Research Topics
Species | Michelle M MielkeSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progressionMichelle M Mielke
Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Alzheimers Dement 8:180-7. 2012..Given this response and existence of side effects, we sought to quantify medication use and benefits in a population-based study of incident AD cases...- The 32-year relationship between cholesterol and dementia from midlife to late lifeM M Mielke
Johns Hopkins University School of Medicine, Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Bayview Alpha Commons Building, 4 floor Room 454, Baltimore, MD 21224, USA
Neurology 75:1888-95. 2010..Cellular and animal studies suggest that hypercholesterolemia contributes to Alzheimer disease (AD). However, the relationship between cholesterol and dementia at the population level is less clear and may vary over the lifespan... - Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume lossMichelle M Mielke
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Alzheimers Dement 6:378-85. 2010..The present objective was to examine whether plasma ceramides varied by AD severity in a well-characterized clinic sample and were associated with cognitive decline and hippocampal volume loss over 1 year... - Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?Michelle M Mielke
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Bayview, Alpha Commons Building, 4th Floor, Room 454, Baltimore, MD 21224, USA
Neuromolecular Med 12:331-40. 2010..Lastly, the potential role of peripheral ceramides in AD pathogenesis is discussed, as well as the possible use of sphingolipids as biomarkers for AD... - Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's diseaseM M Mielke
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neuroimage 46:47-55. 2009.... - Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's diseaseMichelle M Mielke
Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Alzheimers Dis 26:127-34. 2011..Among individuals with a history of stroke or myocardial infarction at baseline, progression of AD is influenced by APOE ε4 carrier status and varies by time after AD diagnosis... - Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study IIMichelle M Mielke
Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 63:619-24. 2008..We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains... - Serum sphingomyelins and ceramides are early predictors of memory impairmentMichelle M Mielke
Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
Neurobiol Aging 31:17-24. 2010..Results suggest serum SM and ceramides vary according to the timing of the onset of memory impairment and may be good pre-clinical predictors, or biomarkers, of memory impairment: a deficit observed early in AD pathogenesis... 
Vascular factors predict rate of progression in Alzheimer diseaseM M Mielke
Johns Hopkins University School of Medicine, Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
Neurology 69:1850-8. 2007..While there is considerable epidemiologic evidence that cardiovascular risk factors increase risk of incident Alzheimer disease (AD), few studies have examined their effect on progression after an established AD diagnosis...- Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late lifeMichelle M Mielke
Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Alzheimer Dis Assoc Disord 20:30-6. 2006..Nonetheless, serum potassium is a modifiable risk factor and further examination of the potassium-dementia relationship is warranted... - Lipids and the pathogenesis of Alzheimer's disease: is there a link?Michelle M Mielke
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, and the Alzheimer s Disease Research Center, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
Int Rev Psychiatry 18:173-86. 2006..Given the many possibilities through which lipids may be directly involved in or contribute to the pathogenesis of AD, the use of lipids as biomarkers for disease progression is discussed, as are other avenues for future research... - Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's diseaseMichelle M Mielke
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Alzheimers Dement 8:105-13. 2012.... - Apolipoprotein E genotype and lifetime cognitive declineNicholas A Kozauer
Division of Geriatric and Neuropsychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Int Psychogeriatr 20:109-23. 2008..The relationship of apolipoprotein E (APOE) genotype to lifetime cognitive decline was examined over 22 years in a large community-based population study... - Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression StudyJeannie Marie S Leoutsakos
Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Int Psychogeriatr 24:1561-70. 2012..We sought to quantify the relationship in a population-based study of incident AD, and to compare global comorbidity ratings to counts of comorbid conditions and medications as predictors of AD progression... - Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairmentOzioma C Okonkwo
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Arch Neurol 68:113-9. 2011..To examine the effect of specific cerebrospinal fluid (CSF) profiles on the rate of cognitive decline, disease progression, and risk of conversion to Alzheimer disease (AD) dementia in patients with amnestic mild cognitive impairment (MCI)... - Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virusMichelle M Mielke
Department of Psychiatry, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurovirol 16:445-56. 2010..These findings suggest that the sphingomyelin:ceramide ratio for C18:0 may be a reasonable surrogate marker for memory dysfunction in HIV-infected subjects... - Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapiesConstantine G Lyketsos
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, U S A
Int Psychogeriatr 20:871-89. 2008..Several examples are used to illustrate each biomarker utility in the AD context... - Transition to nursing home from assisted living is not associated with dementia or dementia-related problem behaviorsPaul B Rosenberg
Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD, USA
J Am Med Dir Assoc 7:73-8. 2006..To examine risk factors for transition from assisted living (AL) care to skilled nursing facility (SNF) care in a random sample of adults residing in AL... - Plasma sphingomyelins are associated with cognitive progression in Alzheimer's diseaseMichelle M Mielke
Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Alzheimers Dis 27:259-69. 2011..These results suggest that increased SM/ceramide and DHSM/DHCer ratios dose-dependently predict slower progression among AD patients and may be sensitive blood-based biomarkers for clinical progression... - Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer diseaseOzioma C Okonkwo
Department of Neurology, Johns Hopkins School of Medicine, 1620 McElderry St, Reed Hall East 2, Baltimore, MD 21205, USA
Arch Neurol 67:688-96. 2010..To investigate the effect of cerebrospinal fluid (CSF) abnormalities on the rate of decline in everyday function in normal aging, mild cognitive impairment (MCI), and mild Alzheimer disease (AD)... - Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunctionPaul B Rosenberg
Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int J Geriatr Psychiatry 26:364-72. 2011..Since dementia has been associated with a range of neuropsychiatric symptoms (NPS), we sought to examine the prevalence of NPS in MCI and its subtypes... - DTI analyses and clinical applications in Alzheimer's diseaseKenichi Oishi
The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
J Alzheimers Dis 26:287-96. 2011..Application of these findings in clinical practice remains to be demonstrated... - Depressive symptoms predict incident cognitive impairment in cognitive healthy older womenPaul B Rosenberg
Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins Bayview Medical Center, Baltimore MD 21224, USA
Am J Geriatr Psychiatry 18:204-11. 2010..The authors sought to examine whether depression increased the risk of incident cognitive impairment in a longitudinal study of older women... - Predictors of new-onset depression after mild traumatic brain injuryVani Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Neuropsychiatry Clin Neurosci 22:100-4. 2010..Identifying risk factors for mild TBI depression can aid in early diagnosis and treatment... - Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA)Melissa D Morgan
Johns Hopkins University, Baltimore, MD 21224, USA
Alzheimer Dis Assoc Disord 21:199-204. 2007..These findings suggest that depression is a risk factor for AD in the presence of AD pathology, but depression is not a risk factor for AD pathology... - High total cholesterol levels in late life associated with a reduced risk of dementiaM M Mielke
Center on Aging and Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Neurology 64:1689-95. 2005..To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia... - Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's dementiaSarah K Tighe
Johns Hopkins University School of Medicine, Department of Psychiatry, Baltimore, MD, USA
J Neuropsychiatry Clin Neurosci 24:484-8. 2012..Further imaging studies are necessary to elucidate the role of the AC in the pathophysiology of neuropsychiatric symptoms in AD and MCI... - The fornix sign: a potential sign for Alzheimer's disease based on diffusion tensor imagingKenichi Oishi
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neuroimaging 22:365-74. 2012..We investigated a simple imaging sign for Alzheimer's disease (AD), using diffusion tensor imaging (DTI). We hypothesized that a reduction in fractional anisotropy (FA) in the fornix could be utilized as an imaging sign... - Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasmaEsther S Oh
Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Alzheimers Dis 21:769-73. 2010..However, the advantages of electrochemiluminescence detection technology include short processing time and small sample volume. This comparison demonstrates the need for a further study in optimizing this system... - Effects of cardiovascular medications on rate of functional decline in Alzheimer diseaseP B Rosenberg
Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Geriatr Psychiatry 16:883-92. 2008..We examined the association of cardiovascular medication use and rate of functional decline in a population-based cohort of individuals with incident AD... - Differential effects of response-contingent and response-independent nicotine in ratsE C Donny
Department of Psychology, University of Pittsburgh, 412 Langley Hall, Pittsburgh, PA 15260, USA
Eur J Pharmacol 402:231-40. 2000..These differences indicate that nicotine's acute effects are powerfully modified by the presence of a contingency relationship between drug administration and the animal's behavior and that this relationship develops very rapidly... - Caregiver assessment of patients' depression in Alzheimer disease: longitudinal analysis in a drug treatment studyPaul B Rosenberg
Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, 550 N Broadway 308, Baltimore, MD 21205, USA
Am J Geriatr Psychiatry 13:822-6. 2005..Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input... - Hematologic risk factors of vascular disease and their relation to dementiaMichelle M Mielke
Center on Aging and Health and the Alzheimer Disease Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Dement Geriatr Cogn Disord 21:335-52. 2006..A necessary step is to examine multiple hematologic factors simultaneously, rather than in isolation, to determine how these factors are interrelated...
Research Grants
- Blood-based lipid biomarkers reflective of Alzheimer-associated neurodegenerationMichelle Mielke; Fiscal Year: 2007....