YUKARI MANABE

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Implementation and effect of intensified case finding on diagnosis of tuberculosis in a large urban HIV clinic in Uganda: a retrospective cohort study
    Sabine Hermans
    Infectious Diseases Institute, Makerere University College of Health Sciences, PO Box 22418, Kampala, Uganda
    BMC Public Health 12:674. 2012
  2. pmc Cost-effectiveness of early initiation of first-line combination antiretroviral therapy in Uganda
    Joseph Sempa
    Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Public Health 12:736. 2012
  3. pmc The impact on nurses and nurse managers of introducing PEPFAR clinical services in urban government clinics in Uganda
    Joyce Nankumbi
    Department of Nursing, School of Health Sciences, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Int Health Hum Rights 11:S8. 2011
  4. pmc The effects of an HIV project on HIV and non-HIV services at local government clinics in urban Kampala
    Toru Matsubayashi
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    BMC Int Health Hum Rights 11:S9. 2011
  5. pmc Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:381. 2012
  6. pmc Multivitamin supplementation in HIV infected adults initiating antiretroviral therapy in Uganda: the protocol for a randomized double blinded placebo controlled efficacy trial
    David Guwatudde
    School of Public Health, Makerere University College of Health Sciences, PO Box 7072, Kampala, Uganda
    BMC Infect Dis 12:304. 2012
  7. pmc Rifampicin for continuation phase tuberculosis treatment in Uganda: a cost-effectiveness analysis
    Yukari C Manabe
    Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 7:e39187. 2012
  8. pmc Evaluation of portable point-of-care CD4 counter with high sensitivity for detecting patients eligible for antiretroviral therapy
    Yukari C Manabe
    Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda
    PLoS ONE 7:e34319. 2012
  9. pmc Developing independent investigators for clinical research relevant for Africa
    Yukari C Manabe
    Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda
    Health Res Policy Syst 9:44. 2011
  10. pmc Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study
    Kathleen R Page
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BMC Public Health 8:158. 2008

Research Grants

  1. IRON REGULATION & VIRULENCE--MYCOBACTERIUM TUBERCULOSIS
    YUKARI MANABE; Fiscal Year: 2003
  2. LATENCY AND REACTIVATION TUBERCULOSIS
    YUKARI MANABE; Fiscal Year: 2006

Collaborators

Detail Information

Publications31

  1. pmc Implementation and effect of intensified case finding on diagnosis of tuberculosis in a large urban HIV clinic in Uganda: a retrospective cohort study
    Sabine Hermans
    Infectious Diseases Institute, Makerere University College of Health Sciences, PO Box 22418, Kampala, Uganda
    BMC Public Health 12:674. 2012
    ..We sought to determine the associated effect on TB case detection...
  2. pmc Cost-effectiveness of early initiation of first-line combination antiretroviral therapy in Uganda
    Joseph Sempa
    Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Public Health 12:736. 2012
    ..This analysis evaluates the cost-effectiveness of initiating cART at a CD4 count between 250-350 cell/μl (early) versus <250 cell/μl (delayed)...
  3. pmc The impact on nurses and nurse managers of introducing PEPFAR clinical services in urban government clinics in Uganda
    Joyce Nankumbi
    Department of Nursing, School of Health Sciences, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Int Health Hum Rights 11:S8. 2011
    ..This paper evaluates the impact on the nurses from this innovative program to provide more health care in six nurse managed Kampala City Council (KCC) Clinics...
  4. pmc The effects of an HIV project on HIV and non-HIV services at local government clinics in urban Kampala
    Toru Matsubayashi
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    BMC Int Health Hum Rights 11:S9. 2011
    ..The aim of this study was to examine the effect of a PEPFAR-funded HIV/AIDS program on six government-run general clinics in Kampala...
  5. pmc Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:381. 2012
    ..We compared the genotypic resistance patterns between clients with VLM versus immunological monitoring (IM)...
  6. pmc Multivitamin supplementation in HIV infected adults initiating antiretroviral therapy in Uganda: the protocol for a randomized double blinded placebo controlled efficacy trial
    David Guwatudde
    School of Public Health, Makerere University College of Health Sciences, PO Box 7072, Kampala, Uganda
    BMC Infect Dis 12:304. 2012
    ..We propose to evaluate the efficacy of a single recommended daily allowance (RDA) of micronutrients (including vitamins B-complex, C, and E) in slowing disease progression among HIV-infected adults receiving HAART in Uganda...
  7. pmc Rifampicin for continuation phase tuberculosis treatment in Uganda: a cost-effectiveness analysis
    Yukari C Manabe
    Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 7:e39187. 2012
    ..We compared the impact of a continuation phase using 6HE or 4HR on total cost and expected mortality from the perspective of the Ugandan national health system...
  8. pmc Evaluation of portable point-of-care CD4 counter with high sensitivity for detecting patients eligible for antiretroviral therapy
    Yukari C Manabe
    Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda
    PLoS ONE 7:e34319. 2012
    ....
  9. pmc Developing independent investigators for clinical research relevant for Africa
    Yukari C Manabe
    Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda
    Health Res Policy Syst 9:44. 2011
    ....
  10. pmc Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study
    Kathleen R Page
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BMC Public Health 8:158. 2008
    ..Current guidelines recommend screening and treatment for latent TB infection (LTBI) within 5 years of arrival to the U.S. This study evaluates the timing of LTBI therapy among immigrants presenting for care to a public health TB clinic...
  11. pmc U.S. medical resident familiarity with national tuberculosis guidelines
    Petros C Karakousis
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Infect Dis 7:89. 2007
    ..We assessed medical resident knowledge about tuberculosis diagnosis and early management based on American Thoracic Society guidelines...
  12. doi request reprint Unmasked tuberculosis and tuberculosis immune reconstitution inflammatory disease: a disease spectrum after initiation of antiretroviral therapy
    Yukari C Manabe
    Center for Tuberculosis Research, Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    J Infect Dis 199:437-44. 2009
    ..TB diagnostics with improved sensitivity and specificity are urgently needed to detect subclinical TB before it is unmasked...
  13. ncbi request reprint Immune reconstitution inflammatory syndrome: risk factors and treatment implications
    Yukari C Manabe
    Center for Tuberculosis Research, Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    J Acquir Immune Defic Syndr 46:456-62. 2007
    ..We sought to determine clinical risk factors for the development of IRIS...
  14. ncbi request reprint The aerosol rabbit model of TB latency, reactivation and immune reconstitution inflammatory syndrome
    Yukari C Manabe
    Center for Tuberculosis Research, Johns Hopkins University, 720 Rutland Street, Rm 1147B, Baltimore, MD 21205, USA
    Tuberculosis (Edinb) 88:187-96. 2008
    ..Further study of the rabbit model of TB latency, reactivation and IRIS may be important in understanding the immunopathogenesis of these poorly modeled states as well as for improved diagnostics for specific stages of disease...
  15. pmc Naturally attenuated, orally administered Mycobacterium microti as a tuberculosis vaccine is better than subcutaneous Mycobacterium bovis BCG
    Yukari C Manabe
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Infect Immun 70:1566-70. 2002
    ..microti resulted in a statistically significant improvement in protection against aerosol challenge with virulent M. tuberculosis in the murine model compared with subcutaneous M. bovis BCG Pasteur vaccination...
  16. pmc Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis
    Yukari C Manabe
    Department of Medicine, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, 424 North Bond Street, Room 1108, Baltimore, MD 21205, USA
    Infect Immun 71:6004-11. 2003
    ..tuberculosis strains in this region. Correlation of the relative pathogenicity, including disease severity, in the rabbit model with the strain genotype may help identify stage-specific M. tuberculosis genes important in human disease...
  17. pmc Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis
    Yukari C Manabe
    Johns Hopkins University School of Medicine, 1503 E Jefferson Street, RM 108, Baltimore, MD 21231 1004, USA
    Infect Immun 73:5988-94. 2005
    ..This construct can be used to elucidate further the IdeR regulon and its virulence genes and to differentiate these from genes regulated by SirR, which does not have this domain...
  18. pmc Feasibility of magnetic bead technology for concentration of mycobacteria in sputum prior to fluorescence microscopy
    Heidi Albert
    FIND, Foundation for Innovative New Diagnostics, Kampala, Uganda
    BMC Infect Dis 11:125. 2011
    ..Simpler concentration methods that could be applied in peripheral laboratories are urgently needed...
  19. pmc Performance of three LED-based fluorescence microscopy systems for detection of tuberculosis in Uganda
    Heidi Albert
    Tuberculosis Research Laboratory, Foundation for Innovative New Diagnostics, Kampala, Uganda
    PLoS ONE 5:e15206. 2010
    ....
  20. pmc Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH
    Deepak Kaushal
    Department of Medicine, Center for Tuberculosis Research, Johns Hopkins School of Medicine, 424 North Bond Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 99:8330-5. 2002
    ..This phenotype demonstrates that beyond an ability to grow and persist within the host, M. tuberculosis has distinct virulence mechanisms that elicit deleterious host responses and progressive pulmonary disease...
  21. pmc Characterization of the role of the divalent metal ion-dependent transcriptional repressor MntR in the virulence of Staphylococcus aureus
    Masaru Ando
    Division of Disease Control, Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Infect Immun 71:2584-90. 2003
    ..Moreover, constitutive repression by DtxR(E175K) reduces the virulence of S. aureus in the mouse skin abscess model...
  22. pmc Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbits
    Susan E Dorman
    Department of Medicine, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    Infect Immun 72:1700-5. 2004
    ..Preliminary evidence is presented for a cell-mediated immune defect with lower DTH responses and macrophages that have a decreased ability to respond to in vitro stimulation with LPS or M. tuberculosis infection...
  23. pmc Attenuation of late-stage disease in mice infected by the Mycobacterium tuberculosis mutant lacking the SigF alternate sigma factor and identification of SigF-dependent genes by microarray analysis
    Deborah E Geiman
    Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Infect Immun 72:1733-45. 2004
    ..Microarray analysis has identified SigF-dependent genes and a putative SigF consensus recognition site...
  24. ncbi request reprint Short report: modulation of Mycobacterium tuberculosis infection by Plasmodium in the murine model
    Cherise P Scott
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 70:144-8. 2004
    ..13 +/- 0.10, and 2.86 +/- 0.10 versus 2.49 +/- 0.10, respectively) and had increased mortality. In populations where both diseases are endemic, there may be implications for increased incidence of clinically detectable tuberculosis...
  25. pmc Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551
    Anup K Kesavan
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Infect Immun 73:7056-60. 2005
    ..They had significant leukopenia and reduced delayed-type hypersensitivity responses. Malnutrition dampened cell-mediated immunity and would interfere with diagnostic tests that rely on intact CD4 T-cell responses...
  26. pmc Mycobacterium-induced potentiation of type 1 immune responses and protection against malaria are host specific
    Kathleen R Page
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Infect Immun 73:8369-80. 2005
    ..yoelii 17XL. These data indicate that M. tuberculosis-induced potentiation of type 1 immune responses is associated with protection against lethal murine malaria...
  27. pmc Susceptibility to tuberculosis: composition of tuberculous granulomas in Thorbecke and outbred New Zealand White rabbits
    Susana Mendez
    JA Baker Institute for Animal Health, Cornell Veterinary College, Ithaca, NY 14853, USA
    Vet Immunol Immunopathol 122:167-74. 2008
    ..Further delineation of the outbred rabbit's resistant immune response to Mtb infection is warranted...
  28. ncbi request reprint Animal models of cavitation in pulmonary tuberculosis
    Kris L Helke
    Department of Comparative Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Room 811, Baltimore, MD 21205, USA
    Tuberculosis (Edinb) 86:337-48. 2006
    ..Understanding the host-pathogen interaction important to the formation of cavities may lead to new strategies to prevent cavitation and thereby, block transmission...
  29. ncbi request reprint The expanding realm of heterologous immunity: friend or foe?
    Kathleen R Page
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Cell Microbiol 8:185-96. 2006
    ..In particular, we underscore the role of the innate immune system, polarized responses and regulatory mechanisms on heterologous immune responses...
  30. pmc Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosis
    JoAnn M Tufariello
    Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Forchheimer Building, Room 406, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 74:2985-95. 2006
    ..To our knowledge, deltaRv1009 is the first M. tuberculosis mutant to have a specific defect in reactivation without accompanying growth defects in vitro or during acute infection in vivo...
  31. pmc Comparison of C(18)-carboxypropylbetaine and standard N-acetyl-L-cysteine-NaOH processing of respiratory specimens for increasing tuberculosis smear sensitivity in Brazil
    Cherise P Scott
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Clin Microbiol 40:3219-22. 2002
    ....

Research Grants5

  1. IRON REGULATION & VIRULENCE--MYCOBACTERIUM TUBERCULOSIS
    YUKARI MANABE; Fiscal Year: 2003
    ..Elucidation of this iron-dependent IdeR regulon may lead to the identification of virulence determinants, and novel antigens for vaccines and therapeutics. ..
  2. LATENCY AND REACTIVATION TUBERCULOSIS
    YUKARI MANABE; Fiscal Year: 2006
    ..Appropriate animal models are critical to the successful development of tuberculosis vaccines, new drugs and better diagnostic tests for tuberculosis. ..