Research Topics
| Shruti MehtaSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Publications
HIV incidence among injection drug users in Baltimore, Maryland (1988-2004)Shruti H Mehta
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21202, USA
J Acquir Immune Defic Syndr 43:368-72. 2006..We examined recent trends (1999-2004) in HIV incidence among a cohort of injection drug users (IDUs) followed since 1988 in Baltimore, Maryland...
Stability of liver fibrosis among HCV-infected injection drug usersShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Antivir Ther 17:813-21. 2012....
Provider and clinic-level correlates of deferring antiretroviral therapy for people who inject drugs: a survey of North American HIV providersRyan P Westergaard
Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, USA
J Int AIDS Soc 15:10. 2012..We sought to estimate the degree to which providers of HIV care defer initiation of ART because of injection drug use and to identify clinic and provider-level factors associated with resistance to prescribing ART to IDUs...- Factors associated with injection cessation, relapse and initiation in a community-based cohort of injection drug users in Chennai, IndiaShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Addiction 107:349-58. 2012..To characterize factors associated with injection cessation, relapse and initiation... - Cross sectional analysis of respiratory symptoms in an injection drug user cohort: the impact of obstructive lung disease and HIVM Bradley Drummond
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
BMC Pulm Med 10:27. 2010..We characterized the independent and joint effects of HIV and OLD on respiratory symptoms of a cohort of inner-city IDUs... - The intersection between sex and drugs: a cross-sectional study among the spouses of injection drug users in Chennai, IndiaSunil S Solomon
YR Gaitonde Centre for AIDS Research and Education, VHS Adyar, Taramani, Chennai 600113, India
BMC Public Health 11:39. 2011..1 million injection drug users (IDUs) in India; the majority are likely married. We characterize HIV, hepatitis B (HBV) and hepatitis C (HCV) prevalence and the risk environment of a sample of spouses of IDUs... - Serum albumin as a prognostic indicator for HIV disease progressionShruti H Mehta
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
AIDS Res Hum Retroviruses 22:14-21. 2006.... - Temporal trends in highly active antiretroviral therapy initiation among injection drug users in Baltimore, Maryland, 1996-2008Shruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Clin Infect Dis 50:1664-71. 2010..We characterized temporal trends in highly active antiretroviral therapy (HAART) initiation (1996-2008) among treatment-eligible persons in a community-based cohort of current and former injection drug users (IDUs) in Baltimore, Maryland... - High HIV prevalence among a high-risk subgroup of women attending sexually transmitted infection clinics in Pune, IndiaShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21202, USA
J Acquir Immune Defic Syndr 41:75-80. 2006..To investigate changes over a decade in prevalence and correlates of HIV among high-risk women attending sexually transmitted infection (STI) clinics in Pune, India, who deny a history of commercial sex work (CSW)... - Early immunologic and virologic responses to highly active antiretroviral therapy and subsequent disease progression among HIV-infected injection drug usersS H Mehta
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
AIDS Care 19:637-45. 2007..Interventions to reduce treatment interruptions and to provide continuity of HIV care during incarceration among IDUs are needed to improve responses and subsequent survival... - Limited uptake of hepatitis C treatment among injection drug usersShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Community Health 33:126-33. 2008..Low HCV treatment effectiveness was observed in this IDU population. Comprehensive integrated care strategies that incorporate education, case-management and peer support are needed to improve care and treatment of HCV-infected IDUs... - Liver enzyme values in injection drug users with chronic hepatitis CS H Mehta
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
Dig Liver Dis 37:674-80. 2005..Liver enzymes fluctuate in chronic hepatitis C virus infection. However, the range that can be attributed to the course of hepatitis C virus (versus an intercurrent cause of hepatitis) is unknown... - A framework for understanding factors that affect access and utilization of treatment for hepatitis C virus infection among HCV-mono-infected and HIV/HCV-co-infected injection drug usersShruti H Mehta
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
AIDS 19:S179-89. 2005.... - Epidemiology of hepatitis C virus infection & liver disease among injection drug users (IDUs) in Chennai, IndiaShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Indian J Med Res 132:706-14. 2010..We characterized HCV antibody prevalence, viral persistence, genotype and liver disease prevalence among IDUs in Chennai, India as the study of the association of HIV with each of these states is important and there are no data available... - Changes in blood-borne infection risk among injection drug usersShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Infect Dis 203:587-94. 2011..Population-level hepatitis C virus (HCV) infection incidence is a surrogate for community drug-related risk... - Assessment of liver disease (noninvasive methods)Shruti H Mehta
Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, Maryland 21231, USA
Curr Opin HIV AIDS 6:465-71. 2011..Overall, in 2010-2011, 15 studies were published, of which two were excluded because they were published in languages other than English... - Hepatitis C virus infection and incident type 2 diabetesShruti H Mehta
Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA
Hepatology 38:50-6. 2003..05-4.40). In conclusion, pre-existing HCV infection may increase the risk for type 2 diabetes in persons with recognized diabetes risk factors. Additional larger prospective evaluations are needed to confirm these preliminary findings... - Progression of liver fibrosis among injection drug users with chronic hepatitis CLucy E Wilson
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21231-1002, USA
Hepatology 43:788-95. 2006..In this setting with low fibrosis prevalence, FibroSURE, ALT, and APRI tests predict insignificant fibrosis; however, further work is needed to find noninvasive markers of significant liver fibrosis... - Same-sex behavior and high rates of HIV among men attending sexually transmitted infection clinics in Pune, India (1993-2002)Amita Gupta
Division of Infectious Disease, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Acquir Immune Defic Syndr 43:483-90. 2006..To determine HIV/sexually transmitted infection (STI) prevalence, trends, and risk behaviors of men who have sex with men (MSM) and compare these with those of non-MSM attending STI clinics in Pune, India over a 10-year period... - Liver enzyme flares and occult hepatitis B in persons with chronic hepatitis C infectionRajesh Kannangai
Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
J Clin Virol 39:101-5. 2007..Given that typical chronic HBV infections often have periodic flairs in viral replication and liver damage, we hypothesized that occult HBV may also have flares in viral replication that are associated with increased liver enzymes... - Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adultsMark S Sulkowski
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
AIDS 21:2209-16. 2007.... - Effect of micronutrients and iron supplementation on hemoglobin, iron status, and plasma hepatitis C and HIV RNA levels in female injection drug users: a controlled clinical trialRichard D Semba
Department of Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 45:298-303. 2007..Iron deficiency is common among female injection drug users, but it is unclear whether iron supplementation can reduce anemia and improve iron status without increasing plasma hepatitis C virus (HCV) or HIV RNA levels... - Limited effectiveness of antiviral treatment for hepatitis C in an urban HIV clinicShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, USA
AIDS 20:2361-9. 2006..New therapies and treatment strategies are an urgent medical need... - Hepatitis C and progression of HIV diseaseMark S Sulkowski
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St, Room 448, Baltimore, MD 21287 0003, USA
JAMA 288:199-206. 2002..Conflicting reports exist regarding the effect of hepatitis C virus (HCV) on the progression of human immunodeficiency virus (HIV) disease... - The effect of HAART and HCV infection on the development of hyperglycemia among HIV-infected personsShruti H Mehta
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Acquir Immune Defic Syndr 33:577-84. 2003..CONCLUSION: In this urban HIV cohort, the risk of hyperglycemia was increased in HCV-coinfected patients and those prescribed a PI... - Protection against persistence of hepatitis CShruti H Mehta
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
Lancet 359:1478-83. 2002..Our data suggest that immunity against viral persistence can be acquired, and that vaccines should be tested to reduce the burden of HCV-related liver disease... - High prevalence of HIV, HIV/hepatitis C virus coinfection, and risk behaviors among injection drug users in Chennai, India: a cause for concernSunil S Solomon
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 49:327-32. 2008..To estimate the prevalence of HIV and hepatitis C virus (HCV) and hepatitis B virus (HBV) coinfections and current risk behaviors among HIV-positive and -negative injection drug users (IDUs) in Chennai, India... - Factors associated with the perpetration of sexual violence among wine-shop patrons in Chennai, IndiaVivian F Go
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Soc Sci Med 71:1277-84. 2010..HIV interventions that facilitate formal groups that foster positive social support and address a range of HIV risk behaviors including sexually and physically abusive behaviors are recommended to reduce sexual violence... - Survival during renal replacement therapy among African Americans infected with HIV type 1 in urban Baltimore, MarylandMohamed G Atta
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Infect Dis 45:1625-32. 2007..It is unknown how the widespread use of highly active antiretroviral therapy (HAART) has affected survival during RRT in this vulnerable population... - Human immunodeficiency virus-related microbial translocation and progression of hepatitis CAshwin Balagopal
Division of Infectious Diseases, Viral Hepatitis Center, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Gastroenterology 135:226-33. 2008..We hypothesized that HIV promotes liver disease by enhancing microbial translocation... - The profile of injection drug users in Chennai, India: identification of risk behaviours and implications for interventionsSunil S Solomon
Johns Hopkins School of Public Health, Baltimore, Maryland, USA
Subst Use Misuse 45:354-67. 2010.... - Exceeding the limits of liver histology markersShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 1830 E Monument St, Room 455 ID, Baltimore, MD 21287, USA
J Hepatol 50:36-41. 2009..We characterized the magnitude of the impact of error in the "gold standard" on the observed diagnostic accuracy of surrogate markers... - Nonstructured treatment interruptions among injection drug users in Baltimore, MDRavi Kavasery
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 50:360-6. 2009..We characterized patterns of highly active antiretroviral therapy (HAART) use and predictors of nonstructured treatment interruptions (NTIs) among injection drug users (IDUs) in Baltimore, MD... - Assessment of liver fibrosis by transient elastography in persons with hepatitis C virus infection or HIV-hepatitis C virus coinfectionGregory D Kirk
Department of Epidemiology, Schools of Public Health and Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Clin Infect Dis 48:963-72. 2009..We compared elastography with histologic methods among hepatitis C virus (HCV)-infected and human immunodeficiency virus (HIV)-HCV-coinfected participants in an urban, predominantly black study population... - Variations in sexual risks in drug users: emerging themes in a behavioral contextDavid D Celentano
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Helath, 615 North Wolfe Street Suite E 6547, Baltimore, MD 21205, USA
Curr HIV/AIDS Rep 5:212-8. 2008..Special attention is paid to minority populations, both sexual and racial/ethnic, as their marginalized role in contemporary society places special barriers to risk reduction... - Correlates of unsafe syringe acquisition and disposal among injection drug users in Baltimore, MarylandElizabeth T Golub
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Subst Use Misuse 40:1751-64. 2005..These data suggest the need for a more active program involving pharmacists, an expanded syringe access program, and better efforts to enhance safe disposal... - HIV infection is associated with an increased risk for lung cancer, independent of smokingGregory D Kirk
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Clin Infect Dis 45:103-10. 2007..Human immunodeficiency virus (HIV)-infected persons have an elevated risk for lung cancer, but whether the increase reflects solely their heavy tobacco use remains an open question... - Prevalence, correlates, and viral dynamics of hepatitis delta among injection drug usersLauren M Kucirka
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Infect Dis 202:845-52. 2010..Accurate estimates of prevalence and risk factors are important to help clinicians decide who to screen... - The effect of antiretroviral therapy on liver disease among adults with HIV and hepatitis C coinfectionShruti H Mehta
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205-0003, USA
Hepatology 41:123-31. 2005..Recognition of bridging fibrosis and cirrhosis in some but not most patients underscores the importance of identifying and treating liver disease in HIV/HCV coinfected persons... - Progression of fibrosis during chronic hepatitis C is associated with rapid virus evolutionXiao Hong Wang
Viral Hepatitis Center, Div of Inf Dis, Department of Medicine, Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Suite 114, Baltimore, MD 21231, USA, and Southwest Hospital, Chongqing, People s Republic of China
J Virol 81:6513-22. 2007..Thus, in a small but carefully matched cohort we found evidence for rapid neutral evolution of HCV in persons with rapid progression of hepatic fibrosis, suggesting higher turnover of infected cells... - The effect of HIV infection on overdose mortalityCunlin Wang
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
AIDS 19:935-42. 2005..The data suggest a group to target with interventions to reduce overdose mortality rates... - Determinants of alcohol consumption in HIV-uninfected injection drug usersPetra M Sander
Department of Epidemiology, The Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Drug Alcohol Depend 111:173-6. 2010..This study demonstrates that in a large urban cohort of persons with a history of injection drug use, risky drug use and sexual risk behavior are associated with subsequent alcohol consumption... - Mortality risk among new onset injection drug usersDavid Vlahov
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Addiction 99:946-54. 2004..To characterize mortality experience among those who only recently started injection... - Hepatic steatosis and antiretroviral drug use among adults coinfected with HIV and hepatitis C virusMark S Sulkowski
Division of Infectious Diseases Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
AIDS 19:585-92. 2005.... - Hepatitis C virus (HCV) core antigen assay to detect ongoing HCV infection in thai injection drug usersDale M Netski
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland
J Clin Microbiol 42:1631-6. 2004..Reproducibility, low technical requirements, and high throughput should make this assay useful for clinical or research monitoring of HCV levels during active infection... - End-stage renal disease and chronic kidney disease in a cohort of African-American HIV-infected and at-risk HIV-seronegative participants followed between 1988 and 2004Gregory M Lucas
Department of Medicine, Divisions of Infectious Diseases, Bloomberg School of Public Health, John Hopkins University, Baltimore, Maryland, USA
AIDS 21:2435-43. 2007..HIV-infected African-Americans are at increased risk of end-stage renal disease requiring renal replacement therapy (RRT)... - Long-term effectiveness of diagnosing and treating latent tuberculosis infection in a cohort of HIV-infected and at-risk injection drug usersJonathan E Golub
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Acquir Immune Defic Syndr 49:532-7. 2008..Between 1990 and 1998, tuberculin skin tests (TST) and isoniazid preventive therapy (IPT) were provided to injection drug users participating in the AIDS Linked to the Intravenous Experiences cohort... - CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infectionDale M Netski
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, 21231, USA
J Infect Dis 195:857-63. 2007..These disease interactions may result in part from impairment of B cell function, which is CD4(+) T cell dependent... - Knowledge, attitudes, and practices of antiretroviral therapy among HIV-infected adults attending private and public clinics in IndiaSuneil R Ramchandani
Department of Internal Medicine, National Naval Medical Center, Bethesda, Maryland, USA
AIDS Patient Care STDS 21:129-42. 2007..In order to make widespread dissemination of ART effective in India, further educational and programmatic efforts are likely needed to optimize access, treatment awareness, and compliance among patients with HIV... - Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavirMark S Sulkowski
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
AIDS 18:2277-84. 2004.... - Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: role of hepatitis C and B infectionsMark S Sulkowski
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD21205, USA
Hepatology 35:182-9. 2002..Severe hepatotoxicity occurs throughout the course of NNRTI therapy and is more common among patients prescribed nevirapine, those coinfected with HCV or HBV, and those coadministered protease inhibitors... - Peripheral blood count abnormalities among patients with hepatitis C in the United StatesMichael B Streiff
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
Hepatology 35:947-52. 2002..0 x 10(9)/L or platelet counts less than 100 x 10(9)/L. Alternate causes of anemia should be considered for HCV-infected persons with low red blood cell counts... - Perioperative mortality and long-term survival following live kidney donationDorry L Segev
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
JAMA 303:959-66. 2010..More than 6000 healthy US individuals every year undergo nephrectomy for the purposes of live donation; however, safety remains in question because longitudinal outcome studies have occurred at single centers with limited generalizability... - Impact of diabetes on mortality among patients with community-acquired bacteremiaChu Lin Tsai
Department of Emergency Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
J Infect 55:27-33. 2007..To assess the impact of diabetes on 30-day mortality in patients with community-acquired bacteremia.. - Non-fatal overdose and subsequent drug treatment among injection drug usersRobin A Pollini
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, CA 92093, USA
Drug Alcohol Depend 83:104-10. 2006..Interventions that provide drug treatment information and enhance motivation for treatment in the medical setting and policies that reduce barriers to treatment entry among motivated drug users are recommended... - Adherence to antiretroviral therapy and virologic suppression among HIV-infected persons receiving care in private clinics in Mumbai, IndiaBijal Shah
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
Clin Infect Dis 44:1235-44. 2007..Adherence to antiretroviral therapy (ART) and correlates of adherence and virologic suppression among human immunodeficiency virus (HIV)-infected persons receiving ART in private, outpatient clinics in India is unknown... - Prediction of hepatic fibrosis in HIV/HCV co-infected patients using serum fibrosis markers: the SHASTA indexThomas B Kelleher
Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Suite 8E, Boston, MA 02215, USA
J Hepatol 43:78-84. 2005..CONCLUSIONS: Amongst HIV/HCV co-infected patients, serum testing for HA, albumin, and AST (SHASTA Index) was able to accurately stage mild and advanced fibrosis... - Response to overdose among injection drug usersRobin A Pollini
Department of Family and Preventive Medicine, School of Medicine, University of California-San Diego, San Diego, California, USA
Am J Prev Med 31:261-4. 2006..Interventions that provide overdose education and reduce police response to overdose events may improve witness response and reduce mortality associated with drug overdose...
Research Grants
- INCIDENCE OF HIV INFECTION IN A COHORT OF IV DRUG USERSShruti Mehta; Fiscal Year: 2009..The findings from this study will inform HIV prevention and structural interventions and will help to project the future health care needs for aging IDUs with a changing spectrum of morbidity. ..
- INCIDENCE OF HIV INFECTION IN A COHORT OF IV DRUG USERSShruti H Mehta; Fiscal Year: 2010..The findings from this study will inform HIV prevention and structural interventions and will help to project the future health care needs for aging IDUs with a changing spectrum of morbidity. ..
- INCIDENCE OF HIV INFECTION IN A COHORT OF IV DRUG USERSShruti Mehta; Fiscal Year: 2009..The findings from this study will inform HIV prevention and structural interventions and will help to project the future health care needs for aging IDUs with a changing spectrum of morbidity. ..
- INCIDENCE OF HIV INFECTION IN A COHORT OF IV DRUG USERSShruti Mehta; Fiscal Year: 2007..abstract_text> ..
- INCIDENCE OF HIV INFECTION IN A COHORT OF IV DRUG USERSShruti Mehta; Fiscal Year: 2007..abstract_text> ..
- HIV, HCV and Liver Disease Among Injection Drug Users in Chennai, IndiaShruti H Mehta; Fiscal Year: 2010..to inform interventions to reduce the morbidity and mortality associated with drug use, HIV and hepatitis C. ..