Sharon McGrath-Morrow

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint G(1) Phase growth arrest and induction of p21(Waf1/Cip1/Sdi1) in IB3-1 cells treated with 4-sodium phenylbutyrate
    S A McGrath-Morrow
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2533, USA
    J Pharmacol Exp Ther 294:941-7. 2000
  2. pmc Neonatal hyperoxia contributes additively to cigarette smoke-induced chronic obstructive pulmonary disease changes in adult mice
    Sharon A McGrath-Morrow
    Department of Pediatrics, Division of Pediatric Pulmonary, Suite 3029, 200 N Wolfe St Baltimore, MD 21287 2533, USA
    Am J Respir Cell Mol Biol 45:610-6. 2011
  3. doi request reprint Elevated serum IL-8 levels in ataxia telangiectasia
    Sharon A McGrath-Morrow
    Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Pediatr 156:682-4.e1. 2010
  4. pmc Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia
    Sharon McGrath-Morrow
    Dept of Pediatric Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD 21287 2533, USA
    Am J Physiol Lung Cell Mol Physiol 296:L565-73. 2009
  5. doi request reprint Polysomnographic values in adolescents with ataxia telangiectasia
    Sharon A McGrath-Morrow
    Division of Pediatric Pulmonary, The Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    Pediatr Pulmonol 43:674-9. 2008
  6. ncbi request reprint Pulmonary function in adolescents with ataxia telangiectasia
    Sharon McGrath-Morrow
    Division of Pediatric Pulmonology, Department of Pediatrics, The Johns Hopkins Medical Institution, Baltimore, Maryland 21287 2533, USA
    Pediatr Pulmonol 43:59-66. 2008
  7. pmc Impaired lung homeostasis in neonatal mice exposed to cigarette smoke
    Sharon McGrath-Morrow
    Department of Pediatrics, Division of Pediatric Pulmonary, Johns Hopkins Hospital, Park 316 600 N Wolfe St, Baltimore, MD 21287 2533, USA
    Am J Respir Cell Mol Biol 38:393-400. 2008
  8. ncbi request reprint Growth arrest in A549 cells during hyperoxic stress is associated with decreased cyclin B1 and increased p21(Waf1/Cip1/Sdi1) levels
    S A McGrath-Morrow
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1538:90-7. 2001
  9. ncbi request reprint Apoptosis in neonatal murine lung exposed to hyperoxia
    S A McGrath-Morrow
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 25:150-5. 2001
  10. ncbi request reprint Inhibition of glutamine synthetase in a549 cells during hyperoxia
    Sharon A McGrath-Morrow
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 27:99-106. 2002

Collaborators

Detail Information

Publications23

  1. ncbi request reprint G(1) Phase growth arrest and induction of p21(Waf1/Cip1/Sdi1) in IB3-1 cells treated with 4-sodium phenylbutyrate
    S A McGrath-Morrow
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2533, USA
    J Pharmacol Exp Ther 294:941-7. 2000
    ....
  2. pmc Neonatal hyperoxia contributes additively to cigarette smoke-induced chronic obstructive pulmonary disease changes in adult mice
    Sharon A McGrath-Morrow
    Department of Pediatrics, Division of Pediatric Pulmonary, Suite 3029, 200 N Wolfe St Baltimore, MD 21287 2533, USA
    Am J Respir Cell Mol Biol 45:610-6. 2011
    ..These results may be relevant to a growing population of preterm children who sustained lung injury in the newborn period and may be exposed to CS in later life...
  3. doi request reprint Elevated serum IL-8 levels in ataxia telangiectasia
    Sharon A McGrath-Morrow
    Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Pediatr 156:682-4.e1. 2010
    ..0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype...
  4. pmc Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia
    Sharon McGrath-Morrow
    Dept of Pediatric Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD 21287 2533, USA
    Am J Physiol Lung Cell Mol Physiol 296:L565-73. 2009
    ..02). In summary, these findings indicate that Nrf2 increases survival in newborn mice exposed to hyperoxia and that Nrf2 may help attenuate alveolar growth inhibition caused by hyperoxia exposure...
  5. doi request reprint Polysomnographic values in adolescents with ataxia telangiectasia
    Sharon A McGrath-Morrow
    Division of Pediatric Pulmonary, The Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    Pediatr Pulmonol 43:674-9. 2008
    ..Based on these findings, overnight polysomnography should be considered in adolescents with A-T, particularly in those in which there is a clinical suspicion of sleep related breathing abnormalities...
  6. ncbi request reprint Pulmonary function in adolescents with ataxia telangiectasia
    Sharon McGrath-Morrow
    Division of Pediatric Pulmonology, Department of Pediatrics, The Johns Hopkins Medical Institution, Baltimore, Maryland 21287 2533, USA
    Pediatr Pulmonol 43:59-66. 2008
    ..Fifteen A-T adolescents completed lung volume measurements by helium dilution. To assess for reproducibility of spirometry testing, 10 A-T adolescents performed spirometry on three separate occasions...
  7. pmc Impaired lung homeostasis in neonatal mice exposed to cigarette smoke
    Sharon McGrath-Morrow
    Department of Pediatrics, Division of Pediatric Pulmonary, Johns Hopkins Hospital, Park 316 600 N Wolfe St, Baltimore, MD 21287 2533, USA
    Am J Respir Cell Mol Biol 38:393-400. 2008
    ..These findings may in part explain the increased incidence of respiratory symptoms in infants and children exposed to CS...
  8. ncbi request reprint Growth arrest in A549 cells during hyperoxic stress is associated with decreased cyclin B1 and increased p21(Waf1/Cip1/Sdi1) levels
    S A McGrath-Morrow
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1538:90-7. 2001
    ....
  9. ncbi request reprint Apoptosis in neonatal murine lung exposed to hyperoxia
    S A McGrath-Morrow
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 25:150-5. 2001
    ..Finally, it appears that hyperoxic injured cells in neonatal lung undergo both apoptotic and nonapoptotic cell death...
  10. ncbi request reprint Inhibition of glutamine synthetase in a549 cells during hyperoxia
    Sharon A McGrath-Morrow
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 27:99-106. 2002
    ..The higher concentration of Gln, however, did not decrease the percentage of cells undergoing necrosis...
  11. ncbi request reprint The effect of neonatal hyperoxia on the lung of p21Waf1/Cip1/Sdi1-deficient mice
    Sharon A McGrath-Morrow
    Department of Pediatrics, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD 21287 2533, USA
    Am J Respir Cell Mol Biol 30:635-40. 2004
    ..Furthermore, p21 may be important during recovery from lung injury because it is associated with lower levels of oxidative stress and increased oxidative stress may contribute to alveolar growth abnormalities in the p21(-/-) O(2) lung...
  12. ncbi request reprint Vascular endothelial growth factor receptor 2 blockade disrupts postnatal lung development
    Sharon A McGrath-Morrow
    Department of Pediatric Pulmonary, Johns Hopkins Hospital, Park 316 N Wolfe Street, Baltimore, MD 21287 2533, USA
    Am J Respir Cell Mol Biol 32:420-7. 2005
    ..Therefore, VEGFR-2 blockade in the perinatal period disrupts early alveolar development, but the effect is reversible with time, whereas hyperoxic lung injury is associated with ongoing lung structural impairment...
  13. ncbi request reprint VEGF receptor 2 blockade leads to renal cyst formation in mice
    S McGrath-Morrow
    Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Kidney Int 69:1741-8. 2006
    ..Early disruption of VEGFR-2 signaling during the perinatal period results in renal cyst formation, impaired glomerulogenesis, and inflammation. VEGF could be a key link between vascular and cystic changes in kidney cyst formation...
  14. doi request reprint Exposure to neonatal cigarette smoke causes durable lung changes but does not potentiate cigarette smoke-induced chronic obstructive pulmonary disease in adult mice
    Sharon McGrath-Morrow
    Division of Pediatric Pulmonary, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2533, USA
    Exp Lung Res 37:354-63. 2011
    ..Additional studies may be warranted to determine the utility of these genes as biomarkers of respiratory outcomes...
  15. pmc Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice
    Megan Podowski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 122:229-40. 2012
    ..More importantly, our findings provide a preclinical platform for the development of other TGF-β-targeted therapies for patients with COPD...
  16. doi request reprint The critically ill patient with ataxia-telangiectasia: a case series
    Justin L Lockman
    Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, MD, USA
    Pediatr Crit Care Med 13:e84-90. 2012
    ..To describe the presentation, clinical course, and outcomes of critically ill patients with ataxia-telangiectasia...
  17. pmc Critical transition in tissue homeostasis accompanies murine lung senescence
    Carla L Calvi
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20712. 2011
    ..The susceptibility to pulmonary insults is attributed to "low pulmonary reserve", ostensibly reflecting a combination of age-related musculoskeletal, immunologic and intrinsic pulmonary dysfunction...
  18. pmc Safety and caregiver satisfaction with gastrostomy in patients with Ataxia Telangiectasia
    Maureen A Lefton-Greif
    The Ataxia Telangiectasia Clinical Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Orphanet J Rare Dis 6:23. 2011
    ..The primary purposes of this study were to determine whether GT placement in patients with A-T would be tolerated and associated with caregiver satisfaction...
  19. doi request reprint Anesthetic and perioperative risk in the patient with Ataxia-Telangiectasia
    Justin L Lockman
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA
    Paediatr Anaesth 22:256-62. 2012
    ..OBJECTIVES/AIM: To report our relatively large experience with perioperative care for patients with Ataxia-Telangiectasia (A-T) and to identify the nature and frequency of complications...
  20. doi request reprint Long-term pulmonary outcomes of patients with bronchopulmonary dysplasia
    Anita Bhandari
    Division of Pediatric Pulmonology, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Semin Perinatol 37:132-7. 2013
    ....
  21. pmc A pilot study to examine the effect of chronic treatment with immunosuppressive drugs on mucociliary clearance in a vagotomized murine model
    Abhiram R Bhashyam
    Department of Biomedical Engineering, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS ONE 7:e45312. 2012
    ..We hypothesized that chronic treatment with a commonly prescribed regimen of immunosuppressive drugs significantly impairs MCC. We tested this hypothesis in a murine model of lung transplantation...
  22. ncbi request reprint IL-12 overexpression in mice as a model for Sjögren lung disease
    Sharon McGrath-Morrow
    Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Lung Cell Mol Physiol 291:L837-46. 2006
    ..This new mouse model highlights the role of IL-12 in the initiation of Sjögren syndrome...
  23. pmc Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis
    Patrice M Becker
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e27449. 2011
    ....