MIRIAM MINTZER

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Triazolam and zolpidem: effects on human memory and attentional processes
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 144:8-19. 1999
  2. ncbi Dose effects of triazolam and scopolamine on metamemory
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 18:17-31. 2010
  3. ncbi Differential effects of scopolamine and lorazepam on working memory maintenance versus manipulation processes
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Cogn Affect Behav Neurosci 7:120-9. 2007
  4. ncbi A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 192:425-40. 2007
  5. ncbi Dose effects of triazolam on brain activity during episodic memory encoding: a PET study
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 188:445-61. 2006
  6. ncbi Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamine
    Miriam Z Mintzer
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 13:336-47. 2005
  7. ncbi An abuse liability comparison of flunitrazepam and triazolam in sedative drug abusers
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Behav Pharmacol 16:579-84. 2005
  8. ncbi Opioid abuse and cognitive performance
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 78:225-30. 2005
  9. ncbi Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposure
    Miriam Z Mintzer
    Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 178:259-67. 2005
  10. ncbi A dose-effect study of repeated administration of buprenorphine/naloxone on performance in opioid-dependent volunteers
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 74:205-9. 2004

Research Grants

  1. Effects of Opioid Pharmacotherapy on Functioning
    MIRIAM MINTZER; Fiscal Year: 2007
  2. Benzodiazepine Use/Abuse: Effects on Memory Mechanisms
    MIRIAM MINTZER; Fiscal Year: 2007
  3. Neuroimaging of Benzodiazepine-Induced Amnesia
    MIRIAM MINTZER; Fiscal Year: 2003
  4. A Theoretically Based Memory Training Intervention in Mild Cognitive Impairment
    Miriam Z Mintzer; Fiscal Year: 2010

Detail Information

Publications23

  1. ncbi Triazolam and zolpidem: effects on human memory and attentional processes
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 144:8-19. 1999
    ....
  2. ncbi Dose effects of triazolam and scopolamine on metamemory
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 18:17-31. 2010
    ....
  3. ncbi Differential effects of scopolamine and lorazepam on working memory maintenance versus manipulation processes
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Cogn Affect Behav Neurosci 7:120-9. 2007
    ..In addition, the results suggested greater overall slowing of working memory processes with lorazepam...
  4. ncbi A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 192:425-40. 2007
    ..Thus, it is possible that the observed amnestic effects are secondary to more global sedative effects and do not reflect a specific primary benzodiazepine effect on memory mechanisms...
  5. ncbi Dose effects of triazolam on brain activity during episodic memory encoding: a PET study
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 188:445-61. 2006
    ..Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect...
  6. ncbi Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamine
    Miriam Z Mintzer
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 13:336-47. 2005
    ....
  7. ncbi An abuse liability comparison of flunitrazepam and triazolam in sedative drug abusers
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Behav Pharmacol 16:579-84. 2005
    ....
  8. ncbi Opioid abuse and cognitive performance
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 78:225-30. 2005
    ..Further research is necessary to explore the factors underlying performance impairment in MMP and to determine the clinical significance of the observed impairments for daily performance in the natural environment...
  9. ncbi Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposure
    Miriam Z Mintzer
    Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 178:259-67. 2005
    ..However, few parametric studies have been conducted in human participants...
  10. ncbi A dose-effect study of repeated administration of buprenorphine/naloxone on performance in opioid-dependent volunteers
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 74:205-9. 2004
    ..Future studies incorporating larger sample sizes and non-drug controls, as well as directly comparing buprenorphine to methadone and LAAM are needed to further test the hypothesis of limited impairment with buprenorphine...
  11. ncbi A paradoxical dissociation in the effects of midazolam on recollection and automatic processes in the process dissociation procedure
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Am J Psychol 116:213-37. 2003
    ..Such evidence raises important questions about the use of the PDP...
  12. ncbi Acute dose-effects of scopolamine on false recognition
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 153:425-33. 2001
    ....
  13. ncbi Effects of triazolam on brain activity during episodic memory encoding: a PET study
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropsychopharmacology 25:744-56. 2001
    ..Results are discussed in relation to triazolam's effects on mnemonic versus attentional processes...
  14. ncbi Alcohol and false recognition: a dose-effect study
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 159:51-7. 2001
    ....
  15. ncbi Effects of repeated tramadol and morphine administration on psychomotor and cognitive performance in opioid-dependent volunteers
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 111:265-8. 2010
    ..These findings suggest that tramadol is generally a safe medication with respect to cognitive and psychomotor measures and support tramadol's further evaluation as an opioid-dependence treatment...
  16. ncbi Cognitive impairment in methadone maintenance patients
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 67:41-51. 2002
    ....
  17. ncbi Alcohol and triazolam: differential effects on memory, psychomotor performance and subjective ratings of effects
    M Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Behav Pharmacol 13:653-8. 2002
    ..25 mg/70 kg). In addition to characterizing the adverse effects of two widely used psychoactive substances, the present results may also contribute to the understanding of underlying neurochemical mechanisms...
  18. ncbi Lorazepam and scopolamine: A single-dose comparison of effects on human memory and attentional processes
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 6823, USA
    Exp Clin Psychopharmacol 11:56-72. 2003
    ....
  19. ncbi Triazolam-amphetamine interaction: dissociation of effects on memory versus arousal
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioural Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Psychopharmacol 17:17-29. 2003
    ....
  20. ncbi Cognitive and subjective acute dose effects of intramuscular ketamine in healthy adults
    Michelle R Lofwall
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
    Exp Clin Psychopharmacol 14:439-49. 2006
    ....
  21. ncbi Relative abuse liability of GHB in humans: A comparison of psychomotor, subjective, and cognitive effects of supratherapeutic doses of triazolam, pentobarbital, and GHB
    Lawrence P Carter
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2537-51. 2006
    ..Although the likelihood for GHB to be abused is intermediate to triazolam and pentobarbital, the possibility of accidental overdose (ie greater sedation than intended) with GHB appears to be greater...
  22. ncbi Dose effects of triazolam and alcohol on cognitive performance in healthy volunteers
    Bethea A Kleykamp
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 18:1-16. 2010
    ..g., error detection on a choice reaction time task). Future research might examine the clinical implications of the performance impairments reported here given the widespread use of benzodiazepines and alcohol...
  23. ncbi Psychopharmacology of memory
    H Valerie Curran
    Psychopharmacology (Berl) 188:393-6. 2006

Research Grants13

  1. Effects of Opioid Pharmacotherapy on Functioning
    MIRIAM MINTZER; Fiscal Year: 2007
    ..Data from this project may also enhance the scientific understanding of pharmacological and cognitive mechanisms. ..
  2. Benzodiazepine Use/Abuse: Effects on Memory Mechanisms
    MIRIAM MINTZER; Fiscal Year: 2007
    ..Information from this project can also be used to develop cognitive rehabilitation programs and to tailor drug abuse and anxiety treatment interventions to the specific capabilities of long-term users. ..
  3. Neuroimaging of Benzodiazepine-Induced Amnesia
    MIRIAM MINTZER; Fiscal Year: 2003
    ..Results of the proposed research also will enhance the understanding of the functional neuroanatomy of basic human memory processes. ..
  4. A Theoretically Based Memory Training Intervention in Mild Cognitive Impairment
    Miriam Z Mintzer; Fiscal Year: 2010
    ....