Guo li Ming

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint DISC1 partners with GSK3beta in neurogenesis
    Guo li Ming
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 136:990-2. 2009
  2. pmc Adult neurogenesis in the mammalian brain: significant answers and significant questions
    Guo li Ming
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 70:687-702. 2011
  3. pmc Cellular reprogramming: recent advances in modeling neurological diseases
    Guo li Ming
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:16070-5. 2011
  4. pmc Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain
    Xin Duan
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    Cell 130:1146-58. 2007
  5. ncbi request reprint Glial influences on neural stem cell development: cellular niches for adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 15:514-20. 2005
  6. pmc GABA regulates synaptic integration of newly generated neurons in the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 439:589-93. 2006
  7. pmc Development of neural stem cell in the adult brain
    Xin Duan
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 18:108-15. 2008
  8. pmc DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212
    Ju Young Kim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 63:761-73. 2009
  9. ncbi request reprint Adult neurogenesis in the mammalian central nervous system
    Guo li Ming
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:223-50. 2005
  10. ncbi request reprint GABA sets the tempo for activity-dependent adult neurogenesis
    Shaoyu Ge
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB 735, Baltimore, MD 21205, USA
    Trends Neurosci 30:1-8. 2007

Research Grants

Collaborators

Detail Information

Publications61

  1. doi request reprint DISC1 partners with GSK3beta in neurogenesis
    Guo li Ming
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 136:990-2. 2009
    ....
  2. pmc Adult neurogenesis in the mammalian brain: significant answers and significant questions
    Guo li Ming
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 70:687-702. 2011
    ..Building upon the recent progress and aided by new technologies, the adult neurogenesis field is poised to leap forward in the next decade...
  3. pmc Cellular reprogramming: recent advances in modeling neurological diseases
    Guo li Ming
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:16070-5. 2011
    ....
  4. pmc Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain
    Xin Duan
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    Cell 130:1146-58. 2007
    ....
  5. ncbi request reprint Glial influences on neural stem cell development: cellular niches for adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 15:514-20. 2005
    ..Identification of specific niche signals that regulate these sequential steps during adult neurogenesis might lead to strategies to induce functional neurogenesis in other brain regions after injury or degenerative neurological diseases...
  6. pmc GABA regulates synaptic integration of newly generated neurons in the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 439:589-93. 2006
    ....
  7. pmc Development of neural stem cell in the adult brain
    Xin Duan
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 18:108-15. 2008
    ..Future identification of molecular mechanisms and physiological functions of adult neurogenesis will provide further insight into the plasticity and regenerative capacity of the mature central nervous system...
  8. pmc DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212
    Ju Young Kim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 63:761-73. 2009
    ....
  9. ncbi request reprint Adult neurogenesis in the mammalian central nervous system
    Guo li Ming
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:223-50. 2005
    ..Advances in our understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases...
  10. ncbi request reprint GABA sets the tempo for activity-dependent adult neurogenesis
    Shaoyu Ge
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB 735, Baltimore, MD 21205, USA
    Trends Neurosci 30:1-8. 2007
    ..We also discuss an emerging view that GABA serves as a key mediator of neuronal activity in setting the tempo of adult neurogenesis...
  11. pmc Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia
    Eunchai Kang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 72:559-71. 2011
    ..Our findings support a model in which DISC1 regulates distinct aspects of neuronal development through its interaction with different intracellular partners and such epistasis may contribute to increased risk for schizophrenia...
  12. pmc Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis
    Paul M Kim
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:3175-9. 2010
    ..Because D-aspartate is a potential endogenous ligand for NMDA receptors, the loss of which elicits a phenotype resembling DR depletion, D-aspartate may function as a modulator of adult neurogenesis...
  13. pmc Seamless reconstruction of intact adult-born neurons by serial end-block imaging reveals complex axonal guidance and development in the adult hippocampus
    Gerald J Sun
    Institute for Cell Engineering, The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Neurosci 33:11400-11. 2013
    ..Our SEBI approach can be broadly applied for analysis of intact, complex neuronal projections in limitless tissue volume. ..
  14. pmc A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 54:559-66. 2007
    ....
  15. ncbi request reprint Adult neural stem cells and repair of the adult central nervous system
    Eyleen Lay Keow Goh
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Hematother Stem Cell Res 12:671-9. 2003
    ..Here we will review some recent progress of adult neural stem cell research that is applicable to developmental neurobiology and also has potential implications in clinical neuroscience...
  16. pmc Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis
    Mi Hyeon Jang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 12:215-23. 2013
    ....
  17. pmc Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia
    Ju Young Kim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 148:1051-64. 2012
    ....
  18. doi request reprint G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells
    Dengke K Ma
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB735, Baltimore, Maryland 21205, USA
    Stem Cells 26:2131-41. 2008
    ..These mechanistic findings may guide more efficient reprogramming for future therapeutic applications of stem cells. Disclosure of potential conflicts of interest is found at the end of this article...
  19. pmc Neuronal activity modifies the DNA methylation landscape in the adult brain
    Junjie U Guo
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 14:1345-51. 2011
    ..Our study implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system...
  20. pmc Postsynaptic TRPC1 function contributes to BDNF-induced synaptic potentiation at the developing neuromuscular junction
    Julie S McGurk
    The Solomon H Snyder Department of Neuroscience, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:14754-62. 2011
    ....
  21. ncbi request reprint Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord
    Yun Sook Kim
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Neurol 60:716-28. 2006
    ..We sought to define molecular and cellular participants that mediate motor neuron injury in amyotrophic lateral sclerosis using a coculture system...
  22. pmc Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
    Juan Song
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 489:150-4. 2012
    ..Our study identifies a niche cell–signal–receptor trio and a local circuitry mechanism that control the activation and self-renewal mode of quiescent adult neural stem cells in response to neuronal activity and experience...
  23. pmc Life or death: developing cortical interneurons make their own decision
    Juan Song
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    EMBO J 31:4373-4. 2012
    ..In a recent Nature paper, Southwell et al (2012) demonstrate that cortical GABAergic interneuron cell death is intrinsically determined without the need to compete for extrinsic survival signals derived from other cell types...
  24. pmc Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening
    Sangwoo Shim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 64:471-83. 2009
    ..Our study demonstrates a novel physiological function of proline isomerases in chemotropic nerve guidance through TRPC1 gating and may have significant implication in clinical applications of immunophilin-related therapeutic drugs...
  25. doi request reprint Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus
    Juan Song
    1 Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 2 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 3 Department of Pharmacology and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 16:1728-30. 2013
    ..Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis. ..
  26. pmc Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Science 323:1074-7. 2009
    ..Thus, Gadd45b links neuronal circuit activity to epigenetic DNA modification and expression of secreted factors in mature neurons for extrinsic modulation of neurogenesis in the adult brain...
  27. pmc Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells
    Tarja A Juopperi
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Brain 5:17. 2012
    ..The development of experimental systems based on iPSC technology could aid in the identification of molecular lesions and therapeutic treatments...
  28. ncbi request reprint Neurogenesis as a potential therapeutic strategy for neurodegenerative diseases
    Kurt A Sailor
    Johns Hopkins University School of Medicine, Institute for Cell Engineering, Departments of Neurology and Neuroscience, 733 N Broadway, BRB731, Baltimore, MD 21205, USA
    Expert Opin Biol Ther 6:879-90. 2006
    ..This review focuses on adult neurogenesis as a strategy to derive potential therapies, and discusses future directions in the field...
  29. pmc A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampus
    Michael A Bonaguidi
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 22:754-61. 2012
    ....
  30. pmc Modification of hippocampal circuitry by adult neurogenesis
    Juan Song
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Dev Neurobiol 72:1032-43. 2012
    ....
  31. pmc Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond
    Junjie U Guo
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 10:2662-8. 2011
    ..We also discuss how future studies can extend our knowledge of this novel epigenetic modification...
  32. pmc In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
    Michael A Bonaguidi
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:1142-55. 2011
    ..Our study identifies RGLs as self-renewing and multipotent neural stem cells and provides novel insights into in vivo properties of adult neural stem cells...
  33. ncbi request reprint Adult neurogenesis and hippocampal memory function: new cells, more plasticity, new memories?
    Yasuji Kitabatake
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, 733 North Broadway, BRB 706, Baltimore, MD 21205, USA
    Neurosurg Clin N Am 18:105-13, x. 2007
    ....
  34. ncbi request reprint Cellular niches for endogenous neural stem cells in the adult brain
    J Dedrick Jordan
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    CNS Neurol Disord Drug Targets 6:336-41. 2007
    ..We also highlight some of the potential therapeutic targets to be manipulated within neurogenic niche for repair of the adult central nervous system...
  35. pmc Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowth
    Gang Zhang
    Department of Neurology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Neurosci 31:1664-75. 2011
    ..In summary, these studies directly link patient autoantibodies to an intracellular inhibitory signaling pathway involved in anti-ganglioside Ab-mediated inhibition of neurite outgrowth...
  36. pmc Synaptic integration and plasticity of new neurons in the adult hippocampus
    Shaoyu Ge
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    J Physiol 586:3759-65. 2008
    ....
  37. ncbi request reprint New directions in neuroregeneration
    Ju Kim
    Johns Hopkins University School of Medicine, Institute for Cell Engineering, Department of Neurology, 733 N Broadway, BRB 706, Baltimore, MD 21205, USA
    Expert Opin Biol Ther 6:735-8. 2006
    ..This review summarises the known molecular mechanisms of neurite outgrowth inhibition after CNS injury and provides new insights into the potential future direction of neuroregeneration research...
  38. doi request reprint Time-dependent involvement of adult-born dentate granule cells in behavior
    Woon Ryoung Kim
    Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Behav Brain Res 227:470-9. 2012
    ..We further discuss a framework for future investigations of how newly integrated neurons may contribute to hippocampal processing using advanced genetic techniques with enhanced temporal resolution...
  39. pmc Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Brain 2:16. 2009
    ..In culture, fibroblast growth factor-2 (FGF-2) is sufficient to maintain the self-renewal of adult NSCs derived from the adult rat hippocampus. The underlying signalling mechanism is not fully understood...
  40. pmc Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease
    Myoung Hwa Lee
    Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 6 113, Baltimore, MD 21287, USA
    Neurobiol Dis 41:678-87. 2011
    ....
  41. pmc DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Cycle 8:1526-31. 2009
    ..In this article, we review recent findings and discuss functional and evolutionary implications of such mechanisms underlying active DNA demethylation...
  42. doi request reprint A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues
    C Joanne Wang
    Department of Biomedical Engineering and Whitaker Institute of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
    Lab Chip 8:227-37. 2008
    ....
  43. pmc Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    Junjie U Guo
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:423-34. 2011
    ..Our study suggests a TET1-induced oxidation-deamination mechanism for active DNA demethylation in mammals...
  44. doi request reprint Oxysterols drive dopaminergic neurogenesis from stem cells
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21209, USA
    Cell Stem Cell 5:343-4. 2009
    ..In this issue of Cell Stem Cell, Sacchetti et al. (2009) report an unexpected role of liver X receptors and their ligand, oxysterols, in regulating dopaminergic neurogenesis...
  45. pmc DNA modifications and neurological disorders
    Yi Lan Weng
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
    Neurotherapeutics 10:556-67. 2013
    ..Such reversibility of 5mC sheds light on potential mechanisms underlying some neurological disorders and suggests a new route to correct aberrant methylation patterns associated with these disorders...
  46. pmc beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones
    Eyleen L K Goh
    Institute for Cell Engineering, The Johns Hopkins University School of Medicine, MD 21205, USA
    Mol Brain 1:10. 2008
    ..These studies identify β1-integrin as a specific mediator for MAG in growth cone turning responses, acting through FAK activation...
  47. ncbi request reprint Signaling of secreted semaphorins in growth cone steering
    Sangwoo Shim
    Institute for Cell Engineering, Department of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA
    Adv Exp Med Biol 600:52-60. 2007
    ....
  48. pmc Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis
    Dengke K Ma
    The Solomon Snyder Department of Neuroscience, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 1170:664-73. 2009
    ..Here we review extrinsic mechanisms through which adult neurogenesis is regulated by environmental cues, physiological learning-related stimuli, and neuronal activities...
  49. pmc Axonal protective effects of the myelin-associated glycoprotein
    Thien Nguyen
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurosci 29:630-7. 2009
    ..Exploiting this pathway may lead to therapeutic strategies for neurological diseases characterized by axonal loss...
  50. pmc Adult neural stem cells in the mammalian central nervous system
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Res 19:672-82. 2009
    ..Here, we review recent progress on adult NSCs of the mammalian central nervous system, including topics on their identity, niche, function, plasticity, and emerging roles in cancer and regenerative medicine...
  51. pmc Roles of channels and receptors in the growth cone during PNS axonal regeneration
    Sangwoo Shim
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 779, Baltimore, MD 21205, USA
    Exp Neurol 223:38-44. 2010
    ..This review focuses on roles of cell surface ion channels and receptors in the growth cone during Wallerian degeneration and axon regeneration in the PNS...
  52. doi request reprint By hook or by crook: multifaceted DNA-binding properties of MeCP2
    Jaehoon Shin
    Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Cell 152:940-2. 2013
    ..Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG...
  53. ncbi request reprint XTRPC1-dependent chemotropic guidance of neuronal growth cones
    Sangwoo Shim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, Maryland 21205, USA
    Nat Neurosci 8:730-5. 2005
    ..Thus, members of the TRPC family may serve as a key mediator for the Ca2+ influx that regulates axon guidance during development and inhibits axon regeneration in adulthood...
  54. doi request reprint Using chips to simulate the brain as a tool to investigate brain development
    Xiong Li
    Expert Rev Neurother 8:1001-4. 2008
  55. ncbi request reprint Neurogenesis in the adult brain: new strategies for central nervous system diseases
    D Chichung Lie
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Pharmacol Toxicol 44:399-421. 2004
    ..Here, we summarize our current understanding of the mechanisms controlling adult neurogenesis and discuss their implications for the development of new strategies for the treatment of neurodegenerative diseases...
  56. ncbi request reprint Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    Chunmei Zhao
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 26:3-11. 2006
    ..Our study reveals the key morphological transitions of newborn granule neurons during their course of maturation...
  57. ncbi request reprint A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth
    Hung Teh Kao
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 5:431-7. 2002
    ..These results provide a potential molecular approach for stimulating neuron regeneration, after injury and in neurodegenerative diseases...
  58. ncbi request reprint Focal adhesion kinase in netrin-1 signaling
    Xiu Rong Ren
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    Nat Neurosci 7:1204-12. 2004
    ..Taken together, these results indicate a new signaling mechanism for DCC, in which FAK is activated upon netrin-1 stimulation and mediates netrin-1 function; they also identify a critical role for FAK in axon navigation...
  59. pmc BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin
    Zhexing Wen
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Cell Biol 178:107-19. 2007
    ..Together, we show that spatial regulation of ADF/cofilin activity controls the directional responses of the growth cone to BMP7, and Ca2+ influx through TRPC tilts the LIMK-SSH balance toward SSH-mediated repulsion...
  60. ncbi request reprint A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidance
    Zhexing Wen
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neuron 43:835-46. 2004
    ..Finally, CaMKII/CaN-PP1 also mediates netrin-1 guidance. Together, these findings establish a complex Ca2+ mechanism that targets the balance of CaMKII/CaN-PP1 activation to control distinct growth cone responses...
  61. pmc Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain
    Regina L Faulkner
    Center for Neuroscience, University of California, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 105:14157-62. 2008
    ..Our results also indicate a role for DISC1 in presynaptic development and may have implications for the etiology of schizophrenia and related mental disorders...

Research Grants7

  1. Adaptation Mechanisms in Long-range Growth Cone Guidance
    Guo li Ming; Fiscal Year: 2007
    ..immediate signaling mechanisms associated with Deleted in Colorectal Cancer (DCC), a well characterized membrane receptors for netrin-1, with a combination of biochemistry, immunocytochemistry, Ca2+ imaging and growth cone turning assays ..
  2. Calcium signaling in neuronal navigation
    Guo li Ming; Fiscal Year: 2010
    ..Findings from these studies may lead to novel strategies to functionally replace damaged or lost neurons and to promote endogenous repair after injury or degenerative neurological disease. ..