Una McCann

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Altered pain responses in abstinent (±)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Room 5B71c, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 217:475-84. 2011
  2. pmc Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASB
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:1741-50. 2005
  3. pmc Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumers
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neurology 73:2011-7. 2009
  4. pmc Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 200:439-50. 2008
  5. ncbi request reprint Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Synapse 62:91-100. 2008
  6. pmc Sleep deprivation differentially impairs cognitive performance in abstinent methylenedioxymethamphetamine ("Ecstasy") users
    Una D McCann
    Department of Psychiatry and Neurology, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Neurosci 29:14050-6. 2009
  7. ncbi request reprint The effect of catecholamine depletion by alpha-methyl-para-tyrosine on measures of cognitive performance and sleep in abstinent MDMA users
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:1695-706. 2007
  8. ncbi request reprint Effects of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) on sleep and circadian rhythms
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Drive, Baltimore, MD 21224, USA
    ScientificWorldJournal 7:231-8. 2007
  9. ncbi request reprint Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Mol Imaging Biol 9:151-7. 2007
  10. pmc Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions
    Zsolt Szabo
    Division of Nuclear Medicine, Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 43:678-92. 2002

Research Grants

  1. PET Studies of the SERT and DAT in METH Users
    Una D McCann; Fiscal Year: 2010
  2. Sleep and Nocturnal Endocrine Function in MDMA User
    Una McCann; Fiscal Year: 2007
  3. PET Imaging MDMA Neurotoxicity
    Una McCann; Fiscal Year: 2006

Collaborators

Detail Information

Publications43

  1. doi request reprint Altered pain responses in abstinent (±)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Room 5B71c, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 217:475-84. 2011
    ..Brain 5-HT neurons play a role in pain modulation, yet little is known about long-term effects of MDMA on pain function. Notably, MDMA users have been shown to have altered sleep, a phenomenon that can lead to altered pain modulation...
  2. pmc Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASB
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:1741-50. 2005
    ..These quantitative PET data, obtained using validated first- and second-generation SERT PET ligands, provide strong evidence of reduced SERT density in some recreational MDMA users...
  3. pmc Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumers
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neurology 73:2011-7. 2009
    ..The present study sought to determine whether abstinent recreational MDMA users have an increased prevalence of OSA...
  4. pmc Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 200:439-50. 2008
    ....
  5. ncbi request reprint Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users
    Una D McCann
    Department of Psychiatry, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Synapse 62:91-100. 2008
    ..This study was conducted to further investigate potential persistent psychomotor deficits secondary to METH abuse, and their relationship to brain DAT availability, as measured using quantitative PET methods with [(11)C]WIN 35428...
  6. pmc Sleep deprivation differentially impairs cognitive performance in abstinent methylenedioxymethamphetamine ("Ecstasy") users
    Una D McCann
    Department of Psychiatry and Neurology, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Neurosci 29:14050-6. 2009
    ....
  7. ncbi request reprint The effect of catecholamine depletion by alpha-methyl-para-tyrosine on measures of cognitive performance and sleep in abstinent MDMA users
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:1695-706. 2007
    ..More research is needed to determine potential relationships between sleep abnormalities, cognitive deficits and impulsive behavior in abstinent MDMA users...
  8. ncbi request reprint Effects of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) on sleep and circadian rhythms
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Drive, Baltimore, MD 21224, USA
    ScientificWorldJournal 7:231-8. 2007
    ....
  9. ncbi request reprint Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine
    Una D McCann
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Mol Imaging Biol 9:151-7. 2007
    ..This study used quantitative positron emission tomography (PET) with [(11)C] McN5652, a serotonin transporter (SERT) ligand to determine whether humans previously exposed to fenfluramines showed reductions in SERT binding parameters...
  10. pmc Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions
    Zsolt Szabo
    Division of Nuclear Medicine, Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 43:678-92. 2002
    ..The purpose of this study was to compare and contrast (+)-(11)C-McN5652 and (11)C-DASB under various experimental conditions...
  11. ncbi request reprint MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities
    Brendon P Boot
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Eur J Pharmacol 453:239-44. 2002
    ....
  12. ncbi request reprint Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines
    Jie Yuan
    Department of Neurology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 303:831-9. 2002
    ..These findings suggest that the role of metabolic compromise in amphetamine-induced 5-HT neurotoxicity merits further study...
  13. ncbi request reprint Pharmacokinetic profile of single and repeated oral doses of MDMA in squirrel monkeys: relationship to lasting effects on brain serotonin neurons
    Annis Mechan
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:339-50. 2006
    ....
  14. ncbi request reprint Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity
    Jie Yuan
    Departments of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurochem 80:960-9. 2002
    ....
  15. ncbi request reprint Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines
    Tao Xie
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2639-51. 2006
    ....
  16. pmc Dopamine is not essential for the development of methamphetamine-induced neurotoxicity
    Jie Yuan
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurochem 114:1135-42. 2010
    ..Taken together, these findings demonstrate that DA is not essential for the development of METH-induced dopaminergic neurotoxicity and suggest that mechanisms independent of DA warrant more intense investigation...
  17. ncbi request reprint Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicity
    Tao Xie
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurosci 22:274-83. 2002
    ..The precise role of COX1 and other genes in METH neurotoxicity remains to be elucidated...
  18. ncbi request reprint Heating induces aggregation and decreases detection of serotonin transporter protein on western blots
    Michael W McLane
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Synapse 61:875-6. 2007
    ..By omitting the heat denaturation step in the Western blot procedure, better detection of the SERT protein is achieved...
  19. ncbi request reprint Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons
    Tao Xie
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurosci 24:7043-50. 2004
    ..The present findings may have therapeutic implications for neuropathological conditions involving DA neurons...
  20. ncbi request reprint Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine
    George Hatzidimitriou
    Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Synapse 44:51-7. 2002
    ....
  21. doi request reprint Identifying the serotonin transporter signal in Western blot studies of the neurotoxic potential of MDMA and related drugs
    Michael W McLane
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Synapse 65:1368-72. 2011
    ..These data provide further evidence of lasting loss of the SERT protein after exposure to MDMA and other substituted amphetamines...
  22. doi request reprint Approach-avoidance coping conflict in a sample of burn patients at risk for posttraumatic stress disorder
    James A Fauerbach
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Depress Anxiety 26:838-50. 2009
    ..Study objectives were to determine if contradictory coping messages would lead to such approach-avoidance coping conflict and to determine if experiment-induced coping conflict is also associated with higher distress...
  23. ncbi request reprint Can doctors and nurses recognize depression in patients hospitalized with an acute myocardial infarction in the absence of formal screening?
    Roy C Ziegelstein
    Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
    Psychosom Med 67:393-7. 2005
    ....
  24. pmc Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity
    Melanie Mueller
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Drug Metab Dispos 37:2079-86. 2009
    ....
  25. ncbi request reprint Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy")
    George A Ricaurte
    Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Science 297:2260-3. 2002
    ....
  26. doi request reprint Peritraumatic heart rate and posttraumatic stress disorder in patients with severe burns
    Neda F Gould
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, 4940 Eastern Ave, Asthma and Allergy Center, 5B 71B, Baltimore, MD 21224, USA
    J Clin Psychiatry 72:539-47. 2011
    ..This study expands on previous work by evaluating HR in burn patients followed longitudinally for symptoms of acute stress disorder (ASD) and PTSD...
  27. ncbi request reprint The effects of sleep deprivation on pain inhibition and spontaneous pain in women
    Michael T Smith
    Behavioral Sleep Medicine Program, Johns Hopkins Bayview, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA
    Sleep 30:494-505. 2007
    ....
  28. ncbi request reprint Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of adult nonhuman primates
    George A Ricaurte
    Department of Neurology, Johns Hopkins Medical Institutions, 5501 Hopkins Bayview Circle, Rm 5B 71E, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 315:91-8. 2005
    ..Further preclinical and clinical studies are needed to evaluate the dopaminergic neurotoxic potential of therapeutic doses of amphetamine in children as well as adults...
  29. ncbi request reprint Amphetamine neurotoxicity: accomplishments and remaining challenges
    Una D McCann
    Department of Psychiatry, School of Medicine, The Johns Hopkins University, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurosci Biobehav Rev 27:821-6. 2004
    ..Remaining challenges for this line of investigation are outlined, and suggested avenues for addressing these challenges are provided...
  30. ncbi request reprint Individual variation in rapid eye movement sleep is associated with pain perception in healthy women: preliminary data
    Michael T Smith
    Johns Hopkins University School of Medicine, Behavioral Medicine Research Laboratory and Clinic, 600 North Wolfe Street, Meyer 1 108, Baltimore, MD 21287, USA
    Sleep 28:809-12. 2005
    ..Consequently, we sought to evaluate relationships between sleep architecture and laboratory measures of pain processing in healthy women, sleeping under normal conditions...
  31. ncbi request reprint Response to O'Shea and Colado: the MDMA neurotoxicity profile might provide clues to mechanisms
    George A Ricaurte
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Trends Pharmacol Sci 24:275. 2003
  32. ncbi request reprint Depression following acute myocardial infarction: a prospective relationship with ongoing health and function
    James A Fauerbach
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychosomatics 46:355-61. 2005
    ....
  33. ncbi request reprint Recognition and management of complications of new recreational drug use
    George A Ricaurte
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    Lancet 365:2137-45. 2005
    ..We also alert researchers to specific toxic effects of club-drugs on which more basic information is needed...
  34. ncbi request reprint Relationship between temperature, dopaminergic neurotoxicity, and plasma drug concentrations in methamphetamine-treated squirrel monkeys
    Jie Yuan
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 316:1210-8. 2006
    ..In addition, they suggest that interanimal differences presently observed in thermal and neurotoxic responses to METH may be related to individual differences in drug metabolism...
  35. doi request reprint Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive doses
    Melanie Mueller
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 327:38-44. 2008
    ..By raising MDMA concentrations and prolonging its action, nonlinear pharmacokinetics and T(1/2) prolongation, respectively, may influence the likelihood and severity of MDMA toxicities (including brain serotonin neurotoxicity)...
  36. pmc Direct comparison of (+/-) 3,4-methylenedioxymethamphetamine ("ecstasy") disposition and metabolism in squirrel monkeys and humans
    Melanie Mueller
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Ther Drug Monit 31:367-73. 2009
    ....
  37. pmc Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 218:649-65. 2011
    ..This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior...
  38. doi request reprint Sleep disturbance after mild traumatic brain injury: indicator of injury?
    Vani Rao
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 23:201-5. 2011
    ..These pilot findings need to be replicated on larger samples...
  39. ncbi request reprint Pentagastrin-induced sleep panic attacks: panic in the absence of elevated baseline arousal
    Marilla Geraci
    Clinical Center Nursing Department, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 52:1183-9. 2002
    ..It has been suggested that pharmacological challenges that induce panic attacks are confounded by effects of environmental stress, elevated baseline arousal, and expectancy bias...
  40. ncbi request reprint Symptoms of depression predict change in physical health after burn injury
    Brett D Thombs
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Burns 33:292-8. 2007
    ..02), controlling for patient demographics, burn severity, and symptoms of PTSD. These results suggest that patients should be screened for depression, both in-hospital and during rehabilitation after discharge...
  41. ncbi request reprint Performance characteristics of depression screening instruments in survivors of acute myocardial infarction: review of the evidence
    Brett D Thombs
    Johns Hopkins University Evidence Based Practice Center, the Dept of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychosomatics 48:185-94. 2007
    ....
  42. ncbi request reprint Plasma drug concentrations and physiological measures in 'dance party' participants
    Rodney J Irvine
    Department of Clinical and Experimental Pharmacology, University of Adelaide, SA, Australia
    Neuropsychopharmacology 31:424-30. 2006
    ....
  43. ncbi request reprint Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration
    Peter J Winsauer
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Psychopharmacology (Berl) 159:388-96. 2002
    ..Establishing functional deficits as a result of neurotoxic dosing regimens of MDMA has been difficult. However, moderate success has been achieved when sensitive animal models and drug challenge have been used together...

Research Grants10

  1. PET Studies of the SERT and DAT in METH Users
    Una D McCann; Fiscal Year: 2010
    ....
  2. Sleep and Nocturnal Endocrine Function in MDMA User
    Una McCann; Fiscal Year: 2007
    ..Results from the proposed studies will help better define the functional consequences of MDMA exposure in humans, and could shed light on the roles of 5-HT and DA in sleep and nocturnal endocrine function. ..
  3. PET Imaging MDMA Neurotoxicity
    Una McCann; Fiscal Year: 2006
    ..g., dementia, Parkinsonism, depression/anxiety). In addition, the proposed 18FDG studies will address the question of if MDMA exposure leads to altered brain function at the most fundamental level, glucose utilization. ..