Michelle M Mielke

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 8:180-7. 2012
  2. pmc Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Bayview, Alpha Commons Building, 4th Floor, Room 454, Baltimore, MD 21224, USA
    Neuromolecular Med 12:331-40. 2010
  3. pmc The 32-year relationship between cholesterol and dementia from midlife to late life
    M M Mielke
    Johns Hopkins University School of Medicine, Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Bayview Alpha Commons Building, 4 floor Room 454, Baltimore, MD 21224, USA
    Neurology 75:1888-95. 2010
  4. pmc Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
    M M Mielke
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuroimage 46:47-55. 2009
  5. pmc Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study II
    Michelle M Mielke
    Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:619-24. 2008
  6. pmc Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 26:127-34. 2011
  7. pmc Serum sphingomyelins and ceramides are early predictors of memory impairment
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
    Neurobiol Aging 31:17-24. 2010
  8. ncbi request reprint Vascular factors predict rate of progression in Alzheimer disease
    M M Mielke
    Johns Hopkins University School of Medicine, Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
    Neurology 69:1850-8. 2007
  9. pmc Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 6:378-85. 2010
  10. ncbi request reprint Lipids and the pathogenesis of Alzheimer's disease: is there a link?
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, and the Alzheimer s Disease Research Center, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Int Rev Psychiatry 18:173-86. 2006

Detail Information

Publications36

  1. pmc Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 8:180-7. 2012
    ..Given this response and existence of side effects, we sought to quantify medication use and benefits in a population-based study of incident AD cases...
  2. pmc Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Bayview, Alpha Commons Building, 4th Floor, Room 454, Baltimore, MD 21224, USA
    Neuromolecular Med 12:331-40. 2010
    ..Lastly, the potential role of peripheral ceramides in AD pathogenesis is discussed, as well as the possible use of sphingolipids as biomarkers for AD...
  3. pmc The 32-year relationship between cholesterol and dementia from midlife to late life
    M M Mielke
    Johns Hopkins University School of Medicine, Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Bayview Alpha Commons Building, 4 floor Room 454, Baltimore, MD 21224, USA
    Neurology 75:1888-95. 2010
    ..Cellular and animal studies suggest that hypercholesterolemia contributes to Alzheimer disease (AD). However, the relationship between cholesterol and dementia at the population level is less clear and may vary over the lifespan...
  4. pmc Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
    M M Mielke
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuroimage 46:47-55. 2009
    ....
  5. pmc Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study II
    Michelle M Mielke
    Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:619-24. 2008
    ..We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains...
  6. pmc Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 26:127-34. 2011
    ..Among individuals with a history of stroke or myocardial infarction at baseline, progression of AD is influenced by APOE ε4 carrier status and varies by time after AD diagnosis...
  7. pmc Serum sphingomyelins and ceramides are early predictors of memory impairment
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
    Neurobiol Aging 31:17-24. 2010
    ..Results suggest serum SM and ceramides vary according to the timing of the onset of memory impairment and may be good pre-clinical predictors, or biomarkers, of memory impairment: a deficit observed early in AD pathogenesis...
  8. ncbi request reprint Vascular factors predict rate of progression in Alzheimer disease
    M M Mielke
    Johns Hopkins University School of Medicine, Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
    Neurology 69:1850-8. 2007
    ..While there is considerable epidemiologic evidence that cardiovascular risk factors increase risk of incident Alzheimer disease (AD), few studies have examined their effect on progression after an established AD diagnosis...
  9. pmc Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 6:378-85. 2010
    ..The present objective was to examine whether plasma ceramides varied by AD severity in a well-characterized clinic sample and were associated with cognitive decline and hippocampal volume loss over 1 year...
  10. ncbi request reprint Lipids and the pathogenesis of Alzheimer's disease: is there a link?
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, and the Alzheimer s Disease Research Center, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Int Rev Psychiatry 18:173-86. 2006
    ..Given the many possibilities through which lipids may be directly involved in or contribute to the pathogenesis of AD, the use of lipids as biomarkers for disease progression is discussed, as are other avenues for future research...
  11. ncbi request reprint Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late life
    Michelle M Mielke
    Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Alzheimer Dis Assoc Disord 20:30-6. 2006
    ..Nonetheless, serum potassium is a modifiable risk factor and further examination of the potassium-dementia relationship is warranted...
  12. pmc Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 8:105-13. 2012
    ....
  13. pmc The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease
    Paul B Rosenberg
    Johns Hopkins University School of Medicine, Division of Geriatric Psychiatry and Neuropsychiatry, Baltimore, MD 21224, USA
    Am J Geriatr Psychiatry 21:685-95. 2013
    ..Among persons with MCI, depression and anxiety have been associated with an increased risk of incident dementia. We examined whether neuropsychiatric symptoms in MCI increased the risk of incident dementia (all-cause) and incident AD...
  14. ncbi request reprint Apolipoprotein E genotype and lifetime cognitive decline
    Nicholas A Kozauer
    Division of Geriatric and Neuropsychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Int Psychogeriatr 20:109-23. 2008
    ..The relationship of apolipoprotein E (APOE) genotype to lifetime cognitive decline was examined over 22 years in a large community-based population study...
  15. pmc Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study
    Jeannie Marie S Leoutsakos
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Int Psychogeriatr 24:1561-70. 2012
    ..We sought to quantify the relationship in a population-based study of incident AD, and to compare global comorbidity ratings to counts of comorbid conditions and medications as predictors of AD progression...
  16. pmc Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment
    Ozioma C Okonkwo
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Neurol 68:113-9. 2011
    ..To examine the effect of specific cerebrospinal fluid (CSF) profiles on the rate of cognitive decline, disease progression, and risk of conversion to Alzheimer disease (AD) dementia in patients with amnestic mild cognitive impairment (MCI)...
  17. pmc Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus
    Michelle M Mielke
    Department of Psychiatry, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurovirol 16:445-56. 2010
    ..These findings suggest that the sphingomyelin:ceramide ratio for C18:0 may be a reasonable surrogate marker for memory dysfunction in HIV-infected subjects...
  18. pmc Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer's disease
    Milap A Nowrangi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    Alzheimers Dement 9:519-28. 2013
    ..There have not been many studies establishing its longitudinal utility...
  19. doi request reprint A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects
    Veera Venkata Ratnam Bandaru
    From the Department of Neurology, Division of Neuroimmunology and Neurological Infections V V R B, N S, J C M, C P, P C, N J H, and the Department of Psychiatry N J H, The Johns Hopkins University, School of Medicine, Baltimore, MD the Department of Health Sciences Research M M M, Division of Epidemiology, The Mayo Clinic, Rochester, MN HIV Neurobehavioral Research Program and Department of Psychiatry I G, S L, School of Medicine, University of California, San Diego, La Jolla the Department of Psychiatry L C, S M, University of Hawaii, John A Burns School of Medicine, Honolulu and the Department of Neurology V W, Specialized Neurosciences Research Program, University of Puerto Rico Medical Sciences Campus, San Juan
    Neurology 81:1492-9. 2013
    ..In this multicenter cohort study, we sought to identify prognostic and associative metabolic indicators for HIV-associated neurocognitive disorders (HAND)...
  20. pmc Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, U S A
    Int Psychogeriatr 20:871-89. 2008
    ..Several examples are used to illustrate each biomarker utility in the AD context...
  21. ncbi request reprint Transition to nursing home from assisted living is not associated with dementia or dementia-related problem behaviors
    Paul B Rosenberg
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD, USA
    J Am Med Dir Assoc 7:73-8. 2006
    ..To examine risk factors for transition from assisted living (AL) care to skilled nursing facility (SNF) care in a random sample of adults residing in AL...
  22. pmc Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Alzheimers Dis 27:259-69. 2011
    ..These results suggest that increased SM/ceramide and DHSM/DHCer ratios dose-dependently predict slower progression among AD patients and may be sensitive blood-based biomarkers for clinical progression...
  23. pmc Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction
    Paul B Rosenberg
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Geriatr Psychiatry 26:364-72. 2011
    ..Since dementia has been associated with a range of neuropsychiatric symptoms (NPS), we sought to examine the prevalence of NPS in MCI and its subtypes...
  24. pmc Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease
    Ozioma C Okonkwo
    Department of Neurology, Johns Hopkins School of Medicine, 1620 McElderry St, Reed Hall East 2, Baltimore, MD 21205, USA
    Arch Neurol 67:688-96. 2010
    ..To investigate the effect of cerebrospinal fluid (CSF) abnormalities on the rate of decline in everyday function in normal aging, mild cognitive impairment (MCI), and mild Alzheimer disease (AD)...
  25. pmc The fornix sign: a potential sign for Alzheimer's disease based on diffusion tensor imaging
    Kenichi Oishi
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neuroimaging 22:365-74. 2012
    ..We investigated a simple imaging sign for Alzheimer's disease (AD), using diffusion tensor imaging (DTI). We hypothesized that a reduction in fractional anisotropy (FA) in the fornix could be utilized as an imaging sign...
  26. pmc Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's dementia
    Sarah K Tighe
    Johns Hopkins University School of Medicine, Department of Psychiatry, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 24:484-8. 2012
    ..Further imaging studies are necessary to elucidate the role of the AC in the pathophysiology of neuropsychiatric symptoms in AD and MCI...
  27. pmc DTI analyses and clinical applications in Alzheimer's disease
    Kenichi Oishi
    The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Alzheimers Dis 26:287-96. 2011
    ..Application of these findings in clinical practice remains to be demonstrated...
  28. pmc Depressive symptoms predict incident cognitive impairment in cognitive healthy older women
    Paul B Rosenberg
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins Bayview Medical Center, Baltimore MD 21224, USA
    Am J Geriatr Psychiatry 18:204-11. 2010
    ..The authors sought to examine whether depression increased the risk of incident cognitive impairment in a longitudinal study of older women...
  29. pmc Predictors of new-onset depression after mild traumatic brain injury
    Vani Rao
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 22:100-4. 2010
    ..Identifying risk factors for mild TBI depression can aid in early diagnosis and treatment...
  30. pmc Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA)
    Melissa D Morgan
    Johns Hopkins University, Baltimore, MD 21224, USA
    Alzheimer Dis Assoc Disord 21:199-204. 2007
    ..These findings suggest that depression is a risk factor for AD in the presence of AD pathology, but depression is not a risk factor for AD pathology...
  31. ncbi request reprint High total cholesterol levels in late life associated with a reduced risk of dementia
    M M Mielke
    Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 64:1689-95. 2005
    ..To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia...
  32. pmc Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasma
    Esther S Oh
    Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 21:769-73. 2010
    ..However, the advantages of electrochemiluminescence detection technology include short processing time and small sample volume. This comparison demonstrates the need for a further study in optimizing this system...
  33. pmc Effects of cardiovascular medications on rate of functional decline in Alzheimer disease
    P B Rosenberg
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Geriatr Psychiatry 16:883-92. 2008
    ..We examined the association of cardiovascular medication use and rate of functional decline in a population-based cohort of individuals with incident AD...
  34. ncbi request reprint Differential effects of response-contingent and response-independent nicotine in rats
    E C Donny
    Department of Psychology, University of Pittsburgh, 412 Langley Hall, Pittsburgh, PA 15260, USA
    Eur J Pharmacol 402:231-40. 2000
    ..These differences indicate that nicotine's acute effects are powerfully modified by the presence of a contingency relationship between drug administration and the animal's behavior and that this relationship develops very rapidly...
  35. ncbi request reprint Caregiver assessment of patients' depression in Alzheimer disease: longitudinal analysis in a drug treatment study
    Paul B Rosenberg
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, 550 N Broadway 308, Baltimore, MD 21205, USA
    Am J Geriatr Psychiatry 13:822-6. 2005
    ..Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input...
  36. ncbi request reprint Hematologic risk factors of vascular disease and their relation to dementia
    Michelle M Mielke
    Center on Aging and Health and the Alzheimer Disease Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dement Geriatr Cogn Disord 21:335-52. 2006
    ..A necessary step is to examine multiple hematologic factors simultaneously, rather than in isolation, to determine how these factors are interrelated...

Research Grants3