Research Topics
Genomes and Genes
| Rasika A MathiasSummaryAffiliation: Johns Hopkins University Country: USA Publications
| Collaborators
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Detail Information
Publications
Adaptive evolution of the FADS gene cluster within AfricaRasika A Mathias
Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 7:e44926. 2012....- A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery diseaseRasika A Mathias
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
BMC Med Genomics 3:22. 2010..In this study, we leverage independent information from genome-wide linkage and association data to determine loci controlling platelet phenotypes before and after treatment with ASA... - The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African AmericansRasika A Mathias
Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
BMC Genet 12:50. 2011.... - A genome-wide association study on African-ancestry populations for asthmaRasika A Mathias
Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
J Allergy Clin Immunol 125:336-346.e4. 2010..Of the limited genetic studies performed on populations of African descent, notable differences in susceptibility allele frequencies have been observed... - FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island populationRasika A Mathias
Division of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA
J Lipid Res 51:2766-74. 2010.... 
African and non-African admixture components in African Americans and an African Caribbean populationTanda Murray
Johns Hopkins School of Public Health, Epidemiology, Baltimore, Maryland, USA
Genet Epidemiol 34:561-8. 2010..In our sample of individuals of African descent, approximately 400 well-defined AIMs were just as good for detecting substructure as approximately 14,000 random SNPs drawn from a genome-wide panel of markers...- Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populationsCandelaria Vergara
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, Maryland 21224, USA
Am J Respir Crit Care Med 178:1017-22. 2008..This variant provides an evolutionary advantage in malaria-endemic regions, because Duffy antigen/receptor for chemokines-negative erythrocytes are more resistant to infection by P. vivax... - A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11qRasika A Mathias
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Balitmore, USA
BMC Genet 7:38. 2006..While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals... - Application of the regression of offspring on mid-parent method to detect associations between single-nucleotide polymorphisms and the beta 2 electroencephalogram phenotype in the COGA dataMarie Hélène Roy-Gagnon
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr, Baltimore, Maryland 21224, USA
BMC Genet 6:S56. 2005..Significant associations at the 0.0005 level, some of which were parent-specific, were found on chromosomes 1, 2, 5, 6, 7, 8, 11, 12, 15, 16, 17, 18, and 19 with heritability attributable to each SNP ranging from 0.01 to 8%... - Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibriumPriya Duggal
Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
BMC Genet 6:S73. 2005..In addition, we compared the selected SNPs in a multipoint linkage analysis for one region with strong LD. As the number of selected SNPs increased, the LOD score, mean information content, and type I error also increased... 
Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean populationPeter B Chi
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Genet Epidemiol 30:609-19. 2006..We also found a high degree of consistency between TagSNP and Tagger. Using this set of 713 SNPs on chromosome 12q, our study provides insight towards analytic strategies for future studies of complex traits...- Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypesKathleen C Barnes
Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Allergy Clin Immunol 118:70-7. 2006.... - Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American populationPei Song Gao
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 115:982-8. 2005..The T-cell immunoglobulin mucin ( TIM ) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases... - Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPDNadia N Hansel
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Hum Genet 132:79-90. 2013..Genes within these regions were expressed in relevant lung cells and their expression related to airflow limitation suggesting they may represent novel candidate genes for COPD susceptibility... - The robustness of generalized estimating equations for association tests in extended family dataBhoom Suktitipat
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21205, USA
Hum Hered 74:17-26. 2012.... - Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthmaPei Song Gao
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Eur J Hum Genet 18:713-9. 2010..However, our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma... - Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthmaLi Gao
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Allergy Clin Immunol 119:1111-8. 2007..Myosin light chain kinase (MYLK) is a multifunctional protein involved in regulation of airway hyperreactivity and other activities relevant to asthma... - A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestryBrian G Kral
Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Hum Genet 56:224-9. 2011..The findings demonstrate a significant protective effect against incident CAD in African American siblings of persons with premature CAD, with replication in a combination of two additional African American cohorts... - Independent metabolic syndrome variants predict new-onset coronary artery diseaseDhananjay Vaidya
Department of Medicine, Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Diabetes Care 33:1376-8. 2010.... - Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary diseaseNadia N Hansel
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 5:e14226. 2010..Aquaporin-5 (AQP5) can cause mucus overproduction and lower lung function. Genetic variants in the AQP5 gene might be associated with rate of lung function decline in chronic obstructive pulmonary disease (COPD)... - Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traitsAlison P Klein
Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
BMC Genet 6:S20. 2005..The presence of LD between markers may have led to an increased number of false positive regions but no clear relationship between regions of high LD and locations of false positive linkage signals was observed... - Evaluation of random forests performance for genome-wide association studies in the presence of interaction effectsYoonhee Kim
National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
BMC Proc 3:S64. 2009.... - Heritability of quantitative traits associated with type 2 diabetes mellitus in large multiplex families from South IndiaRasika A Mathias
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
Metabolism 58:1439-45. 2009..The evidence for pleiotropic control of insulin and central obesity-related traits supports the presence of an insulin resistance syndrome in South Asians with a tendency for central obesity... - Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analysesRasika A Mathias
Department of Epidemiology, Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
Hum Hered 59:228-38. 2005.... - Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnosesRasika A Mathias
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
Hum Hered 62:157-64. 2006.... - Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studiesThemistocles L Assimes
Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
J Am Coll Cardiol 56:1552-63. 2010..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)... - Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality dataDhananjay Vaidya
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
BMJ 343:d5170. 2011..To use changes in heart disease mortality rates with age to investigate the plausibility of attributing women's lower heart disease mortality than men to the protective effects of premenopausal sex hormones... - Comparison of year-of-exam- and age-matched estimates of heritability in the Framingham Heart Study dataRasika A Mathias
Genometrics Section, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland, USA
BMC Genet 4:S36. 2003.... - Evidence for asthma susceptibility genes on chromosome 11 in an African-American populationShau Ku Huang
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, MD 21224 6801, Baltimore, USA
Hum Genet 113:71-5. 2003..8 cM with a confidence interval spanning the linkage peak. Evidence from both linkage and association analyses suggest that this region of chromosome 11 contains one or more susceptibility genes for asthma in these AA families...