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Genomes and Genes | E MontgomerySummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Serrated colorectal polyps: emerging evidence suggests the need for a reappraisalElizabeth Montgomery
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Adv Anat Pathol 11:143-9. 2004..It is important to separate these polyps, which some have called "sessile serrated polyps" from hyperplastic polyps as they are associated with progression to carcinoma probably through mismatch repair defects...- Is there a way for pathologists to decrease interobserver variability in the diagnosis of dysplasia?Elizabeth Montgomery
Department of Pathology, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Arch Pathol Lab Med 129:174-6. 2005.... - The diagnostic value of beta-catenin immunohistochemistryElizabeth Montgomery
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Adv Anat Pathol 12:350-6. 2005..Immunohistochemistry for beta-catenin may be useful in the differential diagnosis of selected tumors of soft tissue, the gastrointestinal tract, including the pancreas, lung, and female genital tract... - Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancerGuoping Sui
Department of Pathology, Johns Hopkins University School of Medicine, Washington, DC
Mol Cancer 5:73. 2006..In all cases, matched normal tissues from the corresponding site were obtained as germline control. MitoChip analysis was performed on DNA obtained from cryostat-embedded specimens... - Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology GroupHarry H Yoon
Mayo Clinic, Rochester, MN 55905, USA
BMC Cancer 11:176. 2011..As a secondary aim, we investigated the rate of allelic imbalance between germline and tumor DNA... - Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesionsElizabeth Montgomery
Johns Hopkins University School of Medicine, Baltimore, Maryland 21230, USA
Appl Immunohistochem Mol Morphol 14:24-30. 2006..The findings suggest that alterations in Claudin proteins are an early event in tumorigenesis and may provide targets for diagnosis and directed therapy for esophageal adenocarcinoma and its precursors... - Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritisElizabeth Montgomery
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Am J Surg Pathol 26:1296-301. 2002..beta-Catenin staining identifies lesions that are, instead, mesenteric fibromatoses... - Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcomaElizabeth Montgomery
Department of Pathology and Oncology, The Johns Hopkins Hospital, Weinberg 2242, 401 North Broadway, Baltimore, MD 21231, USA
Am J Surg Pathol 33:1364-9. 2009..We describe 6 cases of a poorly recognized vascular neoplasm that can simulate angiosarcoma... - CD44 loss in gastric stromal tumors as a prognostic markerElizabeth Montgomery
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 28:168-77. 2004..Thus, the prognostic value of CD44s and isoform expression in GIST were evaluated by immunohistochemistry of tissue microarrays... - Myofibromas presenting in the oral cavity: a series of 9 casesE Montgomery
The Johns Hopkins University Hosptial, Baltimore, MD, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:343-8. 2000..Solitary myofibromas are well described in the head and neck, but oral examples are less well known, and jaw lesions are rare. We studied the clinicopathologic features of a series of such lesions... - Management of high-grade dysplasia in patients with Barrett's esophagusElizabeth Montgomery
Department of Pathology, Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland 21231, USA
Clin Gastroenterol Hepatol 4:1434-9. 2006..Emerging endoscopic techniques offer an opportunity for better evaluation of patients with Barrett's-associated neoplasia... - Superficial fibromatoses are genetically distinct from deep fibromatosesE Montgomery
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
Mod Pathol 14:695-701. 2001..This difference may account inpart for their divergent clinical manifestations despite their morphologic resemblance to deep fibromatoses... - Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: a follow-up study based on 138 cases from a diagnostic variability studyE Montgomery
Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205, USA
Hum Pathol 32:379-88. 2001..Rebiopsy of ulcerated areas should be considered because they may harbor malignancy. Histologic grading of dysplasia using established criteria is a powerful prognosticator in BE. HUM PATHOL 32:379-388... - CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug targetDonna E Hansel
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Surg Pathol 29:390-9. 2005..These findings suggest a role for CDC2/CDK1 in esophageal adenocarcinogenesis, both as a potential histopathologic marker of dysplasia and a putative treatment target... - Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implicationsEric L Powell
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Am J Surg Pathol 29:1497-504. 2005..This loss of MTAP during 9p21 homozygous deletion might be exploited therapeutically using de novo purine synthesis antimetabolites to treat a subset of invasive gastroesophageal adenocarcinomas and esophageal precursor lesions... - Confocal laser endomicroscopy in Barrett's esophagus and endoscopically inapparent Barrett's neoplasia: a prospective, randomized, double-blind, controlled, crossover trialKerry B Dunbar
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Gastrointest Endosc 70:645-54. 2009..The detection of high-grade dysplasia and cancer in Barrett's esophagus (BE) can be challenging. Confocal laser endomicroscopy (CLE) allows in vivo visualization of mucosal histology during endoscopy... - Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experienceAravind Arepally
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutes, Johns Hopkins Hospital, Blalock 545, 600 N Wolfe St, Baltimore, MD 21287, USA
Radiology 244:138-43. 2007..To prospectively test, in a porcine model, the hypothesis that use of catheter-directed gastric artery chemical embolization (GACE) can result in substantial suppression of systemic ghrelin levels... - Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tractDonna E Hansel
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Surg Pathol 28:347-56. 2004..This up-regulation appears to parallel invasive behavior and may therefore be used as a potential marker for cancer aggressiveness in this system... - Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor modelPramod Bonde
Department of Cardiothoracic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Thorac Cardiovasc Surg 133:763-9. 2007..Support for this comes from the development of esophageal adenocarcinoma in the rat reflux model. However, to date, no systematic characterization of the tumors derived from this model has been reported... - Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinomaMalcolm V Brock
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Clin Cancer Res 9:2912-9. 2003..The association of clinicopathological and biomolecular risk factors to survival and recurrence was performed using the Log-rank test and Cox proportional hazards model for multivariate analysis... - Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cellsRachana Agarwal
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 4:e8002. 2009..In the present study, we report that claudin-11 (CLDN11) is silenced in gastric cancer via hypermethylation of its promoter region... - Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagusMarie E Robert
Department of Pathology, Yale University, New Haven, CT 06520, USA
Am J Clin Pathol 124:519-27. 2005..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed... - Johns Hopkins course: 8th annual Current Topics in Gastrointestinal and Liver PathologyRobert A Anders
Johns Hopkins School of Medicine, Department of Pathology, Division of GI and Liver Pathology, 1550 Orleans Street, Cancer Research Building II, Room 346, Baltimore, MD 21231, USA
Expert Rev Gastroenterol Hepatol 3:33-7. 2009..Key topics included newly recognized staging issues, the application of molecular techniques and practical topics for diagnostic pathologists... - Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesionsSteven C Cunningham
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore Maryland 21231, USA
Cancer Epidemiol Biomarkers Prev 15:281-7. 2006..These findings may prove useful in the diagnosis and therapeutic targeting of gastric adenocarcinoma precursor lesions... - ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinomaG H Su
Department of Oncology, Pathology, and Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 98:3254-7. 2001..Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene... - Myofibrosarcoma: a clinicopathologic studyE Montgomery
Department of Pathology, Georgetown University, Washington, DC, USA
Am J Surg Pathol 25:219-28. 2001..Their clinical importance lies in the resemblance, particularly of low-grade examples, to reactive or pseudosarcomatous conditions... - Leiomyosarcoma of the head and neck: a clinicopathological studyE Montgomery
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
Histopathology 40:518-25. 2002..CONCLUSIONS: Head and neck leiomyosarcomas are rare and aggressive neoplasms which metastasize. Adjuvant therapy has limited effect... - Survival after gastric adenocarcinoma resection: eighteen-year experience at a single institutionSteven C Cunningham
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231-1000, USA
J Gastrointest Surg 9:718-25. 2005..Many of the reported differences among Western series may be due to cohort differences, such as stage of disease, extent of resection, tumor type, and tumor location... - Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesionsBaishali Bhattacharya
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Am J Surg Pathol 29:653-9. 2005..Most fibromatoses have diffuse nuclear staining although occasional examples only focally label... - Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care settingJason Y Park
Department of Pathology, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, TX, USA
Am J Surg Pathol 34:1591-8. 2010..In summary, AMAG occurred with similar frequency across all racial groups. Although PGAs are associated with AMAG, they remain rare in the setting of AMAG... - Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasmsFikret Sahin
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mod Pathol 16:686-91. 2003..Immunohistochemical analysis for Stk11 expression may be a valid surrogate for genetic analysis of STK11 gene mutations in cancers... - Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancerJennifer R Scudiere
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 34:447-53. 2010..Distinguishing SM from pancreatic carcinoma is crucial to appropriate management, as patients with SM may benefit from immunosuppressive therapy... - Are ulcers a marker for invasive carcinoma in Barrett's esophagus? Data from a diagnostic variability study with clinical follow-upElizabeth Montgomery
Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Am J Gastroenterol 97:27-31. 2002..CONCLUSION: If an ulcer accompanies HGD in a biopsy specimen from a patient with BE, it is likely that invasive carcinoma is also present at that time... - Reproducibility of the diagnosis of dysplasia in Barrett esophagus: a reaffirmationE Montgomery
Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205, USA
Hum Pathol 32:368-78. 2001..The criteria used by the group are presented. HUM PATHOL 32:368-978... - Genes expressed in human tumor endotheliumB St Croix
Johns Hopkins Oncology Center, Howard Hughes Medical Institute, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Science 289:1197-202. 2000..These studies demonstrate that tumor and normal endothelium are distinct at the molecular level, a finding that may have significant implications for the development of anti-angiogenic therapies... - Selective decrease in the DNA base excision repair pathway in squamous cell cancer of the esophagusPramod Bonde
Cardiothoracic Renal Research Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Thorac Cardiovasc Surg 133:74-81. 2007.... - A series of vascular tumors and tumorlike lesions of the bladderFabio Tavora
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Am J Surg Pathol 32:1213-9. 2008..Despite the potential for marked hemorrhage, none of the tumors resulted in marked hematuria. Papillary endothelial hyperplasia occurs in the bladder and must be differentiated from angiosarcoma, which has a rapidly fatal outcome... - MKK4 status predicts survival after resection of gastric adenocarcinomaSteven C Cunningham
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231-1000, USA
Arch Surg 141:1095-9; discussion 1100. 2006..This finding may provide a useful prognostic tool in patients with gastric adenocarcinoma... - Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathwayMichael Torbenson
Division of Gastrointestinal Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
Mod Pathol 15:189-96. 2002..Activation of the Wnt signaling pathway appears to be important in a subset of hepatic adenomas but does not result from common beta-catenin or APC mutations and does not appear to be directly linked to hormonal receptor status... - Morphologic characterization of syndromic gastric polypsDora Lam-Himlin
Department of Pathology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD 21231, USA
Am J Surg Pathol 34:1656-62. 2010..Whereas these syndromic polyps are readily diagnosed in the small bowel and colon, histologic features to distinguish gastric JuvPS and PJS from gastric HP polyps are unreliable... - Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux modelGuoping Sui
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Surg Res 134:1-9. 2006..Advancements in experimental therapeutics for esophageal cancers have been hampered by the lack of a reliable preclinical model that recapitulates the biology of human cancer, including in vivo growth in an animal model... - Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act"Todd B Sheridan
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231-2401, USA
Am J Clin Pathol 126:564-71. 2006..No patient was known to have hereditary nonpolyposis colorectal cancer/Lynch syndrome. This study offers additional strong evidence that SSA is truly a precursor to at least a subset of sporadic microsatellite-unstable colorectal cancer... - Solitary testicular myofibroma: a case report and review of the literatureSamson W Fine
Department of Pathology, Johns Hopkins University Hospital, Baltimore, MD, USA
Arch Pathol Lab Med 129:1322-5. 2005..To our knowledge, this is the first report of a myofibroma localized within the testis... - Medication-induced upper gastrointestinal tract injuryZ Chen
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
J Clin Pathol 62:113-9. 2009.... - Leiomyosarcoma of the kidney: a clinicopathologic studyAndrea T Deyrup
Department of Pathology, University of Chicago, Chicago, IL, USA
Am J Surg Pathol 28:178-82. 2004..In summary, the majority of renal leiomyosarcomas are intermediate or high grade with correspondingly poor prognosis... - Duodenal reflux leads to down regulation of DNA mismatch repair pathway in an animal model of esophageal cancerPramod Bonde
Cardiothoracic Renal Molecular Research Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Ann Thorac Surg 83:433-40; discussion 440. 2007..We tested the effect of reflux, either alone or in combination with the human dietary mutagen methyl-n-amyl nitrosamine (MNAN), on DNA damage in adenocarcinoma and squamous cell cancer of the esophagus in a rat model... - Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomasBogdan C Paun
Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Cancer 116:4495-501. 2010.... - Pyloric gland adenoma: an entity distinct from gastric foveolar type adenomaZong Ming Chen
Department of Pathology, Johns Hopkins University, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 33:186-93. 2009..Despite its bland histologic appearance, it is much more likely to be accompanied by background IM and autoimmune gastritis and can evolve into invasive adenocarcinoma displaying pyloric gland differentiation... - Classification and pathologyJulie M Wu
The Johns Hopkins University, Baltimore, MD 21231, USA
Surg Clin North Am 88:483-520, v-vi. 2008..In this article the lesions are described essentially in accordance with the World Health Organization classification... - Incidental anorectal pathologic findings in prostatic needle core biopsies: a 13-year experience from a genitourinary pathology consult serviceHuihui Ye
Department of Pathology, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Hum Pathol 41:1674-81. 2010..Nevertheless, pathologists should evaluate the rectal mucosa for both neoplastic and inflammatory changes to avoid missing clinically significant anorectal diseases... - Histopathology of ulcerative colitis in initial rectal biopsy in childrenKay Washington
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Am J Surg Pathol 26:1441-9. 2002..This difference may be related to a shorter duration of symptoms before biopsy... - Mucosal benign epithelioid nerve sheath tumorsMarc R Lewin
Johns Hopkins Medical Institutions, Weinberg 2242, 401 N. Broadway, Baltimore, MD 21231, USA
Am J Surg Pathol 29:1310-5. 2005..Mucosal epithelioid nerve sheath tumors are a rare entity characterized by prominent epithelioid round to oval cells with an infiltrative growth pattern. These lesions are often discovered incidentally and have a benign clinical course... - Benign nerve sheath tumors on urinary bladder biopsyWenle Wang
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Am J Surg Pathol 32:907-12. 2008..Once recognized as a neurofibroma, it is important to identify it as a diffuse neurofibroma, given its lack of relationship to neurofibromatosis... - Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effectJason A Daniels
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 32:473-7. 2008..Further, epithelial changes associated with taxanes can mimic high-grade dysplasia (HGD) in non-neoplastic gastrointestinal (GI) tract mucosa. Similar changes associated with colchicine are only seen in patients with toxicity... - Mycophenolic acid (cellcept and myofortic) induced injury of the upper GI tractThong Nguyen
Department of Pathology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 33:1355-63. 2009..We studied the pattern of upper GI tract injury in symptomatic patients taking MPA... - Expression of EGFR in gastric stromal tumors: a clinicopathologic studyXiaofei Qiu
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Appl Immunohistochem Mol Morphol 16:310-5. 2008..Expression of EGFR in some gastric GISTs might be of clinical significance with the recent emergence of EGFR-targeted therapies... - Spindle cell lesions of the adult prostateDonna E Hansel
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Mod Pathol 20:148-58. 2007..This review addresses the various entities that may present as spindle cell tumors within the adult prostate and discusses the functional aspects of the differential diagnosis of these lesions... - Paratesticular liposarcoma: a clinicopathologic studyElizabeth Montgomery
Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland USA
Am J Surg Pathol 27:40-7. 2003..There were no metastases and the overall prognosis was good. One DDL recurred and only one of five (20%) developed metastases, but the mean follow-up for DDL was only 24 months... - Do sporadic Peutz-Jeghers polyps exist? Experience of a large teaching hospitalAshlie L Burkart
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
Am J Surg Pathol 31:1209-14. 2007..Our findings suggest that if sporadic PJP exist, they are extremely rare. Moreover, our data suggest that individuals with a single PJP may have a cumulative lifetime risk of cancer similar to those with the syndrome... - Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignanciesElizabeth Montgomery
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cancer Biol Ther 2:248-52. 2003.... - Telomere length abnormalities occur early in the initiation of epithelial carcinogenesisAlan K Meeker
Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Clin Cancer Res 10:3317-26. 2004..6%. The implications of these findings include the potential that telomere length assessment in situ may be a widely useful biomarker for monitoring disease prevention strategies and for improved early diagnosis... - Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behaviorMichael G House
Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 1000, USA
J Gastrointest Surg 7:1004-14; discussion 1014. 2003..This study supports the methylation status of E-cadherin as a prognostic marker for early GIST recurrence and survival... - Fibromatosis of the breast and mutations involving the APC/beta-catenin pathwaySusan C Abraham
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA
Hum Pathol 33:39-46. 2002..The spectrum of beta-catenin and APC alterations is similar to that described for desmoid tumors of the abdomen, paraspinal region, and extremities... - Gastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathologySusan C Abraham
Divison of Gastrointerstinal Liver Pathology, Department of Pahology, Johns Hopkins University School of Medicine, Baltimeore, Maryland
Am J Surg Pathol 26:1276-85. 2002..In any individual patient complete removal of the adenoma should be performed, and thorough biopsy of the surrounding gastric mucosa is essential to understand the clinicopathologic context of the adenoma... - Colchicine effect in a colonic hyperplastic polyp. A lesion mimicking serrated adenomaMichael Torbenson
Division of Gastrointestinal/Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA
Arch Pathol Lab Med 126:615-7. 2002..Distinguishing between hyperplastic polyp and serrated adenoma is important because of the different management implications and the increased potential for neoplastic progression in the latter... - Vaccine impedes the development of reflux-induced esophageal cancer in a surgical rat model: efficacy of the vaccine in a Pre-Barrett's esophagus settingTomoharu Miyashita
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Gastrointest Surg 12:2-7; discussion 7-9. 2008..We developed a granulocyte-macrophage-colony-stimulating factor (GM-CSF) tumor vaccine for esophageal cancer. We evaluated the effectiveness of the vaccine as a prevention option in a surgical reflux rat model of esophageal cancer... - Identification of Fn14/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinomaGeorge S Watts
Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
Int J Cancer 121:2132-9. 2007..Fn14's potential as a therapeutic target was further supported by immunohistochemistry on a tissue microarray of patient samples that showed that Fn14 protein expression increased with disease progression in EAC... - Computerized morphometry as an aid in determining the grade of dysplasia and progression to adenocarcinoma in Barrett's esophagusEdmond Sabo
Department of Pathology, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
Lab Invest 86:1261-71. 2006..Moreover, histomorphometric quantification of nuclear texture is a powerful tool for predicting progression to invasive adenocarcinoma in patients with HGD... - The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathwayDora M Lam-Himlin
Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
Int J Gastrointest Cancer 37:103-9. 2006..The potential role of YAP in tumorigenesis was also reported in a murine genetic screen which identified a genomic amplification of YAP in hepatocellular carcinoma... - Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potentialJulie M Wu
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Am J Clin Pathol 129:416-23. 2008..002). We propose that beta-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps. These findings also suggest that Wnt signaling has a role in SSA development... - High-resolution chromoendoscopy for classifying colonic polyps: a multicenter studyGlenn M Eisen
Division of Gastroenterology, Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
Gastrointest Endosc 55:687-94. 2002..CONCLUSIONS: High-resolution chromoendoscopy with indigo carmine dye demonstrates morphologic detail of diminutive colorectal polyps that can reliably be used to separate adenomatous from nonadenomatous polyps... - Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and updateDavid T Rubin
University of Chicago Medical Center, Chicago, IL 60637, USA
Inflamm Bowel Dis 14:265-74. 2008..This article provides a comprehensive overview of the issues discussed and should act as a guide to shaping the design of future studies in this area... - LKB1 protein expression in human breast cancerHubert Fenton
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Appl Immunohistochem Mol Morphol 14:146-53. 2006..Given recent Western blot results indicating that diminished LKB1 expression in breast carcinomas correlates with shorter relapse-free survival, LKB1 IHC merits evaluation as a potential prognostic marker for breast carcinoma... - Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literatureDengfeng Cao
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Int J Gynecol Pathol 24:196-200. 2005.... - Inflammatory myofibroblastic tumors of the urinary tract: a clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinomaElizabeth A Montgomery
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 30:1502-12. 2006..For these reasons, close follow-up is warranted... - Expression of melanoma antigens in epithelioid gastrointestinal stromal tumors: a potential diagnostic pitfallMehmet L Guler
Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
Arch Pathol Lab Med 132:1302-6. 2008..Most gastric gastrointestinal stromal tumors (GISTs) express CD117/c-kit, as do a subset of metastatic melanomas, leading to a diagnostic dilemma in some cases... - Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopyJulie Wu
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231-2410, USA
Int J Surg Pathol 13:81-5. 2005..With this report, we confirm the utility of a novel immunohistochmical technique for the identification of an ASPS presenting in an unusual locale... - Counting alleles to predict recurrence of early-stage colorectal cancersWei Zhou
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Lancet 359:219-25. 2002..002). INTERPRETATION: In patients without metastasis, allelic imbalance is a better predictor of prognosis than histopathological stage...