Affiliation: Johns Hopkins University
- Functional profiling of the Saccharomyces cerevisiae genomeGuri Giaever
Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
Nature 418:387-91. 2002..Our results validate the yeast gene-deletion collection as a valuable resource for functional genomics...
- Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brainRong Mao
Program in Biochemistry, Cellular and Molecular Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Genomics 81:457-67. 2003..However, it is possible that these gene expression changes ultimately relate to the phenotypic variability of DS...
- Primary and secondary transcriptional effects in the developing human Down syndrome brain and heartRong Mao
Program in Biochemistry, Cellular and Molecular Biology, Johns Hopkins School of Medicine, 1830 East Monument Street, Baltimore, MD 21205, USA
Genome Biol 6:R107. 2005..Also, the statistical significance of differentially expressed genes in human Down syndrome tissues has not been reported...
- Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progressionBrett G Masayesva
Department of Otolaryngology-Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 101:8715-20. 2004..Loss and gain of chromosomal material in solid cancers can alter gene expression over large chromosomal regions, including multiple genes unrelated to malignant progression...
- The use of genomic microarrays to study chromosomal abnormalities in mental retardationRong Mao
Program in Biochemistry, Molecular, and Cellular Biology, Johns Hopkins School of Medicine, and Department of Neurology, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Ment Retard Dev Disabil Res Rev 11:279-85. 2005..Genomic microarrays offer both a genome-wide perspective of chromosomal aberrations as well as higher resolution (to the level of approximately one megabase) compared to alternative available technologies...
- 4p terminal deletion and 11p subtelomeric duplication detected by genomic microarray in a patient with Wolf-Hirschhorn syndrome and an atypical phenotypeDavid A Stevenson
Department of Pediatrics, Division of Medical Genetics, University of Utah, Salt Lake City, Utah, USA
J Pediatr 145:840-2. 2004..Terminal 4p deletions cause Wolf-Hirschhorn syndrome, but the phenotype probably was modified by the paternally derived 11p duplication. This emphasizes the clinical utility of genomic microarray...