Affiliation: Johns Hopkins University
- Neurologic Complications and Considerations in HIV-Infected PersonsJustin McArthur
Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe St, Meyer 6113, Baltimore, MD, 21287, USA
Curr Infect Dis Rep 15:61-6. 2013....
- Painful small fiber neuropathiesJustin C McArthur
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7613, USA
Continuum (Minneap Minn) 18:106-25. 2012..This article reviews the clinical features, pathophysiology, and treatment of small fiber sensory neuropathy...
- Peripheral nerve toxic effects of nitrofurantoinIk Lin Tan
Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Arch Neurol 69:265-8. 2012..To investigate the role of skin biopsy in nitrofurantoin peripheral neuropathy...
- Human immunodeficiency virus-associated dementia: an evolving diseaseJustin C McArthur
The Johns Hopkins University, HIV Neurology Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7609, USA
J Neurovirol 9:205-21. 2003..This article reviews the changing epidemiology of HIV-associated dementia, current concepts of the different patterns of dementia under the influence of highly active antiretroviral therapy, and reviews therapeutic aspects...
- Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapyJustin C McArthur
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7609, USA
Arch Neurol 61:1687-96. 2004..Before the introduction of combination antiretroviral therapy (CART), neurological disease correlated with cerebrospinal fluid (CSF) levels of human immunodeficiency virus (HIV) RNA...
- Human immunodeficiency virus-associated neurocognitive disorders: Mind the gapJustin C McArthur
NIMH Center for Novel Therapeutics for HIV Associated Cognitive Disorders, Johns Hopkins University, Baltimore, MD, USA
Ann Neurol 67:699-714. 2010..Novel therapies aimed at persistent central nervous system inflammation will be needed to close this gap...
- Epidermal nerve fiber density: normative reference range and diagnostic efficiencyJ C McArthur
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Neurol 55:1513-20. 1998..The sensitivity of neuron-specific antibodies permit the identification of the small unmyelinated nerve fibers within the skin...
- Neurological complications of HIV infectionJustin C McArthur
HIV Neurosciences Program, Johns Hopkins University, Baltimore, MD, USA
Lancet Neurol 4:543-55. 2005..The sensory neuropathies associated with HIV infection are a major cause of morbidity; incidence may be increased by the toxic effects of specific antiretroviral drugs within the peripheral nervous system...
- A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291J C McArthur
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Neurology 54:1080-8. 2000..To evaluate the safety and efficacy of recombinant human nerve growth factor (rhNGF) in HIV-associated sensory neuropathy (SN) within a multicenter, placebo-controlled, randomized trial (ACTG 291)...
- The prevalence and incidence of neurocognitive impairment in the HAART eraKevin R Robertson
Department of Neurology, UNC, Chapel Hill, North Carolina 27599, USA
AIDS 21:1915-21. 2007..The effects of HAART on neurological disease are less well understood. The aim of this study was to assess the prevalence and incidence of neurocognitive impairment in individuals who initiated HAART as part of an AIDS clinical trial...
- A comparison of performance-based measures of function in HIV-associated neurocognitive disordersNishiena S Gandhi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neurovirol 17:159-65. 2011..Newer measures of functional performance can be used to objectively evaluate functional impairment in HAND and validate different levels of HAND...
- Platelet decline: an avenue for investigation into the pathogenesis of human immunodeficiency virus -associated dementiaLynn M Wachtman
Department of Molecular and Comparative Pathobiology, The Johns Hopkins University, Baltimore, Maryland 21287 7609, USA
Arch Neurol 64:1264-72. 2007..The identification of biomarkers identifying onset of human immunodeficiency virus-associated dementia (HIV-D) is critical for diagnosis and the elucidation of pathophysiologic pathways...
- The reliability of skin biopsy with measurement of intraepidermal nerve fiber densityA Gordon Smith
University of Utah, Department of Neurology, Salt Lake City, UT 84132, USA
J Neurol Sci 228:65-9. 2005..IENFD measurement is highly reproducible. At least four sections should be analyzed. Reliability does not vary with severity of disease. These findings suggest IENFD may be a useful endpoint measure in future neuropathy treatment trials...
- Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statinsAshok Chauhan
Department of Neurology, Richard Johnson Division of Neuro Immunology and Neurological Infections, The Johns Hopkins University, 509 Pathology, 600 N Wolfe St, Baltimore, MD 21287, USA
FASEB J 21:777-89. 2007..Our findings suggest that ET-1 may be critical in mediating the neuropathogenesis of HIV dementia and that statins may have therapeutic potential in these patients...
- Evolution of HIV dementia with HIV infectionAvindra Nath
Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
Int Rev Psychiatry 20:25-31. 2008..Oxidative stress markers appear to be predictive of active dementia. However, currently there is no specific treatment available for HIV dementia...
- A programmable prompting device improves adherence to highly active antiretroviral therapy in HIV-infected subjects with memory impairmentAdriana S A Andrade
Division of Infectious Diseases, Department of Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
Clin Infect Dis 41:875-82. 2005..Virological and immunological responses were not related to DMAS use in memory-impaired subjects.Conclusion. The DMAS prompting device improved adherence for memory-impaired subjects but not for memory-intact subjects...
- The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathyMichael Polydefkis
Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
Brain 127:1606-15. 2004..These results suggest that regenerative neuropathy trials could include non-neuropathic subjects and that trial duration can be dramatically shortened...
- Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neuronsSanjay C Keswani
Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
Ann Neurol 54:287-96. 2003..This newly described Schwann cell-neuron interaction may be pathogenically relevant not only in HIV-SN but also in other peripheral neuropathies...
- Severity of HIV-associated neuropathy is associated with plasma HIV-1 RNA levelsDavid M Simpson
Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1052, New York, NY 10029, USA
AIDS 16:407-12. 2002..Further studies are needed to determine if aggressive use of antiretroviral drugs, including the use of dideoxynucleosides, may be of benefit to prevent or improve peripheral neuropathy...
- HIV-associated cognitive impairment before and after the advent of combination therapyNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurovirol 8:136-42. 2002..Even though HAART has reduced the incidence of HIV dementia, HIV-associated cognitive impairment continues to be a major clinical problem among individuals with advanced infection...
- The International HIV Dementia Scale: a new rapid screening test for HIV dementiaNed C Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
AIDS 19:1367-74. 2005..The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda...
- Perturbation of sphingolipid metabolism and ceramide production in HIV-dementiaNorman J Haughey
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Neurol 55:257-67. 2004..These results suggest that HIV-1 infection may promote a lipid imbalance in neural cells, resulting in an overproduction of ceramide and consequent cellular dysfunction and death...
- Converging roles for sphingolipids and cell stress in the progression of neuro-AIDSNorman J Haughey
Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
Front Biosci 13:5120-30. 2008....
- HIV dementia: an evolving diseaseJustin C McArthur
Johns Hopkins University HIV Neurosciences Program, Baltimore, MD, USA
J Neuroimmunol 157:3-10. 2004..relating to HIV-dementia, including: (a) are there differing phenotypes or temporal patterns of progression in HIV-dementia? (b) what determines these temporal patterns? and (c), what has been the impact of therapy on HIV dementia?..
- Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performanceChristina M Marra
Department of Neurology, University of Washington School of Medicine, Seattle, USA
AIDS 23:1359-66. 2009..To determine whether antiretroviral regimens with good central nervous system (CNS) penetration control HIV in cerebrospinal fluid (CSF) and improve cognition...
- Progression of HIV-associated dementia treated with HAARTRyan H Dougherty
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
AIDS Read 12:69-74. 2002..3). Age, ethnicity, gender, adherence, and predicted CNS penetrance of HAART were not associated with improved outcomes...
- Role of metabolic syndrome components in HIV-associated sensory neuropathyBeau M Ances
Department of Neurology, Washington University, St Louis, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
AIDS 23:2317-22. 2009..We examined whether MetS or its components predispose individuals to HIV-associated sensory neuropathy (HIV-SN)...
- Case 8: absentminded and "walking like a drunk"Matthew A Joenig
Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
MedGenMed 7:64. 2005
- Therapy Insight: CNS manifestations of HIV-associated immune reconstitution inflammatory syndromeDavid J Riedel
University of Maryland, Baltimore, MD 21287, USA
Nat Clin Pract Neurol 2:557-65. 2006..Furthermore, it is possible that more-chronic forms of the syndrome exist but remain unrecognized. Here, we review the various clinical presentations of CNS IRIS, and discuss options for their management...
- Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsiesGigi J Ebenezer
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7613, USA
Brain 130:2703-14. 2007....
- Diagnostic utility of the subjective peripheral neuropathy screen in HIV-infected persons with peripheral sensory polyneuropathyAnita B Venkataramana
Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
AIDS Read 15:341-4, 348-9, 354. 2005..The SPNS appears to be a useful screening tool for HIV-associated sensory neuropathies; it has a high specificity and a good positive predictive value...
- FK506 is neuroprotective in a model of antiretroviral toxic neuropathySanjay C Keswani
Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
Ann Neurol 53:57-64. 2003....
- New insights into diabetic polyneuropathyMichael Polydefkis
Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
JAMA 290:1371-6. 2003..Such approaches may address some of the challenges of past diabetic polyneuropathy trials...
- Assessment of epidermal nerve fibers: a new diagnostic and predictive tool for peripheral neuropathiesGigi J Ebenezer
Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287 7609, USA
J Neuropathol Exp Neurol 66:1059-73. 2007..In this article we review the state of current research and clinical practice in the use of skin biopsies and epidermal nerve densities...
- Amyloid precursor protein expression in circulating monocytes and brain macrophages from patients with HIV-associated cognitive impairmentAri Vehmas
Department of Neurology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Neuroimmunol 157:99-110. 2004..In the brain, APP appeared as axonal immunoreactivity and diffuse plaques, and APP+ perivascular macrophages were seen in cases with severe dementia. APP may facilitate monocyte entry into the brain...
- Altered cutaneous nerve regeneration in a simian immunodeficiency virus / macaque intracutaneous axotomy modelGigi J Ebenezer
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
J Comp Neurol 514:272-83. 2009....
- Epidermal reinnervation after intracutaneous axotomy in manBindu Rajan
Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287-7609, USA
J Comp Neurol 457:24-36. 2003..These models can be used to study reinnervation of denervated skin in man in different injury models and have relevance for exploring the stimuli for axonal growth and remodeling...
- Depressive symptoms, quality of life, and neuropsychological performance in HIV/AIDS: the impact of gender and injection drug useAmy B Wisniewski
Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
J Neurovirol 11:138-43. 2005..Thus, further study and development of treatment protocols targeted at including women and IDU are needed...
- Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesisCoryse St Hillaire
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Neurovirol 11:535-43. 2005..Additional studies may be warranted to determine whether altered AQP4 expression represents a protective and/or maladaptive response to central nervous system (CNS) inflammation...
- Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDSDima A Hammoud
Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-2182, USA
J Neurovirol 11:346-55. 2005..The findings of this pilot study support a role for glial cell activation in HAD, and that PET with [11C]-R-PK11195 can detect the concomitants of neuronal damage in individuals infected with HIV...
- Mirtazapine use in human immunodeficiency virus-infected patients with progressive multifocal leukoencephalopathyDeanna Cettomai
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Arch Neurol 66:255-8. 2009..An efficacious treatment is needed for human immunodeficiency virus (HIV)-infected and uninfected patients with progressive multifocal leukoencephalopathy (PML)...
- Quantitative MR spectroscopic imaging of brain lesions in patients with AIDS: correlation with [11C-methyl]thymidine PET and thallium-201 SPECTMartin G Pomper
Department of Radiology, Johns Hopkins University, Baltimore, MD 21287-2182, USA
Acad Radiol 9:398-409. 2002..CONCLUSION: PET and SPECT may be more reliable than MR spectroscopic imaging for differentiating benign lesions from primary central nervous system lymphoma in patients with AIDS...
- Reduction of disease activity and disability with high-dose cyclophosphamide in patients with aggressive multiple sclerosisChitra Krishnan
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5371, USA
Arch Neurol 65:1044-51. 2008..To explore the safety and effectiveness of high-dose cyclophosphamide (HiCy) without bone marrow transplantation in patients with aggressive multiple sclerosis (MS)...
- Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosisDavid N Irani
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Ann Neurol 59:237-47. 2006..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis...
- The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous systemScott L Letendre
University of California, 150 W Washington St, San Diego, CA 92103, USA
J Neuroimmune Pharmacol 2:120-7. 2007..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals...
- AIDS dementia complex in ChinaYun Cheng Wu
Department of Neurology, Shanghai First People s Hospital, No 85 Wujin Road, Shanghai 200080, China
J Clin Neurosci 14:8-11. 2007..The median survival of these ADC patients from the time of diagnosis was 4.7 months. In this context, we suggest that early diagnosis and highly active antiretroviral therapy treatment is an urgent priority in developing countries...
- Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous systemScott Letendre
University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
Arch Neurol 65:65-70. 2008..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load...
- Recent developments in the HIV neuropathiesCarlos A Luciano
Specialized Neuroscience Research Program in NeuroAIDS, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00936, USA
Curr Opin Neurol 16:403-9. 2003..A better understanding of the prevailing mechanisms will allow for more effective interventions...
- Nucleoside analogues and neuropathy in the era of HAARTCatherine L Cherry
Department of Infectious Diseases and Microbiology, The Alfred Hospital, Commercial Road, 3181 Prahran, Melbourne, Vic, Australia
J Clin Virol 26:195-207. 2003..A clinically identical SN may also occur as a consequence of exposure to some HIV treatments. In this setting, impaired mitochondrial function is thought to play a role in the development of neurological dysfunction...
- Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammationGareth Jones
University of Calgary, Calgary, Canada
Virology 334:178-93. 2005..Our results suggest that HIV-1 infection of the peripheral nervous system causes axonal degeneration, possibly through the induction of pro-inflammatory cytokines...
- Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infectionFarshid Noorbakhsh
Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
J Immunol 174:7320-9. 2005..001). Thus, neuroinflammation can exert protective effects by which it induces PAR-2 expression with the ensuing abrogation of neuronal death...
- Assessing HIV-associated dementia: modified HIV dementia scale versus the Grooved PegboardHenraya F Davis
Department of Psychology, Johnson C. Smith University, Charlotte, NC, USA
AIDS Read 12:29-31, 38. 2002..However, the M-HDS requires no equipment and is simpler to administer; so it may be more useful for screening by nonneurologists...
- Acute meningoencephalitis in chronic human immunodeficiency virus (HIV) infection: putative central nervous system escape of HIV replicationKaren A Wendel
Division of Infectious Diseases, Oklahoma University Health Science Center, Oklahoma City, OK 73104, USA
Clin Infect Dis 37:1107-11. 2003....
- HIV-associated sensory neuropathiesSanjay C Keswani
AIDS 16:2105-17. 2002
- Clinical validation of the NeuroScreenRonald J Ellis
Department of Neurosciences, UCSD AntiViral Research Center and HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA
J Neurovirol 11:503-11. 2005..However, because it yields substantial numbers of false positives and negatives, the NeuroScreen may be less useful in evaluating individual patients...
- Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenylJadwiga Turchan-Cholewo
Departments of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40546, USA
Neurobiol Dis 23:109-19. 2006..In conclusion, opiate abusers with HIV infection and the ApoE4 allele may be at increased risk of developing dementia. L-deprenyl and a plant estrogen, diosgenin, may have therapeutic potential in this population...
- Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patientsLucette A Cysique
St Vincent s Hospital Clinical School, University of New South Wales, Darlinghurst, Sydney, Australia
J Acquir Immune Defic Syndr 39:426-9. 2005....
- Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairmentValerie Wojna
NeuroAIDS Program, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
J Neurovirol 12:356-64. 2006....
- Is the glass three-quarters full or one-quarter empty?Justin C McArthur
J Infect Dis 194:1628-31. 2006
- Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10Guido van Marle
Department of Clinical Neurosciences, University of Calgary, Calgary AB, Canada
Virology 329:302-18. 2004..Furthermore, Nef molecular diversity was evident in brain tissue among patients with neurological disease and which may influence IP-10 production by astrocytes...
- An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infectionJeffrey J Sevigny
Department of Neurology and Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Arch Neurol 64:97-102. 2007..Several markers of immune activation have been identified as potential prognostic markers for human immunodeficiency virus (HIV)-associated morbidity and mortality, but the results from studies are conflicting...
- Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activationLeonie A Boven
Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
J Neurovirol 13:173-84. 2007..Thus, mutations within the HIV-1 tat gene may exert pathogenic effects contributing to the development of HAD, which are independent of its effects on LTR transactivation...
- Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN riskCatherine L Cherry
Burnet Institute, Melbourne, Victoria, Australia
AIDS Res Hum Retroviruses 24:117-23. 2008..quot; In addition to patient height, cytokine genotype influenced NRTI-SN risk following dNRTI exposure, suggesting inflammation contributes to NRTI-SN...
- NeuroAIDS, drug abuse, and inflammation: building collaborative research activitiesJoan W Berman
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Neuroimmune Pharmacol 1:351-99. 2006..Research priorities were identified. Additional information about this meeting is available through links from the NIDA AIDS Research Program website ( http://www.nida.nih.gov/about/organization/arp/arp-websites.htm )...
- Evaluation of a clinical screening tool for HIV-associated sensory neuropathiesCatherine L Cherry
Burnet Institute, Melbourne, Australia
Neurology 65:1778-81. 2005..To evaluate the performance characteristics of a brief clinical neuropathy screening tool for use in sensory neuropathies complicating HIV infection...
- Through a glass, darkly: cerebrospinal fluid viral load measurements and the pathogenesis of human immunodeficiency virus infection of the central nervous systemKenneth L Tyler
Arch Neurol 59:909-12. 2002
- Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fatCatherine L Cherry
Department of Infectious Diseases and Microbiology, The Alfred Hospital, Melbourne, Australia
J Acquir Immune Defic Syndr 30:271-7. 2002..A reliable and valid laboratory test to detect this is not yet available. The objective of this study was to correlate tissue mtDNA quantification in HIV-infected patients with exposure to nucleoside analogs...
- Another tool for the neurologist's toolboxJustin C McArthur
Ann Neurol 57:163-7. 2005
- Enzyme replacement therapy and intraepidermal innervation density in Fabry diseaseRaphael Schiffmann
Developmental and Metabolic Neurology Branch, NINDS, National Institutes of Health, Bldg 10, Room 3D03, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
Muscle Nerve 34:53-6. 2006..Thermal thresholds remained unchanged. We conclude that epidermal nerve fiber regeneration, as measured in the distal thigh, does not occur in this patient population after 12-18 months of ERT...
- Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissuesMelissa J Churchill
The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
J Neurovirol 12:146-52. 2006..The ability of HIV-1 to integrate in terminally differentiated astrocytes suggests a permanent reservoir of provirus in brain that will impact the development and likely success of strategies aimed at eradicating HIV-1...
- Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1Brandon F Keele
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
J Virol 82:5548-61. 2008..These data indicate that FDCs represent a significant reservoir of infectious and diverse HIV, thereby providing a mechanism for viral persistence for months to years...
- Tissue-specific associations between mitochondrial DNA levels and current treatment status in HIV-infected individualsCatherine L Cherry
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
J Acquir Immune Defic Syndr 42:435-40. 2006..This study examined mtDNA levels in matched samples of peripheral blood mononuclear cells (PBMCs) and subcutaneous fat from a large Australian cohort to examine treatment, clinical, and demographic associations with mtDNA depletion...
- Predicting progression of NeuroAIDSJustin McArthur; Fiscal Year: 2007..Abstract Not Provided: ..
- HIV-sensory neuropathies:risk factors, immunopathologyJustin McArthur; Fiscal Year: 2006..We will extend our studies of the immunopathology of HIV-SN, using our extensive tissue collections to define the relationship of chemokine upregulation to neuropathic pain. ..