Research Topics
Genomes and Genes
Species | Guo li MingSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
DISC1 partners with GSK3beta in neurogenesisGuo li Ming
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 136:990-2. 2009....
Adult neurogenesis in the mammalian brain: significant answers and significant questionsGuo li Ming
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 70:687-702. 2011..Building upon the recent progress and aided by new technologies, the adult neurogenesis field is poised to leap forward in the next decade...- Cellular reprogramming: recent advances in modeling neurological diseasesGuo li Ming
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 31:16070-5. 2011.... - Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brainXin Duan
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
Cell 130:1146-58. 2007.... - GABA regulates synaptic integration of newly generated neurons in the adult brainShaoyu Ge
Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 439:589-93. 2006.... - Development of neural stem cell in the adult brainXin Duan
The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Curr Opin Neurobiol 18:108-15. 2008..Future identification of molecular mechanisms and physiological functions of adult neurogenesis will provide further insight into the plasticity and regenerative capacity of the mature central nervous system... 
GABA sets the tempo for activity-dependent adult neurogenesisShaoyu Ge
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB 735, Baltimore, MD 21205, USA
Trends Neurosci 30:1-8. 2007..We also discuss an emerging view that GABA serves as a key mediator of neuronal activity in setting the tempo of adult neurogenesis...- Adult neurogenesis in the mammalian central nervous systemGuo li Ming
Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Annu Rev Neurosci 28:223-50. 2005..Advances in our understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases... - DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212Ju Young Kim
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 63:761-73. 2009.... - Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophreniaEunchai Kang
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 72:559-71. 2011..Our findings support a model in which DISC1 regulates distinct aspects of neuronal development through its interaction with different intracellular partners and such epistasis may contribute to increased risk for schizophrenia... - Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesisPaul M Kim
The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 107:3175-9. 2010..Because D-aspartate is a potential endogenous ligand for NMDA receptors, the loss of which elicits a phenotype resembling DR depletion, D-aspartate may function as a modulator of adult neurogenesis... - A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brainShaoyu Ge
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 54:559-66. 2007.... - Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophreniaJu Young Kim
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 148:1051-64. 2012.... - Neuronal activity modifies the DNA methylation landscape in the adult brainJunjie U Guo
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 14:1345-51. 2011..Our study implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system... - G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cellsDengke K Ma
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB735, Baltimore, Maryland 21205, USA
Stem Cells 26:2131-41. 2008..These mechanistic findings may guide more efficient reprogramming for future therapeutic applications of stem cells. Disclosure of potential conflicts of interest is found at the end of this article... - Life or death: developing cortical interneurons make their own decisionJuan Song
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
EMBO J 31:4373-4. 2012..In a recent Nature paper, Southwell et al (2012) demonstrate that cortical GABAergic interneuron cell death is intrinsically determined without the need to compete for extrinsic survival signals derived from other cell types... - Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesisMi Hyeon Jang
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell Stem Cell 12:215-23. 2013.... - Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decisionJuan Song
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 489:150-4. 2012..Our study identifies a niche cell–signal–receptor trio and a local circuitry mechanism that control the activation and self-renewal mode of quiescent adult neural stem cells in response to neuronal activity and experience... - Postsynaptic TRPC1 function contributes to BDNF-induced synaptic potentiation at the developing neuromuscular junctionJulie S McGurk
The Solomon H Snyder Department of Neuroscience, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 31:14754-62. 2011.... - Modification of hippocampal circuitry by adult neurogenesisJuan Song
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Dev Neurobiol 72:1032-43. 2012.... - Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyondJunjie U Guo
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cell Cycle 10:2662-8. 2011..We also discuss how future studies can extend our knowledge of this novel epigenetic modification... - In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristicsMichael A Bonaguidi
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 145:1142-55. 2011..Our study identifies RGLs as self-renewing and multipotent neural stem cells and provides novel insights into in vivo properties of adult neural stem cells... - Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel openingSangwoo Shim
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 64:471-83. 2009..Our study demonstrates a novel physiological function of proline isomerases in chemotropic nerve guidance through TRPC1 gating and may have significant implication in clinical applications of immunophilin-related therapeutic drugs... - Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesisDengke K Ma
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
Science 323:1074-7. 2009..Thus, Gadd45b links neuronal circuit activity to epigenetic DNA modification and expression of secreted factors in mature neurons for extrinsic modulation of neurogenesis in the adult brain... - Adult neurogenesis and hippocampal memory function: new cells, more plasticity, new memories?Yasuji Kitabatake
Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, 733 North Broadway, BRB 706, Baltimore, MD 21205, USA
Neurosurg Clin N Am 18:105-13, x. 2007.... - Cellular niches for endogenous neural stem cells in the adult brainJ Dedrick Jordan
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
CNS Neurol Disord Drug Targets 6:336-41. 2007..We also highlight some of the potential therapeutic targets to be manipulated within neurogenic niche for repair of the adult central nervous system... - Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowthGang Zhang
Department of Neurology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
J Neurosci 31:1664-75. 2011..In summary, these studies directly link patient autoantibodies to an intracellular inhibitory signaling pathway involved in anti-ganglioside Ab-mediated inhibition of neurite outgrowth... - Glial influences on neural stem cell development: cellular niches for adult neurogenesisDengke K Ma
Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Curr Opin Neurobiol 15:514-20. 2005..Identification of specific niche signals that regulate these sequential steps during adult neurogenesis might lead to strategies to induce functional neurogenesis in other brain regions after injury or degenerative neurological diseases... - Time-dependent involvement of adult-born dentate granule cells in behaviorWoon Ryoung Kim
Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Behav Brain Res 227:470-9. 2012..We further discuss a framework for future investigations of how newly integrated neurons may contribute to hippocampal processing using advanced genetic techniques with enhanced temporal resolution... - Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cellsDengke K Ma
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mol Brain 2:16. 2009..In culture, fibroblast growth factor-2 (FGF-2) is sufficient to maintain the self-renewal of adult NSCs derived from the adult rat hippocampus. The underlying signalling mechanism is not fully understood... - Synaptic integration and plasticity of new neurons in the adult hippocampusShaoyu Ge
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
J Physiol 586:3759-65. 2008.... - Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic diseaseMyoung Hwa Lee
Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 6 113, Baltimore, MD 21287, USA
Neurobiol Dis 41:678-87. 2011.... - A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cuesC Joanne Wang
Department of Biomedical Engineering and Whitaker Institute of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
Lab Chip 8:227-37. 2008.... - DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylationDengke K Ma
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell Cycle 8:1526-31. 2009..In this article, we review recent findings and discuss functional and evolutionary implications of such mechanisms underlying active DNA demethylation... - A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampusMichael A Bonaguidi
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Curr Opin Neurobiol 22:754-61. 2012.... - Signaling of secreted semaphorins in growth cone steeringSangwoo Shim
Institute for Cell Engineering, Department of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA
Adv Exp Med Biol 600:52-60. 2007.... - Oxysterols drive dopaminergic neurogenesis from stem cellsDengke K Ma
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21209, USA
Cell Stem Cell 5:343-4. 2009..In this issue of Cell Stem Cell, Sacchetti et al. (2009) report an unexpected role of liver X receptors and their ligand, oxysterols, in regulating dopaminergic neurogenesis... - Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brainJunjie U Guo
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 145:423-34. 2011..Our study suggests a TET1-induced oxidation-deamination mechanism for active DNA demethylation in mammals... - Adult neural stem cells and repair of the adult central nervous systemEyleen Lay Keow Goh
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Hematother Stem Cell Res 12:671-9. 2003..Here we will review some recent progress of adult neural stem cell research that is applicable to developmental neurobiology and also has potential implications in clinical neuroscience... - Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cellsTarja A Juopperi
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Brain 5:17. 2012..The development of experimental systems based on iPSC technology could aid in the identification of molecular lesions and therapeutic treatments... - Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesisDengke K Ma
The Solomon Snyder Department of Neuroscience, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Ann N Y Acad Sci 1170:664-73. 2009..Here we review extrinsic mechanisms through which adult neurogenesis is regulated by environmental cues, physiological learning-related stimuli, and neuronal activities... - beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth conesEyleen L K Goh
Institute for Cell Engineering, The Johns Hopkins University School of Medicine, MD 21205, USA
Mol Brain 1:10. 2008..These studies identify β1-integrin as a specific mediator for MAG in growth cone turning responses, acting through FAK activation... - Adult neural stem cells in the mammalian central nervous systemDengke K Ma
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell Res 19:672-82. 2009..Here, we review recent progress on adult NSCs of the mammalian central nervous system, including topics on their identity, niche, function, plasticity, and emerging roles in cancer and regenerative medicine... - Axonal protective effects of the myelin-associated glycoproteinThien Nguyen
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Neurosci 29:630-7. 2009..Exploiting this pathway may lead to therapeutic strategies for neurological diseases characterized by axonal loss... - Neurogenesis as a potential therapeutic strategy for neurodegenerative diseasesKurt A Sailor
Johns Hopkins University School of Medicine, Institute for Cell Engineering, Departments of Neurology and Neuroscience, 733 N. Broadway, BRB731, Baltimore, MD 21205, USA
Expert Opin Biol Ther 6:879-90. 2006..This review focuses on adult neurogenesis as a strategy to derive potential therapies, and discusses future directions in the field... - By hook or by crook: multifaceted DNA-binding properties of MeCP2Jaehoon Shin
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Cell 152:940-2. 2013..Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG... - Roles of channels and receptors in the growth cone during PNS axonal regenerationSangwoo Shim
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 779, Baltimore, MD 21205, USA
Exp Neurol 223:38-44. 2010..This review focuses on roles of cell surface ion channels and receptors in the growth cone during Wallerian degeneration and axon regeneration in the PNS... - New directions in neuroregenerationJu Kim
Johns Hopkins University School of Medicine, Institute for Cell Engineering, Department of Neurology, 733 N. Broadway, BRB 706, Baltimore, MD 21205, USA
Expert Opin Biol Ther 6:735-8. 2006..This review summarises the known molecular mechanisms of neurite outgrowth inhibition after CNS injury and provides new insights into the potential future direction of neuroregeneration research... - XTRPC1-dependent chemotropic guidance of neuronal growth conesSangwoo Shim
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, Maryland 21205, USA
Nat Neurosci 8:730-5. 2005..Thus, members of the TRPC family may serve as a key mediator for the Ca2+ influx that regulates axon guidance during development and inhibits axon regeneration in adulthood... - Neurogenesis in the adult brain: new strategies for central nervous system diseasesD Chichung Lie
Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
Annu Rev Pharmacol Toxicol 44:399-421. 2004..Here, we summarize our current understanding of the mechanisms controlling adult neurogenesis and discuss their implications for the development of new strategies for the treatment of neurodegenerative diseases... - Using chips to simulate the brain as a tool to investigate brain developmentXiong Li
Expert Rev Neurother 8:1001-4. 2008 - A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidanceZhexing Wen
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Neuron 43:835-46. 2004..Finally, CaMKII/CaN-PP1 also mediates netrin-1 guidance. Together, these findings establish a complex Ca2+ mechanism that targets the balance of CaMKII/CaN-PP1 activation to control distinct growth cone responses... - A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowthHung-Teh Kao
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nat Neurosci 5:431-7. 2002..These results provide a potential molecular approach for stimulating neuron regeneration, after injury and in neurodegenerative diseases... - Focal adhesion kinase in netrin-1 signalingXiu Rong Ren
Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
Nat Neurosci 7:1204-12. 2004..Taken together, these results indicate a new signaling mechanism for DCC, in which FAK is activated upon netrin-1 stimulation and mediates netrin-1 function; they also identify a critical role for FAK in axon navigation... - BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilinZhexing Wen
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
J Cell Biol 178:107-19. 2007..Together, we show that spatial regulation of ADF/cofilin activity controls the directional responses of the growth cone to BMP7, and Ca2+ influx through TRPC tilts the LIMK-SSH balance toward SSH-mediated repulsion... - Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampusChunmei Zhao
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 26:3-11. 2006..Our study reveals the key morphological transitions of newborn granule neurons during their course of maturation... - Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brainRegina L Faulkner
Center for Neuroscience, University of California, Davis, CA 95618, USA
Proc Natl Acad Sci U S A 105:14157-62. 2008..Our results also indicate a role for DISC1 in presynaptic development and may have implications for the etiology of schizophrenia and related mental disorders...
Research Grants
- Adaptation Mechanisms in Long-range Growth Cone GuidanceGuo li Ming; Fiscal Year: 2007..immediate signaling mechanisms associated with Deleted in Colorectal Cancer (DCC), a well characterized membrane receptors for netrin-1, with a combination of biochemistry, immunocytochemistry, Ca2+ imaging and growth cone turning assays ..
- Calcium signaling in neuronal navigationGuo li Ming; Fiscal Year: 2010..Findings from these studies may lead to novel strategies to functionally replace damaged or lost neurons and to promote endogenous repair after injury or degenerative neurological disease. ..