Justin McArthur

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Neurologic Complications and Considerations in HIV-Infected Persons
    Justin McArthur
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe St, Meyer 6113, Baltimore, MD, 21287, USA
    Curr Infect Dis Rep 15:61-6. 2013
  2. doi request reprint Painful small fiber neuropathies
    Justin C McArthur
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7613, USA
    Continuum (Minneap Minn) 18:106-25. 2012
  3. doi request reprint Peripheral nerve toxic effects of nitrofurantoin
    Ik Lin Tan
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 69:265-8. 2012
  4. ncbi request reprint Human immunodeficiency virus-associated dementia: an evolving disease
    Justin C McArthur
    The Johns Hopkins University, HIV Neurology Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7609, USA
    J Neurovirol 9:205-21. 2003
  5. ncbi request reprint Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy
    Justin C McArthur
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7609, USA
    Arch Neurol 61:1687-96. 2004
  6. ncbi request reprint Human immunodeficiency virus-associated neurocognitive disorders: Mind the gap
    Justin C McArthur
    NIMH Center for Novel Therapeutics for HIV Associated Cognitive Disorders, Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 67:699-714. 2010
  7. ncbi request reprint Epidermal nerve fiber density: normative reference range and diagnostic efficiency
    J C McArthur
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Neurol 55:1513-20. 1998
  8. ncbi request reprint Neurological complications of HIV infection
    Justin C McArthur
    HIV Neurosciences Program, Johns Hopkins University, Baltimore, MD, USA
    Lancet Neurol 4:543-55. 2005
  9. ncbi request reprint A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291
    J C McArthur
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 54:1080-8. 2000
  10. ncbi request reprint The prevalence and incidence of neurocognitive impairment in the HAART era
    Kevin R Robertson
    Department of Neurology, UNC, Chapel Hill, North Carolina 27599, USA
    AIDS 21:1915-21. 2007

Research Grants

  1. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2002
  2. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2007
  3. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2006
  4. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2006
  5. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2004
  6. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2005
  7. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2005
  8. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2004
  9. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2004
  10. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2003

Detail Information

Publications72

  1. doi request reprint Neurologic Complications and Considerations in HIV-Infected Persons
    Justin McArthur
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe St, Meyer 6113, Baltimore, MD, 21287, USA
    Curr Infect Dis Rep 15:61-6. 2013
    ....
  2. doi request reprint Painful small fiber neuropathies
    Justin C McArthur
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7613, USA
    Continuum (Minneap Minn) 18:106-25. 2012
    ..This article reviews the clinical features, pathophysiology, and treatment of small fiber sensory neuropathy...
  3. doi request reprint Peripheral nerve toxic effects of nitrofurantoin
    Ik Lin Tan
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 69:265-8. 2012
    ..To investigate the role of skin biopsy in nitrofurantoin peripheral neuropathy...
  4. ncbi request reprint Human immunodeficiency virus-associated dementia: an evolving disease
    Justin C McArthur
    The Johns Hopkins University, HIV Neurology Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7609, USA
    J Neurovirol 9:205-21. 2003
    ..This article reviews the changing epidemiology of HIV-associated dementia, current concepts of the different patterns of dementia under the influence of highly active antiretroviral therapy, and reviews therapeutic aspects...
  5. ncbi request reprint Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy
    Justin C McArthur
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7609, USA
    Arch Neurol 61:1687-96. 2004
    ..Before the introduction of combination antiretroviral therapy (CART), neurological disease correlated with cerebrospinal fluid (CSF) levels of human immunodeficiency virus (HIV) RNA...
  6. ncbi request reprint Human immunodeficiency virus-associated neurocognitive disorders: Mind the gap
    Justin C McArthur
    NIMH Center for Novel Therapeutics for HIV Associated Cognitive Disorders, Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 67:699-714. 2010
    ..Novel therapies aimed at persistent central nervous system inflammation will be needed to close this gap...
  7. ncbi request reprint Epidermal nerve fiber density: normative reference range and diagnostic efficiency
    J C McArthur
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Neurol 55:1513-20. 1998
    ..The sensitivity of neuron-specific antibodies permit the identification of the small unmyelinated nerve fibers within the skin...
  8. ncbi request reprint Neurological complications of HIV infection
    Justin C McArthur
    HIV Neurosciences Program, Johns Hopkins University, Baltimore, MD, USA
    Lancet Neurol 4:543-55. 2005
    ..The sensory neuropathies associated with HIV infection are a major cause of morbidity; incidence may be increased by the toxic effects of specific antiretroviral drugs within the peripheral nervous system...
  9. ncbi request reprint A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291
    J C McArthur
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 54:1080-8. 2000
    ..To evaluate the safety and efficacy of recombinant human nerve growth factor (rhNGF) in HIV-associated sensory neuropathy (SN) within a multicenter, placebo-controlled, randomized trial (ACTG 291)...
  10. ncbi request reprint The prevalence and incidence of neurocognitive impairment in the HAART era
    Kevin R Robertson
    Department of Neurology, UNC, Chapel Hill, North Carolina 27599, USA
    AIDS 21:1915-21. 2007
    ..The effects of HAART on neurological disease are less well understood. The aim of this study was to assess the prevalence and incidence of neurocognitive impairment in individuals who initiated HAART as part of an AIDS clinical trial...
  11. ncbi request reprint A comparison of performance-based measures of function in HIV-associated neurocognitive disorders
    Nishiena S Gandhi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurovirol 17:159-65. 2011
    ..Newer measures of functional performance can be used to objectively evaluate functional impairment in HAND and validate different levels of HAND...
  12. ncbi request reprint Platelet decline: an avenue for investigation into the pathogenesis of human immunodeficiency virus -associated dementia
    Lynn M Wachtman
    Department of Molecular and Comparative Pathobiology, The Johns Hopkins University, Baltimore, Maryland 21287 7609, USA
    Arch Neurol 64:1264-72. 2007
    ..The identification of biomarkers identifying onset of human immunodeficiency virus-associated dementia (HIV-D) is critical for diagnosis and the elucidation of pathophysiologic pathways...
  13. ncbi request reprint The reliability of skin biopsy with measurement of intraepidermal nerve fiber density
    A Gordon Smith
    University of Utah, Department of Neurology, Salt Lake City, UT 84132, USA
    J Neurol Sci 228:65-9. 2005
    ..IENFD measurement is highly reproducible. At least four sections should be analyzed. Reliability does not vary with severity of disease. These findings suggest IENFD may be a useful endpoint measure in future neuropathy treatment trials...
  14. ncbi request reprint Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins
    Ashok Chauhan
    Department of Neurology, Richard Johnson Division of Neuro Immunology and Neurological Infections, The Johns Hopkins University, 509 Pathology, 600 N Wolfe St, Baltimore, MD 21287, USA
    FASEB J 21:777-89. 2007
    ..Our findings suggest that ET-1 may be critical in mediating the neuropathogenesis of HIV dementia and that statins may have therapeutic potential in these patients...
  15. doi request reprint Evolution of HIV dementia with HIV infection
    Avindra Nath
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    Int Rev Psychiatry 20:25-31. 2008
    ..Oxidative stress markers appear to be predictive of active dementia. However, currently there is no specific treatment available for HIV dementia...
  16. ncbi request reprint A programmable prompting device improves adherence to highly active antiretroviral therapy in HIV-infected subjects with memory impairment
    Adriana S A Andrade
    Division of Infectious Diseases, Department of Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 41:875-82. 2005
    ..Virological and immunological responses were not related to DMAS use in memory-impaired subjects.Conclusion. The DMAS prompting device improved adherence for memory-impaired subjects but not for memory-intact subjects...
  17. ncbi request reprint The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy
    Michael Polydefkis
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 127:1606-15. 2004
    ..These results suggest that regenerative neuropathy trials could include non-neuropathic subjects and that trial duration can be dramatically shortened...
  18. ncbi request reprint Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Ann Neurol 54:287-96. 2003
    ..This newly described Schwann cell-neuron interaction may be pathogenically relevant not only in HIV-SN but also in other peripheral neuropathies...
  19. ncbi request reprint Severity of HIV-associated neuropathy is associated with plasma HIV-1 RNA levels
    David M Simpson
    Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1052, New York, NY 10029, USA
    AIDS 16:407-12. 2002
    ..To determine if there is an association between plasma HIV-1 RNA levels and severity of HIV-associated distal symmetrical polyneuropathy (DSP)...
  20. ncbi request reprint HIV-associated cognitive impairment before and after the advent of combination therapy
    Ned Sacktor
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurovirol 8:136-42. 2002
    ..Even though HAART has reduced the incidence of HIV dementia, HIV-associated cognitive impairment continues to be a major clinical problem among individuals with advanced infection...
  21. ncbi request reprint The International HIV Dementia Scale: a new rapid screening test for HIV dementia
    Ned C Sacktor
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    AIDS 19:1367-74. 2005
    ..The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale (IHDS) in cohorts from the US and Uganda...
  22. ncbi request reprint Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia
    Norman J Haughey
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Neurol 55:257-67. 2004
    ..These results suggest that HIV-1 infection may promote a lipid imbalance in neural cells, resulting in an overproduction of ceramide and consequent cellular dysfunction and death...
  23. pmc Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS
    Norman J Haughey
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Front Biosci 13:5120-30. 2008
    ....
  24. ncbi request reprint HIV dementia: an evolving disease
    Justin C McArthur
    Johns Hopkins University HIV Neurosciences Program, Baltimore, MD, USA
    J Neuroimmunol 157:3-10. 2004
    ..relating to HIV-dementia, including: (a) are there differing phenotypes or temporal patterns of progression in HIV-dementia? (b) what determines these temporal patterns? and (c), what has been the impact of therapy on HIV dementia?..
  25. pmc Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance
    Christina M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    AIDS 23:1359-66. 2009
    ..To determine whether antiretroviral regimens with good central nervous system (CNS) penetration control HIV in cerebrospinal fluid (CSF) and improve cognition...
  26. ncbi request reprint Progression of HIV-associated dementia treated with HAART
    Ryan H Dougherty
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
    AIDS Read 12:69-74. 2002
    ..3). Age, ethnicity, gender, adherence, and predicted CNS penetrance of HAART were not associated with improved outcomes...
  27. pmc Role of metabolic syndrome components in HIV-associated sensory neuropathy
    Beau M Ances
    Department of Neurology, Washington University, St Louis, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    AIDS 23:2317-22. 2009
    ..We examined whether MetS or its components predispose individuals to HIV-associated sensory neuropathy (HIV-SN)...
  28. pmc Case 8: absentminded and "walking like a drunk"
    Matthew A Joenig
    Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    MedGenMed 7:64. 2005
  29. ncbi request reprint Therapy Insight: CNS manifestations of HIV-associated immune reconstitution inflammatory syndrome
    David J Riedel
    University of Maryland, Baltimore, MD 21287, USA
    Nat Clin Pract Neurol 2:557-65. 2006
    ..Furthermore, it is possible that more-chronic forms of the syndrome exist but remain unrecognized. Here, we review the various clinical presentations of CNS IRIS, and discuss options for their management...
  30. ncbi request reprint Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies
    Gigi J Ebenezer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7613, USA
    Brain 130:2703-14. 2007
    ....
  31. ncbi request reprint Diagnostic utility of the subjective peripheral neuropathy screen in HIV-infected persons with peripheral sensory polyneuropathy
    Anita B Venkataramana
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS Read 15:341-4, 348-9, 354. 2005
    ..The SPNS appears to be a useful screening tool for HIV-associated sensory neuropathies; it has a high specificity and a good positive predictive value...
  32. ncbi request reprint FK506 is neuroprotective in a model of antiretroviral toxic neuropathy
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 53:57-64. 2003
    ....
  33. ncbi request reprint New insights into diabetic polyneuropathy
    Michael Polydefkis
    Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    JAMA 290:1371-6. 2003
    ..Such approaches may address some of the challenges of past diabetic polyneuropathy trials...
  34. ncbi request reprint Assessment of epidermal nerve fibers: a new diagnostic and predictive tool for peripheral neuropathies
    Gigi J Ebenezer
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287 7609, USA
    J Neuropathol Exp Neurol 66:1059-73. 2007
    ..In this article we review the state of current research and clinical practice in the use of skin biopsies and epidermal nerve densities...
  35. ncbi request reprint Amyloid precursor protein expression in circulating monocytes and brain macrophages from patients with HIV-associated cognitive impairment
    Ari Vehmas
    Department of Neurology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Neuroimmunol 157:99-110. 2004
    ..In the brain, APP appeared as axonal immunoreactivity and diffuse plaques, and APP+ perivascular macrophages were seen in cases with severe dementia. APP may facilitate monocyte entry into the brain...
  36. pmc Altered cutaneous nerve regeneration in a simian immunodeficiency virus / macaque intracutaneous axotomy model
    Gigi J Ebenezer
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
    J Comp Neurol 514:272-83. 2009
    ....
  37. ncbi request reprint Epidermal reinnervation after intracutaneous axotomy in man
    Bindu Rajan
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287 7609, USA
    J Comp Neurol 457:24-36. 2003
    ..These models can be used to study reinnervation of denervated skin in man in different injury models and have relevance for exploring the stimuli for axonal growth and remodeling...
  38. ncbi request reprint Depressive symptoms, quality of life, and neuropsychological performance in HIV/AIDS: the impact of gender and injection drug use
    Amy B Wisniewski
    Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Neurovirol 11:138-43. 2005
    ..Thus, further study and development of treatment protocols targeted at including women and IDU are needed...
  39. ncbi request reprint Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesis
    Coryse St Hillaire
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurovirol 11:535-43. 2005
    ..Additional studies may be warranted to determine whether altered AQP4 expression represents a protective and/or maladaptive response to central nervous system (CNS) inflammation...
  40. ncbi request reprint Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS
    Dima A Hammoud
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2182, USA
    J Neurovirol 11:346-55. 2005
    ..The findings of this pilot study support a role for glial cell activation in HAD, and that PET with [11C]-R-PK11195 can detect the concomitants of neuronal damage in individuals infected with HIV...
  41. doi request reprint Mirtazapine use in human immunodeficiency virus-infected patients with progressive multifocal leukoencephalopathy
    Deanna Cettomai
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Neurol 66:255-8. 2009
    ..An efficacious treatment is needed for human immunodeficiency virus (HIV)-infected and uninfected patients with progressive multifocal leukoencephalopathy (PML)...
  42. ncbi request reprint Quantitative MR spectroscopic imaging of brain lesions in patients with AIDS: correlation with [11C-methyl]thymidine PET and thallium-201 SPECT
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287 2182, USA
    Acad Radiol 9:398-409. 2002
    ..The purpose of this study was to examine the metabolic basis for magnetic resonance (MR) spectroscopic imaging findings in focal brain lesions of patients with acquired immunodeficiency syndrome (AIDS)...
  43. pmc Reduction of disease activity and disability with high-dose cyclophosphamide in patients with aggressive multiple sclerosis
    Chitra Krishnan
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5371, USA
    Arch Neurol 65:1044-51. 2008
    ..To explore the safety and effectiveness of high-dose cyclophosphamide (HiCy) without bone marrow transplantation in patients with aggressive multiple sclerosis (MS)...
  44. ncbi request reprint Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis
    David N Irani
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Neurol 59:237-47. 2006
    ..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis...
  45. ncbi request reprint The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Scott L Letendre
    University of California, 150 W Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:120-7. 2007
    ..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals...
  46. ncbi request reprint AIDS dementia complex in China
    Yun Cheng Wu
    Department of Neurology, Shanghai First People s Hospital, No 85 Wujin Road, Shanghai 200080, China
    J Clin Neurosci 14:8-11. 2007
    ..The median survival of these ADC patients from the time of diagnosis was 4.7 months. In this context, we suggest that early diagnosis and highly active antiretroviral therapy treatment is an urgent priority in developing countries...
  47. pmc Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
    ..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load...
  48. ncbi request reprint Recent developments in the HIV neuropathies
    Carlos A Luciano
    Specialized Neuroscience Research Program in NeuroAIDS, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00936, USA
    Curr Opin Neurol 16:403-9. 2003
    ....
  49. ncbi request reprint Nucleoside analogues and neuropathy in the era of HAART
    Catherine L Cherry
    Department of Infectious Diseases and Microbiology, The Alfred Hospital, Commercial Road, 3181 Prahran, Melbourne, Vic, Australia
    J Clin Virol 26:195-207. 2003
    ..A clinically identical SN may also occur as a consequence of exposure to some HIV treatments. In this setting, impaired mitochondrial function is thought to play a role in the development of neurological dysfunction...
  50. ncbi request reprint Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammation
    Gareth Jones
    University of Calgary, Calgary, Canada
    Virology 334:178-93. 2005
    ..Our results suggest that HIV-1 infection of the peripheral nervous system causes axonal degeneration, possibly through the induction of pro-inflammatory cytokines...
  51. ncbi request reprint Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection
    Farshid Noorbakhsh
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    J Immunol 174:7320-9. 2005
    ..001). Thus, neuroinflammation can exert protective effects by which it induces PAR-2 expression with the ensuing abrogation of neuronal death...
  52. ncbi request reprint Assessing HIV-associated dementia: modified HIV dementia scale versus the Grooved Pegboard
    Henraya F Davis
    Department of Psychology, Johnson C Smith University, Charlotte, NC, USA
    AIDS Read 12:29-31, 38. 2002
    ..However, the M-HDS requires no equipment and is simpler to administer; so it may be more useful for screening by nonneurologists...
  53. ncbi request reprint Acute meningoencephalitis in chronic human immunodeficiency virus (HIV) infection: putative central nervous system escape of HIV replication
    Karen A Wendel
    Division of Infectious Diseases, Oklahoma University Health Science Center, Oklahoma City, OK 73104, USA
    Clin Infect Dis 37:1107-11. 2003
    ....
  54. ncbi request reprint HIV-associated sensory neuropathies
    Sanjay C Keswani
    AIDS 16:2105-17. 2002
  55. ncbi request reprint Clinical validation of the NeuroScreen
    Ronald J Ellis
    Department of Neurosciences, UCSD AntiViral Research Center and HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA
    J Neurovirol 11:503-11. 2005
    ..However, because it yields substantial numbers of false positives and negatives, the NeuroScreen may be less useful in evaluating individual patients...
  56. ncbi request reprint Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl
    Jadwiga Turchan-Cholewo
    Departments of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40546, USA
    Neurobiol Dis 23:109-19. 2006
    ..In conclusion, opiate abusers with HIV infection and the ApoE4 allele may be at increased risk of developing dementia. L-deprenyl and a plant estrogen, diosgenin, may have therapeutic potential in this population...
  57. ncbi request reprint Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients
    Lucette A Cysique
    St Vincent s Hospital Clinical School, University of New South Wales, Darlinghurst, Sydney, Australia
    J Acquir Immune Defic Syndr 39:426-9. 2005
    ....
  58. ncbi request reprint Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment
    Valerie Wojna
    NeuroAIDS Program, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
    J Neurovirol 12:356-64. 2006
    ....
  59. ncbi request reprint Is the glass three-quarters full or one-quarter empty?
    Justin C McArthur
    J Infect Dis 194:1628-31. 2006
  60. ncbi request reprint Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10
    Guido van Marle
    Department of Clinical Neurosciences, University of Calgary, Calgary AB, Canada
    Virology 329:302-18. 2004
    ..Furthermore, Nef molecular diversity was evident in brain tissue among patients with neurological disease and which may influence IP-10 production by astrocytes...
  61. ncbi request reprint An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection
    Jeffrey J Sevigny
    Department of Neurology and Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 64:97-102. 2007
    ..Several markers of immune activation have been identified as potential prognostic markers for human immunodeficiency virus (HIV)-associated morbidity and mortality, but the results from studies are conflicting...
  62. ncbi request reprint Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activation
    Leonie A Boven
    Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurovirol 13:173-84. 2007
    ..Thus, mutations within the HIV-1 tat gene may exert pathogenic effects contributing to the development of HAD, which are independent of its effects on LTR transactivation...
  63. doi request reprint Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk
    Catherine L Cherry
    Burnet Institute, Melbourne, Victoria, Australia
    AIDS Res Hum Retroviruses 24:117-23. 2008
    ..In addition to patient height, cytokine genotype influenced NRTI-SN risk following dNRTI exposure, suggesting inflammation contributes to NRTI-SN...
  64. ncbi request reprint NeuroAIDS, drug abuse, and inflammation: building collaborative research activities
    Joan W Berman
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Neuroimmune Pharmacol 1:351-99. 2006
    ..Research priorities were identified. Additional information about this meeting is available through links from the NIDA AIDS Research Program website ( http://www.nida.nih.gov/about/organization/arp/arp-websites.htm )...
  65. ncbi request reprint Evaluation of a clinical screening tool for HIV-associated sensory neuropathies
    Catherine L Cherry
    Burnet Institute, Melbourne, Australia
    Neurology 65:1778-81. 2005
    ..To evaluate the performance characteristics of a brief clinical neuropathy screening tool for use in sensory neuropathies complicating HIV infection...
  66. ncbi request reprint Through a glass, darkly: cerebrospinal fluid viral load measurements and the pathogenesis of human immunodeficiency virus infection of the central nervous system
    Kenneth L Tyler
    Arch Neurol 59:909-12. 2002
  67. ncbi request reprint Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat
    Catherine L Cherry
    Department of Infectious Diseases and Microbiology, The Alfred Hospital, Melbourne, Australia
    J Acquir Immune Defic Syndr 30:271-7. 2002
    ..A reliable and valid laboratory test to detect this is not yet available. The objective of this study was to correlate tissue mtDNA quantification in HIV-infected patients with exposure to nucleoside analogs...
  68. ncbi request reprint Another tool for the neurologist's toolbox
    Justin C McArthur
    Ann Neurol 57:163-7. 2005
  69. ncbi request reprint Enzyme replacement therapy and intraepidermal innervation density in Fabry disease
    Raphael Schiffmann
    Developmental and Metabolic Neurology Branch, NINDS, National Institutes of Health, Bldg 10, Room 3D03, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Muscle Nerve 34:53-6. 2006
    ..Thermal thresholds remained unchanged. We conclude that epidermal nerve fiber regeneration, as measured in the distal thigh, does not occur in this patient population after 12-18 months of ERT...
  70. ncbi request reprint Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues
    Melissa J Churchill
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Neurovirol 12:146-52. 2006
    ..The ability of HIV-1 to integrate in terminally differentiated astrocytes suggests a permanent reservoir of provirus in brain that will impact the development and likely success of strategies aimed at eradicating HIV-1...
  71. pmc Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1
    Brandon F Keele
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    J Virol 82:5548-61. 2008
    ..These data indicate that FDCs represent a significant reservoir of infectious and diverse HIV, thereby providing a mechanism for viral persistence for months to years...
  72. ncbi request reprint Tissue-specific associations between mitochondrial DNA levels and current treatment status in HIV-infected individuals
    Catherine L Cherry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    J Acquir Immune Defic Syndr 42:435-40. 2006
    ..This study examined mtDNA levels in matched samples of peripheral blood mononuclear cells (PBMCs) and subcutaneous fat from a large Australian cohort to examine treatment, clinical, and demographic associations with mtDNA depletion...

Research Grants16

  1. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2002
    ..We will extend our studies of the immunopathology of HIV-SN, using our extensive tissue collections to define the relationship of chemokine upregulation to neuropathic pain. ..
  2. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2007
    ..Abstract Not Provided: ..
  3. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2006
    ..We will extend our studies of the immunopathology of HIV-SN, using our extensive tissue collections to define the relationship of chemokine upregulation to neuropathic pain. ..
  4. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2006
    ..Abstract Not Provided: ..
  5. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2004
    ..We will extend our studies of the immunopathology of HIV-SN, using our extensive tissue collections to define the relationship of chemokine upregulation to neuropathic pain. ..
  6. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2005
    ..We will extend our studies of the immunopathology of HIV-SN, using our extensive tissue collections to define the relationship of chemokine upregulation to neuropathic pain. ..
  7. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2005
    ..Abstract Not Provided: ..
  8. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2004
    ..Abstract Not Provided: ..
  9. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2004
    ..We will extend our studies of the immunopathology of HIV-SN, using our extensive tissue collections to define the relationship of chemokine upregulation to neuropathic pain. ..
  10. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2003
    ..We will extend our studies of the immunopathology of HIV-SN, using our extensive tissue collections to define the relationship of chemokine upregulation to neuropathic pain. ..