Rasika A Mathias

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation
    Yoonhee Kim
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 8:e64179. 2013
  2. ncbi request reprint Introduction to genetics and genomics in asthma: genetics of asthma
    Rasika Ann Mathias
    Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, 3B 79, Baltimore, MD, 21224, USA
    Adv Exp Med Biol 795:125-55. 2014
  3. pmc Adaptive evolution of the FADS gene cluster within Africa
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e44926. 2012
  4. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
  5. pmc A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    BMC Med Genomics 3:22. 2010
  6. pmc A genome-wide association study on African-ancestry populations for asthma
    Rasika A Mathias
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    J Allergy Clin Immunol 125:336-346.e4. 2010
  7. doi request reprint African ancestry is a risk factor for asthma and high total IgE levels in African admixed populations
    Candelaria Vergara
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University JHU, Baltimore, MD, USA
    Genet Epidemiol 37:393-401. 2013
  8. pmc FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population
    Rasika A Mathias
    Division of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA
    J Lipid Res 51:2766-74. 2010
  9. pmc African and non-African admixture components in African Americans and an African Caribbean population
    Tanda Murray
    Johns Hopkins School of Public Health, Epidemiology, Baltimore, Maryland, USA
    Genet Epidemiol 34:561-8. 2010
  10. pmc Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
    Candelaria Vergara
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 178:1017-22. 2008

Detail Information

Publications34

  1. pmc Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation
    Yoonhee Kim
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 8:e64179. 2013
    ....
  2. ncbi request reprint Introduction to genetics and genomics in asthma: genetics of asthma
    Rasika Ann Mathias
    Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, 3B 79, Baltimore, MD, 21224, USA
    Adv Exp Med Biol 795:125-55. 2014
    ..We now look to future integrative approaches of genetics, genomics (Chap. 10), and epigenetics (Chap. 11) to better understand the causal mechanism through which, these genetic loci act in manifesting asthma. ..
  3. pmc Adaptive evolution of the FADS gene cluster within Africa
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e44926. 2012
    ....
  4. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  5. pmc A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    BMC Med Genomics 3:22. 2010
    ..In this study, we leverage independent information from genome-wide linkage and association data to determine loci controlling platelet phenotypes before and after treatment with ASA...
  6. pmc A genome-wide association study on African-ancestry populations for asthma
    Rasika A Mathias
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    J Allergy Clin Immunol 125:336-346.e4. 2010
    ..Of the limited genetic studies performed on populations of African descent, notable differences in susceptibility allele frequencies have been observed...
  7. doi request reprint African ancestry is a risk factor for asthma and high total IgE levels in African admixed populations
    Candelaria Vergara
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University JHU, Baltimore, MD, USA
    Genet Epidemiol 37:393-401. 2013
    ..3, P = 0.04), Barbadians (β = 3.8, P = 0.03), and Brazilians (β = 1.6, P = 0.03). Our findings indicate that African ancestry can account for, at least in part, the association between asthma and its associated trait, tIgE levels...
  8. pmc FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population
    Rasika A Mathias
    Division of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA
    J Lipid Res 51:2766-74. 2010
    ....
  9. pmc African and non-African admixture components in African Americans and an African Caribbean population
    Tanda Murray
    Johns Hopkins School of Public Health, Epidemiology, Baltimore, Maryland, USA
    Genet Epidemiol 34:561-8. 2010
    ..In our sample of individuals of African descent, approximately 400 well-defined AIMs were just as good for detecting substructure as approximately 14,000 random SNPs drawn from a genome-wide panel of markers...
  10. pmc Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
    Candelaria Vergara
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 178:1017-22. 2008
    ..This variant provides an evolutionary advantage in malaria-endemic regions, because Duffy antigen/receptor for chemokines-negative erythrocytes are more resistant to infection by P. vivax...
  11. pmc The robustness of generalized estimating equations for association tests in extended family data
    Bhoom Suktitipat
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21205, USA
    Hum Hered 74:17-26. 2012
    ....
  12. pmc A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Balitmore, USA
    BMC Genet 7:38. 2006
    ..While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals...
  13. pmc Application of the regression of offspring on mid-parent method to detect associations between single-nucleotide polymorphisms and the beta 2 electroencephalogram phenotype in the COGA data
    Marie Hélène Roy-Gagnon
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr, Baltimore, Maryland 21224, USA
    BMC Genet 6:S56. 2005
    ..Significant associations at the 0.0005 level, some of which were parent-specific, were found on chromosomes 1, 2, 5, 6, 7, 8, 11, 12, 15, 16, 17, 18, and 19 with heritability attributable to each SNP ranging from 0.01 to 8%...
  14. pmc Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium
    Priya Duggal
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S73. 2005
    ..In addition, we compared the selected SNPs in a multipoint linkage analysis for one region with strong LD. As the number of selected SNPs increased, the LOD score, mean information content, and type I error also increased...
  15. pmc Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD
    Nadia N Hansel
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hum Genet 132:79-90. 2013
    ..Genes within these regions were expressed in relevant lung cells and their expression related to airflow limitation suggesting they may represent novel candidate genes for COPD susceptibility...
  16. ncbi request reprint Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes
    Kathleen C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 118:70-7. 2006
    ....
  17. ncbi request reprint Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population
    Peter B Chi
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Genet Epidemiol 30:609-19. 2006
    ..We also found a high degree of consistency between TagSNP and Tagger. Using this set of 713 SNPs on chromosome 12q, our study provides insight towards analytic strategies for future studies of complex traits...
  18. ncbi request reprint Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma
    Li Gao
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 119:1111-8. 2007
    ..Myosin light chain kinase (MYLK) is a multifunctional protein involved in regulation of airway hyperreactivity and other activities relevant to asthma...
  19. ncbi request reprint Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 115:982-8. 2005
    ..The T-cell immunoglobulin mucin ( TIM ) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases...
  20. pmc Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
    Pei Song Gao
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Eur J Hum Genet 18:713-9. 2010
    ..However, our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma...
  21. pmc Independent metabolic syndrome variants predict new-onset coronary artery disease
    Dhananjay Vaidya
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Diabetes Care 33:1376-8. 2010
    ....
  22. pmc A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry
    Brian G Kral
    Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Hum Genet 56:224-9. 2011
    ..The findings demonstrate a significant protective effect against incident CAD in African American siblings of persons with premature CAD, with replication in a combination of two additional African American cohorts...
  23. ncbi request reprint Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking
    Sarah H Stephens
    Department of Epidemiology and Public Health, University of Maryland, Baltimore, Maryland, United States of America
    Genet Epidemiol 37:846-59. 2013
    ....
  24. pmc Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease
    Nadia N Hansel
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 5:e14226. 2010
    ..Aquaporin-5 (AQP5) can cause mucus overproduction and lower lung function. Genetic variants in the AQP5 gene might be associated with rate of lung function decline in chronic obstructive pulmonary disease (COPD)...
  25. ncbi request reprint Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses
    Rasika A Mathias
    Department of Epidemiology, Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Hum Hered 59:228-38. 2005
    ....
  26. ncbi request reprint Evidence for asthma susceptibility genes on chromosome 11 in an African-American population
    Shau Ku Huang
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, MD 21224 6801, Baltimore, USA
    Hum Genet 113:71-5. 2003
    ..8 cM with a confidence interval spanning the linkage peak. Evidence from both linkage and association analyses suggest that this region of chromosome 11 contains one or more susceptibility genes for asthma in these AA families...
  27. pmc Evaluation of random forests performance for genome-wide association studies in the presence of interaction effects
    Yoonhee Kim
    National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    BMC Proc 3:S64. 2009
    ....
  28. pmc Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits
    Alison P Klein
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S20. 2005
    ..The presence of LD between markers may have led to an increased number of false positive regions but no clear relationship between regions of high LD and locations of false positive linkage signals was observed...
  29. ncbi request reprint Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil
    Camila Alexandrina Figueiredo
    Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD, USA
    J Allergy Clin Immunol 131:1683-90. 2013
    ..Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG₄ production, protecting against allergies...
  30. pmc Heritability of quantitative traits associated with type 2 diabetes mellitus in large multiplex families from South India
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    Metabolism 58:1439-45. 2009
    ..The evidence for pleiotropic control of insulin and central obesity-related traits supports the presence of an insulin resistance syndrome in South Asians with a tendency for central obesity...
  31. ncbi request reprint Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    Hum Hered 62:157-64. 2006
    ..The objective of this study was to ascertain the most likely inheritance pattern of restless legs syndrome (RLS) using segregation analysis...
  32. pmc Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality data
    Dhananjay Vaidya
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    BMJ 343:d5170. 2011
    ..To use changes in heart disease mortality rates with age to investigate the plausibility of attributing women's lower heart disease mortality than men to the protective effects of premenopausal sex hormones...
  33. pmc Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
    J Am Coll Cardiol 56:1552-63. 2010
    ..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)...
  34. pmc Comparison of year-of-exam- and age-matched estimates of heritability in the Framingham Heart Study data
    Rasika A Mathias
    Genometrics Section, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland, USA
    BMC Genet 4:S36. 2003
    ....