BARBARA MIGEON

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint The single active X in human cells: evolutionary tinkering personified
    Barbara R Migeon
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University, 459 Broadway Research Building, 733 N Broadway, Baltimore, MD 21205, USA
    Hum Genet 130:281-93. 2011
  2. doi request reprint X inactivation, female mosaicism, and sex differences in renal diseases
    Barbara R Migeon
    McKusick Nathans Institute of Genetic Medicine, 459 Broadway Research Building, 733 N Broadway, Baltimore, MD 21205, USA
    J Am Soc Nephrol 19:2052-9. 2008
  3. ncbi request reprint X inactivation in triploidy and trisomy: the search for autosomal transfactors that choose the active X
    Barbara R Migeon
    The McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Eur J Hum Genet 16:153-62. 2008
  4. ncbi request reprint Why females are mosaics, X-chromosome inactivation, and sex differences in disease
    Barbara R Migeon
    McKusick Nathans Institute of Genetic Medicine, 459 Broadway Research Building, 773 N Broadway, Baltimore, MD 21205, USA
    Gend Med 4:97-105. 2007
  5. ncbi request reprint The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases
    Barbara R Migeon
    The McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 295:1428-33. 2006
  6. pmc Differential X reactivation in human placental cells: implications for reversal of X inactivation
    Barbara R Migeon
    The McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 77:355-64. 2005
  7. ncbi request reprint X chromosome inactivation: theme and variations
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore MD, USA
    Cytogenet Genome Res 99:8-16. 2002
  8. ncbi request reprint Human X inactivation center induces random X chromosome inactivation in male transgenic mice
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 3914, USA
    Genomics 59:113-21. 1999
  9. pmc Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: implications for X inactivation
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA
    Am J Hum Genet 69:951-60. 2001
  10. ncbi request reprint Low-copy-number human transgene is recognized as an X inactivation center in mouse ES cells, but fails to induce cis-inactivation in chimeric mice
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Genomics 71:156-62. 2001

Research Grants

  1. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1993
  2. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1980
  3. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1990
  4. GENETIC STUDIES OF HUMAN CELLS
    BARBARA MIGEON; Fiscal Year: 2001

Collaborators

  • Gail Stetten
  • IAIN R MCINTOSH
  • R Reeves
  • Maria Patrizia Bicocchi
  • Fabio Corsolini
  • Mirella Pasino
  • Angelo C Molinari
  • Tiziana Lanza
  • Federico Bottini
  • Maura Acquila
  • Cristina Morerio
  • Elio Boeri
  • A Y Liu
  • B S Torchia
  • R F Siliciano

Detail Information

Publications16

  1. doi request reprint The single active X in human cells: evolutionary tinkering personified
    Barbara R Migeon
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University, 459 Broadway Research Building, 733 N Broadway, Baltimore, MD 21205, USA
    Hum Genet 130:281-93. 2011
    ..Further, I suggest that the initial events in the process-those that precede silencing of future inactive X chromosomes-include randomly choosing the future active X, most likely by repressing its XIST locus...
  2. doi request reprint X inactivation, female mosaicism, and sex differences in renal diseases
    Barbara R Migeon
    McKusick Nathans Institute of Genetic Medicine, 459 Broadway Research Building, 733 N Broadway, Baltimore, MD 21205, USA
    J Am Soc Nephrol 19:2052-9. 2008
    ..Even subtle differences in expression of many of the 1100 X-linked genes may contribute to sex differences in the clinical expression of renal diseases...
  3. ncbi request reprint X inactivation in triploidy and trisomy: the search for autosomal transfactors that choose the active X
    Barbara R Migeon
    The McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Eur J Hum Genet 16:153-62. 2008
    ..Thus, if a single key dose-sensitive gene induces XIST repression, it could reside in one of these locations. Alternatively, more than one dosage-sensitive autosomal locus is required to form the repressor complex...
  4. ncbi request reprint Why females are mosaics, X-chromosome inactivation, and sex differences in disease
    Barbara R Migeon
    McKusick Nathans Institute of Genetic Medicine, 459 Broadway Research Building, 773 N Broadway, Baltimore, MD 21205, USA
    Gend Med 4:97-105. 2007
    ....
  5. ncbi request reprint The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases
    Barbara R Migeon
    The McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 295:1428-33. 2006
    ..As a consequence, most X-linked mutations produce male-only diseases. Yet, in some cases the dynamic interactions between cells in mosaic females lead to female-specific disease manifestations...
  6. pmc Differential X reactivation in human placental cells: implications for reversal of X inactivation
    Barbara R Migeon
    The McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 77:355-64. 2005
    ..We suggest that, along with undermethylation, the apoptotic changes accompanying cessation of cell proliferation contribute to the reversal of inactivation, not only in placental cells, but also in oocytes entering meiosis...
  7. ncbi request reprint X chromosome inactivation: theme and variations
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore MD, USA
    Cytogenet Genome Res 99:8-16. 2002
    ..Elucidating the molecular basis for the single active X requires that we distinguish the mechanisms essential for the basic theme from those responsible for its variations...
  8. ncbi request reprint Human X inactivation center induces random X chromosome inactivation in male transgenic mice
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 3914, USA
    Genomics 59:113-21. 1999
    ..Interspecies XIC trangenes should facilitate further investigation of this process in humans and other mammals...
  9. pmc Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: implications for X inactivation
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA
    Am J Hum Genet 69:951-60. 2001
    ..These differences could explain the fact that X inactivation is not imprinted in human placenta, and they raise questions about the role of TSIX in random X inactivation...
  10. ncbi request reprint Low-copy-number human transgene is recognized as an X inactivation center in mouse ES cells, but fails to induce cis-inactivation in chimeric mice
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Genomics 71:156-62. 2001
    ..Human transgenes in chimeric mice provide a means to uncouple the key steps in this complex pathway and facilitate the search for essential components of the human XIC region...
  11. ncbi request reprint Severe phenotypes associated with inactive ring X chromosomes
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21287 3914, USA
    Am J Med Genet 93:52-7. 2000
    ....
  12. ncbi request reprint Non-random X chromosome inactivation in mammalian cells
    B R Migeon
    Center for Medical Genetics and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cytogenet Cell Genet 80:142-8. 1998
    ..I suggest that the skewing of inactivation patterns observed in human females most often occurs after random X inactivation, and is due mainly to cell selection favoring alleles that provide a relative growth advantage...
  13. ncbi request reprint The human NTT gene: identification of a novel 17-kb noncoding nuclear RNA expressed in activated CD4+ T cells
    A Y Liu
    Department of Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genomics 39:171-84. 1997
    ..Their proximity and shared expression pattern suggest a possible functional relationship...
  14. ncbi request reprint Is Tsix repression of Xist specific to mouse?
    Barbara R Migeon
    Nat Genet 33:337; author reply 337-8. 2003
  15. pmc Species differences in TSIX/Tsix reveal the roles of these genes in X-chromosome inactivation
    Barbara R Migeon
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Hum Genet 71:286-93. 2002
    ..Because human TSIX cannot imprint X inactivation in the placenta, it serves as a mutant for mouse Tsix, providing insights into features responsible for antisense activity in imprinted X inactivation...
  16. ncbi request reprint Familial nonrandom inactivation linked to the X inactivation centre in heterozygotes manifesting haemophilia A
    Maria Patrizia Bicocchi
    Thrombosis and Haemostasis Unit, Department of Haematology and Oncology, Giannina Gaslini Institute, Genova, Italy
    Eur J Hum Genet 13:635-40. 2005
    ..The skewing in this case seems to result from an abnormality in the initial choice process, which prevents the chromosome bearing the mutant FVIII allele from being an inactive X...

Research Grants24

  1. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1993
    ....
  2. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1980
    ..We will continue to develop the D-valine selective system for epithelial cells which have D-amino acid oxidase, an enzyme present only in differentiated cells. ..
  3. GENETIC STUDIES OF HUMAN SOMATIC CELLS
    BARBARA MIGEON; Fiscal Year: 1990
    ..7) We will continue studies of females for X linked mutations to characterize in vivo selection in mosaic cell populations...
  4. GENETIC STUDIES OF HUMAN CELLS
    BARBARA MIGEON; Fiscal Year: 2001
    ....