Research Topics
Genomes and Genes | E MezeySummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathwayE Mezey
Department of Medicine, Johns Hopkins University School of Medicine, 921 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Biochem Biophys Res Commun 285:644-8. 2001..These results suggest that the ubiquitin-proteasome pathway plays a role in the degradation of ADH and in the enhanced degradation of this enzyme by DHT...
The combination of selenium and vitamin E inhibits type I collagen formation in cultured hepatic stellate cellsEsteban Mezey
Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
Biol Trace Elem Res 140:82-94. 2011..This effect is due to a combination of decreased formation, decreased stability and increased degradation of the collagen...- A randomized placebo controlled trial of vitamin E for alcoholic hepatitisEsteban Mezey
Department of Medicine, 921 Ross Building, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
J Hepatol 40:40-6. 2004.... - Effect of leptin on liver alcohol dehydrogenaseEsteban Mezey
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
Biochem Biophys Res Commun 337:1324-9. 2005..The effect of leptin in enhancing translational initiating factors may be of significance in the regulation not only of ADH but also of many other proteins... - A transient increase in c-myc precedes the transdifferentiation of hepatic stellate cells to myofibroblast-like cellsJ J Potter
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
Liver 19:135-44. 1999..The purpose of this study was to determine the presence of retinoids and the expression of the immediate early genes as they relate to the transdifferentiation of liver stellate cells in culture... - Acetaldehyde enhances murine alpha2(I) collagen promoter activity by Ca2+-independent protein kinase C activation in cultured rat hepatic stellate cellsF A Anania
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
Alcohol Clin Exp Res 23:279-84. 1999..Similarly, D609, an inhibitor of DAG production, also inhibited alpha2(I) collagen gene expression. This study shows that collagen production by acetaldehyde is mediated by a calcium-independent PKC mechanism... - Identification of new sites of binding and activation of the murine alpha1(I) collagen promoter by CCAAT/enhancer binding protein betaF A Attard
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA
DNA Cell Biol 20:455-63. 2001..Binding of the 20-kDa C/EBPbeta isoform (p20C/EBPbeta), which is eliminated by mutation at the distal site 3 of C/EBP binding, is necessary for the activation by acetaldehyde of the alpha(1)(I) collagen promoter... - Leptin deficiency reduces but does not eliminate the development of hepatic fibrosis in mice infected with Schistosoma mansoniJames J Potter
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA
Liver 22:173-7. 2002..CONCLUSIONS: This study shows that leptin is a potentiating, but not an essential factor, for the development of hepatic fibrosis, because leptin deficiency reduces but does not prevent the development of hepatic fibrosis... - Effect of STAT5b on rat liver alcohol dehydrogenaseJ J Potter
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA
Arch Biochem Biophys 391:41-8. 2001..These observations indicate that the enhancing effect of GH is mediated by both STAT5b and C/EBP beta... - Identification of elf1, a beta-spectrin, in early mouse liver developmentL Mishra
Department of Medicine, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA
Int J Dev Biol 42:221-4. 1998..5 hepatic tissue. These studies suggest that elf1 may play a role in the emergence of hepatocyte polarity during liver development... - Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in miceLan Wang
Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins University, Baltimore, MD 21205 2195, USA
Biochim Biophys Acta 1772:66-71. 2007..The data also provide evidence that RA reduces CCl4 induced oxidative stress in liver, suggesting that the anti-fibrotic role of RA is not limited to the inhibition of type I collagen expression... 
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gainAnutosh Chakraborty
The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 143:897-910. 2010..IP6K1 knockout mice manifest insulin sensitivity and are resistant to obesity elicited by high-fat diet or aging. Inhibition of IP6K1 may afford a therapeutic approach to obesity and diabetes...- Acetaldehyde activates the promoter of the mouse alpha 2(I) collagen geneA Pares
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Hepatology 19:498-503. 1994..This study shows that acetaldehyde and transforming growth factor-beta 1 independently activate the mouse alpha 2(I) collagen promoter and that this activation is mediated by the same proximal region of the promoter... - Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administrationJames J Potter
Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205-2195, USA
J Hepatol 38:281-8. 2003..The effect of leptin in potentiating fibrogenesis is most likely mediated by TGFbeta1... - Acetaldehyde increases endogenous adiponectin and fibrogenesis in hepatic stellate cells but exogenous adiponectin inhibits fibrogenesisJames J Potter
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Alcohol Clin Exp Res 31:2092-100. 2007.... - Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoterGennadiy Novitskiy
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
J Biol Chem 279:15639-44. 2004..The effects of acetaldehyde in increasing the translocation of NF-kappaB to the nucleus with increased DNA binding activity may be important in mediating the effects of acetaldehyde on other genes... - Endotoxin enhances liver alcohol dehydrogenase by action through upstream stimulatory factor but not by nuclear factor-kappa BJames J Potter
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 278:4353-7. 2003..This study shows that LPS increases ADH and that this effect is mediated by increased binding of USF to the ADH promoter and not by NF-kappaB, which has an inhibitory action... - The adult enhancer factor-1, a Drosophila melanogaster transcriptional repressor, modulates the promoter activity of the rat class-I alcohol dehydrogenase-encoding geneJ J Potter
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Gene 149:325-30. 1994..These experiments suggest an evolutionarily conserved mechanism by which AEF-1 modulates expression of the D. melanogaster and rat ADH genes... - Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytesAki Kaimori
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Hepatology 52:1033-45. 2010..CONCLUSION: Histone deacetylase inhibition abrogates TGFbeta1-induced EMT in hepatocytes and reverses EMT-induced fibrosis by epigenetic modulation of type I collagen... - Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administrationMing Ding
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
Biol Trace Elem Res 133:83-97. 2010..The principal mechanisms for the decreased fibrosis are a lower number of collagen-producing stellate cells and increased collagen degradation... - Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administrationGhazaleh Aram
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Hepatology 49:911-9. 2009..CONCLUSION: Decreased hepatic fibrosis after chronic CCl(4) administration in mice with NADPH oxidase deficiency occurs in the setting of greater necrosis and inflammation but decreased apoptosis... - Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administrationGhazaleh Aram
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
Hepatology 47:2051-8. 2008..CONCLUSION: NO protects against CCl(4)-induced apoptosis. In the absence of iNOS, there is decreased necrosis, increased apoptosis, and reduced liver fibrosis... - Regulation of the murine alpha(2)(I) collagen promoter by retinoic acid and retinoid X receptorsLan Wang
Department of Medicine, 921 Ross Research Building, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Arch Biochem Biophys 401:262-70. 2002..This study shows that the suppressive effect of retinoic acid on the promoter is maximal with a combination of RARbeta and RXRalpha and occurs at more than one RARE site. The effect of retinoic acid is not mediated by AP-2... - Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesisGennadiy Novitskiy
Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins University, Baltimore 21205-2195, MD, USA
Liver Int 26:1248-57. 2006..Likely causes for this inhibitory effects are decreases in the production of ROS in NAD(P)H deficiency and of peroxinitrite radicals in iNOS deficiency... - Leptin enhances the effect of transforming growth factor beta in increasing type I collagen formationMei Tang
Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, 921 Ross Research Building, Baltimore, MD 21205, USA
Biochem Biophys Res Commun 297:906-11. 2002.... - Effects of acetaldehyde and TNF alpha on the inhibitory kappa B-alpha protein and nuclear factor kappa B activation in hepatic stellate cellsGennadiy Novitskiy
Department of Medicine, 921 Ross Research Building, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205-2195, USA
Alcohol Alcohol 40:96-101. 2005.... - Leptin deficiency prevents the activation of the murine alpaha 2(I) collagen promoter by acetaldehydeJames J Potter
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2195, USA
Arch Biochem Biophys 426:73-7. 2004.... - Activation of the human alpha1(I) collagen promoter by leptin is not mediated by transforming growth factor beta responsive elementsMei Tang
Department of Medicine, The Johns Hopkins University School of Medicine, 710 Rutland Avenue, 921 Ross Research Building, Baltimore, MD 21205, USA
Biochem Biophys Res Commun 312:629-33. 2003..In conclusion, this study shows that leptin activates the alpha1 (I) collagen gene and that this effect is not mediated by TGFbeta responsive elements... - Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitroAki Kaimori
Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Biol Chem 282:22089-101. 2007..Our findings support a potentially crucial role for EMT in the development and progression of hepatic fibrogenesis... - Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactorsLan Wang
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Arch Biochem Biophys 428:92-8. 2004.... - Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factorsPolina Sysa
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
DNA Cell Biol 28:425-34. 2009.... - A case of severe benign intrahepatic cholestasis treated with liver transplantationEsteban Mezey
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Gastroenterol 97:475-7. 2002..He underwent orthotopic liver transplantation at age 25 with immediate resolution of his pruritus. At age 30 he is a happy, asymptomatic, fully employed professional...
Research Grants
- HORMONAL REGULATION OF ETHANOL METABOLISMEsteban Mezey; Fiscal Year: 2000....
- HORMONAL REGULATION OF ETHANOL METABOLISMEsteban Mezey; Fiscal Year: 2005..The mechanism whereby acetaldehyde increases nuclear C/EBP-beta protein and binding to the collagen promoter will be determined. ..
- HORMONAL REGULATION OF ETHANOL METABOLISMEsteban Mezey; Fiscal Year: 2007..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effect of TGF p and acetaldehyde on the human i (I) collagen promoter will be investigated. ..
- HORMONAL REGULATION OF ETHANOL METABOLISMEsteban Mezey; Fiscal Year: 2006..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effects of TGF( and acetaldehyde on the human al (I) collagen promoter will be investigated ..
- EFFECTS OF ALCOHOL ON MOLECULAR AND CELLULAR PATHOLOGYEsteban Mezey; Fiscal Year: 2007..The final objective is to instill in the trainee the ability to approach original questions of research relating to the pathogenesis of damaging effects of alcoholism on the body. ..
- ALCOHOL METABOLISM AND HEPATIC FIBROGENESISEsteban Mezey; Fiscal Year: 1980..The possible causes of the increase in the enzyme are being investigated. ..
- HORMONAL REGULATION OF ETHANOL METABOLISMEsteban Mezey; Fiscal Year: 1993..The binding of histone H1 to the alpha2(I) collagen promoter and the effect of its ribosylation on the binding to and expression of this collagen gene will be studied...
- HORMONAL REGULATION OF ETHANOL METABOLISMEsteban Mezey; Fiscal Year: 1991....
- HORMONAL REGULATION OF ETHANOL METABOLISMEsteban Mezey; Fiscal Year: 2010..Furthermore, the role of oxidant stress and nitric oxide as mediators of the activating effect of TGFalpha and acetaldehyde on the human alpha1 (I) collagen promoter will be investigated. ..