Robert A Montgomery

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi HLA incompatible renal transplantation
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Opin Organ Transplant 17:386-92. 2012
  2. ncbi Using donor exchange paradigms with desensitization to enhance transplant rates among highly sensitized patients
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Opin Organ Transplant 16:439-43. 2011
  3. ncbi Living donor exchange programs: theory and practice
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Br Med Bull 98:21-30. 2011
  4. ncbi Successful three-way kidney paired donation with cross-country live donor allograft transport
    R A Montgomery
    Department of Surgery, Johns Hopkins University, Baltimore, MD, USA
    Am J Transplant 8:2163-8. 2008
  5. ncbi Transplanting patients with a positive donor-specific crossmatch: a single center's perspective
    Robert A Montgomery
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pediatr Transplant 8:535-42. 2004
  6. ncbi Domino paired kidney donation: a strategy to make best use of live non-directed donation
    Robert A Montgomery
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet 368:419-21. 2006
  7. ncbi Desensitization in HLA-incompatible kidney recipients and survival
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    N Engl J Med 365:318-26. 2011
  8. ncbi ABO incompatible renal transplantation: a paradigm ready for broad implementation
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Transplantation 87:1246-55. 2009
  9. ncbi Clinical results from transplanting incompatible live kidney donor/recipient pairs using kidney paired donation
    Robert A Montgomery
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 294:1655-63. 2005
  10. ncbi The critical role of plasmapheresis in ABO-incompatible renal transplantation
    Aaron A R Tobian
    Department of Pathology, Transfusion Medicine Division, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Transfusion 48:2453-60. 2008

Research Grants

  1. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006

Detail Information

Publications89

  1. ncbi HLA incompatible renal transplantation
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Opin Organ Transplant 17:386-92. 2012
    ..This review describes the transplantation modalities available to the sensitized patient and discusses aspects of the donor/recipient phenotypes that determine the most suitable option for a particular patient...
  2. ncbi Using donor exchange paradigms with desensitization to enhance transplant rates among highly sensitized patients
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Opin Organ Transplant 16:439-43. 2011
    ..The options for these patients include: remaining on the deceased-donor list, entering a kidney-paired donation scheme, or undergoing desensitization with high-dose IVIg or plasmapheresis and low-dose IVIg...
  3. ncbi Living donor exchange programs: theory and practice
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Br Med Bull 98:21-30. 2011
    ..Kidney paired donation (KPD) allows patients with incompatible live donors to receive compatible or better-matched organs by exchanging donors...
  4. ncbi Successful three-way kidney paired donation with cross-country live donor allograft transport
    R A Montgomery
    Department of Surgery, Johns Hopkins University, Baltimore, MD, USA
    Am J Transplant 8:2163-8. 2008
    ..1 mg/dl. This case provides a blueprint for solving some of the complexities that are inherent in the implementation of a national KPD program in a large country like the United States...
  5. ncbi Transplanting patients with a positive donor-specific crossmatch: a single center's perspective
    Robert A Montgomery
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pediatr Transplant 8:535-42. 2004
    ..In this article we have summarized our evolving experience with the assessment, treatment, transplantation, and monitoring of patients who undergo preconditioning for a (+) XM with a live donor...
  6. ncbi Domino paired kidney donation: a strategy to make best use of live non-directed donation
    Robert A Montgomery
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet 368:419-21. 2006
  7. ncbi Desensitization in HLA-incompatible kidney recipients and survival
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    N Engl J Med 365:318-26. 2011
    ..Whether such antibody depletion results in a survival benefit as compared with waiting for an HLA-compatible kidney is unknown...
  8. ncbi ABO incompatible renal transplantation: a paradigm ready for broad implementation
    Robert A Montgomery
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Transplantation 87:1246-55. 2009
    ....
  9. ncbi Clinical results from transplanting incompatible live kidney donor/recipient pairs using kidney paired donation
    Robert A Montgomery
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 294:1655-63. 2005
    ..Ethical, administrative, and logistical barriers initially proved formidable and prevented the implementation of KPD programs in the United States...
  10. ncbi The critical role of plasmapheresis in ABO-incompatible renal transplantation
    Aaron A R Tobian
    Department of Pathology, Transfusion Medicine Division, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Transfusion 48:2453-60. 2008
    ..This article reviews the literature to provide a historical perspective of TPE for ABO-I kidney transplantation and also provides the Johns Hopkins Hospital protocol with a focus on both titers and TPE...
  11. ncbi Successful renal transplantation across simultaneous ABO incompatible and positive crossmatch barriers
    Daniel S Warren
    The Department of Surgery, The Johns Hopkins University School of Medicine, Balitmore, Maryland, USA
    Am J Transplant 4:561-8. 2004
    ..The ability to cross these two barriers simultaneously is clinically important as sensitized patients have often exhausted their blood type compatible living donors during previous transplants...
  12. ncbi ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Transplant 5:2570-5. 2005
    ....
  13. ncbi Plasmapheresis, CMV hyperimmune globulin, and anti-CD20 allow ABO-incompatible renal transplantation without splenectomy
    Christopher J Sonnenday
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 4:1315-22. 2004
    ..The use of rituximab, allowing avoidance of splenectomy, may further remove one of the significant disincentives to ABOi transplantation, and eliminate the risk of post-splenectomy infections...
  14. ncbi Declining outcomes in simultaneous liver-kidney transplantation in the MELD era: ineffective usage of renal allografts
    Jayme E Locke
    Department of Surgery, Division of Transplantation, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Transplantation 85:935-42. 2008
    ..An unintended consequence of the new system was a rapid increase in the number of simultaneous liver-kidney transplants (SLK) being performed yearly...
  15. ncbi Center-level factors and racial disparities in living donor kidney transplantation
    Erin C Hall
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Am J Kidney Dis 59:849-57. 2012
    ..However, center-level variations in this disparity or the role of center-level factors is unknown...
  16. ncbi Prolonged waiting times for liver transplantation in obese patients
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 248:863-70. 2008
    ..To quantify the independent association between obesity and access to liver transplantation...
  17. ncbi C4d deposition without rejection correlates with reduced early scarring in ABO-incompatible renal allografts
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Pathology 712, Baltimore, MD 21287, USA
    J Am Soc Nephrol 20:197-204. 2009
    ....
  18. ncbi Donor ethnicity influences outcomes following deceased-donor kidney transplantation in black recipients
    Jayme E Locke
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Am Soc Nephrol 19:2011-9. 2008
    ..41; 95% confidence interval 0.2 to 0.87; P = 0.02) among black recipients. These findings suggest that kidneys obtained from black donors after cardiac death may afford the best long-term survival for black recipients...
  19. ncbi Increased risk of graft loss from hepatic artery thrombosis after liver transplantation with older donors
    Zoe A Stewart
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Liver Transpl 15:1688-95. 2009
    ..These findings are of interest in an era of ongoing organ shortages requiring maximum utilization of potential allografts and increasing allocation of older allografts...
  20. ncbi Late graft loss among pediatric recipients of DCD kidneys
    Kyle J Van Arendonk
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Clin J Am Soc Nephrol 6:2705-11. 2011
    ..However, outcomes of DCD kidneys in pediatric recipients remain unclear, primarily because of limited sample sizes...
  21. ncbi Characterization of waiting times in a simulation of kidney paired donation
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Transplant 5:2448-55. 2005
    ..These data provide the first waiting time predictions that can aid patients with incompatible donors in choosing between KPD and desensitization, and can also facilitate planning for a national KPD program...
  22. ncbi Laparoscopic live donor nephrectomy: trends in donor and recipient morbidity following 381 consecutive cases
    Li Ming Su
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Ann Surg 240:358-63. 2004
    ..To review a single-institution 6-year experience with laparoscopic live donor nephrectomy detailing the technical modifications, clinical results, as well as the trends in donor and recipient morbidity...
  23. ncbi Outcomes of renal transplants from Centers for Disease Control and Prevention high-risk donors with prospective recipient viral testing: a single-center experience
    Bonnie E Lonze
    Division of Transplant Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Surg 146:1261-6. 2011
    ..The use of kidneys from deceased donors considered at increased infectious risk represents a strategy to increase the donor pool...
  24. ncbi Patient attitudes toward CDC high infectious risk donor kidney transplantation: inferences from focus groups
    R Lorie Ros
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Clin Transplant 26:247-53. 2012
    ..Significant variation exists in provider willingness to utilize IRD kidneys. Little is known about how patients view these organs. Our aim was to explore patient attitudes toward IRDs and IRD kidney transplantation...
  25. ncbi Live donor champion: finding live kidney donors by separating the advocate from the patient
    Jacqueline M Garonzik-Wang
    Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transplantation 93:1147-50. 2012
    ..We hypothesized that separating the advocate from the patient is important in identifying live donors...
  26. ncbi Defining unacceptable HLA antigens
    Andrea A Zachary
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Curr Opin Organ Transplant 13:405-10. 2008
    ..However, identification of unacceptable antigens is now sufficiently accurate to be used as a virtual crossmatch, which can both prevent the unnecessary shipment of organs and increase the access for sensitized patients...
  27. ncbi ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis
    Zoe A Stewart
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Liver Transpl 15:883-93. 2009
    ..Liver Transpl 15:883-893, 2009. (c) 2009 AASLD...
  28. ncbi Factors associated with and predictive of persistence of donor-specific antibody after treatment with plasmapheresis and intravenous immunoglobulin
    Andrea A Zachary
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2222, USA
    Hum Immunol 66:364-70. 2005
    ..We demonstrate how the types of data generated here can be used to predict elimination or persistence of DSA...
  29. ncbi A computer match program for paired and unconventional kidney exchanges
    Inessa Kaplan
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Transplant 5:2306-8. 2005
    ..With our database of 60 patients and 83 donors, we have been able to identify 122 two-way and 1230 three-way exchanges with an average run time of 30 s...
  30. ncbi Infusion of high-dose intravenous immunoglobulin fails to lower the strength of human leukocyte antigen antibodies in highly sensitized patients
    Nada Alachkar
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transplantation 94:165-71. 2012
    ..HLA antibody reduction and favorable transplantation rates have been reported after treatment with high-dose intravenous immunoglobulin (IVIg)...
  31. ncbi In vitro and ex vivo delivery of short hairpin RNAs for control of hepatitis C viral transcript expression
    Bonnie E Lonze
    Division of Transplant Surgery, Department of Surgery, The John Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Surg 147:384-7. 2012
    ....
  32. ncbi Arteriosclerosis in kidneys from healthy live donors: comparison of wedge and needle core perioperative biopsies
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Pathology 712, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 132:37-42. 2008
    ..There are many studies of histopathologic changes in deceased donor kidneys and how these changes affect subsequent graft function; most are based on wedge rather than needle core biopsies...
  33. ncbi Minimizing risk associated with elderly liver donors by matching to preferred recipients
    Dorry L Segev
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hepatology 46:1907-18. 2007
    ..001; 3-year patient survival: ELD 64%, ALD 77%, ILD 80%, P < 0.001). Conclusion: The risks of ELDs can be substantially minimized by appropriate recipient selection...
  34. ncbi HLA-specific B cells: II. Application to transplantation
    Andrea A Zachary
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Transplantation 83:989-94. 2007
    ..These differences may reflect differences in immune competency and/or exposure to alloantigens. We have investigated the frequencies and phenotypes of HLA-specific B cells to address those possibilities...
  35. ncbi Age and comorbidities are effect modifiers of gender disparities in renal transplantation
    Dorry L Segev
    Department of Surgery, Johns Hopkins University, Baltimore, MD 21205, USA
    J Am Soc Nephrol 20:621-8. 2009
    ..These disparities exist despite similar survival benefits from transplantation for men and women regardless of age or comorbidities...
  36. ncbi Incompatible live-donor kidney transplantation in the United States: results of a national survey
    Jacqueline M Garonzik Wang
    Transplant Surgery, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Ross 771B, Baltimore, MD 21205, USA
    Clin J Am Soc Nephrol 6:2041-6. 2011
    ..The goal of this study was to better understand practice patterns of IKT in the United States...
  37. ncbi A GPS for finding the route to transplantation for the sensitized patient
    Annette M Jackson
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Organ Transplant 17:433-9. 2012
    ..Use of these protocols has revealed various factors that influence which route is the most likely to work for a given patient...
  38. ncbi Outcomes of ABO-incompatible kidney transplantation in the United States
    John R Montgomery
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transplantation 93:603-9. 2012
    ..To date, reports of the outcomes from this practice in the United States have been limited to single-center studies...
  39. ncbi Living kidney donors ages 70 and older: recipient and donor outcomes
    Jonathan C Berger
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin J Am Soc Nephrol 6:2887-93. 2011
    ..Consequently, patients are turning to older living donors. It is unclear if an upper age limit for donation should exist, both in terms of recipient and donor outcomes...
  40. ncbi Candidacy for kidney transplantation of older adults
    Morgan E Grams
    Departments of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 60:1-7. 2012
    ..To develop a prediction model for kidney transplantation (KT) outcomes specific to older adults with end-stage renal disease (ESRD) and to use this model to estimate the number of excellent older KT candidates who lack access to KT...
  41. ncbi Reconstitution of peripheral allospecific CD19+ B-cell subsets after B-lymphocyte depletion therapy in renal transplant patients
    Dessislava Kopchaliiska
    Department of Medicine, Immunogenetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transplantation 87:1394-401. 2009
    ..Here, we report on the reconstitution of human leukocyte antigen (HLA)-specific B lymphocytes in renal transplant patients after treatment with B-lymphocyte depletion...
  42. ncbi Specific and durable elimination of antibody to donor HLA antigens in renal-transplant patients
    Andrea A Zachary
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2222, USA
    Transplantation 76:1519-25. 2003
    ..Attempts to deal with this problem have used plasmapheresis to remove antibodies or high-dose pooled immunoglobulin (IVIg) to down-regulate DSA. However, elimination of antibodies by these methods has been limited in duration or scope...
  43. ncbi Rapid accomodation of an A1 renal allograft after preconditioning for ABO-incompatible transplantation
    Geoff Allen
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Contrib Nephrol 162:35-46. 2009
    ..Little is known about the time course of accommodation. We report a case of a successful ABOi renal transplant recipient who had evidence of accommodation within the first week following transplantation...
  44. ncbi Utilization and outcomes of kidney paired donation in the United States
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transplantation 86:502-10. 2008
    ..Although studies suggest substantial expansion of the donor pool if fully used, few patients in the United States have undergone KPD...
  45. ncbi Multi-detector row CT evaluation of living renal donors prior to laparoscopic nephrectomy
    Satomi Kawamoto
    Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 601 N Caroline St, Room 3254, Baltimore, MD 21287-0801, USA
    Radiographics 24:453-66. 2004
    ..They also must be able to identify variations in vasculature and in renal and extrarenal anatomy that are important for laparoscopic donor nephrectomy...
  46. ncbi ABO-incompatible transplantation: less may be more
    Robert A Montgomery
    Department of Surgery, Johns Hopkins University, Baltimore, MD, USA
    Transplantation 84:S8-9. 2007
    ..This can be accomplished with a modest, brief escalation of immunosuppression and at a lower cost to the health care system than maintaining the patient on dialysis...
  47. ncbi Obesity impacts access to kidney transplantation
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Am Soc Nephrol 19:349-55. 2008
    ....
  48. ncbi Twenty years of liver transplantation for Budd-Chiari syndrome: a national registry analysis
    Dorry L Segev
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Liver Transpl 13:1285-94. 2007
    ..In conclusion, outcomes of LT for BCS are excellent, with further improvements since 2002 associated with a selection shift imposed by MELD-based organ allocation...
  49. ncbi Kidney paired donation: fundamentals, limitations, and expansions
    Sommer E Gentry
    Department of Mathematics, US Naval Academy, Annapolis, MD, USA
    Am J Kidney Dis 57:144-51. 2011
    ....
  50. ncbi Estimates of early death, acute liver failure, and long-term mortality among live liver donors
    Abimereki D Muzaale
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 142:273-80. 2012
    ..We sought to estimate the risk of perioperative mortality or acute liver failure for live liver donors in the United States and avoid selection or ascertainment biases and sample size limitations...
  51. ncbi Steroid avoidance in liver transplantation: meta-analysis and meta-regression of randomized trials
    Dorry L Segev
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Liver Transpl 14:512-25. 2008
    ..We believe that a large, multicenter trial will better define the role of steroid-free regimens in LT...
  52. ncbi Incompatible kidney transplantation: lessons from a decade of desensitization and paired kidney exchange
    Daniel S Warren
    Department of Surgery, Johns Hopkins University, Ross Building Room 765, Baltimore, MD 21205, USA
    Immunol Res 47:257-64. 2010
    ....
  53. ncbi Successful transplantation of cadaveric polycystic liver: case report and review of the literature
    Zoe A Stewart
    Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA
    Transplantation 81:284-6. 2006
    ..We propose that the selective use of polycystic donor livers containing small (<5 cm) cysts with preserved liver parenchyma is safe and appropriate...
  54. ncbi Factors affecting graft survival after liver transplantation from donation after cardiac death donors
    Kwang-Woong Lee
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transplantation 82:1683-8. 2006
    ..CONCLUSIONS: DCD livers from young donors with short DWIT and CIT should be given greater consideration in order to expand the number of available donor organs...
  55. ncbi Modulating alloimmune responses with plasmapheresis and IVIG
    Daniel S Warren
    Departmernt of Surgery, Johns Hopkins University School of Medicine, Ross 765, 720 Rutland Ave, Baltimore, MD 21205, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:215-22. 2005
    ..This review will provide an overview of these therapies and their application to incompatible renal transplantation...
  56. ncbi Association of race and age with survival among patients undergoing dialysis
    Lauren M Kucirka
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    JAMA 306:620-6. 2011
    ..We hypothesized that age and the competing risk of transplantation modify survival differences by race...
  57. ncbi Oxalate deposits in biopsies from native and transplanted kidneys, and impact on graft function
    Serena M Bagnasco
    Department of Pathology, Ross Building, Room 632, 720 Rutland Street, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Nephrol Dial Transplant 24:1319-25. 2009
    ..The purpose of this study was to examine the incidence of oxalate deposits in native and renal allograft biopsies, and its impact on graft function...
  58. ncbi Outcomes and discard of kidneys from pediatric donors after cardiac death
    Nabil N Dagher
    Division of Transplant Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transplantation 91:765-71. 2011
    ..We hypothesized that pediatric organs might be more sensitive to the pathophysiology of cardiac death...
  59. ncbi Generation of humanized animal livers using embryoid body-derived stem cell transplant
    Jayme E Locke
    Division of Transplantation, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Ann Surg 248:487-93. 2008
    ..We sought to use human embryoid body-derived stem cells (EBDs) to populate livers in animals for applications in transplant surgery...
  60. ncbi DNA testing for live kidney donors at risk for autosomal dominant polycystic kidney disease
    Edmund Huang
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transplantation 87:133-7. 2009
    ..We show that DNA diagnostics can be used to enhance safe donation for certain living donor candidates at risk for ADPKD...
  61. ncbi Stem cell mobilization is life saving in an animal model of acute liver failure
    Anthony L Mark
    Department of Surgery, Walter Reed Army Hospital, Bethesda, MD, USA
    Ann Surg 252:591-6. 2010
    ..The aim of this study was to determine whether pharmacologic mobilization of endogenous hematopoietic stem cells (HSCs) can aid in liver repair and improve survival in an animal model of ALF...
  62. ncbi Effect of eliminating priority points for HLA-B matching on racial disparities in kidney transplant rates
    Erin C Hall
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Am J Kidney Dis 58:813-6. 2011
    ..The objective of this study was to quantify the effect of the change in policy regarding priority points for HLA-B matching...
  63. ncbi Isometric tubular epithelial vacuolization in renal allograft biopsy specimens of patients receiving low-dose intravenous immunoglobulin for a positive crossmatch
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Pathology 712, Baltimore, MD 21287, USA
    Transplantation 78:549-56. 2004
    ..A common finding in biopsy specimens of these allografts is isometric vacuolization of proximal tubular epithelium. This finding presents a diagnostic dilemma because it may occur secondary to IVIG treatment or tacrolimus nephrotoxicity...
  64. ncbi HLA-specific B cells: I. A method for their detection, quantification, and isolation using HLA tetramers
    Andrea A Zachary
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transplantation 83:982-8. 2007
    ....
  65. ncbi Excellent outcomes after transplantation of deceased donor kidneys with high terminal creatinine and mild pathologic lesions
    Richard Ugarte
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    Transplantation 80:794-800. 2005
    ..CONCLUSIONS: Under select conditions, kidneys from donors with high terminal creatinine can be used safely with excellent results...
  66. ncbi Expanding the living organ donor pool: positive crossmatch and ABO incompatible renal transplantation
    Mary Jo Holechek
    Adult Abdominal Organ Transplant Service, Johns Hopkins Hospital, Baltimore, MD, USA
    Nephrol Nurs J 30:195-204. 2003
    ....
  67. ncbi Laparoscopic procurement model for living donor liver transplantation
    Peter A Pinto
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287-611, USA
    Clin Transplant 17:39-43. 2003
    ..CONCLUSIONS: This study demonstrates the feasibility of laparoscopic living donor procurement for liver transplantation, from both a technical and a physiological perspective...
  68. ncbi The hazards of basing acceptance of cadaveric renal allografts on pulsatile perfusion parameters alone
    Christopher J Sonnenday
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transplantation 75:2029-33. 2003
    ..The good allograft function in these organs emphasizes the importance of considering all donor factors when making allocation decisions...
  69. ncbi Streamlining ABO antibody titrations for monitoring ABO-incompatible kidney transplants
    R Sue Shirey
    Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287 6667, USA
    Transfusion 50:631-4. 2010
    ..Therefore, we assessed AHG titers by two methods: 1) a revised test tube (TT) method without RT and 2) an anti-immunoglobulin G (IgG) gel microcolumn (IgG gel) method with a goal of streamlining ABO antibody titrations...
  70. ncbi Kidney paired donation and optimizing the use of live donor organs
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
    JAMA 293:1883-90. 2005
    ..Optimized matching affords patients the flexibility of customizing their matching priorities and the security of knowing that the greatest number of high-quality matches will be found and distributed equitably...
  71. ncbi Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha
    Yuichi Nagakawa
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hepatology 42:208-15. 2005
    ..In conclusion, the data presented implicate TNF-alpha as being capable of causing oxidative DNA damage and mtDNA mutation in hepatocytes...
  72. ncbi Perioperative mortality and long-term survival following live kidney donation
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 303:959-66. 2010
    ..More than 6000 healthy US individuals every year undergo nephrectomy for the purposes of live donation; however, safety remains in question because longitudinal outcome studies have occurred at single centers with limited generalizability...
  73. ncbi Amelioration of oxidative mitochondrial DNA damage and deletion after renal ischemic injury by the KATP channel opener diazoxide
    Zhaoli Sun
    Department of Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 749, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 294:F491-8. 2008
    ....
  74. ncbi Humoral immunity and antibody-mediated rejection in solid organ transplantation
    Robert A Montgomery
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Semin Immunol 23:224-34. 2011
    ..In this article, we review our current understanding of antibody-mediated processes in solid organ transplantation and discuss the clinically available treatment options for preventing and treating antibody-mediated rejection...
  75. ncbi Antibody, complement and accommodation in ABO-incompatible transplants
    Karen E King
    Department of Pathology, Johns Hopkins Medical Institutes, 720 Rutland Avenue, Baltimore, Maryland 21205-2196, USA
    Curr Opin Immunol 16:545-9. 2004
    ....
  76. ncbi Over-expression of AIF-1 in liver allografts and peripheral blood correlates with acute rejection after transplantation in rats
    Yuichi Nagakawa
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Transplant 4:1949-57. 2004
    ..These data indicate that high levels of AIF-1 expression reflect aggressive liver allograft rejection and suggest a role for monitoring AIF-1 in peripheral blood leukocytes as a monitor for increased immunosuppression...
  77. ncbi Renal transplant in HIV-positive patients: long-term outcomes and risk factors for graft loss
    Jayme E Locke
    Division of Transplantation, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Arch Surg 144:83-6. 2009
    ....
  78. ncbi Consensus opinion from the antibody working group on the diagnosis, reporting, and risk assessment for antibody-mediated rejection and desensitization protocols
    Robert A Montgomery
    Department of Surgery, Division of Transplantation, Johns Hopkins University School of Medicine, Ross 765/720 Rutland Avenue, Baltimore, MD 21205, USA
    Transplantation 78:181-5. 2004
    ..The Antibody Working Group was assembled in an attempt to provide guidelines for the standardization of nomenclature, diagnostic criteria, reporting, antibody profiling, and risk assessment...
  79. ncbi Therapeutic plasma exchange reduces ABO titers to permit ABO-incompatible renal transplantation
    Aaron A R Tobian
    Transfusion Medicine Division, Department of Pathology, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Transfusion 49:1248-54. 2009
    ..Therapeutic plasma exchange (TPE) is performed to permit ABO-incompatible (ABO-I) kidney transplants, but little is known about how well TPE reduces ABO antibodies or complications related to TPE in this clinical setting...
  80. ncbi Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice
    Pamela A Frischmeyer-Guerrerio
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:10638-43. 2011
    ..These data document that NMD has been functionally incorporated into developmental programs during eukaryotic evolution...
  81. ncbi Concomitant surgery with laparoscopic live donor nephrectomy
    Ernesto P Molmenti
    Johns Hopkins University School of Medicine, Department of Surgery, Baltimore, MD, USA
    Am J Transplant 3:219-23. 2003
    ..This practice is beneficial to both the donor and the recipient, and is likely to become more commonplace with changing practice patterns involving donor evaluation and management...
  82. ncbi Multidetector CT angiography for preoperative evaluation of living laparoscopic kidney donors
    Satomi Kawamoto
    The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 601 N. Caroline St, Rm. 3254, Baltimore, MD 21287-0801, USA
    AJR Am J Roentgenol 180:1633-8. 2003
    ..CONCLUSION: MDCT angiography is highly accurate for detecting vascular anomalies and providing anatomic information for laparoscopic living donor nephrectomy...
  83. ncbi C4d staining of perioperative renal transplant biopsies
    Mark Haas
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
    Transplantation 74:711-7. 2002
    ..However, in other studies, PTC C4d deposits were noted in more than 40% of renal transplant biopsies performed for graft dysfunction and capillary C4d deposition in heart transplants may result from ischemic injury...
  84. ncbi West Nile virus encephalitis in a kidney transplant recipient
    James C Shepherd
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 4:830-3. 2004
    ..Seroepidemiological testing indicated that the infection was most likely acquired from transfusion of fresh frozen plasma at the time of transplantation...
  85. ncbi Provider response to a rare but highly publicized transmission of HIV through solid organ transplantation
    Lauren M Kucirka
    Department of Surgery, The Johns Hopkins University, Baltimore, Maryland, USA
    Arch Surg 146:41-5. 2011
    ..We sought to characterize change in the practice of transplant surgeons resulting from this rare event...
  86. ncbi Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection
    Lorraine C Racusen
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 3:708-14. 2003
    ..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...
  87. ncbi A novel chimeric ribozyme vector produces potent inhibition of ICAM-1 expression on ischemic vascular endothelium
    Christopher J Sonnenday
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MA, USA
    J Gene Med 6:1394-402. 2004
    ....
  88. ncbi Optical access trocar injuries in urological laparoscopic surgery
    Mathew A Thomas
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287-2411, USA
    J Urol 170:61-3. 2003
    ..CONCLUSIONS: Optical access trocars provide a safe and rapid technique for initial trocar placement. Results of this large series support the finding that few trocar related complications are associated with the optical access trocar...
  89. ncbi Ipsilateral orchialgia after laparoscopic donor nephrectomy
    Fernando J Kim
    James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Endourol 17:405-9. 2003
    ..In an effort to assess the incidence of this problem, determine the etiology, and adapt preventive measures, we reviewed our experience...

Research Grants6

  1. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
    ..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..