D J Montell

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Modeling migration and metastasis in Drosophila
    Anna C C Jang
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    J Mammary Gland Biol Neoplasia 12:103-14. 2007
  2. ncbi A protocol for culturing Drosophila melanogaster stage 9 egg chambers for live imaging
    Mohit Prasad
    Department of Biological Chemistry, Center for Cell Dynamics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    Nat Protoc 2:2467-73. 2007
  3. ncbi Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging
    Mohit Prasad
    Department of Biological Chemistry, Center for Cell Dynamics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 12:997-1005. 2007
  4. doi Group choreography: mechanisms orchestrating the collective movement of border cells
    Denise J Montell
    Department of Biological Chemistry, Center for Cell Dynamics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Nat Rev Mol Cell Biol 13:631-45. 2012
  5. ncbi The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development
    D J Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 126:3035-46. 1999
  6. ncbi A kinase gets caspases into shape
    Denise J Montell
    Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
    Cell 126:450-2. 2006
  7. ncbi Command and control: regulatory pathways controlling invasive behavior of the border cells
    D J Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 21205 2185, Baltimore, MD, USA
    Mech Dev 105:19-25. 2001
  8. pmc Metastasis movies, macrophages, molecules and more. Conference on Mechanisms of Invasion and Metastasis
    Denise Montell
    Department of Biological Chemistry, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, 408 WBSB, Baltimore, Maryland 21205, USA
    EMBO Rep 4:458-62. 2003
  9. doi Morphogenetic cell movements: diversity from modular mechanical properties
    Denise J Montell
    Department of Biological Chemistry, Center for Cell Dynamics, Rangos Building, Suite 450, 855 North Wolfe Street, Baltimore, MD 21205, USA
    Science 322:1502-5. 2008
  10. ncbi Border-cell migration: the race is on
    Denise J Montell
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    Nat Rev Mol Cell Biol 4:13-24. 2003

Research Grants

  1. Adhesion dynamics in Drosophila border cell migration
    Denise Montell; Fiscal Year: 2007
  2. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise Montell; Fiscal Year: 2007
  3. Cytoskeleton Dynamics in Developmental Cell Migration
    Denise J Montell; Fiscal Year: 2010
  4. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise J Montell; Fiscal Year: 2010
  5. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise Montell; Fiscal Year: 1999
  6. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise Montell; Fiscal Year: 2003
  7. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise Montell; Fiscal Year: 2009

Collaborators

Detail Information

Publications41

  1. ncbi Modeling migration and metastasis in Drosophila
    Anna C C Jang
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    J Mammary Gland Biol Neoplasia 12:103-14. 2007
    ..Together these studies suggest that Drosophila has much to offer as a model for varied aspects of tumor metastasis...
  2. ncbi A protocol for culturing Drosophila melanogaster stage 9 egg chambers for live imaging
    Mohit Prasad
    Department of Biological Chemistry, Center for Cell Dynamics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    Nat Protoc 2:2467-73. 2007
    ..The entire protocol takes approximately 24 h while the preparation of egg chambers for live imaging requires only 15-20 min...
  3. ncbi Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging
    Mohit Prasad
    Department of Biological Chemistry, Center for Cell Dynamics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 12:997-1005. 2007
    ..These observations provide new insight into the cellular dynamics and molecular mechanisms of cell migration in vivo...
  4. doi Group choreography: mechanisms orchestrating the collective movement of border cells
    Denise J Montell
    Department of Biological Chemistry, Center for Cell Dynamics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Nat Rev Mol Cell Biol 13:631-45. 2012
    ..Here we provide an overview of the molecular choreography of border cells and its more general implications...
  5. ncbi The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development
    D J Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 126:3035-46. 1999
    ..New types of genetic screens promise to fill in some of these gaps in the near future...
  6. ncbi A kinase gets caspases into shape
    Denise J Montell
    Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA
    Cell 126:450-2. 2006
    ..However, DmIKK epsilon-mediated degradation of DIAP1 does not regulate apoptosis as might be predicted but instead regulates actin dynamics, cell morphology, and the differentiation of sensory organ precursor cells...
  7. ncbi Command and control: regulatory pathways controlling invasive behavior of the border cells
    D J Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 21205 2185, Baltimore, MD, USA
    Mech Dev 105:19-25. 2001
    ..This may contribute to the metastatic effects of steroid hormones on certain cancers and the inhibition of metastasis by steroid hormone antagonists such as tamoxifen...
  8. pmc Metastasis movies, macrophages, molecules and more. Conference on Mechanisms of Invasion and Metastasis
    Denise Montell
    Department of Biological Chemistry, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, 408 WBSB, Baltimore, Maryland 21205, USA
    EMBO Rep 4:458-62. 2003
  9. doi Morphogenetic cell movements: diversity from modular mechanical properties
    Denise J Montell
    Department of Biological Chemistry, Center for Cell Dynamics, Rangos Building, Suite 450, 855 North Wolfe Street, Baltimore, MD 21205, USA
    Science 322:1502-5. 2008
    ..A small number of properties used in combination could, in principle, generate a diverse array of cell shapes and arrangements and thus orchestrate the varied morphogenetic events observed during metazoan organ development...
  10. ncbi Border-cell migration: the race is on
    Denise J Montell
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    Nat Rev Mol Cell Biol 4:13-24. 2003
    ..Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion...
  11. ncbi Jing: a downstream target of slbo required for developmental control of border cell migration
    Y Liu
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 128:321-30. 2001
    ..We propose that the need to coordinate cell differentiation with nutritional status may be the link between mammalian adipocytes and Drosophila border cells that led to the conservation of C/EBP and AEBP2...
  12. ncbi Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
    D L Silver
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 107:831-41. 2001
    ..Ectopic expression of either UPD or JAK is sufficient to induce extra epithelial cells to migrate. Thus, a localized signal activates the JAK/STAT pathway in neighboring epithelial cells, causing them to become invasive...
  13. ncbi Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer
    J Bai
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 103:1047-58. 2000
    ..The finding of this type of coactivator required for cell motility suggests a novel role for steroid hormones, in stimulating invasive cell behavior, independent of effects on proliferation...
  14. ncbi Two distinct roles for Ras in a developmentally regulated cell migration
    T Lee
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Development 122:409-18. 1996
    ..Raf activity was dispensable to border cell migration while reduced Ral activity inhibited initiation. We therefore suggest that Ras plays a critical role in the dynamic regulation of border cell migration via a Raf-independent pathway...
  15. ncbi Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system
    T Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Genes Dev 10:2912-21. 1996
    ....
  16. ncbi Multiple Ras signals pattern the Drosophila ovarian follicle cells
    T Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Dev Biol 185:25-33. 1997
    ..These results suggest that, in vivo as in vitro, Ras can have diverse effects on different cells, but, in addition, Ras activity can have different effects on the same cells at different stages in their development...
  17. ncbi Developmental regulation of cell migration. Insight from a genetic approach in Drosophila
    D J Montell
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205 2185, USA
    Cell Biochem Biophys 31:219-29. 1999
    ..Finally, genetic studies have demonstrated that the timing of cell migration is under transcriptional control...
  18. ncbi Identification of mutations that cause cell migration defects in mosaic clones
    Y Liu
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 126:1869-78. 1999
    ..This screen identified many new loci required for border cell migration and our results suggest that this is a useful approach for elucidating the mechanisms involved in cell motility...
  19. ncbi Requirement for the vasa RNA helicase in gurken mRNA localization
    R Tinker
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Dev Biol 199:1-10. 1998
    ....
  20. pmc Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis
    A M Murphy
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Cell Biol 133:617-30. 1996
    ..All three activities were necessary for normal transfer of nurse cell cytoplasm to the oocyte. These results suggest that Rho protein activities have cell type-specific effects on morphogenesis...
  21. ncbi The breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration
    A M Murphy
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 121:2255-63. 1995
    ..Purified Drosophila C/EBP bound eight sites in the btl 5' flanking region by DNAse I footprinting. Taken together these results suggest that btl is a key, direct target for C/EBP in the regulation of border cell migration...
  22. ncbi A Drosophila derailed homolog, doughnut, expressed in invaginating cells during embryogenesis
    S Savant-Bhonsale
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Gene 231:155-61. 1999
    ..These results suggest that DNT associates with a catalytically active kinase, but may not be capable of autophosphorylation...
  23. ncbi Requirement for Par-6 and Bazooka in Drosophila border cell migration
    Elaine M Pinheiro
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Development 131:5243-51. 2004
    ..Taken together, these results indicate that cells need not lose apical/basal polarity in order to invade neighboring tissues and in some cases even require such polarity for proper motility...
  24. ncbi Moving right along: regulation of cell migration during Drosophila development
    D J Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Trends Genet 10:59-62. 1994
    ..Signaling through receptor tyrosine kinases may be a general mechanism for the regulation of cell movement in development and in metastasis...
  25. ncbi torso-like encodes the localized determinant of Drosophila terminal pattern formation
    S Savant-Bhonsale
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Genes Dev 7:2548-55. 1993
    ..Ectopic expression of tsl produced embryos with a phenotype similar to that resulting from constitutively active Tor alleles. These results suggest that localized TSL controls the localized activation of TOR...
  26. ncbi A role for extra macrochaetae downstream of Notch in follicle cell differentiation
    Jennifer C Adam
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Development 131:5971-80. 2004
    ..We propose that EMC functions downstream of Notch and upstream of EYA to regulate main body cell fate specification and differentiation...
  27. ncbi Multiple EGFR ligands participate in guiding migrating border cells
    Jocelyn A McDonald
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Dev Biol 296:94-103. 2006
    ..In addition, only Keren and Spitz were expressed at the appropriate stage in the oocyte, the target of border cell migration. Therefore, a complex combination of EGFR and PVR ligands together guide border cells to the oocyte...
  28. ncbi Requirement for JAK/STAT signaling throughout border cell migration in Drosophila
    Debra L Silver
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 212052, USA
    Development 132:3483-92. 2005
    ..Together, our findings suggest that the requirement for STAT in border cells extends beyond the initial specification and delamination of cells from the epithelium...
  29. ncbi A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration
    Erika R Geisbrecht
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Cell 118:111-25. 2004
    ..These results indicate an apoptosis-independent role for DIAP1-mediated Dronc inhibition in Rac-mediated cell motility...
  30. doi Feedback inhibition of Jak/STAT signaling by apontic is required to limit an invasive cell population
    Michelle Starz-Gaiano
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 14:726-38. 2008
    ..These findings are supported by a mathematical model, which accurately simulates wild-type and mutant phenotypes...
  31. ncbi Myosin VI is required for E-cadherin-mediated border cell migration
    Erika R Geisbrecht
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Nat Cell Biol 4:616-20. 2002
    ..Multiple biochemical mechanisms may exist, therefore, for cadherins to associate with diverse unconventional myosins that are required for normal stereocilium formation or maintenance...
  32. ncbi Analysis of cell migration using Drosophila as a model system
    Jocelyn A McDonald
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 294:175-202. 2005
    ..In addition, we provide protocols for staining embryos and manipulating gene function in each of the migratory populations. Finally, we offer some advice concerning the analysis and interpretation of mutant phenotypes...
  33. ncbi Analysis of cell migration using whole-genome expression profiling of migratory cells in the Drosophila ovary
    Xuejiao Wang
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Dev Cell 10:483-95. 2006
    ..Functional analysis revealed a role for the Notch-activating protease Kuzbanian in border cell migration and identified Tie as a guidance receptor for the border cells...
  34. pmc Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo
    Xiaobo Wang
    Department of Biological Chemistry, Center for Cell Dynamics, Johns Hopkins School of Medicine, 855 North Wolfe Street, Baltimore, MD 21205 USA
    Nat Cell Biol 12:591-7. 2010
    ..Communication between cells of the cluster required Jun amino-terminal kinase (JNK) but not guidance receptor signalling. These studies further show that photoactivatable proteins are effective tools in vivo...
  35. ncbi A new trick for Cyclin-Cdk: activation of STAT
    Debra L Silver
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 4:148-9. 2003
    ..Cdk4 overexpression can bypass requirements for JAK but not STAT. These results demonstrate a new function for Cdk4 and a new mode of STAT activation...
  36. ncbi The social lives of migrating cells in Drosophila
    Denise J Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Curr Opin Genet Dev 16:374-83. 2006
    ..And in border cells, DIAP1 and Dronc, two proteins known mainly for their ability to regulate cell death, were found to control cell migration...
  37. ncbi Genes that drive invasion and migration in Drosophila
    Michelle Starz-Gaiano
    Department of Biological Chemistry, Johns Hopkins Medical Institute, Wood Basic Science Building 413, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Curr Opin Genet Dev 14:86-91. 2004
    ..Comparison of genes that regulate these processes to those that promote tumorigenesis and metastasis in mammals demonstrates that studies in fruit flies are uncovering new genes highly relevant to cancer biology...
  38. ncbi PVF1, a PDGF/VEGF homolog, is sufficient to guide border cells and interacts genetically with Taiman
    Jocelyn A McDonald
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Development 130:3469-78. 2003
    ..In addition, we find that taiman and Pvf1 regulate the dynamic localization of E-cadherin in the border cells, possibly accounting for the interaction between these two pathways...
  39. ncbi Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility
    Debra L Silver
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 64:3550-8. 2004
    ..These results suggest that Janus-activated kinase/STAT signaling may contribute to ovarian cancer cell invasiveness...
  40. ncbi Anchors away! Fos fosters anchor-cell invasion
    Denise J Montell
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Cell 121:816-7. 2005
    ..They demonstrate that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes (encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin)...
  41. ncbi Ovarian cancer metastasis: integrating insights from disparate model organisms
    Honami Naora
    Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Rev Cancer 5:355-66. 2005
    ..Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets...

Research Grants23

  1. Adhesion dynamics in Drosophila border cell migration
    Denise Montell; Fiscal Year: 2007
    ..Finally we propose to study a putative downstream target of Rho in border cells, rhophilin by characterizing the mutant phenotype, epistasis analysis with Rho and by identifying and characterizing interacting proteins. ..
  2. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise Montell; Fiscal Year: 2007
    ..We will also investigate the biochemical mechansims that tether UPD to the cell membrane. ..
  3. Cytoskeleton Dynamics in Developmental Cell Migration
    Denise J Montell; Fiscal Year: 2010
    ..Since cell motility contributes to wound healing and tumor metastasis, these studies could lead to the discovery of new drug targets that could promote healing or inhibit the spread of cancer cells. ..
  4. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise J Montell; Fiscal Year: 2010
    ..Since cell motility contributes to wound healing and tumor metastasis, these studies could lead to the discovery of new drug targets that could promote healing or inhibit the spread of cancer cells. ..
  5. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise Montell; Fiscal Year: 1999
    ..We also propose to test the hypotheses that Dts3 associates with the cytoskeleton and is regulated by tyrosine phosphorylation. ..
  6. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise Montell; Fiscal Year: 2003
    ....
  7. REGULATION OF CELL MIGRATION IN DEVELOPMENT
    Denise Montell; Fiscal Year: 2009
    ..Since cell motility contributes to wound healing and tumor metastasis, these studies could lead to the discovery of new drug targets that could promote healing or inhibit the spread of cancer cells. ..