M I Miller

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Labeled cortical mantle distance maps of the cingulate quantify differences between dementia of the Alzheimer type and healthy aging
    M I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 100:15172-7. 2003
  2. pmc Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping
    Michael I Miller
    Center for Imaging Science, The Whiting School of Engineering, The Johns Hopkins University, 301 Clark Hall, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 102:9685-90. 2005
  3. ncbi request reprint Computational anatomy: shape, growth, and atrophy comparison via diffeomorphisms
    Michael I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 23:S19-33. 2004
  4. pmc Collaborative computational anatomy: an MRI morphometry study of the human brain via diffeomorphic metric mapping
    Michael I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    Hum Brain Mapp 30:2132-41. 2009
  5. pmc The emerging discipline of Computational Functional Anatomy
    Michael I Miller
    Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 45:S16-39. 2009
  6. ncbi request reprint On the metrics and euler-lagrange equations of computational anatomy
    Michael I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Annu Rev Biomed Eng 4:375-405. 2002
  7. pmc Diffeomorphic metric surface mapping in subregion of the superior temporal gyrus
    Marc Vaillant
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 34:1149-59. 2007
  8. ncbi request reprint A stochastic model for studying the laminar structure of cortex from MRI
    Patrick Barta
    Center for Imaging Science, The Johns Hopkins University, Clark Hall 301, 3400 N Charles Street, Baltimore, MD 21218 USA
    IEEE Trans Med Imaging 24:728-42. 2005
  9. pmc Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants
    Kenichi Oishi
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 46:486-99. 2009
  10. pmc Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imaging
    Can Ceritoglu
    The Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21205, USA
    Neuroimage 47:618-27. 2009

Research Grants

  1. Validation of Structural/Functional MRI Localization
    STEVEN G YANTIS; Fiscal Year: 2010
  2. 3D Shape Analysis for Computational Anatomy
    Michael I Miller; Fiscal Year: 2010
  3. Validation of Structural/Functional MRI Localization
    Michael Miller; Fiscal Year: 2005
  4. Core--Brain mapping
    Michael Miller; Fiscal Year: 2002
  5. 3D Shape Analysis for Computational Anatomy
    Michael Miller; Fiscal Year: 2009

Detail Information

Publications64

  1. pmc Labeled cortical mantle distance maps of the cingulate quantify differences between dementia of the Alzheimer type and healthy aging
    M I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 100:15172-7. 2003
    ..The "shape of the cortical mantle" as measured by the cortical mantle distance profiles manifests a pronounced increase in variability with mild DAT...
  2. pmc Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping
    Michael I Miller
    Center for Imaging Science, The Whiting School of Engineering, The Johns Hopkins University, 301 Clark Hall, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 102:9685-90. 2005
    ..Activation patterns are highly localized within the MTL. Whereas the present demonstration has been aimed at enhancing alignment within the MTL, this technique is general and can be applied throughout the brain...
  3. ncbi request reprint Computational anatomy: shape, growth, and atrophy comparison via diffeomorphisms
    Michael I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 23:S19-33. 2004
    ..on the images I for inference and disease testing within anatomical models. This paper reviews recent advances in these three areas applied to shape, growth, and atrophy...
  4. pmc Collaborative computational anatomy: an MRI morphometry study of the human brain via diffeomorphic metric mapping
    Michael I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    Hum Brain Mapp 30:2132-41. 2009
    ..05). Such large scale collaborative analysis of anatomical shapes has the potential to enhance the understanding of neurodevelopmental and neuropsychiatric disorders...
  5. pmc The emerging discipline of Computational Functional Anatomy
    Michael I Miller
    Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 45:S16-39. 2009
    ....
  6. ncbi request reprint On the metrics and euler-lagrange equations of computational anatomy
    Michael I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Annu Rev Biomed Eng 4:375-405. 2002
    ....
  7. pmc Diffeomorphic metric surface mapping in subregion of the superior temporal gyrus
    Marc Vaillant
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 34:1149-59. 2007
    ..The results demonstrate that both the positional and shape variability of the anatomical configurations are being represented by the diffeomorphic maps...
  8. ncbi request reprint A stochastic model for studying the laminar structure of cortex from MRI
    Patrick Barta
    Center for Imaging Science, The Johns Hopkins University, Clark Hall 301, 3400 N Charles Street, Baltimore, MD 21218 USA
    IEEE Trans Med Imaging 24:728-42. 2005
    ....
  9. pmc Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants
    Kenichi Oishi
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 46:486-99. 2009
    ..81 (controls) and 0.82 (patients), suggesting "almost perfect" agreement. A power analysis suggested that the proposed method is suitable for detecting FA and size abnormalities of the white matter in clinical studies...
  10. pmc Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imaging
    Can Ceritoglu
    The Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21205, USA
    Neuroimage 47:618-27. 2009
    ..To improve the accuracy level, cascading and multi-contrast approaches were developed. The accuracy level for the white matter was 1.88+/-0.55 and 2.19+/-0.84 mm for the measured locations in the controls and patients, respectively...
  11. ncbi request reprint Dynamic programming generation of boundaries of local coordinatized submanifolds in the neocortex: application to the planum temporale
    J T Ratnanather
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Neuroimage 20:359-77. 2003
    ..96 for the left PT and 0.94 for the right PT, thus demonstrating the robustness of dynamic programming in defining a coordinate system on the PT. It provides a method with potential significance in the study of neuropsychiatric disorders...
  12. pmc Computational cardiac anatomy using MRI
    Mirza Faisal Beg
    Center for Imaging Science, The Whitaker Biomedical Engineering Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 52:1167-74. 2004
    ..Once heart anatomies have been registered, properties of tissue geometry and cardiac fiber orientation in corresponding regions of different hearts may be quantified...
  13. pmc Landmark-referenced voxel-based analysis of diffusion tensor images of the brainstem white matter tracts: application in patients with middle cerebral artery stroke
    Weihong Zhang
    FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Neuroimage 44:906-13. 2009
    ..We believe that this tool is useful for regional brain normalization of patients with severe anatomical alterations, such as stroke, brain tumor, and lobectomy, for whom standard automated normalization tools may not work properly...
  14. pmc Correction of B0 susceptibility induced distortion in diffusion-weighted images using large-deformation diffeomorphic metric mapping
    Hao Huang
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Magn Reson Imaging 26:1294-302. 2008
    ..This postprocessing method is especially useful for correcting existent DTI data without phase maps...
  15. ncbi request reprint Validating cortical surface analysis of medial prefrontal cortex
    J T Ratnanather
    Center for Imaging Science, The Johns Hopkins University, Baltimore, Maryland 21218-2686, USA
    Neuroimage 14:1058-69. 2001
    ..These methods represent a novel approach to morphometric chacterization of regional cortex features which may be important in the study of psychiatric disorders such as major depression...
  16. ncbi request reprint Imaging-based integrative models of the heart: closing the loop between experiment and simulation
    Raimond L Winslow
    The Whitaker Biomedical Engineering Institute Center for Computational Medicine and Biology, Johns Hopkins University, Baltimore MD 21218, USA
    Novartis Found Symp 247:129-41; discussion 141-3, 144-50, 244-52. 2002
    ..We believe this ability to electrically map and model individual hearts will lead to enhanced understanding of the relationship between anatomical structure, and electrical conduction in the cardiac ventricles...
  17. ncbi request reprint Mapping postnatal mouse brain development with diffusion tensor microimaging
    Jiangyang Zhang
    Johns Hopkins University, School of Medicine, Department of Radiology, Division of NMR Research, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neuroimage 26:1042-51. 2005
    ..The results demonstrate the use of these techniques to three-dimensionally and quantitatively characterize brain growth...
  18. ncbi request reprint Combining anatomical manifold information via diffeomorphic metric mappings for studying cortical thinning of the cingulate gyrus in schizophrenia
    Anqi Qiu
    Division of Bioengineering, National University of Singapore, Singapore 117576
    Neuroimage 37:821-33. 2007
    ..Subjects with schizophrenia had non-uniform cortical thinning over the left and right cingulate gyri, especially in the anterior portion, as compared to healthy comparison subjects...
  19. pmc Region-of-interest-based analysis with application of cortical thickness variation of left planum temporale in schizophrenia and psychotic bipolar disorder
    Anqi Qiu
    Center for Imaging Science, Johns Hopkins University, Baltimore, Maryland, USA
    Hum Brain Mapp 29:973-85. 2008
    ..Moreover, there may be a greater thickness variation in the left PT in psychotic bipolar patients when compared with that in schizophrenic patients...
  20. ncbi request reprint Characterization of mouse brain and its development using diffusion tensor imaging and computational techniques
    Jiangyang Zhang
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD21205, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2252-5. 2006
    ..To characterize the spatial and temporal patterns of mouse brain development, we applied landmark based computational techniques to analyze the database...
  21. pmc Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template
    Susumu Mori
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 40:570-82. 2008
    ..The atlases are freely available and believed to be a useful resource as a target template and for automated parcellation methods...
  22. ncbi request reprint Clutter invariant ATR
    Dmitri Bitouk
    Center for Imaging Science, Whiting School of Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    IEEE Trans Pattern Anal Mach Intell 27:817-21. 2005
    ..Such metrics are formulated using second-order random field models. Our results indicate that this approach significantly improves detection/classification rates of targets in clutter...
  23. pmc Computational method for identifying and quantifying shape features of human left ventricular remodeling
    Siamak Ardekani
    Institute for Computational Medicine, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
    Ann Biomed Eng 37:1043-54. 2009
    ..This approach may be useful in identifying differences in the remodeling process between ICM and NICM populations and possibly in differentiating the populations...
  24. pmc Evolutions equations in computational anatomy
    Laurent Younes
    Center for Imaging Science, The Johns Hopkins University, 3400N Charles St, Baltimore, MD 21218, USA
    Neuroimage 45:S40-50. 2009
    ..These equations include energy minimizing evolutions deriving from Riemannian gradient descent, geodesics, parallel transport and Jacobi fields...
  25. pmc Statistical analysis of twin populations using dissimilarity measurements in hippocampus shape space
    Youngser Park
    Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA
    J Biomed Biotechnol 2008:694297. 2008
    ..In particular, our analysis demonstrates that the high-risk population is closer in shape space to the control population than to the clinically depressed population...
  26. pmc Bayesian template estimation in computational anatomy
    Jun Ma
    Center for Imaging Science and Department of Biomedical Engineering, The Johns Hopkins University, 320 Clark Hall, Baltimore, MD 21218, USA
    Neuroimage 42:252-61. 2008
    ..This leads us to an image matching problem with a Jacobian weight term, and we solve it by deriving the weighted Euler-Lagrange equation. The results of template estimation for hippocampus and cardiac data are presented...
  27. pmc Validation of alternating Kernel mixture method: application to tissue segmentation of cortical and subcortical structures
    Nayoung A Lee
    Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA
    J Biomed Biotechnol 2008:346129. 2008
    ..AKM's superior performance makes it useful for tissue segmentation of subcortical and cortical structures in large-scale neuroimaging studies...
  28. pmc Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy
    Yajing Zhang
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 52:1289-301. 2010
    ..Probabilistic maps of the 59 tract trajectories were created from the normal subjects and were incorporated into our image analysis tool for automated tract-specific quantification...
  29. ncbi request reprint Evidence of structural remodeling in the dyssynchronous failing heart
    Patrick A Helm
    Centers for Cardiovascular Bioinformatics and Modeling, Johns Hopkins University, Baltimore, MD, USA
    Circ Res 98:125-32. 2006
    ..Measured changes in both fiber gradient and sheet structure will affect both the heterogeneity of passive myocardial properties as well as electrical activation of the ventricles...
  30. ncbi request reprint Validation of semiautomated methods for quantifying cingulate cortical metrics in schizophrenia
    J Tilak Ratnanather
    Center for Imaging Science, The Johns Hopkins University, Clark 301, 3400 North Charles St, Baltimore, MD 21218, USA
    Psychiatry Res 132:53-68. 2004
    ..82. In addition, by repeating the entire procedure three times in one subject, we obtained a coefficient of variation of 0.0438 for surface area...
  31. ncbi request reprint Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasis
    Jiangyang Zhang
    Department of Radiology, Division of Nuclear Magnetic Resonance Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:1881-8. 2005
    ..Thus, this technique serves as a powerful tool to efficiently localize temporal and spatial manifestation of morphological phenotype...
  32. pmc High-resolution fMRI investigation of the medial temporal lobe
    C Brock Kirwan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Hum Brain Mapp 28:959-66. 2007
    ..This difference in the pattern of activation may be due to less partial volume sampling in the high-resolution data, resulting in more accentuated regions of activation...
  33. ncbi request reprint Smooth functional and structural maps on the neocortex via orthonormal bases of the Laplace-Beltrami operator
    Anqi Qiu
    Department of Electrical and Computer Engineering, Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    IEEE Trans Med Imaging 25:1296-306. 2006
    ..We present applications of our approach to smoothing sulcal mean curvature, cortical thickness, and functional statistical maps on submanifolds of the neocortex...
  34. ncbi request reprint Estimating linear cortical magnification in human primary visual cortex via dynamic programming
    Anqi Qiu
    Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 31:125-38. 2006
    ..The reliability of these estimates was assessed by comparing results based on data from one quadrant to those based on data from the full hemifield along with a split-half reliability analysis...
  35. ncbi request reprint Large deformation diffeomorphic metric mapping of vector fields
    Yan Cao
    Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA
    IEEE Trans Med Imaging 24:1216-30. 2005
    ..This is illustrated by numerical experiments on DT-MRI heart images...
  36. ncbi request reprint DTI tractography based parcellation of white matter: application to the mid-sagittal morphology of corpus callosum
    Hao Huang
    Johns Hopkins University School of Medicine, Department of Radiology, Division of MRI Research, Baltimore, MD 21205, USA
    Neuroimage 26:195-205. 2005
    ..This approach provides a new tool to investigate callosal morphology and functional relationships...
  37. pmc Multi-contrast human neonatal brain atlas: application to normal neonate development analysis
    Kenichi Oishi
    Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 56:8-20. 2011
    ....
  38. ncbi request reprint Statistics on diffeomorphisms via tangent space representations
    M Vaillant
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroimage 23:S161-9. 2004
    ....
  39. pmc Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter
    Kenichi Oishi
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 43:447-57. 2008
    ..We anticipate that this atlas will be useful resource for atlas-based white matter anatomical studies...
  40. pmc Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 6:378-85. 2010
    ..The present objective was to examine whether plasma ceramides varied by AD severity in a well-characterized clinic sample and were associated with cognitive decline and hippocampal volume loss over 1 year...
  41. pmc Anatomical characterization of human fetal brain development with diffusion tensor magnetic resonance imaging
    Hao Huang
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:4263-73. 2009
    ..The developing fetal brain DTI database presented can be used for education, as an anatomical research reference, and for data registration...
  42. pmc Magnetic resonance imaging and micro-computed tomography combined atlas of developing and adult mouse brains for stereotaxic surgery
    M Aggarwal
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroscience 162:1339-50. 2009
    ....
  43. pmc Atlas-based analysis of neurodevelopment from infancy to adulthood using diffusion tensor imaging and applications for automated abnormality detection
    Andreia V Faria
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 52:415-28. 2010
    ..As a demonstration of future application studies, the brainstem anatomy of cerebral palsy patients was evaluated and the altered anatomy was delineated...
  44. pmc Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images
    Jiangyang Zhang
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 49:2340-51. 2010
    ..This is the first report of longitudinal characterization of brain atrophy in a mouse model of Huntington's disease by using automatic morphological analysis...
  45. ncbi request reprint Measuring and mapping cardiac fiber and laminar architecture using diffusion tensor MR imaging
    Patrick Helm
    The Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21218, USA
    Ann N Y Acad Sci 1047:296-307. 2005
    ....
  46. pmc Evidence of slow maturation of the superior longitudinal fasciculus in early childhood by diffusion tensor imaging
    Jiangyang Zhang
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA, and Diagnostic Radiology Unit, Saint Luc University Hospital, Brussels, Belgium
    Neuroimage 38:239-47. 2007
    ..The result is attributed to slow axonal and/or myelin maturation of this tract, which is believed to be involved in language functions...
  47. pmc Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy
    Jiangyang Zhang
    Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:3160-71. 2009
    ..These data suggest that there is an early imaging signature associated with axon transections that could be used in a variety of neurological disease processes...
  48. pmc Amygdala volume analysis in female twins with major depression
    Melissa A Munn
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Biol Psychiatry 62:415-22. 2007
    ..Furthermore, few of these studies have examined differences in individuals with an onset during childhood or adolescence. This study examined amygdala volume and its potential association with early onset major depression...
  49. ncbi request reprint High-dimensional mapping of the hippocampus in depression
    Joel A Posener
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 160:83-9. 2003
    ..In this study, high-dimensional brain mapping was used to evaluate hippocampal shape and volume in patients with major depressive disorder and healthy comparison subjects...
  50. pmc Abnormalities of hippocampal surface structure in very mild dementia of the Alzheimer type
    Lei Wang
    Alzheimer s Disease Research Center and The Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Neuroimage 30:52-60. 2006
    ..Neurology 55, 1636--1643.] and suggest that inward deformities of the hippocampal surface in proximity to the CA1 subfield and subiculum can be used to distinguish subjects with very mild DAT from nondemented subjects...
  51. pmc Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110, USA
    IEEE Trans Med Imaging 26:462-70. 2007
    ..Further, PCA of the initial momentum leads to correct classification of 12 out of 18 DAT subjects and 22 out of 26 control subjects...
  52. pmc Abnormalities of cingulate gyrus neuroanatomy in schizophrenia
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S Euclid Ave, St Louis, MO 63110, United States
    Schizophr Res 93:66-78. 2007
    ....
  53. ncbi request reprint Computational anatomy and neuropsychiatric disease: probabilistic assessment of variation and statistical inference of group difference, hemispheric asymmetry, and time-dependent change
    John G Csernansky
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 23:S56-68. 2004
    ..g., asymmetry), and changes of shapes over time. Promising preliminary studies employing these approaches to studies of subjects with schizophrenia and very mild to mild Alzheimer's disease (AD) are presented...
  54. pmc Cortical hemisphere registration via large deformation diffeomorphic metric curve mapping
    Anqi Qiu
    Division of Bioengineering, National University of Singapore
    Med Image Comput Comput Assist Interv 10:186-93. 2007
    ..We showed global cortical hemisphere matching and evaluated the mapping accuracy in five subregions of the cortex in fourteen MRI scans...
  55. ncbi request reprint Intrinsic and extrinsic analysis in computational anatomy
    Anqi Qiu
    Division of Bioengineering, National University of Singapore, Singapore
    Neuroimage 39:1803-14. 2008
    ..Both methods show that the left cingulate gyrus tends to become thinner in schizophrenia relative to the healthy control population. However, the intrinsic method increases the statistical power...
  56. pmc Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type
    Anqi Qiu
    Division of Bioengineering, National University of Singapore, 7 Engineering Drive 1, Singapore, Singapore
    Neuroimage 40:68-76. 2008
    ..77 and 0.87, which were obtained in the same training set using the leave-one-out cross validation approach...
  57. ncbi request reprint Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 20:667-82. 2003
    ..These results suggest that different patterns of hippocampal shape change in time as well as different rates of hippocampal volume loss distinguish very mild DAT from healthy aging...
  58. pmc Basal ganglia shape abnormalities in the unaffected siblings of schizophrenia patients
    Daniel Mamah
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 64:111-20. 2008
    ..Our aim was to test the hypothesis that abnormalities of basal ganglia structure are intrinsic features of schizophrenia by assessing basal ganglia volume and shape in the unaffected siblings of schizophrenia subjects...
  59. ncbi request reprint Hippocampal deformities in the unaffected siblings of schizophrenia subjects
    Ralf Tepest
    Department of Psychiatry RT, University of Bonn Medical Center, Bonn, Germany
    Biol Psychiatry 54:1234-40. 2003
    ..The objective of this study was to further elucidate hippocampal deformities as a marker of genetic vulnerability for schizophrenia...
  60. ncbi request reprint Abnormalities of thalamic volume and shape in schizophrenia
    John G Csernansky
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 161:896-902. 2004
    ..However, the pattern of shape change associated with such volume loss has not been investigated. In this study, alterations in thalamic volume, shape, and symmetry were compared in subjects with and without schizophrenia...
  61. ncbi request reprint Hippocampal deformities in schizophrenia characterized by high dimensional brain mapping
    John G Csernansky
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Psychiatry 159:2000-6. 2002
    ..High dimensional brain mapping, which utilizes probabilistic deformations of a neuroanatomical template, was used to characterize disease-related patterns of changes in hippocampal volume, shape, and asymmetry...
  62. pmc Validity of large-deformation high dimensional brain mapping of the basal ganglia in adults with Tourette syndrome
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychiatry Res 154:181-90. 2007
    ..We found no significant volume or shape differences in any of the structures in this small sample of subjects...

Research Grants10

  1. Validation of Structural/Functional MRI Localization
    STEVEN G YANTIS; Fiscal Year: 2010
    ....
  2. 3D Shape Analysis for Computational Anatomy
    Michael I Miller; Fiscal Year: 2010
    ..The increased importance of early onset illness combined with the application to a population-based sample of twin pairs appears as an attractive model for statistical shape analysis software for the neuroscience community. ..
  3. Validation of Structural/Functional MRI Localization
    Michael Miller; Fiscal Year: 2005
    ..abstract_text> ..
  4. Core--Brain mapping
    Michael Miller; Fiscal Year: 2002
    ..abstract_text> ..
  5. 3D Shape Analysis for Computational Anatomy
    Michael Miller; Fiscal Year: 2009
    ..The increased importance of early onset illness combined with the application to a population-based sample of twin pairs appears as an attractive model for statistical shape analysis software for the neuroscience community. ..