Timothy Moran

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Gastric and duodenal features of meals mediate controls of liquid gastric emptying during fill in rhesus monkeys
    T H Moran
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol 277:R1282-90. 1999
  2. doi request reprint Gut peptides in the control of food intake
    T H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Int J Obes (Lond) 33:S7-10. 2009
  3. pmc Intestinal feedback signaling and satiety
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, United States
    Physiol Behav 105:77-81. 2011
  4. pmc Unraveling the obesity of OLETF rats
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, USA
    Physiol Behav 94:71-8. 2008
  5. ncbi request reprint Curt Richter: spontaneous activity and food intake
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, Baltimore, MD 21205, USA
    Appetite 49:368-75. 2007
  6. ncbi request reprint Gastrointestinal satiety signals II. Cholecystokinin
    Timothy H Moran
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205, USA
    Am J Physiol Gastrointest Liver Physiol 286:G183-8. 2004
  7. ncbi request reprint Gut peptide signaling in the controls of food intake
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Ross 618, 720 Rutland Avenue, Johns Hopkins University School of Medicine, Baltimore, MD 21286, USA
    Obesity (Silver Spring) 14:250S-253S. 2006
  8. pmc Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Philos Trans R Soc Lond B Biol Sci 361:1211-8. 2006
  9. ncbi request reprint Gut peptides in the control of food intake: 30 years of ideas
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Physiol Behav 82:175-80. 2004
  10. ncbi request reprint Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 288:R384-8. 2005

Detail Information

Publications84

  1. ncbi request reprint Gastric and duodenal features of meals mediate controls of liquid gastric emptying during fill in rhesus monkeys
    T H Moran
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol 277:R1282-90. 1999
    ..These data reveal that both gastric volume and duodenal negative feedback controls important in gastric emptying following stomach filling also contribute to its control during fill...
  2. doi request reprint Gut peptides in the control of food intake
    T H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Int J Obes (Lond) 33:S7-10. 2009
    ..Together, these actions indicate multiple roles for gut peptides in feeding control...
  3. pmc Intestinal feedback signaling and satiety
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, United States
    Physiol Behav 105:77-81. 2011
    ..Thus, gut peptides are clear targets for future obesity therapeutic developments...
  4. pmc Unraveling the obesity of OLETF rats
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, USA
    Physiol Behav 94:71-8. 2008
    ....
  5. ncbi request reprint Curt Richter: spontaneous activity and food intake
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, Baltimore, MD 21205, USA
    Appetite 49:368-75. 2007
    ....
  6. ncbi request reprint Gastrointestinal satiety signals II. Cholecystokinin
    Timothy H Moran
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205, USA
    Am J Physiol Gastrointest Liver Physiol 286:G183-8. 2004
    ..CCK plays a variety of roles in coordinating gastrointestinal activity and has been demonstrated to be an important mediator for the control of meal size...
  7. ncbi request reprint Gut peptide signaling in the controls of food intake
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Ross 618, 720 Rutland Avenue, Johns Hopkins University School of Medicine, Baltimore, MD 21286, USA
    Obesity (Silver Spring) 14:250S-253S. 2006
    ..Plasma ghrelin levels fall with feeding and rise with food deprivation. All of these gut peptides have vagal or dorsal hindbrain mediation. Their potential as targets for the development of anti-obesity treatments is under study...
  8. pmc Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Philos Trans R Soc Lond B Biol Sci 361:1211-8. 2006
    ..The OLETF rat is a valuable model for characterizing actions of CCK in energy balance and has provided novel insights into interactions between exercise and food intake...
  9. ncbi request reprint Gut peptides in the control of food intake: 30 years of ideas
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Physiol Behav 82:175-80. 2004
    ....
  10. ncbi request reprint Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 288:R384-8. 2005
    ..Together, these data suggest that PYY(3-36) has the ability to reduce food intake in acute test situations in nonhuman primates. Whether this is a physiological action of the endogenous peptide remains to be determined...
  11. ncbi request reprint Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Psychobiol 48:360-7. 2006
    ..These lasting metabolic effects of exercise may be secondary to an exercise induced reduction in DMH NPY mRNA expression...
  12. ncbi request reprint Leptin modulation of peripheral controls of meal size
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, United States
    Physiol Behav 89:511-6. 2006
    ....
  13. ncbi request reprint The effects of piracetam on cognitive performance in a mouse model of Down's syndrome
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Physiol Behav 77:403-9. 2002
    ..The 300-mg/kg/day-piracetam dose was associated with a reversal of the nocturnal spontaneous hyperactivity in Ts65Dn. These data do not provide support for piracetam treatment for individuals with DS...
  14. ncbi request reprint Responsivity to NPY and melanocortins in obese OLETF rats lacking CCK-A receptors
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Physiol Behav 75:397-402. 2002
    ....
  15. pmc Adiposity signaling and meal size control
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Physiol Behav 103:21-4. 2011
    ..The original work by Woods and colleagues provided the necessary experimental paradigms for these advances...
  16. ncbi request reprint Within-meal gut feedback signaling
    T H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Int J Obes Relat Metab Disord 25:S39-41. 2001
    ..Blocking or eliminating these feedback signals results in increased meal size demonstrating their role in meal termination...
  17. ncbi request reprint Cholecystokinin and satiety: current perspectives
    T H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nutrition 16:858-65. 2000
    ....
  18. doi request reprint Fructose and satiety
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Nutr 139:1253S-1256S. 2009
    ..On balance, the case for fructose being less satiating than glucose or HFCS being less satiating than sucrose is not compelling...
  19. ncbi request reprint Curt Richter and regulatory physiology
    T H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 279:R357-63. 2000
    ..As current research takes a more molecular focus, Richter's ideas on behavior in the service of the internal milieu maintain their currency, and the search for the molecular bases for these relationships should serve as a research focus...
  20. pmc Minireview: Gut peptides: targets for antiobesity drug development?
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 150:2526-30. 2009
    ..Whether any individual approach will have significant long-term efficacy remains to be demonstrated. Approaches that target multiple systems may hold the most promise...
  21. doi request reprint Hypothalamic nutrient sensing and energy balance
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Forum Nutr 63:94-101. 2010
    ..The underlying mechanisms through which various nutrients affect food intake and overall energy balance involve both specific and shared neuronal substrates...
  22. pmc Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance
    Liang Yang
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:179-90. 2009
    ..Together, these results indicate that DMH NPY plays an important role in modulating food intake and energy balance and its dysregulation causes disordered energy balance leading to obesity...
  23. ncbi request reprint Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment
    Eun Kyoung Kim
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Endocrinol Metab 283:E867-79. 2002
    ..Collectively, these results demonstrate that FAS is present and active in neurons and suggests that C75 may alter food intake via interactions within the arcuate-PVN pathway mediated by NPY...
  24. ncbi request reprint Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia
    Maiko Kawaguchi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 618, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1800-5. 2005
    ..Central CRF antagonist injection further increased DMH CRF mRNA expression in exercised rats. Together, these data suggest that DMH CRF play a critical role in the anorexia resulting from increased voluntary exercise...
  25. ncbi request reprint Looking for food in all the right places?
    Timothy H Moran
    Departments of Psychiatry and Behavioral Sciences and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Metab 3:233-4. 2006
    ..2006), demonstrate novel actions of the orexigenic peptide ghrelin in hippocampal synaptic architecture, LTP, and learning and memory. These data suggest functional links between metabolic signaling and higher neural function...
  26. ncbi request reprint C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure
    Yajun Tu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 146:486-93. 2005
    ..The patterns of the changes in central and peripheral gene expression that occur with C75 treatment provide mechanisms to explain the reduced food intake and increased energy expenditure observed with C75...
  27. ncbi request reprint Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass
    Jagan N Thupari
    Johns Hopkins Univ School of Medicine, Bldg AA, Rm 154A, 4940 Eastern Ave, Baltimore, MD 21224, USA
    Am J Physiol Endocrinol Metab 287:E97-E104. 2004
    ..Inhibition of FAS and stimulation of CPT I provide a means to achieve stable, sustained weight loss in DIO mice...
  28. ncbi request reprint Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei
    Ian Miller
    Departments of Neuroscience and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroreport 15:925-9. 2004
    ..This pattern of results suggests a shift from hindbrain-initiated short-term actions to activation of hypothalamic mechanisms that could mediate the long-term anorectic responses to C75...
  29. ncbi request reprint C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
    Eun Kyoung Kim
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 279:19970-6. 2004
    ..These data indicate that modulation of FAS activity in the hypothalamus can alter energy perception via AMPK, which functions as a physiological energy sensor in the hypothalamus...
  30. ncbi request reprint Recent advances in obesity: adiposity signaling and fat metabolism in energy homeostasis
    Susan Aja
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Adv Psychosom Med 27:1-23. 2006
    ....
  31. pmc Energy balance and hypothalamic effects of a high-protein/low-carbohydrate diet
    Kimberly P Kinzig
    Purdue University, Department of Psychological Sciences, United States
    Physiol Behav 92:454-60. 2007
    ..1 vs. CH: 100+/-37.7) expression compared to CH controls. These data suggest that the macronutrient content of diets differentially influences hypothalamic gene expression in ways that can affect overall intake...
  32. ncbi request reprint Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet
    Kimberly P Kinzig
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA
    Obes Res 13:1672-82. 2005
    ..To model how consuming a low-carbohydrate (LC) diet influences food intake and body weight...
  33. ncbi request reprint Lateral ventricular ghrelin and fourth ventricular ghrelin induce similar increases in food intake and patterns of hypothalamic gene expression
    Kimberly P Kinzig
    Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1565-9. 2006
    ..These data demonstrate that ghrelin can affect food intake and hypothalamic gene expression through interactions at multiple brain sites...
  34. ncbi request reprint Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficits
    Mikhail V Pletnikov
    Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 944:97-107. 2002
    ..The present data demonstrate that the same environmental insult can produce differential neuroanatomical and behavioral abnormalities in genetically different inbred rat strains...
  35. ncbi request reprint Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments
    Mikhail V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 944:108-23. 2002
    ..The present data provide new insights into the pathogenic events that lead to differential responses to pharmacological treatments in genetically different animals following exposure to the same environmental challenge...
  36. ncbi request reprint Diurnal and nocturnal nursing behavior in the OLETF rat
    Mariana Schroeder
    Psychology Department and the Gonda Goldschmied Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    Dev Psychobiol 49:323-33. 2007
    ....
  37. ncbi request reprint Weight gain and maternal behavior in CCK1 deficient rats
    Mariana Schroeder
    Psychology Department and Gonda Goldschmied Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    Physiol Behav 89:402-9. 2006
    ..Taken together, these data demonstrate that OLETF males and females are heavier from birth and suggest that maternal factors may contribute to weight differences between the strains...
  38. pmc Dose combinations of exendin-4 and salmon calcitonin produce additive and synergistic reductions in food intake in nonhuman primates
    Nicholas T Bello
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Univ School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 299:R945-52. 2010
    ..Such data suggest Ex-4 and sCT interact in an overall additive fashion to reduce food intake and further the understanding of how GLP-1 and amylin agonist combinations influence feeding behavior...
  39. ncbi request reprint Peptides that regulate food intake: separable mechanisms for dorsal hindbrain CART peptide to inhibit gastric emptying and food intake
    Ulrika Smedh
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1418-26. 2003
    ..These data demonstrate differential mediation of the feeding and gastric inhibitory effects of CARTp and suggest that CARTp-induced inhibition of gastric emptying does not contribute to this peptide's ability to inhibit food intake...
  40. ncbi request reprint Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: implications for the control of food intake
    Gary J Schwartz
    Bourne Behavioral Research Laboratory, Department of Psychiatry, WMC Cornell University, White Plains, New York 10605, USA
    Endocrinology 143:3779-84. 2002
    ..These data suggest a mechanistic framework for considering how feeding behavior occurring in meals is altered by challenges to energy homeostasis, such as fasting and overfeeding...
  41. ncbi request reprint Cholecystokinin-8 increases Fos-like immunoreactivity in the brainstem and myenteric neurons of rats through CCK1 receptors
    Stephen Gulley
    Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Peptides 26:1617-22. 2005
    ..In the LETO rats only 40 microg/kg CCK-8 increased Fos-LI in the myenteric plexus of the jejunum. This study demonstrates that CCK-8 activates the brainstem and myenteric neurons through the CCK1 receptor...
  42. pmc Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys
    Nicholas T Bello
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 295:R76-81. 2008
    ..These data demonstrate that salmon calcitonin acutely and consistently decreases food intake mainly through reductions in meal sizes in nonhuman primates...
  43. ncbi request reprint Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
    Sheng Bi
    Dept of Psychiatry and Behavioral Sciences, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, Ross 618, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1030-6. 2003
    ..Together, these data suggest that arcuate and DMH NPY gene expression are differentially regulated. DMH NPY-expressing neurons do not appear to be under the direct control of leptin signaling...
  44. ncbi request reprint Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brain
    Mikhail V Pletnikov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cerebellum 2:62-70. 2003
    ....
  45. ncbi request reprint Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight
    Susan Aja
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 294:R352-61. 2008
    ..These results suggest a role for brain CPT-1 in the regulation of energy balance and implicate CPT-1 stimulation as a pharmacological approach to weight loss...
  46. pmc Factors contributing to obesity in bombesin receptor subtype-3-deficient mice
    Ellen E Ladenheim
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland 21205, USA
    Endocrinology 149:971-8. 2008
    ..However, our finding that pair-feeding did not completely normalize fat distribution and plasma leptin levels suggests there is also a metabolic dysregulation that may contribute to, or sustain, their obese phenotype...
  47. pmc Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
    Su Gao
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:17358-63. 2007
    ..Together, these findings highlight site-specific impacts of hypothalamic ACC activation in leptin's anorectic signaling cascade...
  48. pmc Differential brain activation in anorexia nervosa to Fat and Thin words during a Stroop task
    Graham W Redgrave
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neuroreport 19:1181-5. 2008
    ..Mechanisms underlying attentional bias in anorexia nervosa likely differ under conditions of positive and negative valence. This paradigm is a promising tool to examine neural mediation of emotional response in anorexia nervosa...
  49. pmc Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation
    Ellen E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Endocrinology 150:672-8. 2009
    ....
  50. pmc Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity
    Lisa M Davis
    Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Neuroendocrinology 89:152-62. 2009
    ....
  51. pmc Prenatal stress or high-fat diet increases susceptibility to diet-induced obesity in rat offspring
    Kellie L K Tamashiro
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes 58:1116-25. 2009
    ..In this study, we used an animal model to determine the metabolic consequences of maternal prenatal stress and high-fat feeding on the developing offspring...
  52. pmc Repeated binge access to a palatable food alters feeding behavior, hormone profile, and hindbrain c-Fos responses to a test meal in adult male rats
    Nicholas T Bello
    Dept of Psychiatry and Behavioral Sciences, Johns Hopkins Univ School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 297:R622-31. 2009
    ..These results suggest that repeated cycles of acute calorie restriction followed by palatable food produce physiological alterations that may facilitate overconsumption of a highly palatable food during limited-access periods...
  53. doi request reprint Nutrient specific feeding and endocrine effects of jejunal infusions
    Megan J Dailey
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Obesity (Silver Spring) 18:904-10. 2010
    ..Thus, particular nutrients are more effective at producing decreases in food intake, body weight, and inducing changes in peptide levels and could lead to a novel therapy for obesity...
  54. pmc Oral sensory and cephalic hormonal responses to fat and non-fat liquids in bulimia nervosa
    Nicholas T Bello
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Physiol Behav 99:611-7. 2010
    ..05, for both). These data suggest that bulimic women have different orosensory responses that are not influenced by opioid receptor antagonism, evident in hormonal responses, or dependent on the fat content of a similarly textured liquid...
  55. pmc Experience with activity based anorexia enhances conditioned taste aversion learning in rats
    Nu Chu Liang
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Physiol Behav 102:51-7. 2011
    ..These findings have implications for understanding the persistence of aberrant eating behaviors in eating disorders...
  56. ncbi request reprint Response to acute food deprivation in OLETF rats lacking CCK-A receptors
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Physiol Behav 79:655-61. 2003
    ....
  57. ncbi request reprint Differential roles for cholecystokinin a receptors in energy balance in rats and mice
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 145:3873-80. 2004
    ..The deficit in CCK's action in the control of DMH NPY gene expression may play a major role in the obese phenotype in OLETF rats...
  58. ncbi request reprint Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, Maryland 21205, USA
    Endocrinology 146:1676-85. 2005
    ....
  59. pmc Perinatal environment and its influences on metabolic programming of offspring
    Kellie L K Tamashiro
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, United States
    Physiol Behav 100:560-6. 2010
    ..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009...
  60. ncbi request reprint Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression
    Susan Aja
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Peptides 27:157-64. 2006
    ..These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation...
  61. ncbi request reprint Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats
    Susan Aja
    Department of Psychiatry and Behavioural Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 291:R148-54. 2006
    ..Overall, the data suggest that gene expression changes leading to altered melanocortin signaling are important for the hypophagic response to intracerebroventricular C75...
  62. ncbi request reprint The dorsal vagal complex as a site for cocaine- and amphetamine-regulated transcript peptide to suppress gastric emptying
    Ulrika Smedh
    Department of Psychiatry and Behavioural Science, John Hopkins University School of Medecine, Baltimore, Maryland, USA
    Am J Physiol Regul Integr Comp Physiol 291:R124-30. 2006
    ..The results indicate that the DVC is a target site for CRF and CARTp to inhibit gastric emptying and that the vagus mediates dorsal hindbrain effects of CARTp on gastric motor function...
  63. pmc Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 293:R55-63. 2007
    ..Together, these data provide further evidence for differential roles of CCK1 receptors in the controls of food intake and body weight in rats and mice...
  64. ncbi request reprint Actions of CCK in the controls of food intake and body weight: lessons from the CCK-A receptor deficient OLETF rat
    Sheng Bi
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropeptides 36:171-81. 2002
    ..Thus, the obesity in the OLETF rats may be the outcome of two regulatory disruptions, one depending upon a peripheral within meal satiety pathway and the other depending upon a central pathway critical to overall energy balance...
  65. ncbi request reprint The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size
    Karen A Scott
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 293:R983-7. 2007
    ..Again, these reductions were due to specific effects on meal size. These results demonstrate that activation of GLP-1 pathways has potent effects on the controls of meal size and overall food intake in a nonhuman primate model...
  66. pmc Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
    Anutosh Chakraborty
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 143:897-910. 2010
    ..IP6K1 knockout mice manifest insulin sensitivity and are resistant to obesity elicited by high-fat diet or aging. Inhibition of IP6K1 may afford a therapeutic approach to obesity and diabetes...
  67. pmc Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats
    Abdelhak Mansouri
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Am J Physiol Regul Integr Comp Physiol 295:R799-805. 2008
    ..We conclude that intraperitoneal injections of low doses of C75 inhibit eating in a behaviorally specific manner and that this effect does not require abdominal vagal afferents...
  68. ncbi request reprint Preobesity in the infant OLETF rat: the role of suckling
    Mariana Schroeder
    Psychology Department and Gonda Goldschmied Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    Dev Psychobiol 49:685-91. 2007
    ..OLETF dams increased their average nursing time over the PN weeks, while control dams decreased their nursing time toward weaning. The results suggest an important contribution of OLETF pups toward their own preobese development...
  69. ncbi request reprint Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders
    Mikhail V Pletnikov
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Front Biosci 7:d593-607. 2002
    ....
  70. ncbi request reprint Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum
    Mikhail V Ovanesov
    Division of Neurobiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 13:185-94. 2007
    ..The present data are the first in vivo evidence that GLU excitotoxicity might contribute to BDV-associated neuronal injury in the striatum...
  71. ncbi request reprint Bromocriptine reduces steatosis in obese rodent models
    Lisa M Davis
    Johns Hopkins Bloomberg School of Public Health, Department of International Health, Center for Human Nutrition, Baltimore, MD 21205 2179, USA
    J Hepatol 45:439-44. 2006
    ..Bromocriptine may have anti-obesity, insulin-sensitizing, lipolytic, and antioxidant properties. We, therefore, hypothesized that bromocriptine would improve markers of nonalcoholic fatty liver disease in obese rodent models...
  72. ncbi request reprint p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease
    Byoung Il Bae
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 47:29-41. 2005
    ..Genetic deletion of p53 suppresses neurodegeneration in mHtt-Tg flies and neurobehavioral abnormalities of mHtt-Tg mice. Our findings suggest that p53 links nuclear and mitochondrial pathologies characteristic of HD...
  73. ncbi request reprint Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus
    Karen Lancaster
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Behav Brain Res 176:141-8. 2007
    ..Co-localization of activated microglia and dying Purkinje cells in BDV-infected rats suggests that the BDV model could be used to study a pathogenic link of Purkinje cell dropout and neuroinflammation to abnormal social behaviors...
  74. ncbi request reprint Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice
    Lisa E Olson
    University of Redlands, Redlands, CA 92373, USA
    Hum Mol Genet 16:774-82. 2007
    ..Thus, although the prediction of the critical region hypothesis was disproved, novel gene dosage effects were identified, which help to define how trisomy for this segment of the chromosome contributes to phenotypes of DS...
  75. ncbi request reprint Insulin, glucose, and pancreatic polypeptide responses to a test meal in restricting type anorexia nervosa before and after weight restoration
    Kimberly P Kinzig
    Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Am J Physiol Endocrinol Metab 292:E1441-6. 2007
    ..The delay in insulin release and elevated PP levels did not correct with short-term refeeding and may contribute to the high relapse rates and maintenance of AN...
  76. ncbi request reprint Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats
    Susan Aja
    Behav Neurosci 116:918-21. 2002
    ..These data demonstrate that 4V CART's actions in ingestive behavior are not specific to nutrients and suggest that aspects of 4V CART's actions in reducing intake may be secondary to the production of an aversive state...
  77. ncbi request reprint Pancreatic polypeptide: more than just another gut hormone?
    Timothy H Moran
    Gastroenterology 124:1542-4. 2003
  78. ncbi request reprint Striatal microinfusion of Tourette syndrome and PANDAS sera: failure to induce behavioral changes
    Christopher R Loiselle
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mov Disord 19:390-6. 2004
    ..Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune-mediated hypotheses for pediatric movement disorders...
  79. pmc Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model
    Wanli W Smith
    Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Mol Genet 19:2087-98. 2010
    ..These studies demonstrate that synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein toxicity in vivo...
  80. ncbi request reprint Chemical sympathectomy attenuates myenteric but not dorsal vagal complex Fos-like immunoreactivity induced by cholecystokinin-8 in the rat
    Stephen Gulley
    Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Brain Res 1064:119-25. 2005
    ..These findings demonstrate that sympathetic neurons play a role in mediating the myenteric Fos-LI response to CCK. They also suggest differential mediation of myenteric and DVC responses to CCK...
  81. ncbi request reprint Neurobiology of exercise
    Rod K Dishman
    Department of Exercise Science, The University of Georgia, Ramsey Center, 330 River Road, Athens, GA 30602 6554, USA
    Obesity (Silver Spring) 14:345-56. 2006
    ....
  82. ncbi request reprint Context-dependent transduction of within-meal afferent signaling
    Timothy H Moran
    Am J Physiol Regul Integr Comp Physiol 286:R816-7. 2004
  83. ncbi request reprint What happens in the vagus,...?
    Nicholas T Bello
    Am J Physiol Regul Integr Comp Physiol 292:R2122-3. 2007
  84. ncbi request reprint Principles for interpreting interactions among the multiple systems that influence food intake
    Randy J Seeley
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Am J Physiol Regul Integr Comp Physiol 283:R46-53. 2002
    ..Furthermore, the possibilities of using intake measures other than cumulative intake and complementary nonbehavioral endpoints are encouraged...

Research Grants49

  1. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy H Moran; Fiscal Year: 2010
    ..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
  2. Low Carbohydrate Diets: Feeding and Endocrine Signaling
    Timothy Moran; Fiscal Year: 2006
    ..abstract_text> ..
  3. ENERGY BALANCE IN THE OBESE CCK A RECEPTOR DEFICIENT RAT
    Timothy Moran; Fiscal Year: 2005
    ....
  4. GASTROINTESTINAL INTEGRATION AND FEEDING
    Timothy Moran; Fiscal Year: 2004
    ....
  5. Society for the Study of Ingestive Behavior Annual Meet
    Timothy Moran; Fiscal Year: 2003
    ..abstract_text> ..
  6. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy Moran; Fiscal Year: 2007
    ..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
  7. Energy Balance in the Obese CCK-A Receptor Deficient Rat
    Timothy Moran; Fiscal Year: 2009
    ....
  8. GASTROINTESTINAL INTEGRATION AND FEEDING
    Timothy Moran; Fiscal Year: 2009
    ..Overall, these experiments will provide important information on the relative roles and integrative actions of peptide systems involved in feeding control. ..
  9. Energy Balance in the Obese CCK-A Receptor Deficient Rat
    Timothy H Moran; Fiscal Year: 2010
    ....
  10. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy Moran; Fiscal Year: 2009
    ..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
  11. GASTROINTESTINAL INTEGRATION AND FEEDING
    Timothy Moran; Fiscal Year: 1999
    ..The dynamics of transpyloric flow to simultaneous microstructural analysis of food intake will be related. ..
  12. BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENT
    Timothy Moran; Fiscal Year: 2002
    ....
  13. GASTROINTESTINAL INTEGRATION AND FEEDING
    Timothy Moran; Fiscal Year: 1993
    ..Together these experiments will increase our knowledge of basic physiology of the gastrointestinal unit, identify the contribution of CCK to this physiology and illuminate the mechanisms by which CCK modulates food intake...