EDGAR RAYMOND MILLER

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A multi-level system quality improvement intervention to reduce racial disparities in hypertension care and control: study protocol
    Lisa A Cooper
    Department of Medicine, Johns Hopkins University School of Medicine, 2024 East Monument Street, Suite 2 515, Baltimore, Maryland 21287, USA
    Implement Sci 8:60. 2013
  2. pmc The effects of n-3 long-chain polyunsaturated fatty acid supplementation on biomarkers of kidney injury in adults with diabetes: results of the GO-FISH trial
    Edgar R Miller
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 36:1462-9. 2013
  3. ncbi request reprint Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    Edgar R Miller
    The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 142:37-46. 2005
  4. ncbi request reprint A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study
    Edgar R Miller
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 2 624, Baltimore, MD 21205 2223, USA
    Atherosclerosis 183:175-82. 2005
  5. ncbi request reprint Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularization
    Edgar R Miller
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2233, USA
    Coron Artery Dis 14:163-9. 2003
  6. pmc The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: meta-analysis of clinical trials
    Edgar R Miller
    Johns Hopkins School of Medicine, The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Nutr 89:1937-45. 2009
  7. doi request reprint Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels
    Edgar R Miller
    The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Cardiol 106:517-27. 2010
  8. ncbi request reprint Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials
    Joachim Bleys
    Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Nutr 84:880-7; quiz 954-5. 2006
  9. doi request reprint Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population
    Brad C Astor
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Am J Epidemiol 167:1226-34. 2008
  10. ncbi request reprint Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT)
    Edgar R Miller
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    Hypertension 40:612-8. 2002

Research Grants

Detail Information

Publications47

  1. pmc A multi-level system quality improvement intervention to reduce racial disparities in hypertension care and control: study protocol
    Lisa A Cooper
    Department of Medicine, Johns Hopkins University School of Medicine, 2024 East Monument Street, Suite 2 515, Baltimore, Maryland 21287, USA
    Implement Sci 8:60. 2013
    ..By intervening on multiple levels, this project aims to reduce disparities in blood pressure control and improve guideline concordant hypertension care...
  2. pmc The effects of n-3 long-chain polyunsaturated fatty acid supplementation on biomarkers of kidney injury in adults with diabetes: results of the GO-FISH trial
    Edgar R Miller
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 36:1462-9. 2013
    ..In the context of prior studies, these results provide a strong rationale for long-term trials of n-3 PUFA on chronic kidney disease progression...
  3. ncbi request reprint Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    Edgar R Miller
    The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 142:37-46. 2005
    ..However, several trials of high-dosage vitamin E supplementation showed non-statistically significant increases in total mortality...
  4. ncbi request reprint A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study
    Edgar R Miller
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 2 624, Baltimore, MD 21205 2223, USA
    Atherosclerosis 183:175-82. 2005
    ..We tested the hypothesis that consumption of a healthy diet rich in fruits and vegetables and reduced in saturated fat, total fat, and cholesterol will concomitantly reduce oxidative stress and Ab-oxLDL...
  5. ncbi request reprint Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularization
    Edgar R Miller
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2233, USA
    Coron Artery Dis 14:163-9. 2003
    ..While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent of LDL-c levels remains to be established...
  6. pmc The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: meta-analysis of clinical trials
    Edgar R Miller
    Johns Hopkins School of Medicine, The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Nutr 89:1937-45. 2009
    ..Although epidemiologic and experimental studies suggest that n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation may prevent or slow the progression of kidney disease, evidence from clinical trials is inconsistent...
  7. doi request reprint Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels
    Edgar R Miller
    The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Cardiol 106:517-27. 2010
    ..This interaction may have important implications for recommendations of FA supplement use. In the meantime, FA supplementation should not be recommended as a means to prevent or treat CVD or stroke...
  8. ncbi request reprint Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials
    Joachim Bleys
    Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Nutr 84:880-7; quiz 954-5. 2006
    ..Although trials have not shown a benefit of these supplements on clinical cardiovascular events, it is unknown whether they affect the progression of atherosclerosis as measured by imaging techniques...
  9. doi request reprint Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population
    Brad C Astor
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Am J Epidemiol 167:1226-34. 2008
    ..These data support recent recommendations defining chronic kidney disease and stratifying subsequent risks based on both decreased GFR and albuminuria...
  10. ncbi request reprint Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT)
    Edgar R Miller
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    Hypertension 40:612-8. 2002
    ..001), net of control. In conclusion, among hypertensive overweight adults already on antihypertensive medication, a comprehensive lifestyle intervention can substantially lower blood pressure and improve blood pressure control...
  11. ncbi request reprint The effects of macronutrients on blood pressure and lipids: an overview of the DASH and OmniHeart trials
    Edgar R Miller
    National Institute on Aging, National Institutes of Health, 3001 South Hanover Street, 5th Floor, Room NM 530, Baltimore, MD 21225, USA
    Curr Atheroscler Rep 8:460-5. 2006
    ..Furthermore, these results also document substantial flexibility that should enhance the ability of individuals to consume a heart-healthy diet...
  12. ncbi request reprint New high blood pressure guidelines create new at-risk classification: changes in blood pressure classification by JNC 7
    Edgar R Miller
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Cardiovasc Nurs 19:367-71; quiz 372-3. 2004
    ..Recognition of prehypertension provides important opportunities to prevent hypertension and cardiovascular disease...
  13. doi request reprint Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial disease
    Jared P Reis
    Welch Center for Prevention, Epidemiology, and Clinical Research and the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Am J Clin Nutr 88:1469-77. 2008
    ..Racial differences in cardiovascular risk factors do not fully explain the higher prevalence of lower-extremity peripheral arterial disease (PAD) in black adults...
  14. pmc Changes in serum potassium mediate thiazide-induced diabetes
    Tariq Shafi
    Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21224 2780, USA
    Hypertension 52:1022-9. 2008
    ..Potassium supplementation might prevent thiazide-induced diabetes. This hypothesis can and should be tested in a randomized trial...
  15. pmc Blood pressure control among persons without and with chronic kidney disease: US trends and risk factors 1999-2006
    Laura C Plantinga
    Departments of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Hypertension 54:47-56. 2009
    ..Although some improvement has occurred over time, uncontrolled blood pressure remains highly prevalent, especially in subjects with chronic kidney disease and in nonwhites, older persons, and women. Therapy appears suboptimal...
  16. ncbi request reprint Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
    JAMA 294:2455-64. 2005
    ..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...
  17. ncbi request reprint Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trial
    Thomas P Erlinger
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 108:150-4. 2003
    ..Inflammatory mediators regulate key aspects of lipid metabolism. We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet...
  18. pmc Independent but coordinated trials: insights from the practice-based Opportunities for Weight Reduction Trials Collaborative Research Group
    Hsin Chieh Yeh
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Clin Trials 7:322-32. 2010
    ..Still, efforts were made to coordinate and standardize several aspects of the trials. The three trials formed a collaborative group, the 'Practice-based Opportunities for Weight Reduction (POWER) Trials Collaborative Research Group.'..
  19. ncbi request reprint Nurse case management of hypercholesterolemia in patients with coronary heart disease: results of a randomized clinical trial
    Jerilyn K Allen
    School of Nursing, Johns Hopkins University, Baltimore, MD 21205 2110, USA
    Am Heart J 144:678-86. 2002
    ..This study tested the effectiveness of a nurse case management program to lower blood lipids in patients with CHD...
  20. pmc Left ventricular dysfunction as a risk factor for cardiovascular and noncardiovascular hospitalizations in African Americans
    Saul Blecker
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am Heart J 160:488-95. 2010
    ..We assessed whether left ventricular (LV) systolic dysfunction was associated with increased risk of both cardiovascular and noncardiovascular hospitalizations in a community sample of African Americans...
  21. pmc Intensive blood-pressure control in hypertensive chronic kidney disease
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    N Engl J Med 363:918-29. 2010
    ..Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients...
  22. ncbi request reprint The rationale and design of the AASK cohort study
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, 21205, USA
    J Am Soc Nephrol 14:S166-72. 2003
    ..Such results might eventually lead to new strategies that delay or prevent ESRD...
  23. pmc Prevalence of chronic kidney disease in persons with undiagnosed or prehypertension in the United States
    Deidra C Crews
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Hypertension 55:1102-9. 2010
    ..37 [95% CI: 2.00 to 2.81]). Chronic kidney disease is prevalent in undiagnosed and prehypertension. Earlier identification and treatment of both these conditions may prevent or delay morbidity and mortality from chronic kidney disease...
  24. ncbi request reprint Concentrations of B vitamins and homocysteine in children with sickle cell anemia
    Jodi B Segal
    Department of Medicine and Pediatrics, The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine and Medical Institutions, Baltimore, MD 21205, USA
    South Med J 97:149-55. 2004
    ..We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover...
  25. pmc Racial differences in urinary potassium excretion
    Sharon Turban
    Division of Nephrology, Johns Hopkins University School of Medicine, 1830 E Monument Street, Suite 416, Baltimore, MD 21205, USA
    J Am Soc Nephrol 19:1396-402. 2008
    ..39), and 903 mg/d in the DASH group (P < 0.001). Racial differences in urinary K excretion seem to reflect more than intake differences; further studies are needed to understand their potential impact on clinical outcomes...
  26. pmc Serum selenium and serum lipids in US adults
    Joachim Bleys
    Departments of Epidemiology and Medicine, The Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, Madrid, Spain
    Am J Clin Nutr 88:416-23. 2008
    ..However, the effects of selenium intake on the lipid profile in selenium-replete populations, such as the United States, are largely unknown...
  27. pmc Patient awareness of chronic kidney disease: trends and predictors
    Laura C Plantinga
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Arch Intern Med 168:2268-75. 2008
    ..The impact of recent guidelines for early detection and prevention of chronic kidney disease (CKD) on patient awareness of disease and factors that might be associated with awareness have not been well described...
  28. pmc Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis
    Jared P Reis
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Atherosclerosis 207:585-90. 2009
    ..Additional research is needed to determine whether vitamin D may influence the progression of atherosclerosis, including the effects of supplementation on the atherosclerotic process...
  29. ncbi request reprint The effect of ambient temperature and barometric pressure on ambulatory blood pressure variability
    Megan Jehn
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument Street, Baltimore, MD 21205 2223, USA
    Am J Hypertens 15:941-5. 2002
    ..The effect of ambient temperature on cardiovascular disease has previously been studied. Less known are the effects of climate on blood pressure (BP) regulation, specifically, the role of temperature on BP variability...
  30. ncbi request reprint Dietary recommendations for obese patients with chronic kidney disease
    Cheryl A M Anderson
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Adv Chronic Kidney Dis 13:394-402. 2006
    ..This review describes dietary factors important in optimizing nutritional status of obese patients with CKD. Additionally, current clinical practice guidelines and strategies for meeting them are discussed...
  31. ncbi request reprint The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial
    Han Yao Huang
    Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 52:1843-7. 2005
    ..Previous studies have suggested a uricosuric effect of vitamin C. Whether vitamin C reduces serum uric acid is unknown. We undertook this study to determine the effects of vitamin C supplementation on serum uric acid concentrations...
  32. doi request reprint Vitamin D status and cardiometabolic risk factors in the United States adolescent population
    Jared P Reis
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Pediatrics 124:e371-9. 2009
    ..We examined whether low serum vitamin D levels (25-hydroxyvitamin D [25(OH)D]) are associated with cardiovascular risk factors in US adolescents aged 12 to 19 years...
  33. ncbi request reprint Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trial
    David W Harsha
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Hypertension 43:393-8. 2004
    ..There were no significant interactions between the effects of sodium and the DASH diet on serum lipids. In conclusion, changes in dietary sodium intake over the range of 50 to 150 mmol/d did not affect blood lipid concentrations...
  34. ncbi request reprint The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials
    Sun Ha Jee
    Department of Epidemiology and Disease Control, Yonsei University Graduate School of Health Science and Management, Seoul, Korea
    Am J Hypertens 15:691-6. 2002
    ..An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design...
  35. ncbi request reprint Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney disease
    Denyse Thornley-Brown
    Division of Nephrology, University of Alabama at Birmingham, USA
    Arch Intern Med 166:797-805. 2006
    ..We compared the incidence of type 2 diabetes mellitus (DM) and the composite outcome of impaired fasting glucose or DM (IFG/DM) for the African American Study of Kidney Disease and Hypertension interventions...
  36. ncbi request reprint The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods
    Harold I Feldman
    Center for Clinical Epidemiology, Philadelphia, 19104, USA
    J Am Soc Nephrol 14:S148-53. 2003
    ..Insights from CRIC should lead to the formulation of hypotheses regarding therapy that will serve as the basis for targeted interventional trials focused on reducing the burden of CRI and CVD...
  37. ncbi request reprint The DASH diet enhances the blood pressure response to losartan in hypertensive patients
    Paul R Conlin
    Division of Endocrinology, Diabetes and Hypertension PRC, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 16:337-42. 2003
    ..We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension...
  38. ncbi request reprint The DASH diet for high blood pressure: from clinical trial to dinner table
    Njeri Karanja
    Kaiser Permanente Center for Health Research, Portland, OR 97227, USA
    Cleve Clin J Med 71:745-53. 2004
    ..These studies have greatly expanded our knowledge of nonpharmacologic interventions to prevent and manage hypertension. They also underscore the need for diet and lifestyle counseling in the primary care setting...
  39. ncbi request reprint Blood pressure control, drug therapy, and kidney disease
    Gabriel Contreras
    University of Miami, Miami, FL, USA
    Hypertension 46:44-50. 2005
    ..These secondary analyses suggest a benefit of the low BP goal among patients assigned to amlodipine, but they must be interpreted cautiously...
  40. ncbi request reprint An editorial update: Annus horribilis for vitamin E
    Eliseo Guallar
    Ann Intern Med 143:143-5. 2005
  41. ncbi request reprint Direct, progressive association of cardiovascular risk factors with incident proteinuria: results from the Korea Medical Insurance Corporation (KMIC) study
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, The Yonsei University, Seoul, South Korea
    Arch Intern Med 165:2299-304. 2005
    ..Proteinuria is a major risk factor for the progression of kidney disease and the development of cardiovascular disease. Little is known, however, about risk factors for incident proteinuria...
  42. ncbi request reprint Evidence-based medicine and vitamin E supplementation
    Harri Hemilä
    Am J Clin Nutr 86:261-2; author reply 262-4. 2007
  43. pmc Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial
    Jeremy D Furtado
    Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 87:1623-30. 2008
    ..Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins...
  44. ncbi request reprint Roundtable discussion: hypertension, renal disease, and diabetes
    Marvin Moser
    J Clin Hypertens (Greenwich) 4:113-9. 2002
    ..Following a symposium on Hypertension in Atlanta, Georgia on April 25, 2001, which was sponsored by the National Heart, Lung, and Blood Institute, a panel was convened to discuss the problems of renal disease and hypertension...
  45. doi request reprint Metabolic syndrome, proteinuria, and the risk of progressive CKD in hypertensive African Americans
    Janice Lea
    Emory University, Atlanta, GA 30322, USA
    Am J Kidney Dis 51:732-40. 2008
    ..The purpose of this study is to examine whether metabolic syndrome is associated with kidney disease progression in hypertensive African Americans...
  46. ncbi request reprint Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial
    Han Yao Huang
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore 21205 2223, USA
    Am J Clin Nutr 76:549-55. 2002
    ..Evidence predominantly from in vitro studies suggests that antioxidant vitamins can prevent lipid peroxidation and that vitamin C and vitamin E have synergistic effects. However, in vivo evidence in support of these hypotheses is sparse...
  47. ncbi request reprint Body mass index and incident ischemic heart disease in South Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Disease Control, Graduate School of Health Science and Management, Yonsei University, Seoul, Republic of Korea
    Am J Epidemiol 162:42-8. 2005
    ..The association of BMI with IHD in this cohort of relatively young South Korean men and women was progressive over the range of BMI values, with no threshold of change in risk and no indication of a U-shaped relation at low BMI levels...

Research Grants2

  1. Dietary carbohydrate & glycemic index effects on oxidation & inflammation
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..End of Abstract) ..