Affiliation: Johns Hopkins University
- Operational implementation of LED fluorescence microscopy in screening tuberculosis suspects in an urban HIV clinic in UgandaHeidi Albert
Foundation for Innovative New Diagnostics FIND, Kampala, Uganda
PLoS ONE 8:e72556. 2013..We sought to compare the operational performance of three LED FM methods compared to light microscopy in a cohort of HIV-positive tuberculosis (TB) suspects at an urban clinic in a high TB burden country...
- Implementation and effect of intensified case finding on diagnosis of tuberculosis in a large urban HIV clinic in Uganda: a retrospective cohort studySabine Hermans
Infectious Diseases Institute, Makerere University College of Health Sciences, PO Box 22418, Kampala, Uganda
BMC Public Health 12:674. 2012..We sought to determine the associated effect on TB case detection...
- Cost-effectiveness of early initiation of first-line combination antiretroviral therapy in UgandaJoseph Sempa
Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda
BMC Public Health 12:736. 2012..This analysis evaluates the cost-effectiveness of initiating cART at a CD4 count between 250-350 cell/μl (early) versus <250 cell/μl (delayed)...
- The impact on nurses and nurse managers of introducing PEPFAR clinical services in urban government clinics in UgandaJoyce Nankumbi
Department of Nursing, School of Health Sciences, College of Health Sciences, Makerere University, Kampala, Uganda
BMC Int Health Hum Rights 11:S8. 2011..This paper evaluates the impact on the nurses from this innovative program to provide more health care in six nurse managed Kampala City Council (KCC) Clinics...
- The effects of an HIV project on HIV and non-HIV services at local government clinics in urban KampalaToru Matsubayashi
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
BMC Int Health Hum Rights 11:S9. 2011..The aim of this study was to examine the effect of a PEPFAR-funded HIV/AIDS program on six government-run general clinics in Kampala...
- Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in UgandaSteven J Reynolds
Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
BMC Infect Dis 12:381. 2012..We compared the genotypic resistance patterns between clients with VLM versus immunological monitoring (IM)...
- Multivitamin supplementation in HIV infected adults initiating antiretroviral therapy in Uganda: the protocol for a randomized double blinded placebo controlled efficacy trialDavid Guwatudde
School of Public Health, Makerere University College of Health Sciences, PO Box 7072, Kampala, Uganda
BMC Infect Dis 12:304. 2012..We propose to evaluate the efficacy of a single recommended daily allowance (RDA) of micronutrients (including vitamins B-complex, C, and E) in slowing disease progression among HIV-infected adults receiving HAART in Uganda...
- Rifampicin for continuation phase tuberculosis treatment in Uganda: a cost-effectiveness analysisYukari C Manabe
Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda
PLoS ONE 7:e39187. 2012..We compared the impact of a continuation phase using 6HE or 4HR on total cost and expected mortality from the perspective of the Ugandan national health system...
- Evaluation of portable point-of-care CD4 counter with high sensitivity for detecting patients eligible for antiretroviral therapyYukari C Manabe
Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda
PLoS ONE 7:e34319. 2012....
- Developing independent investigators for clinical research relevant for AfricaYukari C Manabe
Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda
Health Res Policy Syst 9:44. 2011....
- Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective studyKathleen R Page
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
BMC Public Health 8:158. 2008..Current guidelines recommend screening and treatment for latent TB infection (LTBI) within 5 years of arrival to the U.S. This study evaluates the timing of LTBI therapy among immigrants presenting for care to a public health TB clinic...
- U.S. medical resident familiarity with national tuberculosis guidelinesPetros C Karakousis
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
BMC Infect Dis 7:89. 2007..We assessed medical resident knowledge about tuberculosis diagnosis and early management based on American Thoracic Society guidelines...
- Unmasked tuberculosis and tuberculosis immune reconstitution inflammatory disease: a disease spectrum after initiation of antiretroviral therapyYukari C Manabe
Center for Tuberculosis Research, Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
J Infect Dis 199:437-44. 2009..TB diagnostics with improved sensitivity and specificity are urgently needed to detect subclinical TB before it is unmasked...
- Immune reconstitution inflammatory syndrome: risk factors and treatment implicationsYukari C Manabe
Center for Tuberculosis Research, Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
J Acquir Immune Defic Syndr 46:456-62. 2007..We sought to determine clinical risk factors for the development of IRIS...
- The aerosol rabbit model of TB latency, reactivation and immune reconstitution inflammatory syndromeYukari C Manabe
Center for Tuberculosis Research, Johns Hopkins University, 720 Rutland Street, Rm 1147B, Baltimore, MD 21205, USA
Tuberculosis (Edinb) 88:187-96. 2008..Further study of the rabbit model of TB latency, reactivation and IRIS may be important in understanding the immunopathogenesis of these poorly modeled states as well as for improved diagnostics for specific stages of disease...
- Naturally attenuated, orally administered Mycobacterium microti as a tuberculosis vaccine is better than subcutaneous Mycobacterium bovis BCGYukari C Manabe
Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Infect Immun 70:1566-70. 2002..microti resulted in a statistically significant improvement in protection against aerosol challenge with virulent M. tuberculosis in the murine model compared with subcutaneous M. bovis BCG Pasteur vaccination...
- Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosisYukari C Manabe
Department of Medicine, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, 424 North Bond Street, Room 1108, Baltimore, MD 21205, USA
Infect Immun 71:6004-11. 2003..tuberculosis strains in this region. Correlation of the relative pathogenicity, including disease severity, in the rabbit model with the strain genotype may help identify stage-specific M. tuberculosis genes important in human disease...
- Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosisYukari C Manabe
Johns Hopkins University School of Medicine, 1503 E Jefferson Street, RM 108, Baltimore, MD 21231 1004, USA
Infect Immun 73:5988-94. 2005..This construct can be used to elucidate further the IdeR regulon and its virulence genes and to differentiate these from genes regulated by SirR, which does not have this domain...
- Feasibility of magnetic bead technology for concentration of mycobacteria in sputum prior to fluorescence microscopyHeidi Albert
FIND, Foundation for Innovative New Diagnostics, Kampala, Uganda
BMC Infect Dis 11:125. 2011..Simpler concentration methods that could be applied in peripheral laboratories are urgently needed...
- Performance of three LED-based fluorescence microscopy systems for detection of tuberculosis in UgandaHeidi Albert
Tuberculosis Research Laboratory, Foundation for Innovative New Diagnostics, Kampala, Uganda
PLoS ONE 5:e15206. 2010....
- Mycobacterium-induced potentiation of type 1 immune responses and protection against malaria are host specificKathleen R Page
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Infect Immun 73:8369-80. 2005..yoelii 17XL. These data indicate that M. tuberculosis-induced potentiation of type 1 immune responses is associated with protection against lethal murine malaria...
- Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigHDeepak Kaushal
Department of Medicine, Center for Tuberculosis Research, Johns Hopkins School of Medicine, 424 North Bond Street, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 99:8330-5. 2002..This phenotype demonstrates that beyond an ability to grow and persist within the host, M. tuberculosis has distinct virulence mechanisms that elicit deleterious host responses and progressive pulmonary disease...
- Characterization of the role of the divalent metal ion-dependent transcriptional repressor MntR in the virulence of Staphylococcus aureusMasaru Ando
Division of Disease Control, Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Infect Immun 71:2584-90. 2003..Moreover, constitutive repression by DtxR(E175K) reduces the virulence of S. aureus in the mouse skin abscess model...
- The expanding realm of heterologous immunity: friend or foe?Kathleen R Page
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Cell Microbiol 8:185-96. 2006..In particular, we underscore the role of the innate immune system, polarized responses and regulatory mechanisms on heterologous immune responses...
- Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbitsSusan E Dorman
Department of Medicine, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
Infect Immun 72:1700-5. 2004..Preliminary evidence is presented for a cell-mediated immune defect with lower DTH responses and macrophages that have a decreased ability to respond to in vitro stimulation with LPS or M. tuberculosis infection...
- Attenuation of late-stage disease in mice infected by the Mycobacterium tuberculosis mutant lacking the SigF alternate sigma factor and identification of SigF-dependent genes by microarray analysisDeborah E Geiman
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Infect Immun 72:1733-45. 2004..Microarray analysis has identified SigF-dependent genes and a putative SigF consensus recognition site...
- Short report: modulation of Mycobacterium tuberculosis infection by Plasmodium in the murine modelCherise P Scott
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Trop Med Hyg 70:144-8. 2004..13 +/- 0.10, and 2.86 +/- 0.10 versus 2.49 +/- 0.10, respectively) and had increased mortality. In populations where both diseases are endemic, there may be implications for increased incidence of clinically detectable tuberculosis...
- Susceptibility to tuberculosis: composition of tuberculous granulomas in Thorbecke and outbred New Zealand White rabbitsSusana Mendez
JA Baker Institute for Animal Health, Cornell Veterinary College, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 122:167-74. 2008..Further delineation of the outbred rabbit's resistant immune response to Mtb infection is warranted...
- Animal models of cavitation in pulmonary tuberculosisKris L Helke
Department of Comparative Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Room 811, Baltimore, MD 21205, USA
Tuberculosis (Edinb) 86:337-48. 2006..Understanding the host-pathogen interaction important to the formation of cavities may lead to new strategies to prevent cavitation and thereby, block transmission...
- Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551Anup K Kesavan
Department of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
Infect Immun 73:7056-60. 2005..They had significant leukopenia and reduced delayed-type hypersensitivity responses. Malnutrition dampened cell-mediated immunity and would interfere with diagnostic tests that rely on intact CD4 T-cell responses...
- Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosisJoAnn M Tufariello
Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Forchheimer Building, Room 406, 1300 Morris Park Ave, Bronx, NY 10461, USA
Infect Immun 74:2985-95. 2006..To our knowledge, deltaRv1009 is the first M. tuberculosis mutant to have a specific defect in reactivation without accompanying growth defects in vitro or during acute infection in vivo...
- Comparison of C(18)-carboxypropylbetaine and standard N-acetyl-L-cysteine-NaOH processing of respiratory specimens for increasing tuberculosis smear sensitivity in BrazilCherise P Scott
Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
J Clin Microbiol 40:3219-22. 2002....
- IRON REGULATION & VIRULENCE--MYCOBACTERIUM TUBERCULOSISYUKARI MANABE; Fiscal Year: 2003..Elucidation of this iron-dependent IdeR regulon may lead to the identification of virulence determinants, and novel antigens for vaccines and therapeutics. ..
- LATENCY AND REACTIVATION TUBERCULOSISYUKARI MANABE; Fiscal Year: 2006..Appropriate animal models are critical to the successful development of tuberculosis vaccines, new drugs and better diagnostic tests for tuberculosis. ..