Mary E McCaul

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Serum 6-beta-naltrexol levels are related to alcohol responses in heavy drinkers
    M E McCaul
    The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 24:1385-91. 2000
  2. ncbi Predictors of outpatient treatment retention: patient versus substance use characteristics
    M E McCaul
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Comprehensive Women s Center, 911 N Broadway, Baltimore, MD 21205, USA
    Drug Alcohol Depend 62:9-17. 2001
  3. ncbi The role of psychosocial treatments in pharmacotherapy for alcoholism
    Mary E McCaul
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Addict 12:S41-52. 2003
  4. ncbi Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 32:2310-20. 2007
  5. ncbi Striatal dopamine release and family history of alcoholism
    Cynthia A Munro
    Department of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 30:1143-51. 2006
  6. ncbi The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Alcohol 46:511-7. 2012
  7. ncbi Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacks
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 33:246-54. 2008
  8. ncbi Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects
    Elise M Weerts
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:653-65. 2008
  9. ncbi Alcohol consumption and CD4 T-cell count response among persons initiating antiretroviral therapy
    Stefan Kowalski
    Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 61:455-61. 2012
  10. ncbi Positron emission tomography imaging of mu- and delta-opioid receptor binding in alcohol-dependent and healthy control subjects
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 35:2162-73. 2011

Research Grants

  1. PET IMAGING OF BRAIN OPIOID RECEPTORS IN ALCOHOLISM
    Mary McCaul; Fiscal Year: 2002

Collaborators

Detail Information

Publications33

  1. ncbi Serum 6-beta-naltrexol levels are related to alcohol responses in heavy drinkers
    M E McCaul
    The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 24:1385-91. 2000
    ..This paper reports a secondary data analysis of a human laboratory study that examines the relationship between serum levels of 6-beta-naltrexol, the major, biologically active metabolite of naltrexone, and subjective effects of alcohol...
  2. ncbi Predictors of outpatient treatment retention: patient versus substance use characteristics
    M E McCaul
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Comprehensive Women s Center, 911 N Broadway, Baltimore, MD 21205, USA
    Drug Alcohol Depend 62:9-17. 2001
    ....
  3. ncbi The role of psychosocial treatments in pharmacotherapy for alcoholism
    Mary E McCaul
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Addict 12:S41-52. 2003
    ..Directions for future research in this area are also suggested...
  4. ncbi Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 32:2310-20. 2007
    ..The results are consistent with preclinical findings showing an interrelationship between glucocorticoids and mesolimbic DA dynamics, which may influence psychostimulant self-administration in humans...
  5. ncbi Striatal dopamine release and family history of alcoholism
    Cynthia A Munro
    Department of Medicine, The John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 30:1143-51. 2006
    ..CONCLUSIONS: Using amphetamine to provoke mesolimbic dopamine, we did not show significant differences in dopamine release, subjective responses, or stress hormone measures as a function of family history of alcoholism...
  6. ncbi The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Alcohol 46:511-7. 2012
    ..However pathways governing the relationship between naloxone-induced cortisol and mu opioid receptor availability are disrupted during early abstinence in AD subjects...
  7. ncbi Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacks
    Rachel Y Chong
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychoneuroendocrinology 33:246-54. 2008
    ..We hypothesized that whites would differ from blacks in HPA axis response to a psychological stressor...
  8. ncbi Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects
    Elise M Weerts
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:653-65. 2008
    ..Further investigations on the relationship between individual differences in delta-OR blockade by naltrexone and clinical outcomes should be explored...
  9. ncbi Alcohol consumption and CD4 T-cell count response among persons initiating antiretroviral therapy
    Stefan Kowalski
    Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 61:455-61. 2012
    ..We evaluated the longitudinal association of alcohol use with immunologic response to combination antiretroviral therapy (ART) among HIV-infected individuals...
  10. ncbi Positron emission tomography imaging of mu- and delta-opioid receptor binding in alcohol-dependent and healthy control subjects
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 35:2162-73. 2011
    ....
  11. ncbi Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Neuropsychopharmacol 16:47-53. 2013
    ..9%) compared to AA subjects (93.1%), but this was not significant. We are the first to demonstrate using PET in healthy normal and AD subjects that the A118G SNP alters OPRM1 availability...
  12. ncbi Naloxone-induced cortisol predicts mu opioid receptor binding potential in specific brain regions of healthy subjects
    Gary S Wand
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
    Psychoneuroendocrinology 36:1453-9. 2011
    ..The opioid receptor antagonist naloxone is not merely a non-specific pharmacologic activator of the HPA axis; it provides information about individual differences in opioid receptor availability...
  13. ncbi The relationship between naloxone-induced cortisol and delta opioid receptor availability in mesolimbic structures is disrupted in alcohol-dependent subjects
    Gary S Wand
    Departments of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Addict Biol 18:181-92. 2013
    ....
  14. ncbi Dissociative changes in the Bmax and KD of dopamine D2/D3 receptors with aging observed in functional subdivisions of the striatum: a revisit with an improved data analysis method
    Hiroto Kuwabara
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 53:805-12. 2012
    ..However, existing methods have limited applications to the whole striatum, putamen, or caudate nucleus. Improved methods are required to examine B(max) and K(D) in detailed functional striatal subdivisions that are becoming widely used...
  15. ncbi Hormonal responses to psychological stress and family history of alcoholism
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:2255-63. 2006
    ..Furthermore, the findings suggest that the association between the hypothalamic-pituitary-adrenal axis hormonal response and the subjective perception of stress might be deranged in offspring of alcoholics...
  16. ncbi Alcohol consumption among HIV-infected women: impact on time to antiretroviral therapy and survival
    Robyn C Neblett
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Womens Health (Larchmt) 20:279-86. 2011
    ..We sought to determine factors associated with alcohol use among HIV-infected women engaged in clinical care and if baseline alcohol use was associated with time to combination antiretroviral therapy (cART) and death in this population...
  17. ncbi Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge
    Mary Ann C Stephens
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 550 N Broadway, Ste 115, Baltimore, MD 21205, USA
    Psychopharmacology (Berl) 224:223-30. 2012
    ..Serotonin transporter (5-HTT) genotype has been studied as a marker of HPA axis dysregulation and for predicting risk of psychopathology, with mixed findings...
  18. ncbi Study design and participant characteristics of a randomized controlled trial of directly administered antiretroviral therapy in opioid treatment programs
    Bernadette Anna Mullen
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Infect Dis 11:45. 2011
    ..Prior work from our group and others suggests that directly administered antiretroviral therapy (DAART) delivered in opioid treatment programs (OTPs) may increase rates of viral suppression...
  19. ncbi Screening for hazardous drinking using the Michigan Alcohol Screening Test-Geriatric Version (MAST-G) in elderly persons with acute cerebrovascular accidents
    Doug Johnson-Greene
    Division of Rehabilitation Psychology and Neuropsychology, Department of Physical Medicine and Rehabilitation, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alcohol Clin Exp Res 33:1555-61. 2009
    ....
  20. ncbi Sex differences in striatal dopamine release in healthy adults
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 59:966-74. 2006
    ..Our findings indicate that future studies should control for sex and may have implications for the interpretation of sex differences in other illnesses involving the striatum...
  21. ncbi Hormone responses to social stress in abstinent alcohol-dependent subjects and social drinkers with no history of alcohol dependence
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 29:1133-8. 2005
    ..The aim of the present study was to compare ACTH, cortisol, and prolactin responses to a psychological stressor in abstinent alcohol-dependent subjects matched to healthy control subjects...
  22. ncbi Outpatient treatment entry and health care utilization after a combined medical/substance abuse intervention for hospitalized medical patients
    THOMAS P O'TOOLE
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Gen Intern Med 17:334-40. 2002
    ..Drug-abusing patients utilize extensive amounts of health services resources, yet the acute medical hospitalization has typically not been used effectively to engage patients in substance abuse treatment...
  23. ncbi Directly administered antiretroviral therapy in methadone clinics is associated with improved HIV treatment outcomes, compared with outcomes among concurrent comparison groups
    Gregory M Lucas
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 42:1628-35. 2006
    ..Directly administered antiretroviral therapy (DAART) in methadone clinics has the potential to improve treatment outcomes for human immunodeficiency virus (HIV)-infected injection drug users (IDUs)...
  24. ncbi GABRA2 markers moderate the subjective effects of alcohol
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Addict Biol 18:357-69. 2013
    ..Our findings provide further evidence that variation within GABRA2 is associated with attenuated negative responses to alcohol, a known risk factor for vulnerability to alcohol use disorders...
  25. ncbi The relationship between recent alcohol use and sexual behaviors: gender differences among sexually transmitted disease clinic patients
    Heidi E Hutton
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 32:2008-15. 2008
    ..Few studies have investigated this by gender or in an STD clinic. This cross-sectional study examined the association between binge drinking and risky sexual behaviors/STDs among patients attending an urban STD clinic...
  26. ncbi Adherence, drug use, and treatment failure in a methadone-clinic-based program of directly administered antiretroviral therapy
    Gregory M Lucas
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    AIDS Patient Care STDS 21:564-74. 2007
    ..Given that a relatively small proportion of the total ART doses were supervised in many patients, future studies should assess how DAART affects adherence with nonsupervised doses and retention to ART...
  27. ncbi Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
    Badreddine Bencherif
    Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, 601 N Caroline Street, Baltimore, MD 21287, USA
    Biol Psychiatry 55:255-62. 2004
    ..The endogenous opioid system has been linked to alcohol dependence through animal and human studies. We investigated the relationship between alcohol craving and brain mu opioid receptors (mu-OR) in alcohol-dependent subjects...
  28. ncbi Alcohol effects during acamprosate treatment: a dose-response study in humans
    Susan M Brasser
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224-6823, USA
    Alcohol Clin Exp Res 28:1074-83. 2004
    ..CONCLUSIONS: Acamprosate does not alter alcohol pharmacokinetics, acute physiological or psychomotor alcohol effects, or most subjective alcohol effects...
  29. ncbi Detection of alcohol and drug problems in an urban gynecology clinic
    Anne E Gupman
    National Institute on Drug Abuse, Intramural Research Program, Departments of Psychiatry and Behavioral Sciences and of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Reprod Med 47:404-10. 2002
    ....
  30. ncbi Research priorities for alcoholism treatment
    Mary E McCaul
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Recent Dev Alcohol 16:405-14. 2003
    ....
  31. ncbi Co-occurring psychiatric disorders in women with addictions
    Geetanjali Chander
    Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument Street, 8033, Baltimore, MD 21287, USA
    Obstet Gynecol Clin North Am 30:469-81. 2003
    ..Recognition and referral for both psychiatric and substance use disorders are critical for long-term health and psychosocial improvement...
  32. ncbi A multi-site dose ranging study of nalmefene in the treatment of alcohol dependence
    Raymond F Anton
    Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Psychopharmacol 24:421-8. 2004
    ..However, possibly because of variation among the sites or the comparatively small sample size, there was no evidence of superior efficacy outcomes with nalmefene treatment...
  33. ncbi Factors associated with lifetime history of drug treatment among substance dependent women
    Benita Walton-Moss
    Johns Hopkins University, Baltimore, Maryland 21205, United States
    Addict Behav 31:246-53. 2006
    ....

Research Grants1

  1. PET IMAGING OF BRAIN OPIOID RECEPTORS IN ALCOHOLISM
    Mary McCaul; Fiscal Year: 2002
    ..abstract_text> ..