Research Topics
Species | W H MatsuiSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
The role of growth factors in the activity of pharmacological differentiation agentsWilliam H Matsui
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cell Growth Differ 13:275-83. 2002..These data suggest that many pharmacological differentiating agents require both cell cycle arrest and lineage-specific growth factors for full activity and may explain why these agents have demonstrated only limited clinical efficacy...- Quantitative analysis of bone marrow CD34 cells in aplastic anemia and hypoplastic myelodysplastic syndromesW H Matsui
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Leukemia 20:458-62. 2006..Quantification of marrow CD34+ cells may serve as an important tool for distinguishing between AA and hMDS... - Strategies to eliminate cancer stem cells: clinical implicationsCarol Ann Huff
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, Baltimore, MD 21231, USA
Eur J Cancer 42:1293-7. 2006..Re-examining both our pre-clinical and clinical drug development paradigms to include the cancer stem cell concept has the potential to revolutionize the treatment of many cancers... 
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistanceWilliam Matsui
The Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 68:190-7. 2008..Our results suggest that circulating clonotypic B-cell populations represent multiple myeloma stem cells, and the relative drug resistance of these cells is mediated by processes that protect normal stem cells from toxic injury...- Autologous stem cell transplantation and multiple myeloma cancer stem cellsWilliam Matsui
The Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Division of Hematologic Malignancies, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Blood Marrow Transplant 18:S27-32. 2012..Putative CSCs have been identified in MM, and their characterization may lead to the development of novel maintenance strategies that inhibit the production of new tumor cells, prevent disease relapse, and improve overall survival... - Concise review: Emerging concepts in clinical targeting of cancer stem cellsZeshaan A Rasheed
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Stem Cells 29:883-7. 2011..We will review current evidence supporting the role of CSCs in clinical oncology and discuss potential barriers and strategies in designing trials examining CSC-targeting agents... - Characterization of clonogenic multiple myeloma cellsWilliam Matsui
Sidney Kimmel Comprehensive Cancer Center, John Hopkins University School of Medicine, Bunting Blaustein Cancer Research Bldg, Rm 245, 1650 Orleans St, Baltimore, MD 21231, USA
Blood 103:2332-6. 2004..These data suggest that MM "stem cells" are CD138- B cells with the ability to replicate and subsequently differentiate into malignant CD138+ plasma cells... - Anti-tumour activity of interferon-alpha in multiple myeloma: role of interleukin 6 and tumor cell differentiationWilliam Matsui
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Br J Haematol 121:251-8. 2003..These results suggest that the differentiating activities of IFN-alpha may play a role in its clinical antimyeloma activity and provide the rationale for clinical differentiation therapy in MM... - Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemiaWilliam Matsui
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Br J Haematol 128:853-62. 2005..The combined use of pharmacologic differentiating agents and growth factors may improve the clinical efficacy of differentiation therapy in APL... - Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinomaZeshaan A Rasheed
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Natl Cancer Inst 102:340-51. 2010..Aldehyde dehydrogenase (ALDH) activity can identify tumor-initiating cells and normal stem cells from several human tissues. We examined the prognostic significance and functional features of ALDH expression in pancreatic adenocarcinoma... - Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursorsKimberly Noonan
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cancer Res 65:2026-34. 2005..Taken together, these results highlight the intrinsic tumor specificity of MILs and describe a novel approach for the generation of tumor-specific T-cell populations suitable for adoptive immunotherapy of multiple myeloma... - DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagationPeng Sun
Department of Neurology, The Johns Hopkins University School of Medicine and The Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21205, USA
Stem Cells 27:1473-86. 2009..Our findings are the first to implicate noncanonical Notch signaling in the regulation of neoplastic stem-like cells and suggest novel neoplastic stem cell targeting treatment strategies for GBM and potentially other solid malignancies... - HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamideLeo Luznik
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
Biol Blood Marrow Transplant 14:641-50. 2008..02). Nonmyeloablative HLA-haploidentical BMT with posttransplantation Cy is associated with acceptable rates of fatal graft failure and severe aGVHD or cGVHD... - Urothelial carcinoma: stem cells on the edgeWilliam D Brandt
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Cancer Metastasis Rev 28:291-304. 2009..In this review, we discuss the implications of these findings in understanding CSCs and in better understanding how UroCas form, progress, and should be treated... - Hedgehog signaling maintains a tumor stem cell compartment in multiple myelomaCraig D Peacock
Sidney Kimmel Comprehensive Cancer Center and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 104:4048-53. 2007..The potential existence of similar relationships in other adult cancers may have important biologic and clinical implications for the study of aberrant Hh signaling... - Mantle cell lymphoma activation enhances bortezomib sensitivitySarah K Brennan
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Blood 116:4185-91. 2010..Our data suggest that CpG may target clonogenic and resistant ALDH(+) cells as well as improve the activity of proteasome inhibitors in MCL... - Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitorsAkil Merchant
The Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Blood 115:2391-6. 2010..Moreover, they suggest that Gli1 and Smoothened may not be functionally redundant, and direct GLI1 inhibitors may be needed to effectively block HH/GLI1 activity in human disease... - Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastomaEli E Bar
Johns Hopkins University School of Medicine, Department of Pathology, 720 Rutland Avenue, Ross Building 558, Baltimore, Maryland 21205, USA
Stem Cells 25:2524-33. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphomaJavier Bolaños-Meade
George W Santos Bone Marrow Transplant Service, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Biol Blood Marrow Transplant 13:1185-91. 2007..The administration of oral cyclosporine followed by interleukin-2 and gamma-interferon is generally not well tolerated, and does not appear to be an effective method to induce autologous GVHD in patients receiving autologous PBSC grafts... - Characterization of chronic myeloid leukemia stem cellsJonathan M Gerber
Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
Am J Hematol 86:31-7. 2011..These expression patterns suggest that PROTEINASE 3, SURVIVIN, and hTERT are not optimal therapeutic targets in CML stem cells; whereas PRAME and WT1 seem promising... - Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancerTianyun Jiang
Departments of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 69:845-54. 2009..Intrinsic tumor cell heterogeneity, including variation in key regulatory factors such as ASCL1, can modulate tumorigenicity in SCLC... - A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic developmentAntonio Jimeno
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231 1000, USA
Mol Cancer Ther 8:310-4. 2009..Direct tumor xenografts are a valid platform to test multicompartment therapeutic approaches in pancreatic cancer... - The paradox of response and survival in cancer therapeuticsCarol Ann Huff
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
Blood 107:431-4. 2006..In this article, we discuss the evidence for cancer stem cells in hematologic malignancies and possible ways to begin targeting these cells and measuring clinical effectiveness of such treatment approaches... - Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheresEli E Bar
Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD 21287, USA
Am J Pathol 177:1491-502. 2010.... - High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host diseaseLeo Luznik
Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Blood 115:3224-30. 2010..These results suggest that high-dose posttransplantation cyclophosphamide is an effective single-agent prophylaxis of acute and chronic GVHD after BuCy conditioning and HLA-matched BMT (clinicaltrials.gov no. NCT00134017)... - An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancerGeorg Feldmann
Department of Pathology, Johns Hopkins University School of Medicine, CRB2, Room 316, 1550 Orleans Street, Baltimore, MD 21231, USA
Mol Cancer Ther 7:2725-35. 2008.... - Multiple myeloma cancer stem cellsCarol Ann Huff
Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, CRB245, 1650 Orleans St, Baltimore, MD 21231, USA
J Clin Oncol 26:2895-900. 2008..We review evidence that functional heterogeneity exists in multiple myeloma and discuss potential strategies and clinical implications of the stem-cell model of cancer in this disease... - Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumorsXing Fan
Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Cancer Res 66:7445-52. 2006..Stem-like cells in brain tumors thus seem to be selectively vulnerable to agents inhibiting the Notch pathway... - Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancersGeorg Feldmann
Department of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
Cancer Res 67:2187-96. 2007.... - Circulating clonotypic B cells in classic Hodgkin lymphomaRichard J Jones
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Blood 113:5920-6. 2009..Although the clinical significance of circulating clonotypic B cells in HL remains unclear, these data suggest they may be the initiating cells for HL... - The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicityJosh Lauring
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Department of Chemical and Biomolecular Engineering, Baltimore, MD 21231, USA
Blood 111:856-64. 2008..These results provide the first direct evidence that MMSET plays a significant role in t(4;14) MM and suggest that therapies targeting this gene could impact this particular subset of poor-prognosis patients... - Higher serum folate levels are associated with a lower risk of atopy and wheezeElizabeth C Matsui
Division of Pediatric Allergy and Immunology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
J Allergy Clin Immunol 123:1253-9.e2. 2009..Folic acid is known to be associated with inflammatory diseases, but the relationship between folic acid and allergic diseases is unclear... - Cancer stem cells in multiple myelomaNilanjan Ghosh
Division of Hematologic Malignancies, Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
Cancer Lett 277:1-7. 2009..We review studies that have examined clonogenic cells in multiple myeloma, highlight controversies regarding the cell of origin in multiple myeloma, and discuss potential targeting strategies... - Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimenJ Bolanos-Meade
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Bone Marrow Transplant 43:477-80. 2009..The combination of fludarabine and alemtuzumab is an effective and well-tolerated salvage conditioning regimen for patients who experience graft failure after blood or marrow transplants... - Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancerMichael E Mullendore
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Cancer Res 15:2291-301. 2009..Aberrant activation of the Notch signaling pathway is commonly observed in human pancreatic cancer, although the mechanism(s) for this activation has not been elucidated... - Targeting Hedgehog--a cancer stem cell pathwayAkil A Merchant
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Clin Cancer Res 16:3130-40. 2010..The diverse nature of Hh signaling in human cancers suggests that disease-specific factors must be carefully considered to identify the optimal use of novel pathway inhibitors... - Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cellsJoyce E Ohm
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 70:7662-73. 2010..Our findings suggest that by studying the process of induced reprogramming, we may gain significant insight into the origins of epigenetic gene silencing associated with human tumorigenesis, and add to means of assessing iPS for safety... - Multiple myeloma: a paradigm for translation of the cancer stem cell hypothesisJasmin Roya Agarwal
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Anticancer Agents Med Chem 10:116-20. 2010..Here we review the identification and characterization of MM CSCs, the role of Hh in MM, and issues to be considered during the early clinical testing of CSC targeting agents... - Cancer stem cells: controversies in multiple myelomaSarah K Brennan
Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA
J Mol Med (Berl) 87:1079-85. 2009..Moreover, we speculate how these inconsistencies may be resolved through studies by integrating advancements in both myeloma and stem cell biology... - Therapeutic implications of leukemic stem cell pathwaysSaranya Chumsri
Department of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA
Clin Cancer Res 13:6549-54. 2007..The translation of novel and existing leukemic stem cell-directed therapies into clinical practice, however, will require changes in clinical trial design and the inclusion of stem cell biomarkers as correlative end points... - Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNHWilliam J Savage
Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
Exp Hematol 37:42-51. 2009..Investigate the contribution of PIG-A mutations to clonal expansion in paroxysmal nocturnal hemoglobinuria (PNH)... 
Smoothening the controversial role of hedgehog in hematopoiesisAkil A Merchant
Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Baltimore, MD 21231, USA
Cell Stem Cell 4:470-1. 2009..In this issue of Cell Stem Cell, two separate reports (Hofmann et al., 2009; Gao et al., 2009) examine whether the Hedgehog signaling pathway modulates normal adult hematopoietic stem cells and blood formation...- Cancer stem cells: are we missing the target?Richard J Jones
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
J Natl Cancer Inst 96:583-5. 2004 - Enhanced cytotoxicity of rituximab following genetic and biochemical disruption of glycosylphosphatidylinositol anchored proteinsNagaprasad Nagajothi
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231-1000, USA
Leuk Lymphoma 45:795-9. 2004..Thus, genetic and biochemical interruption of GPI anchor proteins augments sensitivity to rituximab... - Graft-versus-host reactions and the effectiveness of donor lymphocyte infusionsCarol Ann Huff
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, MD 21231, USA
Biol Blood Marrow Transplant 12:414-21. 2006..However, with the exception of CML, most patients die of their underlying disease because of insufficient antitumor activity even with active GVHD... - Association of Foxp3 regulatory gene expression with graft-versus-host diseaseYuji Miura
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Blood 104:2187-93. 2004..The decrease in regulatory mechanisms after transplantation appears to provide an environment permissive to the development of GVHD...
Research Grants
- Biology of Multiple Myeloma Stem CellsWilliam Matsui; Fiscal Year: 2007..Both clinical outcomes and laboratory correlates will be integrated to serve as the foundation for the development of subsequent generations of clinical trials. ..
- Cancer Stem Cell Targeting in Multiple MyelomaWilliam Matsui; Fiscal Year: 2009....
- Cancer Stem Cell Targeting in Multiple MyelomaWilliam H Matsui; Fiscal Year: 2010....
- Cancer Stem Cell Targeting in Multiple MyelomaWilliam Matsui; Fiscal Year: 2009..abstract_text> ..