M G McInnis

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene
    H Chen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21287, USA
    Eur J Hum Genet 9:922-30. 2001
  2. ncbi request reprint Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12
    M G McInnis
    Department of Psychiatry and Human Behavior, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Mol Psychiatry 8:288-98. 2003
  3. ncbi request reprint Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships
    J B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 157:2048-50. 2000
  4. ncbi request reprint Trapping and sequence analysis of 1138 putative exons from human chromosome 18
    H Chen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21278 7463, USA
    Mol Psychiatry 8:619-23. 2003
  5. ncbi request reprint The familial aggregation of psychotic symptoms in bipolar disorder pedigrees
    J B Potash
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 158:1258-64. 2001
  6. ncbi request reprint Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates
    P P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Mol Psychiatry 12:630-9. 2007
  7. pmc Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect
    O C Stine
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 57:1384-94. 1995
  8. pmc Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series
    F J McMahon
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 61:1397-404. 1997
  9. ncbi request reprint Integrating clinical and laboratory data in genetic studies of complex phenotypes: a network-based data management system
    F J McMahon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7381, USA
    Am J Med Genet 81:248-56. 1998
  10. ncbi request reprint Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis
    D Avramopoulos
    Department of Psychiatry, Johns Hopkins University, School of Medicine, North Wolfe Street, Baltimore, MD 21287, USA
    Mol Psychiatry 9:191-6. 2004

Collaborators

Detail Information

Publications24

  1. ncbi request reprint NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene
    H Chen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21287, USA
    Eur J Hum Genet 9:922-30. 2001
    ..Its position in a region of linkage for autosomal dominant orthostatic hypotensive disorder and its potential role in regulating ENaC make NEDD4L a candidate gene for this disorder...
  2. ncbi request reprint Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12
    M G McInnis
    Department of Psychiatry and Human Behavior, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Mol Psychiatry 8:288-98. 2003
    ..There was evidence consistent with paternal imprinting at the loci on 13q12 and 1q41...
  3. ncbi request reprint Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships
    J B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 157:2048-50. 2000
    ..This study examined the clinical and familial relationships between comorbid alcoholism and attempted suicide in affectively ill relatives of probands with bipolar I disorder...
  4. ncbi request reprint Trapping and sequence analysis of 1138 putative exons from human chromosome 18
    H Chen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21278 7463, USA
    Mol Psychiatry 8:619-23. 2003
    ..On average, there were two exons for a matched transcript (known genes and ESTs). Therefore, the 850 novel exons may represent hundreds of novel genes on chromosome 18...
  5. ncbi request reprint The familial aggregation of psychotic symptoms in bipolar disorder pedigrees
    J B Potash
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 158:1258-64. 2001
    ..The authors tested this hypothesis in families ascertained for a genetic study of bipolar disorder...
  6. ncbi request reprint Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates
    P P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Mol Psychiatry 12:630-9. 2007
    ..These findings further demonstrate the value of considering clinical features that may reflect the underlying heterogeneity of disease in order to facilitate gene mapping...
  7. pmc Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect
    O C Stine
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 57:1384-94. 1995
    ..The number of loci involved, and their precise location, require further study....
  8. pmc Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series
    F J McMahon
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 61:1397-404. 1997
    ..Multipoint nonparametric linkage analysis in the new sample combined with the original sample of families supports linkage on chromosome 18q, but the susceptibility gene is not well localized...
  9. ncbi request reprint Integrating clinical and laboratory data in genetic studies of complex phenotypes: a network-based data management system
    F J McMahon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7381, USA
    Am J Med Genet 81:248-56. 1998
    ..We describe a comprehensive system that manages clinical, DNA, cell line, and genotype data, but since the system is modular, researchers can set up only those elements which they need immediately, expanding later as needed...
  10. ncbi request reprint Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis
    D Avramopoulos
    Department of Psychiatry, Johns Hopkins University, School of Medicine, North Wolfe Street, Baltimore, MD 21287, USA
    Mol Psychiatry 9:191-6. 2004
    ..Biologically, plausible candidate genes in this region include thyroglobulin, KCNQ3 coding for a voltage-gated potassium channel and the gene for brain adenyl-cyclase (ADCY8)...
  11. ncbi request reprint Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees
    T Swift-Scanlan
    George Browne Genetics Laboratory, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Public Health, Baltimore, Maryland, USA
    Psychiatr Genet 12:43-7. 2002
    ..We failed to find any association between the (CTG)n NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees...
  12. ncbi request reprint Novel CAG/CTG repeat expansion mutations do not contribute to the genetic risk for most cases of bipolar disorder or schizophrenia
    T Tsutsumi
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University of School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 124:15-9. 2004
    ..We conclude that novel CAG/CTG repeat expansions are not a common genetic risk factor for bipolar disorder or schizophrenia...
  13. ncbi request reprint A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1
    T S Breschel
    George Browne Genetics Laboratory, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Mol Genet 6:1855-63. 1997
    ..These enlarged alleles may arise, at least in part, via somatic mutation...
  14. ncbi request reprint cDNAs with long CAG trinucleotide repeats from human brain
    R L Margolis
    Laboratory of Molecular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Genet 100:114-22. 1997
    ..These genes are therefore candidates for diseases featuring anticipation, neurodegeneration, or abnormalities of neurodevelopment...
  15. ncbi request reprint cDNA cloning of a human homologue of the Caenorhabditis elegans cell fate-determining gene mab-21: expression, chromosomal localization and analysis of a highly polymorphic (CAG)n trinucleotide repeat
    R L Margolis
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Hum Mol Genet 5:607-16. 1996
    ....
  16. ncbi request reprint Characterization of cDNA clones containing CCA trinucleotide repeats derived from human brain
    R L Margolis
    Laboratory of Molecular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Somat Cell Mol Genet 21:279-84. 1995
    ..Expansion mutations at these loci should be considered as possible candidates in evaluating the genetic etiologies of diseases linked to chromosomes 5, 19, and 20...
  17. ncbi request reprint The assent of a nation: genethics and Iceland
    M G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7463, USA
    Clin Genet 55:234-9. 1999
    ....
  18. ncbi request reprint Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms
    S H Li
    Department of Psychiatry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205 2196
    Genomics 16:572-9. 1993
    ....
  19. ncbi request reprint Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33
    Y S Chen
    Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    Mol Psychiatry 9:87-92; image 5. 2004
    ....
  20. ncbi request reprint Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor
    P Sklar
    Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Mol Psychiatry 7:579-93. 2002
    ..5 kb 3'. Therefore, this study of 76 candidate genes has identified BDNF as a potential risk allele that will require additional study to confirm...
  21. ncbi request reprint Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12
    S E Holmes
    Nat Genet 23:391-2. 1999
  22. ncbi request reprint Alpha-2 macroglobulin is genetically associated with Alzheimer disease
    D Blacker
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
    Nat Genet 19:357-60. 1998
    ....
  23. ncbi request reprint Structure of the human CRFB4 gene: comparison with its IFNAR neighbor
    G Lutfalla
    Institut de Genetique Moleculaire, CNRS UMR 9942, Montpellier, France
    J Mol Evol 41:338-44. 1995
    ..A pseudogene for USF has been identified in the IFNAR gene and a new definition for the repetitive sequence MER37 is proposed. The polymorphism associated with two CA repeats present in the CRFB4 gene is described...
  24. ncbi request reprint Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
    L Hendriks
    Department of Biochemistry, Born Bunge Foundation, University of Antwerp UIA, Belgium
    Nat Genet 1:218-21. 1992
    ..These results suggest that the clinically distinct entities, presenile dementia and cerebral amyloid angiopathy, can be caused by the same mutation in the APP gene...