E Mezey

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway
    E Mezey
    Department of Medicine, Johns Hopkins University School of Medicine, 921 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 285:644-8. 2001
  2. doi The combination of selenium and vitamin E inhibits type I collagen formation in cultured hepatic stellate cells
    Esteban Mezey
    Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
    Biol Trace Elem Res 140:82-94. 2011
  3. ncbi A randomized placebo controlled trial of vitamin E for alcoholic hepatitis
    Esteban Mezey
    Department of Medicine, 921 Ross Building, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Hepatol 40:40-6. 2004
  4. ncbi Effect of leptin on liver alcohol dehydrogenase
    Esteban Mezey
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Biochem Biophys Res Commun 337:1324-9. 2005
  5. ncbi A transient increase in c-myc precedes the transdifferentiation of hepatic stellate cells to myofibroblast-like cells
    J J Potter
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Liver 19:135-44. 1999
  6. ncbi Acetaldehyde enhances murine alpha2(I) collagen promoter activity by Ca2+-independent protein kinase C activation in cultured rat hepatic stellate cells
    F A Anania
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Alcohol Clin Exp Res 23:279-84. 1999
  7. ncbi Identification of new sites of binding and activation of the murine alpha1(I) collagen promoter by CCAAT/enhancer binding protein beta
    F A Attard
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA
    DNA Cell Biol 20:455-63. 2001
  8. ncbi Leptin deficiency reduces but does not eliminate the development of hepatic fibrosis in mice infected with Schistosoma mansoni
    James J Potter
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Liver 22:173-7. 2002
  9. ncbi Effect of STAT5b on rat liver alcohol dehydrogenase
    J J Potter
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA
    Arch Biochem Biophys 391:41-8. 2001
  10. ncbi Identification of elf1, a beta-spectrin, in early mouse liver development
    L Mishra
    Department of Medicine, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    Int J Dev Biol 42:221-4. 1998

Research Grants

  1. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2000
  2. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2005
  3. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2007
  4. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2006
  5. EFFECTS OF ALCOHOL ON MOLECULAR AND CELLULAR PATHOLOGY
    Esteban Mezey; Fiscal Year: 2007
  6. ALCOHOL METABOLISM AND HEPATIC FIBROGENESIS
    Esteban Mezey; Fiscal Year: 1980
  7. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 1993
  8. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 1991
  9. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2010

Collaborators

Detail Information

Publications32

  1. ncbi Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway
    E Mezey
    Department of Medicine, Johns Hopkins University School of Medicine, 921 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 285:644-8. 2001
    ..These results suggest that the ubiquitin-proteasome pathway plays a role in the degradation of ADH and in the enhanced degradation of this enzyme by DHT...
  2. doi The combination of selenium and vitamin E inhibits type I collagen formation in cultured hepatic stellate cells
    Esteban Mezey
    Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
    Biol Trace Elem Res 140:82-94. 2011
    ..This effect is due to a combination of decreased formation, decreased stability and increased degradation of the collagen...
  3. ncbi A randomized placebo controlled trial of vitamin E for alcoholic hepatitis
    Esteban Mezey
    Department of Medicine, 921 Ross Building, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Hepatol 40:40-6. 2004
    ....
  4. ncbi Effect of leptin on liver alcohol dehydrogenase
    Esteban Mezey
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Biochem Biophys Res Commun 337:1324-9. 2005
    ..The effect of leptin in enhancing translational initiating factors may be of significance in the regulation not only of ADH but also of many other proteins...
  5. ncbi A transient increase in c-myc precedes the transdifferentiation of hepatic stellate cells to myofibroblast-like cells
    J J Potter
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Liver 19:135-44. 1999
    ..The purpose of this study was to determine the presence of retinoids and the expression of the immediate early genes as they relate to the transdifferentiation of liver stellate cells in culture...
  6. ncbi Acetaldehyde enhances murine alpha2(I) collagen promoter activity by Ca2+-independent protein kinase C activation in cultured rat hepatic stellate cells
    F A Anania
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Alcohol Clin Exp Res 23:279-84. 1999
    ..Similarly, D609, an inhibitor of DAG production, also inhibited alpha2(I) collagen gene expression. This study shows that collagen production by acetaldehyde is mediated by a calcium-independent PKC mechanism...
  7. ncbi Identification of new sites of binding and activation of the murine alpha1(I) collagen promoter by CCAAT/enhancer binding protein beta
    F A Attard
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA
    DNA Cell Biol 20:455-63. 2001
    ..Binding of the 20-kDa C/EBPbeta isoform (p20C/EBPbeta), which is eliminated by mutation at the distal site 3 of C/EBP binding, is necessary for the activation by acetaldehyde of the alpha(1)(I) collagen promoter...
  8. ncbi Leptin deficiency reduces but does not eliminate the development of hepatic fibrosis in mice infected with Schistosoma mansoni
    James J Potter
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Liver 22:173-7. 2002
    ....
  9. ncbi Effect of STAT5b on rat liver alcohol dehydrogenase
    J J Potter
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA
    Arch Biochem Biophys 391:41-8. 2001
    ..These observations indicate that the enhancing effect of GH is mediated by both STAT5b and C/EBP beta...
  10. ncbi Identification of elf1, a beta-spectrin, in early mouse liver development
    L Mishra
    Department of Medicine, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
    Int J Dev Biol 42:221-4. 1998
    ..5 hepatic tissue. These studies suggest that elf1 may play a role in the emergence of hepatocyte polarity during liver development...
  11. ncbi Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in mice
    Lan Wang
    Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins University, Baltimore, MD 21205 2195, USA
    Biochim Biophys Acta 1772:66-71. 2007
    ..The data also provide evidence that RA reduces CCl4 induced oxidative stress in liver, suggesting that the anti-fibrotic role of RA is not limited to the inhibition of type I collagen expression...
  12. pmc Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
    Anutosh Chakraborty
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 143:897-910. 2010
    ..IP6K1 knockout mice manifest insulin sensitivity and are resistant to obesity elicited by high-fat diet or aging. Inhibition of IP6K1 may afford a therapeutic approach to obesity and diabetes...
  13. ncbi Acetaldehyde activates the promoter of the mouse alpha 2(I) collagen gene
    A Pares
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Hepatology 19:498-503. 1994
    ..This study shows that acetaldehyde and transforming growth factor-beta 1 independently activate the mouse alpha 2(I) collagen promoter and that this activation is mediated by the same proximal region of the promoter...
  14. ncbi Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration
    James J Potter
    Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
    J Hepatol 38:281-8. 2003
    ..Leptin, a product of the obese (ob) gene is present in activated stellate cells. This study investigated whether leptin is essential for the development of hepatic fibrosis caused by various agents...
  15. ncbi Acetaldehyde increases endogenous adiponectin and fibrogenesis in hepatic stellate cells but exogenous adiponectin inhibits fibrogenesis
    James J Potter
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 31:2092-100. 2007
    ....
  16. ncbi Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter
    Gennadiy Novitskiy
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Biol Chem 279:15639-44. 2004
    ..The effects of acetaldehyde in increasing the translocation of NF-kappaB to the nucleus with increased DNA binding activity may be important in mediating the effects of acetaldehyde on other genes...
  17. ncbi Endotoxin enhances liver alcohol dehydrogenase by action through upstream stimulatory factor but not by nuclear factor-kappa B
    James J Potter
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:4353-7. 2003
    ..This study shows that LPS increases ADH and that this effect is mediated by increased binding of USF to the ADH promoter and not by NF-kappaB, which has an inhibitory action...
  18. ncbi The adult enhancer factor-1, a Drosophila melanogaster transcriptional repressor, modulates the promoter activity of the rat class-I alcohol dehydrogenase-encoding gene
    J J Potter
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Gene 149:325-30. 1994
    ..These experiments suggest an evolutionarily conserved mechanism by which AEF-1 modulates expression of the D. melanogaster and rat ADH genes...
  19. doi Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes
    Aki Kaimori
    Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hepatology 52:1033-45. 2010
    ..CONCLUSION: Histone deacetylase inhibition abrogates TGFbeta1-induced EMT in hepatocytes and reverses EMT-induced fibrosis by epigenetic modulation of type I collagen...
  20. pmc Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration
    Ming Ding
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Biol Trace Elem Res 133:83-97. 2010
    ..The principal mechanisms for the decreased fibrosis are a lower number of collagen-producing stellate cells and increased collagen degradation...
  21. pmc Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration
    Ghazaleh Aram
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Hepatology 49:911-9. 2009
    ..Matrix metalloproteinase-2 (MMP-2) and MMP-9 mRNA increased more in the gp91(phox(-/-) ) than in WT mice after CCl(4.) Tissue inhibitor of metalloproteinase 1 (TIMP-1) and TIMP-2 increased after CCl(4) only in the gp91(phox(-/-) ) mice...
  22. doi Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration
    Ghazaleh Aram
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Hepatology 47:2051-8. 2008
    ..05). However, MMP-9 and TIMP-1 protein, determined by western blot, were similarly increased after CCl(4) in both groups of mice...
  23. ncbi Regulation of the murine alpha(2)(I) collagen promoter by retinoic acid and retinoid X receptors
    Lan Wang
    Department of Medicine, 921 Ross Research Building, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Arch Biochem Biophys 401:262-70. 2002
    ..This study shows that the suppressive effect of retinoic acid on the promoter is maximal with a combination of RARbeta and RXRalpha and occurs at more than one RARE site. The effect of retinoic acid is not mediated by AP-2...
  24. ncbi Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesis
    Gennadiy Novitskiy
    Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins University, Baltimore 21205 2195, MD, USA
    Liver Int 26:1248-57. 2006
    ..This study determined the roles of NAD(P)H oxidase, which generates reactive oxygen species (ROS), and of inducible nitric oxide synthase (iNOS), which generates nitric oxide (NO) on the development of hepatic fibrosis in mice...
  25. ncbi Leptin enhances the effect of transforming growth factor beta in increasing type I collagen formation
    Mei Tang
    Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, 921 Ross Research Building, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 297:906-11. 2002
    ....
  26. ncbi Effects of acetaldehyde and TNF alpha on the inhibitory kappa B-alpha protein and nuclear factor kappa B activation in hepatic stellate cells
    Gennadiy Novitskiy
    Department of Medicine, 921 Ross Research Building, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
    Alcohol Alcohol 40:96-101. 2005
    ..This study determined the effects of acetaldehyde in comparison to the effects of TNFalpha on inhibitory kappa B-alpha (IkappaB-alpha) protein and NF-kappaB activation in hepatic stellate cells...
  27. ncbi Leptin deficiency prevents the activation of the murine alpaha 2(I) collagen promoter by acetaldehyde
    James J Potter
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Arch Biochem Biophys 426:73-7. 2004
    ....
  28. ncbi Activation of the human alpha1(I) collagen promoter by leptin is not mediated by transforming growth factor beta responsive elements
    Mei Tang
    Department of Medicine, The Johns Hopkins University School of Medicine, 710 Rutland Avenue, 921 Ross Research Building, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 312:629-33. 2003
    ..In conclusion, this study shows that leptin activates the alpha1 (I) collagen gene and that this effect is not mediated by TGFbeta responsive elements...
  29. ncbi Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    Aki Kaimori
    Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 282:22089-101. 2007
    ..Our findings support a potentially crucial role for EMT in the development and progression of hepatic fibrogenesis...
  30. ncbi Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors
    Lan Wang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Biochem Biophys 428:92-8. 2004
    ....
  31. pmc Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors
    Polina Sysa
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    DNA Cell Biol 28:425-34. 2009
    ....
  32. ncbi A case of severe benign intrahepatic cholestasis treated with liver transplantation
    Esteban Mezey
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Gastroenterol 97:475-7. 2002
    ..He underwent orthotopic liver transplantation at age 25 with immediate resolution of his pruritus. At age 30 he is a happy, asymptomatic, fully employed professional...

Research Grants40

  1. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2000
    ....
  2. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2005
    ..The mechanism whereby acetaldehyde increases nuclear C/EBP-beta protein and binding to the collagen promoter will be determined. ..
  3. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2007
    ..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effect of TGF p and acetaldehyde on the human i (I) collagen promoter will be investigated. ..
  4. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2006
    ..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effects of TGF( and acetaldehyde on the human al (I) collagen promoter will be investigated ..
  5. EFFECTS OF ALCOHOL ON MOLECULAR AND CELLULAR PATHOLOGY
    Esteban Mezey; Fiscal Year: 2007
    ..The final objective is to instill in the trainee the ability to approach original questions of research relating to the pathogenesis of damaging effects of alcoholism on the body. ..
  6. ALCOHOL METABOLISM AND HEPATIC FIBROGENESIS
    Esteban Mezey; Fiscal Year: 1980
    ..The possible causes of the increase in the enzyme are being investigated. ..
  7. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 1993
    ..The binding of histone H1 to the alpha2(I) collagen promoter and the effect of its ribosylation on the binding to and expression of this collagen gene will be studied...
  8. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 1991
    ....
  9. HORMONAL REGULATION OF ETHANOL METABOLISM
    Esteban Mezey; Fiscal Year: 2010
    ..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effect of TGFalpha and acetaldehyde on the human alpha1 (I) collagen promoter will be investigated. ..