Stephen C Mathai

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc The minimal important difference in the 6-minute walk test for patients with pulmonary arterial hypertension
    Stephen C Mathai
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 1830 E Monument Street, Room 516, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 186:428-33. 2012
  2. doi request reprint Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension
    Stephen C Mathai
    Divisions of Pulmonary and Critical Care Medicine, Cardiology, and Rheumatology, Department of Medicine, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA
    J Rheumatol 38:2410-8. 2011
  3. pmc Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension
    Aránzazu Campo
    MD, Division of Pulmonary and Critical Care Medicine, 1830 E Monument St, Fifth Floor, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 182:252-60. 2010
  4. pmc Pulmonary capillary wedge pressure augments right ventricular pulsatile loading
    Ryan J Tedford
    Division of Cardiology, Johns Hopkins Medical Institutions, Ross 858, 720 Rutland Ave, Baltimore, MD 21205, USA
    Circulation 125:289-97. 2012
  5. pmc Increased right ventricular Septomarginal trabeculation mass is a novel marker for pulmonary hypertension: comparison with ventricular mass index and right ventricular mass
    Jens Vogel-Claussen
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Invest Radiol 46:567-75. 2011
  6. doi request reprint Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease
    Stephen C Mathai
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 60:569-77. 2009
  7. doi request reprint PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support
    Ryan J Tedford
    Divisions of Cardiology and Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Circ Heart Fail 1:213-9. 2008
  8. pmc Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study
    Monda L Shehata
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St, Nelson Basement MRI 110, Baltimore, MD 21287, USA
    Radiology 266:114-22. 2013
  9. pmc Pulmonary arterial hypertension associated with systemic sclerosis
    Stephen C Mathai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Expert Rev Respir Med 5:267-79. 2011
  10. pmc Therapy for pulmonary arterial hypertension associated with systemic sclerosis
    Stephen C Mathai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Rheumatol 21:642-8. 2009

Research Grants

Collaborators

Detail Information

Publications24

  1. pmc The minimal important difference in the 6-minute walk test for patients with pulmonary arterial hypertension
    Stephen C Mathai
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 1830 E Monument Street, Room 516, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 186:428-33. 2012
    ....
  2. doi request reprint Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension
    Stephen C Mathai
    Divisions of Pulmonary and Critical Care Medicine, Cardiology, and Rheumatology, Department of Medicine, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA
    J Rheumatol 38:2410-8. 2011
    ..But its role in systemic sclerosis (SSc)-associated PAH has not been established. Our objective was to validate the TAPSE in the assessment of RV function and prediction of survival in SSc-PAH...
  3. pmc Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension
    Aránzazu Campo
    MD, Division of Pulmonary and Critical Care Medicine, 1830 E Monument St, Fifth Floor, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 182:252-60. 2010
    ..Objectives: To identify risk factors of mortality in a well-characterized cohort of patients with PAH related to systemic sclerosis (SSc-PAH)...
  4. pmc Pulmonary capillary wedge pressure augments right ventricular pulsatile loading
    Ryan J Tedford
    Division of Cardiology, Johns Hopkins Medical Institutions, Ross 858, 720 Rutland Ave, Baltimore, MD 21205, USA
    Circulation 125:289-97. 2012
    ....
  5. pmc Increased right ventricular Septomarginal trabeculation mass is a novel marker for pulmonary hypertension: comparison with ventricular mass index and right ventricular mass
    Jens Vogel-Claussen
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Invest Radiol 46:567-75. 2011
    ....
  6. doi request reprint Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease
    Stephen C Mathai
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 60:569-77. 2009
    ..This study was undertaken to characterize determinants of survival among SSc patients with either type of PH who received PAH-specific therapy...
  7. doi request reprint PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support
    Ryan J Tedford
    Divisions of Cardiology and Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Circ Heart Fail 1:213-9. 2008
    ..We tested the hypothesis that when PH persists after adequate left ventricle unloading via recent left ventricular assist device (LVAD) therapy, phosphodiesterase type 5A inhibition would decrease PH in this population...
  8. pmc Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study
    Monda L Shehata
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St, Nelson Basement MRI 110, Baltimore, MD 21287, USA
    Radiology 266:114-22. 2013
    ....
  9. pmc Pulmonary arterial hypertension associated with systemic sclerosis
    Stephen C Mathai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Expert Rev Respir Med 5:267-79. 2011
    ....
  10. pmc Therapy for pulmonary arterial hypertension associated with systemic sclerosis
    Stephen C Mathai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Rheumatol 21:642-8. 2009
    ..Systemic sclerosis is commonly complicated by pulmonary arterial hypertension (PAH-SSc) and is a leading cause of death in this population. We will review existing challenges and recent advances in the treatment of this disease...
  11. doi request reprint Systemic sclerosis-related pulmonary hypertension associated with interstitial lung disease: impact of pulmonary arterial hypertension therapies
    Jerome Le Pavec
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Arthritis Rheum 63:2456-64. 2011
    ..This study was undertaken to evaluate our experience with PH-ILD with regard to the efficacy and safety of PAH therapies in this patient cohort...
  12. pmc Identification of candidate genes in scleroderma-related pulmonary arterial hypertension
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
    Transl Res 151:197-207. 2008
    ..Deciphering the role of genes involved in vascular remodeling and PAH development may reveal new treatment targets for this devastating disorder...
  13. pmc Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling
    Monda L Shehata
    Department of Radiology, Johns Hopkins University, 600 N Wolfe St, Nelson Basement, MRI 143, Baltimore, MD 21287, USA
    AJR Am J Roentgenol 196:87-94. 2011
    ....
  14. ncbi request reprint Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases
    Reda E Girgis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Heart Lung Transplant 24:1626-31. 2005
    ..Scant data are available regarding PAH associated with the scleroderma spectrum of diseases (APAH-SSD). Here we review our experience with bosentan in these 2 groups...
  15. pmc Pulmonary arterial hypertension in connective tissue diseases
    Stephen C Mathai
    Pulmonary Hypertension Program, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21205, USA
    Heart Fail Clin 8:413-25. 2012
    ..Select patients with CTD-PAH may be candidates for lung transplantation, but results are less favorable than for IPAH because of comorbidities and complications specifically associated with CTD...
  16. doi request reprint Pulmonary hypertension topics
    Stephen C Mathai
    Johns Hopkins University, School of Medicine, Division of Pulmonary and Critical Care Medicine, MD, USA
    Expert Rev Respir Med 6:503-5. 2012
    ..These include original research on registries, prognosis, disease management, clinical trials, novel therapies, echocardiographic assessments and exercise hemodynamics...
  17. doi request reprint Cardiac complications of systemic sclerosis: recent progress in diagnosis
    Adel Boueiz
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Curr Opin Rheumatol 22:696-703. 2010
    ..This article reviews the current information about cardiac dysfunction in scleroderma, with special emphasis on its detection and prognostic implications...
  18. ncbi request reprint Pulmonary hypertension associated with chronic respiratory disease
    Reda E Girgis
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
    Clin Chest Med 28:219-32, x. 2007
    ..Clinicians should carefully consider the possibility of PH during the diagnostic evaluation of chronic respiratory disorders. The usefulness of pharmacologic therapy directed toward PH remains to be determined...
  19. pmc Erythroid-specific transcriptional changes in PBMCs from pulmonary hypertension patients
    Chris Cheadle
    Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e34951. 2012
    ..The hypothesis tested in this study was that chronic exposure of PBMCs to a hypertensive environment in remodeled pulmonary vessels would be reflected by specific transcriptional changes in these cells...
  20. ncbi request reprint Tricuspid annular displacement predicts survival in pulmonary hypertension
    Paul R Forfia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Asthma and Allergy Center, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 174:1034-41. 2006
    ..Right ventricular (RV) function is an important determinant of prognosis in pulmonary hypertension. However, noninvasive assessment of the RV function is often limited by complex geometry and poor endocardial definition...
  21. ncbi request reprint N-terminal brain natriuretic peptide in scleroderma-associated pulmonary arterial hypertension
    Stephen C Mathai
    Eur Heart J 28:140-1; author reply 141. 2007
  22. pmc Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension
    Paul R Forfia
    Cardiovascular Division, Heart Failure Transplant Program, University of Pennsylvania School of Medicine, 3400 Spruce Street, 6 Penn Tower, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 177:1364-9. 2008
    ..Hyponatremia is associated with decompensated heart failure and poor prognosis in patients with left ventricular systolic dysfunction...
  23. doi request reprint Sleep quality and health-related quality of life in idiopathic pulmonary fibrosis
    Vidya Krishnan
    MetroHealth Medical Center, Cleveland, OH, USA
    Chest 134:693-8. 2008
    ..Although fatigue is a prominent symptom for patients with IPF, little is known about sleep quality in patients with IPF...
  24. ncbi request reprint Clinical differences between idiopathic and scleroderma-related pulmonary hypertension
    Micah R Fisher
    Emory University, Atlanta, Georgia, USA
    Arthritis Rheum 54:3043-50. 2006
    ..This study tested the hypothesis that an increased prevalence of left heart disease might explain the higher mortality in patients with PAH-Scl compared with patients with IPAH...

Research Grants1

  1. Prognostic Factors, Genetics, and Therapy in PAH-SSD
    STEPHEN MATHAI; Fiscal Year: 2006
    ....