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Genomes and GenesSpecies | L B MinorSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Dehiscence of bone overlying the superior canal as a cause of apparent conductive hearing lossLloyd B Minor
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Otol Neurotol 24:270-8. 2003..To identify patients with superior semicircular canal dehiscence and apparent conductive hearing loss and to define the cause of the air-bone gap...- Labyrinthine fistulae: pathobiology and managementLloyd B Minor
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Curr Opin Otolaryngol Head Neck Surg 11:340-6. 2003.... - Symptoms and signs in superior canal dehiscence syndromeL B Minor
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 942:259-73. 2001.... - Ménière's diseaseLloyd B Minor
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
Curr Opin Neurol 17:9-16. 2004..The pathologic process involves distortion of the membranous labyrinth with the formation of endolymphatic hydrops. This review describes the pathogenesis and etiology as well as the diagnosis and treatment of Ménière's disease... - Vestibular-evoked myogenic potentials in the diagnosis of superior canal dehiscence syndromeS O Streubel
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Acta Otolaryngol Suppl 545:41-9. 2001..Rather than being based upon a single test, the diagnosis of SCD syndrome is best established when the characteristic symptoms, signs, VEMP response, and CT imaging all indicate SCD... - Sound- and/or pressure-induced vertigo due to bone dehiscence of the superior semicircular canalL B Minor
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21203 6402, USA
Arch Otolaryngol Head Neck Surg 124:249-58. 1998..To describe anatomical findings and outcome in 2 patients undergoing plugging of the superior semicircular canal for treatment of these symptoms... - Changes in the angular vestibulo-ocular reflex after a single dose of intratympanic gentamicin for Ménière's diseaseJ P Carey
Department of Otolaryngology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 956:581-4. 2002 - Horizontal vestibuloocular reflex evoked by high-acceleration rotations in the squirrel monkey. IV. Responses after spectacle-induced adaptationR A Clendaniel
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0910, USA
J Neurophysiol 86:1594-611. 2001..While this model is substantially different from earlier models of VOR adaptation, it accounts for the data in the present experiments and also predicts the findings observed in the earlier studies... - Superior canal dehiscence: mechanisms of pressure sensitivity in a chinchilla modelT P Hirvonen
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Otolaryngol Head Neck Surg 127:1331-6. 2001..A rigid seal applied to the fenestra abolished pressure sensitivity while maintaining physiologic rotational sensitivity... - Translational vestibulo-ocular reflex evoked by a "head heave" stimulusS Ramat
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 942:95-113. 2001..These findings provide a basis for further development of this technique as a clinical test and as a method for quantitative evaluation of otolith function... - Relationship between time- and frequency-domain analyses of angular head movements in the squirrel monkeyM Armand
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287-0910, USA
J Comput Neurosci 11:217-39. 2001..We show that the wavelet transform, a novel method as applied to the signal analysis goals of this study, is the most useful technique for relating time- and frequency-domain information during a continuous signal... - Superior canal dehiscence is not due to cephalic displacement of the labyrinthValeria L Potyagaylo
The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann N Y Acad Sci 1039:498-502. 2005..Results showed that neither was the case. Instead, the defect may be in the process of ossification above the superior canal... - Angular vestibulo-ocular reflex gains correlate with vertigo control after intratympanic gentamicin treatment for Meniere's diseaseFrank R Lin
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann Otol Rhinol Laryngol 114:777-85. 2005..CONCLUSIONS: Our results suggest that successful treatment of Meniere's disease is closely related to attenuation of semicircular canal function as measured by horizontal canal aVOR gains... - Clinical manifestations of superior semicircular canal dehiscenceLloyd B Minor
Department of Otolaryngology--Head and Neck Surgery, The Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Baltimore, MD 21287, USA
Laryngoscope 115:1717-27. 2005..Surgical repair of the dehiscence can achieve control of the symptoms and signs. Canal plugging achieves long-term control more often than does resurfacing... - Search-coil head-thrust and caloric tests in Ménière's diseaseHong Ju Park
Department of Otolaryngology--Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
Acta Otolaryngol 125:852-7. 2005..Two subjects with unilateral MD had 100% UW, but none had >30% asymmetry on HTTs... 
Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstructionCharles C Della Santina
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Rm JHOC 6253, Baltimore, MD 21287, USA
J Assoc Res Otolaryngol 6:191-206. 2005..5 +/- 5.1 degrees, and 105.6 +/- 6.6 degrees, respectively. The mean anterior SCC-contralateral posterior SCC angle was 15.3 +/- 7.2 degrees. The absolute orientations of human SCC are more nearly orthogonal than previously reported...- The vestibulo-ocular reflex response to head impulses rarely decreases after cochlear implantationAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Otol Neurotol 26:655-60. 2005..Measure vestibular function using the head impulse test and assess the change in function due to unilateral cochlear implantation... - Meniere's Disease and MigraineLloyd B Minor
Department of Otolaryngology--Head and Neck Surgery, Johns Hopkins Medicine, 601 N Caroline St, Baltimore, MD 21287, USA
Arch Otolaryngol Head Neck Surg 131:460. 2005 - The effect of binocular eye position and head rotation plane on the human torsional vestibuloocular reflexAmerico A Migliaccio
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, MA 21205, USA
Vision Res 46:2475-86. 2006.... - Axis of eye rotation changes with head-pitch orientation during head impulses about earth-verticalAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Assoc Res Otolaryngol 7:140-50. 2006..Thus, even when the orientation of Listing's plane and eye position in the orbit are fixed, the axis of eye rotation during the VOR reflects a compromise between the requirements of Listing's law and a perfectly compensatory VOR... - Dynamics of the horizontal vestibuloocular reflex after unilateral labyrinthectomy: response to high frequency, high acceleration, and high velocity rotationsSoroush G Sadeghi
Department of Physiology, Aerospace Medical Research Unit, McGill University, 3655 Drummond St, H3G 1Y6 Montreal, QC Canada
Exp Brain Res 175:471-84. 2006..We conclude that the compensated VOR has comparable response dynamics for impulses and sinusoidal head movements... 
Superior canal dehiscence plugging reduces dizziness handicapBenjamin T Crane
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0910, USA
Laryngoscope 118:1809-13. 2008..The size of the dehiscence as measured during surgery, subject age, vestibular-evoked myogenic potentials threshold, and degree of conductive hearing loss (CHL) were also considered...- Rotational responses of vestibular-nerve afferents innervating the semicircular canals in the C57BL/6 mouseDavid M Lasker
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Building Suite 710, 720 Rutland Ave, Baltimore, MD 21205, USA
J Assoc Res Otolaryngol 9:334-48. 2008.... - Vestibular-evoked myogenic potential thresholds normalize on plugging superior canal dehiscenceMiriam S Welgampola
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 70:464-72. 2008..Lowered thresholds for eliciting vestibular-evoked myogenic potentials (VEMPs) provide additional conformation... - Retention of VOR gain following short-term VOR adaptationMichael C Schubert
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 N Caroline St, JHOC Room 6245, Baltimore, MD 21287 0910, USA
Exp Brain Res 187:117-27. 2008..We also show that the adapting head position determines the magnitude of VOR adaptation... - Longitudinal results with intratympanic dexamethasone in the treatment of Ménière's diseaseMaria Soledad Boleas-Aguirre
Clinica Universitaria de Navarra, School of Medicine, University of Navarra, Pamplona, Spain
Otol Neurotol 29:33-8. 2008..To assess patient satisfaction with vertigo control using intratympanic (IT) dexamethasone (12 mg/mL) for medically refractory unilateral Ménière's disease... - Vergence-mediated modulation of the human angular vestibulo-ocular reflex is unaffected by canal pluggingAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 710, 720 Rutland Avenue, Baltimore, MD 21205, USA
Exp Brain Res 186:581-7. 2008..We hypothesize that canal plugging, unlike gentamicin or galvanic ablation, has no effect on vergence-mediated modulation of the AVOR because plugging does not preferentially affect irregular afferents... - Semicircular canal function before and after surgery for superior canal dehiscenceJohn P Carey
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Otol Neurotol 28:356-64. 2007..To characterize semicircular canal function before and after surgery for superior semicircular canal dehiscence (SCD) syndrome... - Response of vestibular-nerve afferents to active and passive rotations under normal conditions and after unilateral labyrinthectomySoroush G Sadeghi
Department of Physiology, McGill University, 3655 Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
J Neurophysiol 97:1503-14. 2007..Taken together, our findings show that changes in response properties of the vestibular afferent population are not likely to play a major role in the long-term changes associated with compensation after unilateral labyrinthectomy... - Auditory function in patients with surgically treated superior semicircular canal dehiscenceCharles J Limb
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Otol Neurotol 27:969-80. 2006..To characterize preoperative and postoperative audiologic findings in patients with superior semicircular canal dehiscence syndrome... - Gaze position corrective eye movements in normal subjects and in patients with vestibular deficitsGrace C Y Peng
Department of Neurology, The Johns Hopkins University, Pathology 2-210, 600 N. Wolfe Street, Baltimore, MD 21287-6921, USA
Ann N Y Acad Sci 1039:337-48. 2005..This response may come in the form of high-velocity GPCs or smaller-amplitude oscillations... - High-resolution CT findings suggest a developmental abnormality underlying superior canal dehiscence syndromeTimo P Hirvonen
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0910, USA
Acta Otolaryngol 123:477-81. 2003..0001). CONCLUSION: These findings support the notion that there is a developmental abnormality underlying SCD syndrome. When dehiscence is found on one side, the contralateral side is likely to be thin... - Comparison of head thrust test with head autorotation test reveals that the vestibulo-ocular reflex is enhanced during voluntary head movementsCharles C Della Santina
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, 601 N Caroline St, Baltimore, MD 21287-0910, USA
Arch Otolaryngol Head Neck Surg 128:1044-54. 2002.... - Prominent expression of Narp in central vestibular pathways: selective effect of labyrinth ablationIrving M Reti
Department of Psychiatry and Behavioural Sciences, The Johns Hopkins University School of Medicine, Baltimore MD, USA
Eur J Neurosci 16:1949-58. 2002..As previous studies implicate Narp in synaptic plasticity, these findings suggest that this IEG may mediate ongoing adjustments in synaptic strength or connectivity in several pathways linked to the vestibular system... - Differential adaptation of the linear and nonlinear components of the horizontal vestibuloocular reflex in squirrel monkeysRichard A Clendaniel
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
J Neurophysiol 88:3534-40. 2002..There were comparable changes in the response to steps of acceleration. We interpret these results to indicate that separate processes drive the adaptation of the linear and nonlinear components of the response... - Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Ménière's diseaseJohn P Carey
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
J Assoc Res Otolaryngol 3:430-43. 2002..This finding suggests that intratympanic gentamicin causes a partial vestibular lesion that may involve preservation of spontaneous discharge and/or rotational sensitivity of afferents... - CT evaluation of bone dehiscence of the superior semicircular canal as a cause of sound- and/or pressure-induced vertigoClifford J Belden
Department of Radiology, Brooke Army Medical Center, San Antonio, TX, USA
Radiology 226:337-43. 2003..5-mm-collimated CT with reformation in the plane of the SSC. CONCLUSION: The positive predictive value of CT in identification of SSC dehiscence syndrome improves with 0.5-mm-collimated helical CT and reformation in the SSC plane... - Vergence-mediated changes in the axis of eye rotation during the human vestibulo-ocular reflex can occur independent of eye positionAmerico A Migliaccio
Eye and Ear Research Unit, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia
Exp Brain Res 151:238-48. 2003..5 g and may have contributed to the increased torsional component observed during near viewing. Our data show that vergence-mediated eye movements obey a VOR/Listing's Law compromise strategy independent of the initial eye position... - Long-term hearing outcome in patients receiving intratympanic gentamicin for Ménière's diseaseIee Ching Wu
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Laryngoscope 113:815-20. 2003..Treatment with additional intratympanic injection(s) of gentamicin did not result in a change in hearing. CONCLUSION: The risk of hearing loss in patients treated with infrequent intratympanic injection(s) of gentamicin is low... - Vergence-mediated modulation of the human horizontal angular VOR provides evidence of pathway-specific changes in VOR dynamicsDavid M Lasker
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 956:324-37. 2002..The response asymmetries arise because the near-viewing pathway is more susceptible to inhibitory cutoff than is the far-viewing pathway... - Cochlear implantation in patients with bilateral Ménière's syndromeLawrence R Lustig
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
Otol Neurotol 24:397-403. 2003..To evaluate the indications and clinical outcomes (audiologic and vestibular) in patients with Ménière's syndrome who have undergone cochlear implantation... - Dehiscence of bone overlying the superior semicircular canal as a cause of an air-bone gap on audiometry: a case studyKenneth M Cox
Department of Communication Sciences and Disorders, Radford University, Radford, VA 24142, USA
Am J Audiol 12:11-6. 2003..Normal acoustic immittance findings in the presence of conductive hearing loss should alert clinicians to the possibility of inner ear cause of an air-bone gap due to superior canal dehiscence... - Phase-plane analysis of gaze stabilization to high acceleration head thrusts: a continuum across normal subjects and patients with loss of vestibular functionGrace C Y Peng
Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
J Neurophysiol 91:1763-81. 2004..Similar patterns of challenge and compensation were observed in both patients with vestibular loss and normal subjects... - Vestibulo-ocular physiology underlying vestibular hypofunctionMichael C Schubert
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 710 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
Phys Ther 84:373-85. 2004..The purposes of this article are to review the anatomy and physiology of the vestibular system and to describe the neurophysiological mechanisms responsible for the vestibulo-ocular abnormalities in patients with vestibular hypofunction... - Acoustic responses of vestibular afferents in a model of superior canal dehiscenceJohn P Carey
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
Otol Neurotol 25:345-52. 2004..Afferents innervating the superior semicircular canal are rendered especially sensitive to acoustic stimulation when there is a dehiscence of the superior canal. Other vestibular end organs are also more sensitive to acoustic stimulation... - Vergence-mediated modulation of the human horizontal vestibulo-ocular reflex is eliminated by a partial peripheral gentamicin lesionAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, Ross Building, Room 710, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
Exp Brain Res 159:92-8. 2004..Our findings are consistent with the hypothesis that irregular afferents provide the necessary signal for vergence-mediated modulation of the VOR... - The three-dimensional vestibulo-ocular reflex evoked by high-acceleration rotations in the squirrel monkeyAmerico A Migliaccio
Department of Otolaryngology Head and Neck Surgery, Ross Building, Room 710, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Exp Brain Res 159:433-46. 2004..In addition, we show that the gain, phase and axis of eye rotation during LARP and RALP head rotations can be predicted once the pitch and roll responses are characterized... - Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchillaTimo P Hirvonen
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline St, 6th Floor, Baltimore, MD 21287-0910, USA
J Neurophysiol 93:643-55. 2005.... - Responses of irregularly discharging chinchilla semicircular canal vestibular-nerve afferents during high-frequency head rotationsTimothy E Hullar
Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 S Euclid Ave 8115, Saint Louis, MO 63110, USA
J Neurophysiol 93:2777-86. 2005.... - Semicircular canal afferents similarly encode active and passive head-on-body rotations: implications for the role of vestibular efferenceKathleen E Cullen
Aerospace Medical Research Unit, Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
J Neurosci 22:RC226. 2002..Our results indicate that semicircular canal afferents encode information about head rotation similarly for self generated and passively applied head-on-body movements... - Inexpensive system for real-time 3-dimensional video-oculography using a fluorescent marker arrayAmerico A Migliaccio
Department of Otolaryngology-Head and Neck Surgery, Laboratory of Vestibular Neurophysiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Neurosci Methods 143:141-50. 2005..laniger). The in vivo positional difference between the two methods was <3.1% for each component of 3-D eye position... - Hemangioma of the external auditory canalCharles J Limb
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0910, USA
Otolaryngol Head Neck Surg 126:74-5. 2002