C Montell

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi The TRP superfamily of cation channels
    Craig Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Sci STKE 2005:re3. 2005
  2. ncbi Phototransduction and retinal degeneration in Drosophila
    Tao Wang
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pflugers Arch 454:821-47. 2007
  3. pmc Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel
    Tao Wang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Cell Biol 171:685-94. 2005
  4. pmc Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
    Tao Wang
    Department of Biological Chemistry, Department of Neuroscience, and Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 177:305-16. 2007
  5. pmc Drosophila TRPM channel is essential for the control of extracellular magnesium levels
    Thomas Hofmann
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Marburg, Germany
    PLoS ONE 5:e10519. 2010
  6. pmc Drosophila visual transduction
    Craig Montell
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Neurosci 35:356-63. 2012
  7. ncbi Thermosensation: hot findings make TRPNs very cool
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 13:R476-8. 2003
  8. ncbi The latest waves in calcium signaling
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 122:157-63. 2005
  9. ncbi Physiology, phylogeny, and functions of the TRP superfamily of cation channels
    C Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Sci STKE 2001:re1. 2001
  10. pmc TRP channels in Drosophila photoreceptor cells
    Craig Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Physiol 567:45-51. 2005

Research Grants

  1. TRP CHANNEL SIGNALING COMPLEX AND ITS ROLE IN VISION
    Craig Montell; Fiscal Year: 2001
  2. Genetic models of retinal degeneration
    Craig Montell; Fiscal Year: 2009
  3. TRP channels and their roles in visual transduction
    Craig Montell; Fiscal Year: 2003
  4. Molecular genetics of thermotaxis
    Craig Montell; Fiscal Year: 2010
  5. TRP channels and their roles in visual transduction
    Craig Montell; Fiscal Year: 2006
  6. Molecular Genetics of Taste Transduction
    Craig Montell; Fiscal Year: 2010
  7. Genetic models of retinal degeneration
    Craig Montell; Fiscal Year: 2009
  8. Molecular genetics of thermotaxis
    Craig Montell; Fiscal Year: 2009
  9. Regulation of TRP channels and visual transduction by PIs
    Craig Montell; Fiscal Year: 2010
  10. Molecular Genetics of Taste Transduction
    Craig Montell; Fiscal Year: 2007

Collaborators

Detail Information

Publications84

  1. ncbi The TRP superfamily of cation channels
    Craig Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Sci STKE 2005:re3. 2005
    ..Each of the TRP subfamilies are represented by members in worms and flies, providing the potential for using genetic approaches to characterize the normal functions and activation mechanisms of these channels...
  2. ncbi Phototransduction and retinal degeneration in Drosophila
    Tao Wang
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pflugers Arch 454:821-47. 2007
    ....
  3. pmc Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel
    Tao Wang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Cell Biol 171:685-94. 2005
    ..This retinal degeneration was greatly suppressed by elimination of the Na(+)/Ca(2+) exchanger, CalX, indicating that the cell death was due primarily to deficient Ca(2+) entry rather than disruption of the TRP-anchoring function...
  4. pmc Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
    Tao Wang
    Department of Biological Chemistry, Department of Neuroscience, and Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 177:305-16. 2007
    ..Another class B scavenger receptor, NINAD, functions upstream of SANTA MARIA in the uptake of carotenoids, enabling us to propose a pathway involving multiple extraretinal cell types and proteins essential for the formation of rhodopsin...
  5. pmc Drosophila TRPM channel is essential for the control of extracellular magnesium levels
    Thomas Hofmann
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Marburg, Germany
    PLoS ONE 5:e10519. 2010
    ..These data provide the first evidence for a role for a Drosophila TRP channel in Mg2+ homeostasis, and underscore a broad and evolutionarily conserved role for TRPM channels in Mg2+ homeostasis...
  6. pmc Drosophila visual transduction
    Craig Montell
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Neurosci 35:356-63. 2012
    ..In this review, I focus on recent advances in the fly visual system, including the discovery of a visual cycle and insights into the machinery and mechanisms involved in generating a light response in photoreceptor cells...
  7. ncbi Thermosensation: hot findings make TRPNs very cool
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 13:R476-8. 2003
    ..Recent work on the mouse ANKTM1 and Drosophila Painless proteins shows that members of a third TRP subfamily, TRPN, also function in thermosensation...
  8. ncbi The latest waves in calcium signaling
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 122:157-63. 2005
    ..Insights gleaned from mechanistic studies offered the potential for new therapeutic approaches to combat a variety of diseases resulting from alterations in Ca2+ homeostasis...
  9. ncbi Physiology, phylogeny, and functions of the TRP superfamily of cation channels
    C Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Sci STKE 2001:re1. 2001
    ..Recent studies suggest that alterations in the activities of SOC and TRP channels may be at the heart of several additional neurodegenerative diseases. Thus, TRP channels may prove to be important new targets for drug discovery...
  10. pmc TRP channels in Drosophila photoreceptor cells
    Craig Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Physiol 567:45-51. 2005
    ....
  11. ncbi Drosophila TRP channels
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pflugers Arch 451:19-28. 2005
    ..As a result, the repertoire of biological roles attributed to Drosophila TRPs has increased considerably and is likely to lead to many additional surprises over the next few years...
  12. ncbi Visual transduction in Drosophila
    C Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Cell Dev Biol 15:231-68. 1999
    ..The characterization of this complex has led to a re-evaluation of the mechanisms underlying the activation and deactivation of the phototransduction cascade...
  13. ncbi Mg2+ homeostasis: the Mg2+nificent TRPM chanzymes
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 13:R799-801. 2003
    ..Recent studies demonstrate that these 'chanzymes' are essential for Mg(2+) homeostasis, which is critical for human health and cell viability...
  14. ncbi The TRP channels, a remarkably functional family
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 108:595-8. 2002
    ..Moreover, the biological roles of TRP channels appear to be equally diverse and range from roles in pain perception to male aggression...
  15. ncbi The venerable inveterate invertebrate TRP channels
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Calcium 33:409-17. 2003
    ..As many of these functions may be conserved among the mammalian TRPs, the invertebrate TRPs offer valuable genetic handles for characterizing the functions of these cation channels in vivo...
  16. ncbi Thermoregulation: channels that are cool to the core
    Craig Montell
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 17:R885-7. 2007
    ..Recent studies have provided strong evidence that at least one TRP channel, TRPV1, is also essential for the maintenance of internal body temperature...
  17. ncbi Dynamic regulation of the INAD signaling scaffold becomes crystal clear
    Craig Montell
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 131:19-21. 2007
    ..2007) now show that a PDZ domain in INAD, a scaffold protein in photoreceptor cells of the fruit fly, undergoes a light-dependent conformational change, which has important consequences for signaling and animal behavior...
  18. doi TRP channels: it's not the heat, it's the humidity
    Craig Montell
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 18:R123-6. 2008
    ..A recent study has shown that TRP channels are required for hygrosensation in Drosophila, further expanding the repertoire of sensory modalities mediated by TRP channels...
  19. doi In search of the holy grail for Drosophila TRP
    Craig Montell
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 58:825-7. 2008
    ..These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles...
  20. pmc A taste of the Drosophila gustatory receptors
    Craig Montell
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 19:345-53. 2009
    ..Several GRs appear to be expressed in multiple cell types that are not associated with contact chemosensation raising the possibility that these proteins may have roles that extend beyond the detection of tastants and pheromones...
  21. ncbi Preventing a Perm with TRPV3
    Craig Montell
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 141:218-20. 2010
    ..Cheng et al. (2010) now demonstrate that the calcium-permeable channel TRPV3 is required for these EGFR-dependent functions...
  22. doi The history of TRP channels, a commentary and reflection
    Craig Montell
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pflugers Arch 461:499-506. 2011
    ..Mutations in many TRP channels result in disease, including a variety of sensory impairments...
  23. pmc Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins
    X Z Xu
    Department of Biological Chemistry and Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 142:545-55. 1998
    ..Thus, we propose that the INAD supramolecular complex is a higher order signaling web consisting of an extended network of INAD molecules through which a G protein-coupled cascade is tethered...
  24. ncbi Retinal targets for calmodulin include proteins implicated in synaptic transmission
    X Z Xu
    Departments of Biological Chemistry and Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:31297-307. 1998
    ..Thus, it appears that calmodulin functions as a Ca2+ sensor for a broad diversity of retinal proteins, some of which are implicated in synaptic transmission...
  25. ncbi TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL
    X Z Xu
    Department of Biological Chemistry and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 26:647-57. 2000
    ..While TRPL and TRPgamma homomultimers are constitutively active, we demonstrate that TRPL-TRPgamma heteromultimers form a regulated phospholipase C- (PLC-) stimulated channel...
  26. pmc TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells
    H S Li
    Department of Biological Chemistry and Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 150:1411-22. 2000
    ..Rather, the primary function of the TRP/ INAD complex is to form the core unit required for localization of the signalplex to the rhabdomeres...
  27. ncbi New light on TRP and TRPL
    C Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pharmacol 52:755-63. 1997
    ..The human TRP-related proteins may mediate many of the store-operated conductances that have been identified previously in a plethora of human cells...
  28. ncbi Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex
    J Chevesich
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 18:95-105. 1997
    ..Furthermore, disruption of this interaction results in retinal degeneration. We propose that the TRP channel is linked to NORPA and RH1 to facilitate feedback regulation of these upstream signaling molecules...
  29. ncbi Requirement for the NINAC kinase/myosin for stable termination of the visual cascade
    H S Li
    Departments of Biological Chemistry and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 18:9601-6. 1998
    ..This phenotype suggests that a mechanism exists to prevent reactivation of the visual cascade and that p174 participates in this process...
  30. ncbi repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system
    W C Xiong
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205
    Genes Dev 8:981-94. 1994
    ..The repo gene encoded a homeo domain protein suggesting that it might be a transcriptional regulator of genes required for glial development...
  31. ncbi Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD
    P D Wes
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 2:447-53. 1999
    ..Disruption of the NINAC/INAD interaction delayed termination of the photoreceptor response. Thus one role of this signaling complex is in rapid deactivation of the photoresponse...
  32. pmc Distinct roles of the Drosophila ninaC kinase and myosin domains revealed by systematic mutagenesis
    J A Porter
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Cell Biol 122:601-12. 1993
    ....
  33. pmc Calmodulin binding to Drosophila NinaC required for termination of phototransduction
    J A Porter
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    EMBO J 14:4450-9. 1995
    ..These results suggest that calmodulin binding to both C1 and C2 is required in vivo for termination of phototransduction...
  34. ncbi Coassembly of TRP and TRPL produces a distinct store-operated conductance
    X Z Xu
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 89:1155-64. 1997
    ..We propose that the light-activated current in photoreceptor cells is produced by a combination of TRP homo- and TRP-TRPL heteromultimers...
  35. ncbi Regulation of the rhodopsin protein phosphatase, RDGC, through interaction with calmodulin
    S J Lee
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 32:1097-106. 2001
    ....
  36. ncbi TRP trapped in fly signaling web
    C Montell
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Neurobiol 8:389-97. 1998
    ..The INAD complex does not appear to be a particle, but a massive signaling web composed of an INAD polymer with which some of the target proteins associate through complex multivalent interactions...
  37. ncbi Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels
    H T Ma
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 276:18888-96. 2001
    ....
  38. ncbi Dependence of calmodulin localization in the retina on the NINAC unconventional myosin
    J A Porter
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Science 262:1038-42. 1993
    ..A general function of unconventional myosins may be to control the subcellular distribution of calmodulin...
  39. pmc TRPC1, a human homolog of a Drosophila store-operated channel
    P D Wes
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 92:9652-6. 1995
    ..TRPC1 was expressed at the highest levels in the fetal brain and in the adult heart, brain, testis, and ovaries. Evidence is also presented that TRPC1 represents the archetype of a family of related human proteins...
  40. pmc RIC, a calmodulin-binding Ras-like GTPase
    P D Wes
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    EMBO J 15:5839-48. 1996
    ..While Ric and RIT were widely expressed, expression of RIN was confined to the neuron system...
  41. ncbi tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye
    W C Xiong
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Genes Dev 7:1085-96. 1993
    ..We propose that p69 is required to repress expression of genes that are incompatible with development of photoreceptor cell fates, whereas p88 appears to be required to repress genes that promote the R7 cell fate...
  42. pmc The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C
    Tao Wang
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 57:56-68. 2008
    ..Moreover, this work demonstrates that a PLCbeta derivative that does not promote TRP channel activation, still contributes to signaling in vivo...
  43. ncbi Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX
    Tao Wang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 45:367-78. 2005
    ..These results illustrate the critical role of Ca(2+) for proper signaling and provide genetic evidence that Ca(2+) overload is responsible for a form of retinal degeneration resulting from defects in the TRP channel...
  44. pmc Differential localizations of and requirements for the two Drosophila ninaC kinase/myosins in photoreceptor cells
    J A Porter
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore 21205
    J Cell Biol 116:683-93. 1992
    ..This suggests that the p174 myosin-I type tail is the domain responsible for association with the rhabdomeres and that the substrate for the p174 putative kinase may be a rhabdomeric protein important in photo-transduction...
  45. ncbi Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development
    M Nakamura
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Neuron 13:67-81. 1994
    ..We propose that the msi protein regulates sensillum development by controlling the expression of target genes at the posttranscriptional level...
  46. pmc Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform
    X Z Xu
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:10692-7. 2001
    ..We propose that control of translocation through interaction between MLSN-S and MLSN-L represents a mode for regulating ion channel activity...
  47. ncbi Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway
    Seung Jae Lee
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA
    Curr Biol 14:2076-85. 2004
    ..It has been presumed that the visual impairment resulting from long-term, continuous exposure to ambient light is a secondary consequence of the effects of light on retinal morphology, but this has not been addressed...
  48. ncbi Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein
    Tao Wang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:5187-94. 2005
    ..Moreover, our data implicate Drosophila retinal pigment cells as functioning in the conversion of dietary all-trans-retinol to 11-cis-retinal and suggest that these cells are the closest invertebrate equivalent to the RPE...
  49. pmc Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila
    Seung Jae Lee
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:11874-9. 2004
    ..These data point to an evolutionarily conserved role for GPRK1 in modulating the amplitude of the visual response...
  50. ncbi Defective proboscis extension response (DPR), a member of the Ig superfamily required for the gustatory response to salt
    Makoto Nakamura
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 22:3463-72. 2002
    ..In addition, DPR defines a large previously unknown group of > or =20 highly related Ig-containing proteins...
  51. ncbi Light-dependent translocation of visual arrestin regulated by the NINAC myosin III
    Seung Jae Lee
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 43:95-103. 2004
    ..These data demonstrate that the light-dependent translocation of Arr2 into the rhabdomeres requires PI-mediated interactions between Arr2 and the NINAC myosin III...
  52. pmc Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons
    Young Kwon
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 30:10465-71. 2010
    ..We conclude that the decision to select the preferred over slightly cooler temperatures requires iav and is achieved by activating chordotonal neurons, which in turn induces repulsive behaviors, due to an increase in high angle turns...
  53. pmc Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons
    Sang Hoon Kim
    Departmentsof Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:8440-5. 2010
    ..Given that mammalian TRPA1 is required for responding to noxious chemicals, many of which cause pain and injury, our analysis underscores the evolutionarily conserved role for TRPA1 channels in chemical avoidance...
  54. ncbi Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response
    Young Kwon
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 16:723-9. 2006
    ..The genetic interactions with both rdgA and Pld indicate that Laza functions in the convergence of both PLC- and PLD-coupled signaling in vivo...
  55. ncbi Defective glia induce neuronal apoptosis in the repo visual system of Drosophila
    W C Xiong
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 14:581-90. 1995
    ..Subsequent to the laminar cell death, the retinal cells in the repo visual system also degenerated, indicating that the retinal cell death was due to retrograde degeneration...
  56. ncbi Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin
    Seung Jae Lee
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 39:121-32. 2003
    ..Since phospholipase C activity is required for activation of Drosophila phototransduction, these data point to a dual role of PIs in phototransduction...
  57. ncbi TRP channels
    Kartik Venkatachalam
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Biochem 76:387-417. 2007
    ..TRP channels are important for human health as mutations in at least four TRP channels underlie disease...
  58. pmc Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2
    Rebecca Elsaesser
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Center for Sensory Biology, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:4740-5. 2010
    ..Our findings demonstrate that light-induced translocation of Arr2 occurs through a noncanonical rhodopsin/Rac2 pathway, which is distinct from the classical phototransduction cascade...
  59. pmc A Drosophila gustatory receptor essential for aversive taste and inhibiting male-to-male courtship
    Seok Jun Moon
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 19:1623-7. 2009
    ..Thus, rather than regulating GR trafficking, GR33a may be a coreceptor required for sensing all nonvolatile repulsive chemicals, including tastants and pheromones...
  60. ncbi p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease
    Byoung Il Bae
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 47:29-41. 2005
    ..Genetic deletion of p53 suppresses neurodegeneration in mHtt-Tg flies and neurobehavioral abnormalities of mHtt-Tg mice. Our findings suggest that p53 links nuclear and mitochondrial pathologies characteristic of HD...
  61. ncbi Take a TRP to beat the heat
    Michael J Caterina
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 19:415-8. 2005
  62. pmc Dependence on a retinophilin/myosin complex for stability of PKC and INAD and termination of phototransduction
    Kartik Venkatachalam
    Department of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 30:11337-45. 2010
    ..We conclude that the slower termination of the photoresponse in retin(1) resulted from a requirement for the Retin/NINAC complex for stability of INAD and PKC...
  63. pmc Avoiding DEET through insect gustatory receptors
    Youngseok Lee
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 67:555-61. 2010
    ..Since 0.02% DEET elicited action potentials, we conclude that DEET directly activates of GRNs. We suggest that the effectiveness of DEET in pest control owes to its dual action in inducing avoidance simultaneously via GRNs and ORNs...
  64. pmc Multiple gustatory receptors required for the caffeine response in Drosophila
    Youngseok Lee
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:4495-500. 2009
    ....
  65. ncbi Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade
    Young Kwon
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, 855 North Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 11:871-3. 2008
    ..We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range...
  66. pmc A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen
    Hong Xu
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    EMBO J 23:811-22. 2004
    ..We propose that lysosomal tetraspanins in mammalian cells may also function in the downregulation of rhodopsin and other G-protein-coupled receptors, in response to intense or prolonged agonist stimulation...
  67. pmc Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila
    Yuchen Jiao
    Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 18:1797-801. 2008
    ..These data suggest that Drosophila sugar receptors function as multimers and that Gr64f is required broadly as a coreceptor for the detection of sugars...
  68. ncbi A flagellar polycystin-2 homolog required for male fertility in Drosophila
    Terry J Watnick
    Department of Medicine, Division of Nephrology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 13:2179-84. 2003
    ..The finding that Amo functions in sperm flagella supports a common and evolutionarily conserved role for polycystin-2 proteins in both motile and nonmotile axonemal-containing structures...
  69. ncbi Molecular genetics of Drosophila TRP channels
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Novartis Found Symp 258:3-12; discussion 12-7, 98-102, 263-6. 2004
    ..Thus, the fruitfly continues to provide a valuable in vivo model to characterize the functions, interacting partners and activation mechanisms of TRP-related proteins...
  70. pmc A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging
    Yuchen Jiao
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:14110-5. 2007
    ..These data demonstrate that multiple Grs are coexpressed with Gr5a and that Drosophila Gr64a is required for the responses to multiple sugars...
  71. ncbi A taste receptor required for the caffeine response in vivo
    Seok Jun Moon
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 16:1812-7. 2006
    ..Gr66a is the first gustatory receptor shown to be essential for caffeine-induced behavior and activity of gustatory receptor cells in vivo...
  72. pmc Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6
    Young Kwon
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 25:491-503. 2007
    ..2. We propose that regulation of CaM binding by PIs provides a mode for integration of channel regulation by Ca(2+) and PIs...
  73. ncbi TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel
    Thomas Hofmann
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21215, USA
    Curr Biol 13:1153-8. 2003
    ..The voltage modulation and rapid kinetics provide TRPM5 with an excellent set of properties for participating in signaling in taste receptors and other excitable cells...
  74. ncbi A phosphoinositide synthase required for a sustained light response
    Tao Wang
    Department of Biological Chemistry, The Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:12816-25. 2006
    ..Because the dpis1 mutation eliminates production of an enzyme essential for PIP2 regeneration, our data argue against activation of TRP and TRPL through a reduction of inhibitory PIP2...
  75. pmc A Drosophila model for LRRK2-linked parkinsonism
    Zhaohui Liu
    Department of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 105:2693-8. 2008
    ..These flies may provide a useful model for studying LRRK2-linked pathogenesis and for future therapeutic screens for PD intervention...
  76. pmc Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells
    Kartik Venkatachalam
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 135:838-51. 2008
    ..Since hematopoietic cells in humans are involved in clearance of apoptotic cells, our results raise the possibility that bone marrow transplantation may limit the progression of MLIV...
  77. pmc Requirement for an enzymatic visual cycle in Drosophila
    Xiaoyue Wang
    Center for Sensory Biology, Departments of Biological Chemistry and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 20:93-102. 2010
    ..However, a visual cycle is thought to be absent in invertebrates such as the fruit fly Drosophila melanogaster...
  78. ncbi In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila transient receptor potential channel
    Che H Liu
    Department of Physiology Development and Neuroscience, Cambridge University, Cambridge CB2 3DY, United Kingdom
    J Neurosci 27:604-15. 2007
    ..We found that Asp621 mutations profoundly affected several key aspects of the light response and caused light-dependent retinal degeneration...
  79. ncbi Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development
    Susan M W Harrison
    T H Morgan School of Biological Sciences, University of Kentucky, Lexington, Kentucky 40506 0225, USA
    Dev Dyn 232:817-26. 2005
    ..We conclude that the activation of the Ras cascade may be an important in vivo requisite to the transduction of signals through RIC and that the binding of calmodulin to RIC may negatively regulate this small GTPase...
  80. ncbi A unified nomenclature for the superfamily of TRP cation channels
    Craig Montell
    Mol Cell 9:229-31. 2002
  81. ncbi Exciting trips for TRPs
    Craig Montell
    Nat Cell Biol 6:690-2. 2004
  82. ncbi From protein dynamics to animal behavior: new insights into complex cell regulatory mechanisms
    Craig Montell
    Curr Opin Cell Biol 16:115-8. 2004
  83. ncbi A mint of mutations in TRPM8 leads to cool results
    Craig Montell
    Nat Neurosci 9:466-8. 2006
  84. ncbi International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels
    David E Clapham
    Howard Hughes Medical Institute, Children s Hospital, 1309 Enders Building, 320 Longwood Ave, Boston, MA 02115, USA
    Pharmacol Rev 55:591-6. 2003
    ..The complete Compendium, including data tables for each member of the TRP channel family, can be found at http://www.iuphar-db.org/iuphar-ic/...

Research Grants50

  1. TRP CHANNEL SIGNALING COMPLEX AND ITS ROLE IN VISION
    Craig Montell; Fiscal Year: 2001
    ....
  2. Genetic models of retinal degeneration
    Craig Montell; Fiscal Year: 2009
    ..The long-term goal of the proposed research is to identify new therapies to reduce the severities of human retinal degenerations. ..
  3. TRP channels and their roles in visual transduction
    Craig Montell; Fiscal Year: 2003
    ..Moreover, defects in TRP channels have been associated with changes in growth control and one TRP-related protein, TRPM1, may be a tumor suppressor. ..
  4. Molecular genetics of thermotaxis
    Craig Montell; Fiscal Year: 2010
    ....
  5. TRP channels and their roles in visual transduction
    Craig Montell; Fiscal Year: 2006
    ..Moreover, defects in TRP channels have been associated with changes in growth control and one TRP-related protein, TRPM1, may be a tumor suppressor. ..
  6. Molecular Genetics of Taste Transduction
    Craig Montell; Fiscal Year: 2010
    ..Given the apparent parallels between mammalian and Drosophila taste transduction, these studies should provide important new insights into the mechanisms of gustatory transduction that apply to human taste receptor cells. ..
  7. Genetic models of retinal degeneration
    Craig Montell; Fiscal Year: 2009
    ..The long-term goal of the proposed research is to identify new therapies to reduce the severities of human retinal degenerations. ..
  8. Molecular genetics of thermotaxis
    Craig Montell; Fiscal Year: 2009
    ....
  9. Regulation of TRP channels and visual transduction by PIs
    Craig Montell; Fiscal Year: 2010
    ..Given that the molecular mechanisms underlying the activation of these human TRPs are poorly understood, Drosophila TRP provides an in vivo model for defining the mechanisms regulating TRP channels. ..
  10. Molecular Genetics of Taste Transduction
    Craig Montell; Fiscal Year: 2007
    ..Given the apparent parallels between mammalian and Drosophila taste transduction, these studies should provide important new insights into the mechanisms of gustatory transduction that apply to human taste receptor cells. ..
  11. Dynamic regulation of a G protein signaling complex
    Craig Montell; Fiscal Year: 2007
    ..Therefore, the proposed studies should contribute to a general understanding of the mechanisms regulating phototransduction, as well as provide new insights into the mechanisms underlying certain forms of retinal degeneration. ..
  12. TRP channels and their roles in visual transduction
    Craig Montell; Fiscal Year: 2007
    ..Moreover, defects in TRP channels have been associated with changes in growth control and one TRP-related protein, TRPM1, may be a tumor suppressor. ..
  13. Molecular Genetics of Taste Transduction
    Craig Montell; Fiscal Year: 2006
    ..Given the apparent parallels between mammalian and Drosophila taste transduction, these studies should provide important new insights into the mechanisms of gustatory transduction that apply to human taste receptor cells. ..
  14. Dynamic regulation of a G protein signaling complex
    Craig Montell; Fiscal Year: 2006
    ..Therefore, the proposed studies should contribute to a general understanding of the mechanisms regulating phototransduction, as well as provide new insights into the mechanisms underlying certain forms of retinal degeneration. ..
  15. Molecular genetics of thermotaxis
    Craig Montell; Fiscal Year: 2009
    ....
  16. Regulation of TRP channels and visual transduction by PIs
    Craig Montell; Fiscal Year: 2009
    ..Given that the molecular mechanisms underlying the activation of these human TRPs are poorly understood, Drosophila TRP provides an in vivo model for defining the mechanisms regulating TRP channels. ..
  17. Molecular genetics of thermotaxis
    Craig Montell; Fiscal Year: 2009
    ....
  18. Molecular Genetics of Taste Transduction
    Craig Montell; Fiscal Year: 2009
    ..Given the apparent parallels between mammalian and Drosophila taste transduction, these studies should provide important new insights into the mechanisms of gustatory transduction that apply to human taste receptor cells. ..
  19. Genetic models of retinal degeneration
    Craig Montell; Fiscal Year: 2010
    ..The long-term goal of the proposed research is to identify new therapies to reduce the severities of human retinal degenerations. ..
  20. Dynamic regulation of a G protein signaling complex
    Craig Montell; Fiscal Year: 2005
    ..Therefore, the proposed studies should contribute to a general understanding of the mechanisms regulating phototransduction, as well as provide new insights into the mechanisms underlying certain forms of retinal degeneration. ..
  21. Conference Proposal: Calcium and Cell Function
    Craig Montell; Fiscal Year: 2004
    ..The topics to be covered at the meeting are of fundamental importance and are relevant to understanding the bases of a diseases such as neurodegeneration, communicative disorders, aging, cancer, kidney and cardiovascular disease. ..
  22. MUTAGENESIS OF NINAC--DROSOPHILA NEURAL KINASE/MYOSIN
    Craig Montell; Fiscal Year: 1990
    ..Homologs of many of these molecules may be found in other organisms including humans and may lead to a better understanding of human and may lead to a better understanding of human retinal diseases caused by defects in these molecules...
  23. TRP CHANNEL SIGNALING COMPLEX AND ITS ROLE IN VISION
    Craig Montell; Fiscal Year: 1999
    ....
  24. CONTROL OF A G PROTEIN CASCADE BY A PDZ DOMAIN PROTEIN
    Craig Montell; Fiscal Year: 1999
    ..A long range goal of the current research will be to ascertain whether similar retinal dystrophies result from mutations in these vertebrate homologs. ..
  25. MUTAGENESIS OF NINAC--DROSOPHILA NEURAL KINASE/MYOSIN
    Craig Montell; Fiscal Year: 1991
    ..Homologs of many of these molecules may be found in other organisms including humans and may lead to a better understanding of human and may lead to a better understanding of human retinal diseases caused by defects in these molecules...
  26. MUTAGENESIS OF NINAC--DROSOPHILA NEURAL KINASE/MYOSIN
    Craig Montell; Fiscal Year: 1992
    ..Homologs of many of these molecules may be found in other organisms including humans and may lead to a better understanding of human and may lead to a better understanding of human retinal diseases caused by defects in these molecules...
  27. Dynamic regulation of a G protein signaling complex
    Craig Montell; Fiscal Year: 2004
    ..Therefore, the proposed studies should contribute to a general understanding of the mechanisms regulating phototransduction, as well as provide new insights into the mechanisms underlying certain forms of retinal degeneration. ..
  28. Dynamic regulation of a G protein signaling complex
    Craig Montell; Fiscal Year: 2003
    ..Therefore, the proposed studies should contribute to a general understanding of the mechanisms regulating phototransduction, as well as provide new insights into the mechanisms underlying certain forms of retinal degeneration. ..
  29. CONTROL OF A G PROTEIN CASCADE BY A PDZ DOMAIN PROTEIN
    Craig Montell; Fiscal Year: 2002
    ..A long range goal of the current research will be to ascertain whether similar retinal dystrophies result from mutations in these vertebrate homologs. ..
  30. TRP CHANNEL SIGNALING COMPLEX AND ITS ROLE IN VISION
    Craig Montell; Fiscal Year: 2002
    ....
  31. CONTROL OF A G PROTEIN CASCADE BY A PDZ DOMAIN PROTEIN
    Craig Montell; Fiscal Year: 2001
    ..A long range goal of the current research will be to ascertain whether similar retinal dystrophies result from mutations in these vertebrate homologs. ..
  32. CONTROL OF A G PROTEIN CASCADE BY A PDZ DOMAIN PROTEIN
    Craig Montell; Fiscal Year: 2000
    ..A long range goal of the current research will be to ascertain whether similar retinal dystrophies result from mutations in these vertebrate homologs. ..
  33. TRP CHANNEL SIGNALING COMPLEX AND ITS ROLE IN VISION
    Craig Montell; Fiscal Year: 2000
    ....
  34. MUTAGENESIS OF NINAC--DROSOPHILA NEURAL KINASE/MYOSIN
    Craig Montell; Fiscal Year: 1993
    ..Homologs of many of these molecules may be found in other organisms including humans and may lead to a better understanding of human and may lead to a better understanding of human retinal diseases caused by defects in these molecules...