in the white matter... - Towards multimodal atlases of the human brainArthur W Toga
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
Nat Rev Neurosci 7:952-66. 2006..These integrative approaches have provided significant impetus for the human brain mapping initiatives, and have important applications in health and disease... - Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremiaMahmood Amiry-Moghaddam
Centre for Molecular Biology and Neuroscience, and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
FASEB J 18:542-4. 2004..The resolution of the molecular basis and subcellular site of osmotically driven brain water uptake should help design new therapies for acute brain edema... - Stroke patients' evolving symptoms assessed by tractographyKei Yamada
Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto City, Kyoto, Japan
J Magn Reson Imaging 20:923-9. 2004..To test the hypothesis that an interval evolution in the location of the depicted sensorimotor tract relative to the infarct (the "tract-infarct relationship") may be related to stroke victims' symptom progression... - Brain fiber tracking with clinically feasible diffusion-tensor MR imaging: initial experienceKei Yamada
Department of Radiology, Kyoto Prefectural University of Medicine, Kajii cyo, Kawaramachi Hirokoji Sagaru, Kamigyo ku, Kyoto City, Kyoto 602 8566, Japan
Radiology 227:295-301. 2003..This diffusion-tensor MR imaging method with the parallel imaging technique allows clinically feasible brain fiber tracking... - Diffusion-tensor MR imaging and fiber tractography: a new method of describing aberrant fiber connections in developmental CNS anomaliesSeung Koo Lee
Department of Radiology, Yonsei University College of Medicine, 134 Shinchondong, Seodaemungu, Seoul 120 752, Korea
Radiographics 25:53-65; discussion 66-8. 2005..Future studies will focus on determining the significance of the aberrant fiber connections and their relationships to the clinical manifestations of CNS anomalies...
Research Grants
- MR Microimaging of Mouse Brain DevelopmentSusumu Mori; Fiscal Year: 2007..This project was made possible through collaboration with Drs. Moil (MRI), Sidman (neuroanatomy), and Miller (computational neuroanatomy). ..
- Human White Matter Tract Mapping by Diffusion MRISusumu Mori; Fiscal Year: 2006....
- MR-Based Study of Hypomyelination by Lead PoisoningSusumu Mori; Fiscal Year: 2007..Using the MRI-based technique and normative database established under Aim 1 and 2, we will perform comprehensive myelination studies to examine the hypothesis ..
- Human White Matter Tract Mapping by Diffusion MRISusumu Mori; Fiscal Year: 2007..Aim 3: Acquisition and analyses of DTI data of normal aging population: In this aim, we will expand our effort to middle age and aging population to study normal aging process of the white matter. ..
- Human White Matter Tract Mapping by Diffusion MRISusumu Mori; Fiscal Year: 2007..For type specifications, see instructions on page 6.) RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
- Human White Matter Tract Mapping by Diffusion MRISusumu Mori; Fiscal Year: 2009..Aim 3: Acquisition and analyses of DTI data of normal aging population: In this aim, we will expand our effort to middle age and aging population to study normal aging process of the white matter. ..
- MR Microimaging of Mouse Brain DevelopmentSusumu Mori; Fiscal Year: 2009..We believe that these atlases will be important resources for a wide range of neuroscience researches. ..
- Human White Matter Tract Mapping by Diffusion MRISusumu Mori; Fiscal Year: 2010..Aim 3: Acquisition and analyses of DTI data of normal aging population: In this aim, we will expand our effort to middle age and aging population to study normal aging process of the white matter. ..
- DtiStudio: Resource Software for Diffusion Tensor ImagingSusumu Mori; Fiscal Year: 2010..This also provides an environment for open source. Aim 4: Upgrade to integrate new technologies. ..
- Mouse Brain Development Study by MRISusumu Mori; Fiscal Year: 2003..abstract_text> ..
- MR Microimaging of Alzheimer's Mouse ModelsSusumu Mori; Fiscal Year: 2005..Hypothesis: The amyloid plaque detection and volume measurements can be achieved in vivo. To confirm these hypotheses, 2 mouse strains of the AD model will be studied at 4 different ages. ..
- MR Microimaging of Mouse Brain DevelopmentSusumu Mori; Fiscal Year: 2010..We believe that these atlases will be important resources for a wide range of neuroscience researches. ..