EDGAR RAYMOND MILLER
Affiliation: Johns Hopkins University
- A multi-level system quality improvement intervention to reduce racial disparities in hypertension care and control: study protocolLisa A Cooper
Department of Medicine, Johns Hopkins University School of Medicine, 2024 East Monument Street, Suite 2 515, Baltimore, Maryland 21287, USA
Implement Sci 8:60. 2013..By intervening on multiple levels, this project aims to reduce disparities in blood pressure control and improve guideline concordant hypertension care...
- The effects of n-3 long-chain polyunsaturated fatty acid supplementation on biomarkers of kidney injury in adults with diabetes: results of the GO-FISH trialEdgar R Miller
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Diabetes Care 36:1462-9. 2013..In the context of prior studies, these results provide a strong rationale for long-term trials of n-3 PUFA on chronic kidney disease progression...
- Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortalityEdgar R Miller
The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
Ann Intern Med 142:37-46. 2005..However, several trials of high-dosage vitamin E supplementation showed non-statistically significant increases in total mortality...
- A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding studyEdgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 2 624, Baltimore, MD 21205 2223, USA
Atherosclerosis 183:175-82. 2005..We tested the hypothesis that consumption of a healthy diet rich in fruits and vegetables and reduced in saturated fat, total fat, and cholesterol will concomitantly reduce oxidative stress and Ab-oxLDL...
- Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularizationEdgar R Miller
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2233, USA
Coron Artery Dis 14:163-9. 2003..While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent of LDL-c levels remains to be established...
- The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: meta-analysis of clinical trialsEdgar R Miller
Johns Hopkins School of Medicine, The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Am J Clin Nutr 89:1937-45. 2009..Although epidemiologic and experimental studies suggest that n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation may prevent or slow the progression of kidney disease, evidence from clinical trials is inconsistent...
- Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levelsEdgar R Miller
The Johns Hopkins School of Medicine, Baltimore, MD, USA
Am J Cardiol 106:517-27. 2010..This interaction may have important implications for recommendations of FA supplement use. In the meantime, FA supplementation should not be recommended as a means to prevent or treat CVD or stroke...
- Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trialsJoachim Bleys
Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Am J Clin Nutr 84:880-7; quiz 954-5. 2006..Although trials have not shown a benefit of these supplements on clinical cardiovascular events, it is unknown whether they affect the progression of atherosclerosis as measured by imaging techniques...
- Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US populationBrad C Astor
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Am J Epidemiol 167:1226-34. 2008..These data support recent recommendations defining chronic kidney disease and stratifying subsequent risks based on both decreased GFR and albuminuria...
- Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT)Edgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
Hypertension 40:612-8. 2002..001), net of control. In conclusion, among hypertensive overweight adults already on antihypertensive medication, a comprehensive lifestyle intervention can substantially lower blood pressure and improve blood pressure control...
- The effects of macronutrients on blood pressure and lipids: an overview of the DASH and OmniHeart trialsEdgar R Miller
National Institute on Aging, National Institutes of Health, 3001 South Hanover Street, 5th Floor, Room NM 530, Baltimore, MD 21225, USA
Curr Atheroscler Rep 8:460-5. 2006..Furthermore, these results also document substantial flexibility that should enhance the ability of individuals to consume a heart-healthy diet...
- New high blood pressure guidelines create new at-risk classification: changes in blood pressure classification by JNC 7Edgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Cardiovasc Nurs 19:367-71; quiz 372-3. 2004..Recognition of prehypertension provides important opportunities to prevent hypertension and cardiovascular disease...
- Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial diseaseJared P Reis
Welch Center for Prevention, Epidemiology, and Clinical Research and the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
Am J Clin Nutr 88:1469-77. 2008..Racial differences in cardiovascular risk factors do not fully explain the higher prevalence of lower-extremity peripheral arterial disease (PAD) in black adults...
- Changes in serum potassium mediate thiazide-induced diabetesTariq Shafi
Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21224 2780, USA
Hypertension 52:1022-9. 2008..Potassium supplementation might prevent thiazide-induced diabetes. This hypothesis can and should be tested in a randomized trial...
- Blood pressure control among persons without and with chronic kidney disease: US trends and risk factors 1999-2006Laura C Plantinga
Departments of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Hypertension 54:47-56. 2009..Although some improvement has occurred over time, uncontrolled blood pressure remains highly prevalent, especially in subjects with chronic kidney disease and in nonwhites, older persons, and women. Therapy appears suboptimal...
- Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trialLawrence J Appel
Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
JAMA 294:2455-64. 2005..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...
- Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trialThomas P Erlinger
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 108:150-4. 2003..Inflammatory mediators regulate key aspects of lipid metabolism. We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet...
- Independent but coordinated trials: insights from the practice-based Opportunities for Weight Reduction Trials Collaborative Research GroupHsin Chieh Yeh
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Clin Trials 7:322-32. 2010..Still, efforts were made to coordinate and standardize several aspects of the trials. The three trials formed a collaborative group, the 'Practice-based Opportunities for Weight Reduction (POWER) Trials Collaborative Research Group.'..
- Nurse case management of hypercholesterolemia in patients with coronary heart disease: results of a randomized clinical trialJerilyn K Allen
School of Nursing, Johns Hopkins University, Baltimore, MD 21205 2110, USA
Am Heart J 144:678-86. 2002..This study tested the effectiveness of a nurse case management program to lower blood lipids in patients with CHD...
- Left ventricular dysfunction as a risk factor for cardiovascular and noncardiovascular hospitalizations in African AmericansSaul Blecker
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am Heart J 160:488-95. 2010..We assessed whether left ventricular (LV) systolic dysfunction was associated with increased risk of both cardiovascular and noncardiovascular hospitalizations in a community sample of African Americans...
- Intensive blood-pressure control in hypertensive chronic kidney diseaseLawrence J Appel
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
N Engl J Med 363:918-29. 2010..Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients...
- The rationale and design of the AASK cohort studyLawrence J Appel
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, 21205, USA
J Am Soc Nephrol 14:S166-72. 2003..Such results might eventually lead to new strategies that delay or prevent ESRD...
- Prevalence of chronic kidney disease in persons with undiagnosed or prehypertension in the United StatesDeidra C Crews
Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Hypertension 55:1102-9. 2010..37 [95% CI: 2.00 to 2.81]). Chronic kidney disease is prevalent in undiagnosed and prehypertension. Earlier identification and treatment of both these conditions may prevent or delay morbidity and mortality from chronic kidney disease...
- Concentrations of B vitamins and homocysteine in children with sickle cell anemiaJodi B Segal
Department of Medicine and Pediatrics, The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine and Medical Institutions, Baltimore, MD 21205, USA
South Med J 97:149-55. 2004..We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover...
- Racial differences in urinary potassium excretionSharon Turban
Division of Nephrology, Johns Hopkins University School of Medicine, 1830 E Monument Street, Suite 416, Baltimore, MD 21205, USA
J Am Soc Nephrol 19:1396-402. 2008..39), and 903 mg/d in the DASH group (P < 0.001). Racial differences in urinary K excretion seem to reflect more than intake differences; further studies are needed to understand their potential impact on clinical outcomes...
- Serum selenium and serum lipids in US adultsJoachim Bleys
Departments of Epidemiology and Medicine, The Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, Madrid, Spain
Am J Clin Nutr 88:416-23. 2008..However, the effects of selenium intake on the lipid profile in selenium-replete populations, such as the United States, are largely unknown...
- Patient awareness of chronic kidney disease: trends and predictorsLaura C Plantinga
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Arch Intern Med 168:2268-75. 2008..The impact of recent guidelines for early detection and prevention of chronic kidney disease (CKD) on patient awareness of disease and factors that might be associated with awareness have not been well described...
- Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosisJared P Reis
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Atherosclerosis 207:585-90. 2009..Additional research is needed to determine whether vitamin D may influence the progression of atherosclerosis, including the effects of supplementation on the atherosclerotic process...
- The effect of ambient temperature and barometric pressure on ambulatory blood pressure variabilityMegan Jehn
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument Street, Baltimore, MD 21205 2223, USA
Am J Hypertens 15:941-5. 2002..The effect of ambient temperature on cardiovascular disease has previously been studied. Less known are the effects of climate on blood pressure (BP) regulation, specifically, the role of temperature on BP variability...
- Dietary recommendations for obese patients with chronic kidney diseaseCheryl A M Anderson
Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Adv Chronic Kidney Dis 13:394-402. 2006..This review describes dietary factors important in optimizing nutritional status of obese patients with CKD. Additionally, current clinical practice guidelines and strategies for meeting them are discussed...
- The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trialHan Yao Huang
Johns Hopkins University, Baltimore, Maryland 21205, USA
Arthritis Rheum 52:1843-7. 2005..Previous studies have suggested a uricosuric effect of vitamin C. Whether vitamin C reduces serum uric acid is unknown. We undertook this study to determine the effects of vitamin C supplementation on serum uric acid concentrations...
- Vitamin D status and cardiometabolic risk factors in the United States adolescent populationJared P Reis
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Pediatrics 124:e371-9. 2009..We examined whether low serum vitamin D levels (25-hydroxyvitamin D [25(OH)D]) are associated with cardiovascular risk factors in US adolescents aged 12 to 19 years...
- Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trialDavid W Harsha
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Hypertension 43:393-8. 2004..There were no significant interactions between the effects of sodium and the DASH diet on serum lipids. In conclusion, changes in dietary sodium intake over the range of 50 to 150 mmol/d did not affect blood lipid concentrations...
- The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trialsSun Ha Jee
Department of Epidemiology and Disease Control, Yonsei University Graduate School of Health Science and Management, Seoul, Korea
Am J Hypertens 15:691-6. 2002..An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design...
- Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney diseaseDenyse Thornley-Brown
Division of Nephrology, University of Alabama at Birmingham, USA
Arch Intern Med 166:797-805. 2006..We compared the incidence of type 2 diabetes mellitus (DM) and the composite outcome of impaired fasting glucose or DM (IFG/DM) for the African American Study of Kidney Disease and Hypertension interventions...
- The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and MethodsHarold I Feldman
Center for Clinical Epidemiology, Philadelphia, 19104, USA
J Am Soc Nephrol 14:S148-53. 2003..Insights from CRIC should lead to the formulation of hypotheses regarding therapy that will serve as the basis for targeted interventional trials focused on reducing the burden of CRI and CVD...
- The DASH diet enhances the blood pressure response to losartan in hypertensive patientsPaul R Conlin
Division of Endocrinology, Diabetes and Hypertension PRC, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Hypertens 16:337-42. 2003..We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension...
- The DASH diet for high blood pressure: from clinical trial to dinner tableNjeri Karanja
Kaiser Permanente Center for Health Research, Portland, OR 97227, USA
Cleve Clin J Med 71:745-53. 2004..These studies have greatly expanded our knowledge of nonpharmacologic interventions to prevent and manage hypertension. They also underscore the need for diet and lifestyle counseling in the primary care setting...
- Blood pressure control, drug therapy, and kidney diseaseGabriel Contreras
University of Miami, Miami, FL, USA
Hypertension 46:44-50. 2005..These secondary analyses suggest a benefit of the low BP goal among patients assigned to amlodipine, but they must be interpreted cautiously...
- An editorial update: Annus horribilis for vitamin EEliseo Guallar
Ann Intern Med 143:143-5. 2005
- Direct, progressive association of cardiovascular risk factors with incident proteinuria: results from the Korea Medical Insurance Corporation (KMIC) studySun Ha Jee
Department of Epidemiology and Health Promotion, Graduate School of Public Health, The Yonsei University, Seoul, South Korea
Arch Intern Med 165:2299-304. 2005..Proteinuria is a major risk factor for the progression of kidney disease and the development of cardiovascular disease. Little is known, however, about risk factors for incident proteinuria...
- Evidence-based medicine and vitamin E supplementationHarri Hemilä
Am J Clin Nutr 86:261-2; author reply 262-4. 2007
- Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart TrialJeremy D Furtado
Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 87:1623-30. 2008..Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins...
- Roundtable discussion: hypertension, renal disease, and diabetesMarvin Moser
J Clin Hypertens (Greenwich) 4:113-9. 2002..Following a symposium on Hypertension in Atlanta, Georgia on April 25, 2001, which was sponsored by the National Heart, Lung, and Blood Institute, a panel was convened to discuss the problems of renal disease and hypertension...
- Metabolic syndrome, proteinuria, and the risk of progressive CKD in hypertensive African AmericansJanice Lea
Emory University, Atlanta, GA 30322, USA
Am J Kidney Dis 51:732-40. 2008..The purpose of this study is to examine whether metabolic syndrome is associated with kidney disease progression in hypertensive African Americans...
- Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trialHan Yao Huang
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore 21205 2223, USA
Am J Clin Nutr 76:549-55. 2002..Evidence predominantly from in vitro studies suggests that antioxidant vitamins can prevent lipid peroxidation and that vitamin C and vitamin E have synergistic effects. However, in vivo evidence in support of these hypotheses is sparse...
- Body mass index and incident ischemic heart disease in South Korean men and womenSun Ha Jee
Department of Epidemiology and Disease Control, Graduate School of Health Science and Management, Yonsei University, Seoul, Republic of Korea
Am J Epidemiol 162:42-8. 2005..The association of BMI with IHD in this cohort of relatively young South Korean men and women was progressive over the range of BMI values, with no threshold of change in risk and no indication of a U-shaped relation at low BMI levels...