E Montgomery

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Serrated colorectal polyps: emerging evidence suggests the need for a reappraisal
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Adv Anat Pathol 11:143-9. 2004
  2. ncbi request reprint Is there a way for pathologists to decrease interobserver variability in the diagnosis of dysplasia?
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Arch Pathol Lab Med 129:174-6. 2005
  3. ncbi request reprint The diagnostic value of beta-catenin immunohistochemistry
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Adv Anat Pathol 12:350-6. 2005
  4. ncbi request reprint Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions
    Elizabeth Montgomery
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21230, USA
    Appl Immunohistochem Mol Morphol 14:24-30. 2006
  5. pmc Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer
    Guoping Sui
    Department of Pathology, Johns Hopkins University School of Medicine, Washington, DC
    Mol Cancer 5:73. 2006
  6. pmc Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group
    Harry H Yoon
    Mayo Clinic, Rochester, MN 55905, USA
    BMC Cancer 11:176. 2011
  7. ncbi request reprint Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Surg Pathol 26:1296-301. 2002
  8. doi request reprint Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma
    Elizabeth Montgomery
    Department of Pathology and Oncology, The Johns Hopkins Hospital, Weinberg 2242, 401 North Broadway, Baltimore, MD 21231, USA
    Am J Surg Pathol 33:1364-9. 2009
  9. ncbi request reprint CD44 loss in gastric stromal tumors as a prognostic marker
    Elizabeth Montgomery
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 28:168-77. 2004
  10. ncbi request reprint Myofibromas presenting in the oral cavity: a series of 9 cases
    E Montgomery
    The Johns Hopkins University Hosptial, Baltimore, MD, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:343-8. 2000

Detail Information

Publications78

  1. ncbi request reprint Serrated colorectal polyps: emerging evidence suggests the need for a reappraisal
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Adv Anat Pathol 11:143-9. 2004
    ..It is important to separate these polyps, which some have called "sessile serrated polyps" from hyperplastic polyps as they are associated with progression to carcinoma probably through mismatch repair defects...
  2. ncbi request reprint Is there a way for pathologists to decrease interobserver variability in the diagnosis of dysplasia?
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Arch Pathol Lab Med 129:174-6. 2005
    ....
  3. ncbi request reprint The diagnostic value of beta-catenin immunohistochemistry
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Adv Anat Pathol 12:350-6. 2005
    ..Immunohistochemistry for beta-catenin may be useful in the differential diagnosis of selected tumors of soft tissue, the gastrointestinal tract, including the pancreas, lung, and female genital tract...
  4. ncbi request reprint Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions
    Elizabeth Montgomery
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21230, USA
    Appl Immunohistochem Mol Morphol 14:24-30. 2006
    ..The findings suggest that alterations in Claudin proteins are an early event in tumorigenesis and may provide targets for diagnosis and directed therapy for esophageal adenocarcinoma and its precursors...
  5. pmc Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer
    Guoping Sui
    Department of Pathology, Johns Hopkins University School of Medicine, Washington, DC
    Mol Cancer 5:73. 2006
    ..In all cases, matched normal tissues from the corresponding site were obtained as germline control. MitoChip analysis was performed on DNA obtained from cryostat-embedded specimens...
  6. pmc Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group
    Harry H Yoon
    Mayo Clinic, Rochester, MN 55905, USA
    BMC Cancer 11:176. 2011
    ..As a secondary aim, we investigated the rate of allelic imbalance between germline and tumor DNA...
  7. ncbi request reprint Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Surg Pathol 26:1296-301. 2002
    ..beta-Catenin staining identifies lesions that are, instead, mesenteric fibromatoses...
  8. doi request reprint Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma
    Elizabeth Montgomery
    Department of Pathology and Oncology, The Johns Hopkins Hospital, Weinberg 2242, 401 North Broadway, Baltimore, MD 21231, USA
    Am J Surg Pathol 33:1364-9. 2009
    ..We describe 6 cases of a poorly recognized vascular neoplasm that can simulate angiosarcoma...
  9. ncbi request reprint CD44 loss in gastric stromal tumors as a prognostic marker
    Elizabeth Montgomery
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 28:168-77. 2004
    ..Thus, the prognostic value of CD44s and isoform expression in GIST were evaluated by immunohistochemistry of tissue microarrays...
  10. ncbi request reprint Myofibromas presenting in the oral cavity: a series of 9 cases
    E Montgomery
    The Johns Hopkins University Hosptial, Baltimore, MD, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:343-8. 2000
    ..Solitary myofibromas are well described in the head and neck, but oral examples are less well known, and jaw lesions are rare. We studied the clinicopathologic features of a series of such lesions...
  11. ncbi request reprint Management of high-grade dysplasia in patients with Barrett's esophagus
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Gastroenterol Hepatol 4:1434-9. 2006
    ..Emerging endoscopic techniques offer an opportunity for better evaluation of patients with Barrett's-associated neoplasia...
  12. ncbi request reprint Superficial fibromatoses are genetically distinct from deep fibromatoses
    E Montgomery
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Mod Pathol 14:695-701. 2001
    ..This difference may account inpart for their divergent clinical manifestations despite their morphologic resemblance to deep fibromatoses...
  13. ncbi request reprint Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: a follow-up study based on 138 cases from a diagnostic variability study
    E Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Pathol 32:379-88. 2001
    ..Rebiopsy of ulcerated areas should be considered because they may harbor malignancy. Histologic grading of dysplasia using established criteria is a powerful prognosticator in BE. HUM PATHOL 32:379-388...
  14. ncbi request reprint CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:390-9. 2005
    ..These findings suggest a role for CDC2/CDK1 in esophageal adenocarcinogenesis, both as a potential histopathologic marker of dysplasia and a putative treatment target...
  15. ncbi request reprint Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications
    Eric L Powell
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Am J Surg Pathol 29:1497-504. 2005
    ..This loss of MTAP during 9p21 homozygous deletion might be exploited therapeutically using de novo purine synthesis antimetabolites to treat a subset of invasive gastroesophageal adenocarcinomas and esophageal precursor lesions...
  16. pmc Confocal laser endomicroscopy in Barrett's esophagus and endoscopically inapparent Barrett's neoplasia: a prospective, randomized, double-blind, controlled, crossover trial
    Kerry B Dunbar
    Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastrointest Endosc 70:645-54. 2009
    ..The detection of high-grade dysplasia and cancer in Barrett's esophagus (BE) can be challenging. Confocal laser endomicroscopy (CLE) allows in vivo visualization of mucosal histology during endoscopy...
  17. ncbi request reprint Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experience
    Aravind Arepally
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutes, Johns Hopkins Hospital, Blalock 545, 600 N Wolfe St, Baltimore, MD 21287, USA
    Radiology 244:138-43. 2007
    ..To prospectively test, in a porcine model, the hypothesis that use of catheter-directed gastric artery chemical embolization (GACE) can result in substantial suppression of systemic ghrelin levels...
  18. ncbi request reprint Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Surg Pathol 28:347-56. 2004
    ..This up-regulation appears to parallel invasive behavior and may therefore be used as a potential marker for cancer aggressiveness in this system...
  19. ncbi request reprint Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model
    Pramod Bonde
    Department of Cardiothoracic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 133:763-9. 2007
    ..Support for this comes from the development of esophageal adenocarcinoma in the rat reflux model. However, to date, no systematic characterization of the tumors derived from this model has been reported...
  20. ncbi request reprint Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma
    Malcolm V Brock
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 9:2912-9. 2003
    ..The association of clinicopathological and biomolecular risk factors to survival and recurrence was performed using the Log-rank test and Cox proportional hazards model for multivariate analysis...
  21. pmc Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells
    Rachana Agarwal
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e8002. 2009
    ..In the present study, we report that claudin-11 (CLDN11) is silenced in gastric cancer via hypermethylation of its promoter region...
  22. ncbi request reprint Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus
    Marie E Robert
    Department of Pathology, Yale University, New Haven, CT 06520, USA
    Am J Clin Pathol 124:519-27. 2005
    ..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed...
  23. doi request reprint Johns Hopkins course: 8th annual Current Topics in Gastrointestinal and Liver Pathology
    Robert A Anders
    Johns Hopkins School of Medicine, Department of Pathology, Division of GI and Liver Pathology, 1550 Orleans Street, Cancer Research Building II, Room 346, Baltimore, MD 21231, USA
    Expert Rev Gastroenterol Hepatol 3:33-7. 2009
    ..Key topics included newly recognized staging issues, the application of molecular techniques and practical topics for diagnostic pathologists...
  24. ncbi request reprint Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions
    Steven C Cunningham
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore Maryland 21231, USA
    Cancer Epidemiol Biomarkers Prev 15:281-7. 2006
    ..These findings may prove useful in the diagnosis and therapeutic targeting of gastric adenocarcinoma precursor lesions...
  25. pmc ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma
    G H Su
    Department of Oncology, Pathology, and Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 98:3254-7. 2001
    ..Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene...
  26. ncbi request reprint Myofibrosarcoma: a clinicopathologic study
    E Montgomery
    Department of Pathology, Georgetown University, Washington, DC, USA
    Am J Surg Pathol 25:219-28. 2001
    ..Their clinical importance lies in the resemblance, particularly of low-grade examples, to reactive or pseudosarcomatous conditions...
  27. ncbi request reprint Leiomyosarcoma of the head and neck: a clinicopathological study
    E Montgomery
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Histopathology 40:518-25. 2002
    ..The behaviour of leiomyosarcoma is site-related and there are few data on such tumours located in the head and neck. We studied the clinicopathological features of these lesions...
  28. ncbi request reprint Survival after gastric adenocarcinoma resection: eighteen-year experience at a single institution
    Steven C Cunningham
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    J Gastrointest Surg 9:718-25. 2005
    ..Many of the reported differences among Western series may be due to cohort differences, such as stage of disease, extent of resection, tumor type, and tumor location...
  29. ncbi request reprint Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions
    Baishali Bhattacharya
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:653-9. 2005
    ..Most fibromatoses have diffuse nuclear staining although occasional examples only focally label...
  30. doi request reprint Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting
    Jason Y Park
    Department of Pathology, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, TX, USA
    Am J Surg Pathol 34:1591-8. 2010
    ..In summary, AMAG occurred with similar frequency across all racial groups. Although PGAs are associated with AMAG, they remain rare in the setting of AMAG...
  31. ncbi request reprint Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms
    Fikret Sahin
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:686-91. 2003
    ..Immunohistochemical analysis for Stk11 expression may be a valid surrogate for genetic analysis of STK11 gene mutations in cancers...
  32. pmc Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer
    Jennifer R Scudiere
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 34:447-53. 2010
    ..Distinguishing SM from pancreatic carcinoma is crucial to appropriate management, as patients with SM may benefit from immunosuppressive therapy...
  33. ncbi request reprint Are ulcers a marker for invasive carcinoma in Barrett's esophagus? Data from a diagnostic variability study with clinical follow-up
    Elizabeth Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Gastroenterol 97:27-31. 2002
    ..We correlated follow-up information from 138 patients with Barrett's esophagus and varying degrees of dysplasia with the presence of ulcers...
  34. ncbi request reprint Reproducibility of the diagnosis of dysplasia in Barrett esophagus: a reaffirmation
    E Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Pathol 32:368-78. 2001
    ..The criteria used by the group are presented. HUM PATHOL 32:368-978...
  35. ncbi request reprint Genes expressed in human tumor endothelium
    B St Croix
    Johns Hopkins Oncology Center, Howard Hughes Medical Institute, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Science 289:1197-202. 2000
    ..These studies demonstrate that tumor and normal endothelium are distinct at the molecular level, a finding that may have significant implications for the development of anti-angiogenic therapies...
  36. ncbi request reprint Selective decrease in the DNA base excision repair pathway in squamous cell cancer of the esophagus
    Pramod Bonde
    Cardiothoracic Renal Research Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Thorac Cardiovasc Surg 133:74-81. 2007
    ....
  37. doi request reprint A series of vascular tumors and tumorlike lesions of the bladder
    Fabio Tavora
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1213-9. 2008
    ..Despite the potential for marked hemorrhage, none of the tumors resulted in marked hematuria. Papillary endothelial hyperplasia occurs in the bladder and must be differentiated from angiosarcoma, which has a rapidly fatal outcome...
  38. ncbi request reprint MKK4 status predicts survival after resection of gastric adenocarcinoma
    Steven C Cunningham
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Arch Surg 141:1095-9; discussion 1100. 2006
    ..Lack of expression of the tumor-suppressor gene MKK4 is significantly correlated with poor survival after resection of gastric adenocarcinoma...
  39. ncbi request reprint Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathway
    Michael Torbenson
    Division of Gastrointestinal Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Mod Pathol 15:189-96. 2002
    ..Activation of the Wnt signaling pathway appears to be important in a subset of hepatic adenomas but does not result from common beta-catenin or APC mutations and does not appear to be directly linked to hormonal receptor status...
  40. doi request reprint Morphologic characterization of syndromic gastric polyps
    Dora Lam-Himlin
    Department of Pathology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD 21231, USA
    Am J Surg Pathol 34:1656-62. 2010
    ..Whereas these syndromic polyps are readily diagnosed in the small bowel and colon, histologic features to distinguish gastric JuvPS and PJS from gastric HP polyps are unreliable...
  41. ncbi request reprint Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux model
    Guoping Sui
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Surg Res 134:1-9. 2006
    ..Advancements in experimental therapeutics for esophageal cancers have been hampered by the lack of a reliable preclinical model that recapitulates the biology of human cancer, including in vivo growth in an animal model...
  42. ncbi request reprint Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act"
    Todd B Sheridan
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231 2401, USA
    Am J Clin Pathol 126:564-71. 2006
    ..No patient was known to have hereditary nonpolyposis colorectal cancer/Lynch syndrome. This study offers additional strong evidence that SSA is truly a precursor to at least a subset of sporadic microsatellite-unstable colorectal cancer...
  43. ncbi request reprint Solitary testicular myofibroma: a case report and review of the literature
    Samson W Fine
    Department of Pathology, Johns Hopkins University Hospital, Baltimore, MD, USA
    Arch Pathol Lab Med 129:1322-5. 2005
    ..To our knowledge, this is the first report of a myofibroma localized within the testis...
  44. doi request reprint Medication-induced upper gastrointestinal tract injury
    Z Chen
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Clin Pathol 62:113-9. 2009
    ....
  45. ncbi request reprint Leiomyosarcoma of the kidney: a clinicopathologic study
    Andrea T Deyrup
    Department of Pathology, University of Chicago, Chicago, IL, USA
    Am J Surg Pathol 28:178-82. 2004
    ..In summary, the majority of renal leiomyosarcomas are intermediate or high grade with correspondingly poor prognosis...
  46. ncbi request reprint Duodenal reflux leads to down regulation of DNA mismatch repair pathway in an animal model of esophageal cancer
    Pramod Bonde
    Cardiothoracic Renal Molecular Research Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ann Thorac Surg 83:433-40; discussion 440. 2007
    ..We tested the effect of reflux, either alone or in combination with the human dietary mutagen methyl-n-amyl nitrosamine (MNAN), on DNA damage in adenocarcinoma and squamous cell cancer of the esophagus in a rat model...
  47. pmc Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas
    Bogdan C Paun
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 116:4495-501. 2010
    ....
  48. doi request reprint Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma
    Zong Ming Chen
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 33:186-93. 2009
    ..Despite its bland histologic appearance, it is much more likely to be accompanied by background IM and autoimmune gastritis and can evolve into invasive adenocarcinoma displaying pyloric gland differentiation...
  49. doi request reprint Classification and pathology
    Julie M Wu
    The Johns Hopkins University, Baltimore, MD 21231, USA
    Surg Clin North Am 88:483-520, v-vi. 2008
    ..In this article the lesions are described essentially in accordance with the World Health Organization classification...
  50. doi request reprint Incidental anorectal pathologic findings in prostatic needle core biopsies: a 13-year experience from a genitourinary pathology consult service
    Huihui Ye
    Department of Pathology, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 41:1674-81. 2010
    ..Nevertheless, pathologists should evaluate the rectal mucosa for both neoplastic and inflammatory changes to avoid missing clinically significant anorectal diseases...
  51. ncbi request reprint Histopathology of ulcerative colitis in initial rectal biopsy in children
    Kay Washington
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Surg Pathol 26:1441-9. 2002
    ..This difference may be related to a shorter duration of symptoms before biopsy...
  52. ncbi request reprint Mucosal benign epithelioid nerve sheath tumors
    Marc R Lewin
    Johns Hopkins Medical Institutions, Weinberg 2242, 401 N Broadway, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:1310-5. 2005
    ..Mucosal epithelioid nerve sheath tumors are a rare entity characterized by prominent epithelioid round to oval cells with an infiltrative growth pattern. These lesions are often discovered incidentally and have a benign clinical course...
  53. doi request reprint Benign nerve sheath tumors on urinary bladder biopsy
    Wenle Wang
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:907-12. 2008
    ..Once recognized as a neurofibroma, it is important to identify it as a diffuse neurofibroma, given its lack of relationship to neurofibromatosis...
  54. doi request reprint Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effect
    Jason A Daniels
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:473-7. 2008
    ..Further, epithelial changes associated with taxanes can mimic high-grade dysplasia (HGD) in non-neoplastic gastrointestinal (GI) tract mucosa. Similar changes associated with colchicine are only seen in patients with toxicity...
  55. doi request reprint Mycophenolic acid (cellcept and myofortic) induced injury of the upper GI tract
    Thong Nguyen
    Department of Pathology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 33:1355-63. 2009
    ..We studied the pattern of upper GI tract injury in symptomatic patients taking MPA...
  56. doi request reprint Expression of EGFR in gastric stromal tumors: a clinicopathologic study
    Xiaofei Qiu
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Appl Immunohistochem Mol Morphol 16:310-5. 2008
    ..Expression of EGFR in some gastric GISTs might be of clinical significance with the recent emergence of EGFR-targeted therapies...
  57. ncbi request reprint Spindle cell lesions of the adult prostate
    Donna E Hansel
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Mod Pathol 20:148-58. 2007
    ..This review addresses the various entities that may present as spindle cell tumors within the adult prostate and discusses the functional aspects of the differential diagnosis of these lesions...
  58. ncbi request reprint Paratesticular liposarcoma: a clinicopathologic study
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland USA
    Am J Surg Pathol 27:40-7. 2003
    ..There were no metastases and the overall prognosis was good. One DDL recurred and only one of five (20%) developed metastases, but the mean follow-up for DDL was only 24 months...
  59. ncbi request reprint Do sporadic Peutz-Jeghers polyps exist? Experience of a large teaching hospital
    Ashlie L Burkart
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Surg Pathol 31:1209-14. 2007
    ..Our findings suggest that if sporadic PJP exist, they are extremely rare. Moreover, our data suggest that individuals with a single PJP may have a cumulative lifetime risk of cancer similar to those with the syndrome...
  60. ncbi request reprint Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 2:248-52. 2003
    ....
  61. ncbi request reprint Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis
    Alan K Meeker
    Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:3317-26. 2004
    ..In the present study, we address whether the previous findings are broadly applicable to human epithelial cancer precursors in general...
  62. ncbi request reprint Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 1000, USA
    J Gastrointest Surg 7:1004-14; discussion 1014. 2003
    ..This study supports the methylation status of E-cadherin as a prognostic marker for early GIST recurrence and survival...
  63. ncbi request reprint Fibromatosis of the breast and mutations involving the APC/beta-catenin pathway
    Susan C Abraham
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Hum Pathol 33:39-46. 2002
    ..The spectrum of beta-catenin and APC alterations is similar to that described for desmoid tumors of the abdomen, paraspinal region, and extremities...
  64. ncbi request reprint Gastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology
    Susan C Abraham
    Divison of Gastrointerstinal Liver Pathology, Department of Pahology, Johns Hopkins University School of Medicine, Baltimeore, Maryland
    Am J Surg Pathol 26:1276-85. 2002
    ..In any individual patient complete removal of the adenoma should be performed, and thorough biopsy of the surrounding gastric mucosa is essential to understand the clinicopathologic context of the adenoma...
  65. ncbi request reprint Colchicine effect in a colonic hyperplastic polyp. A lesion mimicking serrated adenoma
    Michael Torbenson
    Division of Gastrointestinal Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Arch Pathol Lab Med 126:615-7. 2002
    ..Distinguishing between hyperplastic polyp and serrated adenoma is important because of the different management implications and the increased potential for neoplastic progression in the latter...
  66. ncbi request reprint Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a Pre-Barrett's esophagus setting
    Tomoharu Miyashita
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Gastrointest Surg 12:2-7; discussion 7-9. 2008
    ..We developed a granulocyte-macrophage-colony-stimulating factor (GM-CSF) tumor vaccine for esophageal cancer. We evaluated the effectiveness of the vaccine as a prevention option in a surgical reflux rat model of esophageal cancer...
  67. ncbi request reprint Identification of Fn14/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma
    George S Watts
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Int J Cancer 121:2132-9. 2007
    ..Fn14's potential as a therapeutic target was further supported by immunohistochemistry on a tissue microarray of patient samples that showed that Fn14 protein expression increased with disease progression in EAC...
  68. ncbi request reprint Computerized morphometry as an aid in determining the grade of dysplasia and progression to adenocarcinoma in Barrett's esophagus
    Edmond Sabo
    Department of Pathology, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Lab Invest 86:1261-71. 2006
    ..Moreover, histomorphometric quantification of nuclear texture is a powerful tool for predicting progression to invasive adenocarcinoma in patients with HGD...
  69. doi request reprint The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway
    Dora M Lam-Himlin
    Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
    Int J Gastrointest Cancer 37:103-9. 2006
    ..The potential role of YAP in tumorigenesis was also reported in a murine genetic screen which identified a genomic amplification of YAP in hepatocellular carcinoma...
  70. doi request reprint Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential
    Julie M Wu
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Clin Pathol 129:416-23. 2008
    ..002). We propose that beta-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps. These findings also suggest that Wnt signaling has a role in SSA development...
  71. ncbi request reprint High-resolution chromoendoscopy for classifying colonic polyps: a multicenter study
    Glenn M Eisen
    Division of Gastroenterology, Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
    Gastrointest Endosc 55:687-94. 2002
    ..Chromoendoscopy may reliably separate adenomatous from nonadenomatous polyps. The aim of this multicenter trial was to determine the accuracy of high-resolution chromoendoscopy for the determination of colonic polyp histology...
  72. ncbi request reprint Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update
    David T Rubin
    University of Chicago Medical Center, Chicago, IL 60637, USA
    Inflamm Bowel Dis 14:265-74. 2008
    ..This article provides a comprehensive overview of the issues discussed and should act as a guide to shaping the design of future studies in this area...
  73. ncbi request reprint LKB1 protein expression in human breast cancer
    Hubert Fenton
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Appl Immunohistochem Mol Morphol 14:146-53. 2006
    ..Given recent Western blot results indicating that diminished LKB1 expression in breast carcinomas correlates with shorter relapse-free survival, LKB1 IHC merits evaluation as a potential prognostic marker for breast carcinoma...
  74. ncbi request reprint Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Int J Gynecol Pathol 24:196-200. 2005
    ....
  75. ncbi request reprint Inflammatory myofibroblastic tumors of the urinary tract: a clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma
    Elizabeth A Montgomery
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1502-12. 2006
    ..For these reasons, close follow-up is warranted...
  76. doi request reprint Expression of melanoma antigens in epithelioid gastrointestinal stromal tumors: a potential diagnostic pitfall
    Mehmet L Guler
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
    Arch Pathol Lab Med 132:1302-6. 2008
    ..Most gastric gastrointestinal stromal tumors (GISTs) express CD117/c-kit, as do a subset of metastatic melanomas, leading to a diagnostic dilemma in some cases...
  77. ncbi request reprint Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy
    Julie Wu
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 2410, USA
    Int J Surg Pathol 13:81-5. 2005
    ..With this report, we confirm the utility of a novel immunohistochmical technique for the identification of an ASPS presenting in an unusual locale...
  78. ncbi request reprint Counting alleles to predict recurrence of early-stage colorectal cancers
    Wei Zhou
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Lancet 359:219-25. 2002
    ..However, measurements of such imbalances are difficult. We used a new, quantitative approach to investigate the prognostic value of chromosome imbalances in early-stage colorectal cancers...