Research Topics
Species | Una McCannSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Altered pain responses in abstinent (±)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") usersUna D McCann
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Room 5B71c, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 217:475-84. 2011..Brain 5-HT neurons play a role in pain modulation, yet little is known about long-term effects of MDMA on pain function. Notably, MDMA users have been shown to have altered sleep, a phenomenon that can lead to altered pain modulation...
Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASBUna D McCann
Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 30:1741-50. 2005..These quantitative PET data, obtained using validated first- and second-generation SERT PET ligands, provide strong evidence of reduced SERT density in some recreational MDMA users...- Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumersUna D McCann
Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Neurology 73:2011-7. 2009..The present study sought to determine whether abstinent recreational MDMA users have an increased prevalence of OSA... - Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performanceUna D McCann
Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 200:439-50. 2008.... 
Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine usersUna D McCann
Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Synapse 62:91-100. 2008..This study was conducted to further investigate potential persistent psychomotor deficits secondary to METH abuse, and their relationship to brain DAT availability, as measured using quantitative PET methods with [(11)C]WIN 35428...- Sleep deprivation differentially impairs cognitive performance in abstinent methylenedioxymethamphetamine ("Ecstasy") usersUna D McCann
Department of Psychiatry and Neurology, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Neurosci 29:14050-6. 2009.... - The effect of catecholamine depletion by alpha-methyl-para-tyrosine on measures of cognitive performance and sleep in abstinent MDMA usersUna D McCann
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 32:1695-706. 2007..More research is needed to determine potential relationships between sleep abnormalities, cognitive deficits and impulsive behavior in abstinent MDMA users... - Effects of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) on sleep and circadian rhythmsUna D McCann
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Drive, Baltimore, MD 21224, USA
ScientificWorldJournal 7:231-8. 2007.... - Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramineUna D McCann
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Mol Imaging Biol 9:151-7. 2007..This study used quantitative positron emission tomography (PET) with [(11)C] McN5652, a serotonin transporter (SERT) ligand to determine whether humans previously exposed to fenfluramines showed reductions in SERT binding parameters... - Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditionsZsolt Szabo
Division of Nuclear Medicine, Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Nucl Med 43:678-92. 2002..11)C-DASB may offer some advantages. Additional studies are needed to further characterize the properties and capabilities of both ligands in health and disease... - MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densitiesBrendon P Boot
Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Eur J Pharmacol 453:239-44. 2002.... - Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetaminesJie Yuan
Department of Neurology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Pharmacol Exp Ther 303:831-9. 2002..These findings suggest that the role of metabolic compromise in amphetamine-induced 5-HT neurotoxicity merits further study... - Pharmacokinetic profile of single and repeated oral doses of MDMA in squirrel monkeys: relationship to lasting effects on brain serotonin neuronsAnnis Mechan
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:339-50. 2006.... - Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicityJie Yuan
Departments of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurochem 80:960-9. 2002.... - Loss of serotonin transporter protein after MDMA and other ring-substituted amphetaminesTao Xie
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:2639-51. 2006.... - Dopamine is not essential for the development of methamphetamine-induced neurotoxicityJie Yuan
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurochem 114:1135-42. 2010..Taken together, these findings demonstrate that DA is not essential for the development of METH-induced dopaminergic neurotoxicity and suggest that mechanisms independent of DA warrant more intense investigation... - Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicityTao Xie
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurosci 22:274-83. 2002..The precise role of COX1 and other genes in METH neurotoxicity remains to be elucidated... - Heating induces aggregation and decreases detection of serotonin transporter protein on western blotsMichael W McLane
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Synapse 61:875-6. 2007..By omitting the heat denaturation step in the Western blot procedure, better detection of the SERT protein is achieved... - Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neuronsTao Xie
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurosci 24:7043-50. 2004..The present findings may have therapeutic implications for neuropathological conditions involving DA neurons... - Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramineGeorge Hatzidimitriou
Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Synapse 44:51-7. 2002.... - Identifying the serotonin transporter signal in Western blot studies of the neurotoxic potential of MDMA and related drugsMichael W McLane
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Synapse 65:1368-72. 2011..These data provide further evidence of lasting loss of the SERT protein after exposure to MDMA and other substituted amphetamines... - Approach-avoidance coping conflict in a sample of burn patients at risk for posttraumatic stress disorderJames A Fauerbach
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Depress Anxiety 26:838-50. 2009..Study objectives were to determine if contradictory coping messages would lead to such approach-avoidance coping conflict and to determine if experiment-induced coping conflict is also associated with higher distress... - Can doctors and nurses recognize depression in patients hospitalized with an acute myocardial infarction in the absence of formal screening?Roy C Ziegelstein
Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
Psychosom Med 67:393-7. 2005.... - Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicityMelanie Mueller
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
Drug Metab Dispos 37:2079-86. 2009.... - Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy")George A Ricaurte
Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Science 297:2260-3. 2002.... - Peritraumatic heart rate and posttraumatic stress disorder in patients with severe burnsNeda F Gould
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, 4940 Eastern Ave, Asthma and Allergy Center, 5B 71B, Baltimore, MD 21224, USA
J Clin Psychiatry 72:539-47. 2011..This study expands on previous work by evaluating HR in burn patients followed longitudinally for symptoms of acute stress disorder (ASD) and PTSD... - The effects of sleep deprivation on pain inhibition and spontaneous pain in womenMichael T Smith
Behavioral Sleep Medicine Program, Johns Hopkins Bayview, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA
Sleep 30:494-505. 2007.... - Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of adult nonhuman primatesGeorge A Ricaurte
Department of Neurology, Johns Hopkins Medical Institutions, 5501 Hopkins Bayview Circle, Rm 5B 71E, Baltimore, MD 21224, USA
J Pharmacol Exp Ther 315:91-8. 2005..Further preclinical and clinical studies are needed to evaluate the dopaminergic neurotoxic potential of therapeutic doses of amphetamine in children as well as adults... - Amphetamine neurotoxicity: accomplishments and remaining challengesUna D McCann
Department of Psychiatry, School of Medicine, The Johns Hopkins University, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Neurosci Biobehav Rev 27:821-6. 2004..Remaining challenges for this line of investigation are outlined, and suggested avenues for addressing these challenges are provided... - Individual variation in rapid eye movement sleep is associated with pain perception in healthy women: preliminary dataMichael T Smith
Johns Hopkins University School of Medicine, Behavioral Medicine Research Laboratory and Clinic, 600 North Wolfe Street, Meyer 1 108, Baltimore, MD 21287, USA
Sleep 28:809-12. 2005..Consequently, we sought to evaluate relationships between sleep architecture and laboratory measures of pain processing in healthy women, sleeping under normal conditions... - Response to O'Shea and Colado: the MDMA neurotoxicity profile might provide clues to mechanismsGeorge A Ricaurte
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Trends Pharmacol Sci 24:275. 2003 - Depression following acute myocardial infarction: a prospective relationship with ongoing health and functionJames A Fauerbach
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychosomatics 46:355-61. 2005.... - Recognition and management of complications of new recreational drug useGeorge A Ricaurte
Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
Lancet 365:2137-45. 2005..We also alert researchers to specific toxic effects of club-drugs on which more basic information is needed... - Relationship between temperature, dopaminergic neurotoxicity, and plasma drug concentrations in methamphetamine-treated squirrel monkeysJie Yuan
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Pharmacol Exp Ther 316:1210-8. 2006..In addition, they suggest that interanimal differences presently observed in thermal and neurotoxic responses to METH may be related to individual differences in drug metabolism... - Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive dosesMelanie Mueller
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Pharmacol Exp Ther 327:38-44. 2008..By raising MDMA concentrations and prolonging its action, nonlinear pharmacokinetics and T(1/2) prolongation, respectively, may influence the likelihood and severity of MDMA toxicities (including brain serotonin neurotoxicity)... - Direct comparison of (+/-) 3,4-methylenedioxymethamphetamine ("ecstasy") disposition and metabolism in squirrel monkeys and humansMelanie Mueller
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Ther Drug Monit 31:367-73. 2009.... - Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effectsRoland R Griffiths
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
Psychopharmacology (Berl) 218:649-65. 2011..This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior... - Sleep disturbance after mild traumatic brain injury: indicator of injury?Vani Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Neuropsychiatry Clin Neurosci 23:201-5. 2011..These pilot findings need to be replicated on larger samples... - Pentagastrin-induced sleep panic attacks: panic in the absence of elevated baseline arousalMarilla Geraci
Clinical Center Nursing Department, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 52:1183-9. 2002..CONCLUSIONS: These data demonstrate the ability to induce panic during a period of diminishing arousal and indicate that panic attacks can occur in the absence of elevated arousal and environmental stress... - Symptoms of depression predict change in physical health after burn injuryBrett D Thombs
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Burns 33:292-8. 2007..02), controlling for patient demographics, burn severity, and symptoms of PTSD. These results suggest that patients should be screened for depression, both in-hospital and during rehabilitation after discharge... - Performance characteristics of depression screening instruments in survivors of acute myocardial infarction: review of the evidenceBrett D Thombs
Johns Hopkins University Evidence Based Practice Center, the Dept of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychosomatics 48:185-94. 2007.... - Plasma drug concentrations and physiological measures in 'dance party' participantsRodney J Irvine
Department of Clinical and Experimental Pharmacology, University of Adelaide, SA, Australia
Neuropsychopharmacology 31:424-30. 2006.... - Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administrationPeter J Winsauer
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
Psychopharmacology (Berl) 159:388-96. 2002..Establishing functional deficits as a result of neurotoxic dosing regimens of MDMA has been difficult. However, moderate success has been achieved when sensitive animal models and drug challenge have been used together...
Research Grants
- PET Studies of the SERT and DAT in METH UsersUna D McCann; Fiscal Year: 2010....
- Sleep and Nocturnal Endocrine Function in MDMA UserUna McCann; Fiscal Year: 2007..Results from the proposed studies will help better define the functional consequences of MDMA exposure in humans, and could shed light on the roles of 5-HT and DA in sleep and nocturnal endocrine function. ..
- PET Imaging MDMA NeurotoxicityUna McCann; Fiscal Year: 2006..g., dementia, Parkinsonism, depression/anxiety). In addition, the proposed 18FDG studies will address the question of if MDMA exposure leads to altered brain function at the most fundamental level, glucose utilization. ..