Anirban Maitra

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy
    Dipankar Pramanik
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Oncotarget 3:640-50. 2012
  2. ncbi request reprint New Advances in the Pathogenesis and Progression of Barrett's Esophagus
    M M Streppel
    Department of Pathology, Division of Gastrointestinal and Liver Pathology, Johns Hopkins School of Medicine, Sidney Kimmel David Koch Cancer Research Building, 1550 Orleans Street, Room 341, Baltimore, Maryland 21231, USA
    Curr Mol Med 14:58-68. 2014
  3. pmc Performance of mitochondrial DNA mutations detecting early stage cancer
    John P Jakupciak
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    BMC Cancer 8:285. 2008
  4. pmc A molecular scheme for improved characterization of human embryonic stem cell lines
    Richard Josephson
    Stem Cell Center, American Type Culture Collection ATCC, Manassas, VA, USA
    BMC Biol 4:28. 2006
  5. ncbi request reprint Molecular pathogenesis of pancreatic cancer
    Anirban Maitra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Best Pract Res Clin Gastroenterol 20:211-26. 2006
  6. pmc Pancreatic cancer
    Anirban Maitra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Annu Rev Pathol 3:157-88. 2008
  7. ncbi request reprint Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays
    Anirban Maitra
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Clin Cancer Res 9:5988-95. 2003
  8. ncbi request reprint Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    Anirban Maitra
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:902-12. 2003
  9. ncbi request reprint Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells
    Nijaguna B Prasad
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 65:1619-26. 2005
  10. pmc Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer
    Savita Bisht
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mol Cancer Ther 9:2255-64. 2010

Research Grants

  1. A Sequencing Microarray for Mitochondrial Mutations
    Anirban Maitra; Fiscal Year: 2004
  2. Hedgehog Inhibitors in Pancreas Cancer
    Anirban Maitra; Fiscal Year: 2005
  3. Hedgehog Inhibitors in Pancreas Cancer
    Anirban Maitra; Fiscal Year: 2006
  4. Hedgehog signaling in pancreatic neoplasia
    Anirban Maitra; Fiscal Year: 2006
  5. Hedgehog Inhibitors in Pancreas Cancer
    Anirban Maitra; Fiscal Year: 2007
  6. Hedgehog Inhibitors in Pancreas Cancer
    Anirban Maitra; Fiscal Year: 2009
  7. Developmental Signaling Pathways in Pancreatic Cancer
    Anirban Maitra; Fiscal Year: 2010

Detail Information

Publications118 found, 100 shown here

  1. pmc A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy
    Dipankar Pramanik
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Oncotarget 3:640-50. 2012
    ..A composite DOX-curcumin nanoparticle that overcomes both MDR-based DOX chemoresistance and DOX-induced cardiotoxicity holds promise for providing lasting and safe anticancer therapy...
  2. ncbi request reprint New Advances in the Pathogenesis and Progression of Barrett's Esophagus
    M M Streppel
    Department of Pathology, Division of Gastrointestinal and Liver Pathology, Johns Hopkins School of Medicine, Sidney Kimmel David Koch Cancer Research Building, 1550 Orleans Street, Room 341, Baltimore, Maryland 21231, USA
    Curr Mol Med 14:58-68. 2014
    ....
  3. pmc Performance of mitochondrial DNA mutations detecting early stage cancer
    John P Jakupciak
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    BMC Cancer 8:285. 2008
    ..The detection of mtDNA mutations in body fluids using resequencing microarrays, which are more sensitive than other sequencing methods, could provide a strategy to measure mutation loads in remote anatomical sites...
  4. pmc A molecular scheme for improved characterization of human embryonic stem cell lines
    Richard Josephson
    Stem Cell Center, American Type Culture Collection ATCC, Manassas, VA, USA
    BMC Biol 4:28. 2006
    ..However, hESC must be routinely analyzed at the genomic level to guard against deleterious changes during extensive propagation, expansion, and manipulation in vitro...
  5. ncbi request reprint Molecular pathogenesis of pancreatic cancer
    Anirban Maitra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Best Pract Res Clin Gastroenterol 20:211-26. 2006
    ..This chapter will provide an overview of the molecular pathogenesis of pancreatic cancer with emphasis on clinical applications...
  6. pmc Pancreatic cancer
    Anirban Maitra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Annu Rev Pathol 3:157-88. 2008
    ....
  7. ncbi request reprint Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays
    Anirban Maitra
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Clin Cancer Res 9:5988-95. 2003
    ..Global expression microarrays can document abnormal pathways that impact on tumorigenesis and disease progression...
  8. ncbi request reprint Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    Anirban Maitra
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:902-12. 2003
    ....
  9. ncbi request reprint Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells
    Nijaguna B Prasad
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 65:1619-26. 2005
    ..These data show frequent up-regulation of foregut markers in early PanIN lesions and suggest that PanIN development may involve Hedgehog-mediated conversion to a gastric epithelial differentiation program...
  10. pmc Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer
    Savita Bisht
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mol Cancer Ther 9:2255-64. 2010
    ..NanoCurc is a promising new formulation that is able to overcome a major impediment for the clinical translation of curcumin to cancer patients by improving systemic bioavailability, and by extension, therapeutic efficacy...
  11. pmc Hedgehog signaling is required for effective regeneration of exocrine pancreas
    Volker Fendrich
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 135:621-31. 2008
    ..Given the known role of Hh signaling in exocrine pancreatic cancer, these findings may provide a mechanistic link between injury-induced activation of pancreatic progenitors and subsequent pancreatic neoplasia...
  12. ncbi request reprint Gene expression profiling identifies markers of ampullary adenocarcinoma
    N Tjarda Van Heek
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Biol Ther 3:651-6. 2004
    ..001). Measurement of markers of ampullary cancer such as osteopontin may aid in the early detection and differential diagnosis of patients with periampullary lesions...
  13. ncbi request reprint Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer
    Antonio Jimeno
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, School of Medicine, The Johns Hopkins University, The Baunting and Blaustein Cancer Research Building, 1650 Orleans Street, Room 1M89, Baltimore, MD 21231, USA
    Mol Cancer Ther 6:1079-88. 2007
    ..In addition, the data support the efficacy of combined epidermal growth factor receptor and MAPK inhibitors in biliary and pancreatic cancers, providing the basis to test this combination in the clinic...
  14. ncbi request reprint Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays
    Belen Rubio-Viqueira
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Cancer Ther 6:515-23. 2007
    ..Ultimately, an approach of this nature may facilitate the further refinement of patient selection in favor of individuals with molecular profiles, predicting a greater likelihood of therapeutic benefit...
  15. doi request reprint The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway
    Dora M Lam-Himlin
    Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
    Int J Gastrointest Cancer 37:103-9. 2006
    ..The potential role of YAP in tumorigenesis was also reported in a murine genetic screen which identified a genomic amplification of YAP in hepatocellular carcinoma...
  16. pmc An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, CRB2, Room 316, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:2725-35. 2008
    ....
  17. ncbi request reprint Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression
    Steven R Hustinx
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:1254-61. 2004
    ..TAGmapper should prove to be a powerful tool for the discovery of novel tumor markers through assignment of uncharacterized SAGE tags...
  18. ncbi request reprint Comprehensive proteomic analysis of human pancreatic juice
    Mads Grønborg
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Proteome Res 3:1042-55. 2004
    ..The proteins identified in this study could be directly assessed for their potential as biomarkers for pancreatic cancer by quantitative proteomics methods or immunoassays...
  19. ncbi request reprint Expression and prognostic significance of 14-3-3sigma and ERM family protein expression in periampullary neoplasms
    Steven R Hustinx
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Cancer Biol Ther 4:596-601. 2005
    ..4; 0.9-2.2, p = 0.14). Aberrant expression of 14-3-3sigma may contribute to the outcome of patients with pancreatic ductal adenocarcinoma...
  20. pmc Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
    Zeshaan A Rasheed
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Natl Cancer Inst 102:340-51. 2010
    ..Aldehyde dehydrogenase (ALDH) activity can identify tumor-initiating cells and normal stem cells from several human tissues. We examined the prognostic significance and functional features of ALDH expression in pancreatic adenocarcinoma...
  21. pmc Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia
    Jan Bart M Koorstra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mod Pathol 22:1439-45. 2009
    ..Loss of p53 function appears to be a critical determinant for bypassing this checkpoint and the subsequent progression to invasive adenocarcinoma...
  22. ncbi request reprint Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
    Christine A Iacobuzio-Donahue
    Departments of Pathology, Surgery, Oncology, and Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 63:8614-22. 2003
    ....
  23. pmc Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
    Shinichi Yabuuchi
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Lett 335:41-51. 2013
    ..In summary, our preclinical data suggest that PF-03084014 has greater anti-tumor activity in combination with gemcitabine in PDA and provides rationale for further investigation of this combination in PDA...
  24. pmc The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models
    Masamichi Mizuma
    Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cancer Ther 11:1999-2009. 2012
    ..Our findings strengthen the rationale for small-molecule inhibition of Notch signaling as a therapeutic strategy in PDAC...
  25. ncbi request reprint Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach
    Mads Grønborg
    Department of Biological Chemistry, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Proteomics 5:157-71. 2006
    ..28 was obtained, confirming previously reported poor associations between RNA and protein expression studies...
  26. pmc Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas
    Marco Dal Molin
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD 21231, USA
    Hum Pathol 43:585-91. 2012
    ..We did not observe correlation between Brg1 expression and IPMN subtype or with location of the cyst. We provide first evidence that Brg1 expression is lost in noninvasive cystic precursor lesions of pancreatic adenocarcinoma...
  27. pmc Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Biol Ther 12:598-609. 2011
    ..Treatment with the cyclin-dependent kinase inhibitor SCH727965 alone or in combination is a highly promising novel experimental therapeutic strategy against pancreatic cancer...
  28. ncbi request reprint Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model
    Pramod Bonde
    Department of Cardiothoracic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 133:763-9. 2007
    ..Support for this comes from the development of esophageal adenocarcinoma in the rat reflux model. However, to date, no systematic characterization of the tumors derived from this model has been reported...
  29. pmc The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma
    Alvarez Hector
    Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Biol Ther 10:1009-18. 2010
    ..Axl RTK is an adverse prognostic factor in EAC. The availability of small molecule inhibitors of Axl function provides a tractable strategy for molecular therapy of established EAC...
  30. pmc Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 67:2187-96. 2007
    ....
  31. doi request reprint Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer
    Antonio Jimeno
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231 1000, USA
    Cancer Res 68:2841-9. 2008
    ..These results suggest a phenomenon of pathway addiction and support the value of unbiased system biology approaches in drug development...
  32. doi request reprint The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis
    Gang Ming Zou
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Cell Physiol 219:209-18. 2009
    ..Inhibition of the Ape-1/Ref-1 redox domain with E3330 or comparable angiogenesis inhibitors might be a potent therapeutic strategy in solid tumors...
  33. pmc Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer
    Guoping Sui
    Department of Pathology, Johns Hopkins University School of Medicine, Washington, DC
    Mol Cancer 5:73. 2006
    ..In all cases, matched normal tissues from the corresponding site were obtained as germline control. MitoChip analysis was performed on DNA obtained from cryostat-embedded specimens...
  34. ncbi request reprint MKK4 status predicts survival after resection of gastric adenocarcinoma
    Steven C Cunningham
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Arch Surg 141:1095-9; discussion 1100. 2006
    ..Lack of expression of the tumor-suppressor gene MKK4 is significantly correlated with poor survival after resection of gastric adenocarcinoma...
  35. ncbi request reprint Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Mod Pathol 18:752-61. 2005
    ....
  36. pmc Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas
    Seung Woo Park
    Department of Surgery, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 134:2080-90. 2008
    ..To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of both normal and oncogenic KRAS-expressing pancreatic progenitor cells in living zebrafish embryos...
  37. pmc GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct
    Hanno Matthaei
    Departments of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    HPB (Oxford) 14:677-83. 2012
    ..Intraductal papillary neoplasms of the bile ducts (IPNBs) morphologically resemble pancreatic IPMNs. This study sought to assess the mutational status of GNAS at codon 201 in IPNBs...
  38. ncbi request reprint In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities
    Savita Bisht
    Department of Pathology, Johns Hopkins University School of Medicine, CRB2, Room 345, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:3878-88. 2008
    ..01) compared with control tumors. These data indicate that NMA622 nanoparticles provide a suitable platform for oral delivery of water-insoluble drugs like rapamycin for cancer therapy...
  39. pmc Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer
    Kwang Hyuck Lee
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Pancreatology 9:293-301. 2009
    ....
  40. pmc Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas
    Norihiro Sato
    Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 164:903-14. 2004
    ..0001). Our findings suggest that preoperative assessment of gene expression profiles may be able to differentiate invasive from noninvasive IPMNs...
  41. ncbi request reprint Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy
    Steven R Hustinx
    Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 4:83-6. 2005
    ..Thus, pancreatic cancer is a promising cancer type in which to explore novel chemotherapeutic strategies to exploit the selective loss of MTAP function...
  42. pmc The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target
    Jan Bart M Koorstra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Biol Ther 8:618-26. 2009
    ..The Axl receptor tyrosine kinase is implicated in cellular transformation and tumor progression, although its role in pancreatic cancer has not been previously documented...
  43. pmc Molecular determinants of retinoic acid sensitivity in pancreatic cancer
    Sonal Gupta
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 18:280-9. 2012
    ..To identify a predictive molecular "signature" for sensitivity to retinoic acid in pancreatic cancer...
  44. pmc Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for diagnosis and therapy
    Hector Alvarez
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nanomedicine 4:295-301. 2008
    ..Anti-mesothelin antibody-conjugated nanoparticles can be useful for the diagnosis and therapy of mesothelin-overexpressing esophageal adenocarcinomas...
  45. pmc Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
    Yuchen Jiao
    1 The Ludwig Center, Johns Hopkins University, Baltimore, Maryland, USA 2 Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland, USA 3 Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA 4
    Nat Genet 45:1470-3. 2013
    ..In contrast, TP53 was the most frequently altered gene in a series of nine gallbladder carcinomas. These discoveries highlight the key role of dysregulated chromatin remodeling in intrahepatic cholangiocarcinomas. ..
  46. pmc Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon
    Mirte M Streppel
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231 2410, USA
    Hum Pathol 43:1755-63. 2012
    ..We propose that mucin 16 may function as a prognostic marker and therapeutic target in the future...
  47. pmc Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
    Roeland F de Wilde
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mod Pathol 25:1033-9. 2012
    ....
  48. pmc MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
    Nils Habbe
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Biol Ther 8:340-6. 2009
    ..Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented...
  49. pmc A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists
    Venugopal Chenna
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Mol Cancer Ther 11:165-73. 2012
    ..No demonstrable hematologic or biochemical abnormalities were observed with NanoHHI administration. NanoHHI should be amenable to clinical translation in settings where tumors acquire mutational resistance to current Smo antagonists...
  50. ncbi request reprint Assessment of celecoxib pharmacodynamics in pancreatic cancer
    Antonio Jimeno
    The Sol Goldman Pancreatic Cancer Research Center, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, 1650 Orleans Street, Room 1M89, Baltimore, MD 21231, USA
    Mol Cancer Ther 5:3240-7. 2006
    ..The direct pancreatic cancer xenograft model proved to be a valuable tool for drug evaluation and biological studies and showed similar results to those observed in resected pancreatic cancer specimens...
  51. pmc New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8
    Zarir E Karanjawala
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 32:188-96. 2008
    ..New markers to distinguish benign reactive glands from infiltrating ductal adenocarcinoma of the pancreas are needed...
  52. pmc Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells
    Safia N Salaria
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Cancer Biol Ther 6:324-8. 2007
    ..This hypothesis was based on reverse transcriptase-polymerase chain reaction analyses of bulk pancreatic tissue, yet pancreatic cancer is a complex admixture of neoplastic epithelial cells and desmoplastic stroma...
  53. pmc Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling
    Georg Feldmann
    Departments of Pathology, Oncology, and Medicine, and The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 70:4460-9. 2010
    ..Conversely, restoring Ral function rescued the effects of CDK5 inhibition in pancreatic cancer cells. Our findings identify CDK5 as a pharmacologically tractable target to degrade Ras signaling in pancreatic cancer...
  54. ncbi request reprint Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
    Norihiro Sato
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 63:4158-66. 2003
    ..These results indicate that gene hypomethylation is a frequent epigenetic event in pancreatic cancer and is commonly associated with the overexpression of affected genes...
  55. pmc Altered telomeres in tumors with ATRX and DAXX mutations
    Christopher M Heaphy
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Science 333:425. 2011
    ..ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system. These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes...
  56. ncbi request reprint Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents
    Antonio Jimeno
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 65:3003-10. 2005
    ....
  57. pmc GNAS Sequencing Identifies IPMN-specific Mutations in a Subgroup of Diminutive Pancreatic Cysts Referred to as "Incipient IPMNs"
    Hanno Matthaei
    Departments of Pathology Oncology Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine Ludwig Center for Cancer Genetics Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD Department of Pathology, Microbiology, Immunology, Vanderbilt University Medical Center, Nashville, TN Departments of General, Visceral, Thoracic and Vascular Surgery Prostate Cancer Research Institute of Pathology, University of Bonn, Bonn, Germany
    Am J Surg Pathol 38:360-3. 2014
    ..Additional studies in a larger cohort are needed to define the relationship of incipient IPMNs to larger IPMNs and, more importantly, to determine their clinical significance. ..
  58. pmc Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia
    Mitsuro Kanda
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 142:730-733.e9. 2012
    ..These findings could improve our understanding of the development and progression of these premalignant lesions...
  59. pmc Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
    Hum Mutat 33:100-3. 2012
    ..These findings suggest that the aberrant chromatin remodeling consequent to ARID1A inactivation contributes to a variety of different types of neoplasms...
  60. pmc Elevated microRNA miR-21 levels in pancreatic cyst fluid are predictive of mucinous precursor lesions of ductal adenocarcinoma
    Ji Kon Ryu
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Pancreatology 11:343-50. 2011
    ..Deregulated microRNA (miRNAs) expression is widespread in pancreatic cancer. We assessed whether aberrant miRNAs in pancreatic cyst fluid could be used as potential biomarkers for cystic precursor lesions of pancreatic cancer...
  61. ncbi request reprint Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers
    Collins A Karikari
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Ther 4:1860-6. 2005
    ..Inhibitors of de novo purine synthesis can be a potential mechanism-based strategy for treatment of biliary tract cancers, one third of which show complete loss of MTAP function...
  62. pmc A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
    Antonio Jimeno
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231 1000, USA
    Mol Cancer Ther 8:310-4. 2009
    ..Direct tumor xenografts are a valid platform to test multicompartment therapeutic approaches in pancreatic cancer...
  63. ncbi request reprint Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:1081-9; discussion 1090-1. 2004
    ....
  64. ncbi request reprint Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion
    Steven R Hustinx
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 18:959-63. 2005
    ..The concordant loss of expression of both genes in PanIN lesions demonstrates that homozygous deletions of the p16 tumor suppressor gene can occur in noninvasive precursor lesions...
  65. ncbi request reprint CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:390-9. 2005
    ..These findings suggest a role for CDC2/CDK1 in esophageal adenocarcinogenesis, both as a potential histopathologic marker of dysplasia and a putative treatment target...
  66. pmc Expression of Yes-associated protein in common solid tumors
    Angela A Steinhardt
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 39:1582-9. 2008
    ....
  67. ncbi request reprint Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47
    Anirban Maitra
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Pathol 118:52-9. 2002
    ..Fascin and HSP47 are novel tumor markers with potential diagnostic and therapeutic implications for pancreatic carcinoma. These results establish the usefulness of global expression platforms to identify novel tumor markers...
  68. ncbi request reprint Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Surgery 134:902-8; discussion 909. 2003
    ..The aberrant promoter methylation of the mismatch repair gene, hMLH1, is associated with microsatellite instability (MSI) in cancer cells and often is associated with a favorable prognosis...
  69. ncbi request reprint Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions
    Anil V Parwani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231 2410, USA
    Mod Pathol 16:299-308. 2003
    ..It is noteworthy that all of these alterations occur at the level of carcinoma in situ...
  70. ncbi request reprint Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma
    Donna E Hansel
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 19:772-9. 2006
    ..We conclude that telomere shortening is a consistent and early finding in the development of biliary tract carcinoma...
  71. ncbi request reprint An in vivo platform for translational drug development in pancreatic cancer
    Belen Rubio-Viqueira
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center and the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:4652-61. 2006
    ....
  72. pmc Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway
    Oliver A Kent
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 24:2754-9. 2010
    ..Additionally, KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling...
  73. pmc Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
    Jian Wu
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 108:21188-93. 2011
    ..These results highlight the essential role of ubiquitin ligases in these neoplasms and have important implications for the diagnosis and treatment of patients with cystic tumors...
  74. pmc MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
    N V Rajeshkumar
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 17:2799-806. 2011
    ..Investigate the efficacy and pharmacodynamic effects of MK-1775, a potent Wee1 inhibitor, in both monotherapy and in combination with gemcitabine (GEM) using a panel of p53-deficient and p53 wild-type human pancreatic cancer xenografts...
  75. pmc Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology
    Chanjuan Shi
    The Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center David Koch Cancer Research Building II, Suite 341 1550 Orleans St Baltimore, MD 21231, USA
    J Mol Diagn 11:583-9. 2009
    ..These data demonstrate that KRAS2 mutations are detectable in both bile and serum using LigAmp. This technology has the potential for early biliary tract carcinoma detection and possibly for residual disease monitoring post-therapy...
  76. pmc Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Pathol 162:1151-62. 2003
    ..The genes and expressed sequence tags presented in this study provide clues to the pathobiology of pancreatic cancer and implicate a large number of potentially new molecular markers for the detection and treatment of pancreatic cancer...
  77. pmc Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Baltimore, MD 21231, USA
    Science 324:217. 2009
    ..These results illustrate that complete, unbiased sequencing of protein-coding genes can lead to the identification of a gene responsible for a hereditary disease...
  78. ncbi request reprint Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater
    Donna E Hansel
    MBBS, Department of Surgery, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 771, Baltimore, MD 21205, USA
    J Clin Oncol 23:1811-8. 2005
    ..We assessed the expression of these putative intestinal epithelial-specific transcription factors and their influence on patient outcome...
  79. ncbi request reprint Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Surg Pathol 28:347-56. 2004
    ..This up-regulation appears to parallel invasive behavior and may therefore be used as a potential marker for cancer aggressiveness in this system...
  80. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
    ..These results uncover a universal size-control mechanism in metazoan...
  81. pmc Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer
    Kieran Brune
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1067-76. 2006
    ..The multifocal nature of familial pancreatic neoplasia suggests that surveillance of these patients is warranted after partial pancreatectomy...
  82. pmc Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    Sian Jones
    Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1801-6. 2008
    ..Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis...
  83. ncbi request reprint Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma
    Jens Koopmann
    Department of Pathology and Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 13:487-91. 2004
    ..One candidate tumor marker recently identified by global gene expression analysis of pancreatic cancer is the secreted glycophosphoprotein osteopontin (OPN). In this study, we evaluate OPN as a serum marker of pancreatic adenocarcinoma...
  84. pmc Differential membrane proteomics using 18O-labeling to identify biomarkers for cholangiocarcinoma
    Troels Zakarias Kristiansen
    McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Proteome Res 7:4670-7. 2008
    ..In light of recent reports showing that Golgi membrane protein 1 is detectable in serum, further investigation into validation of this protein has the potential to provide a biomarker for early detection of cholangiocarcinomas...
  85. pmc Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer
    Murali D Bashyam
    Department of Pathology, Stanford University, Stanford, CA, USA
    Neoplasia 7:556-62. 2005
    ..Our findings suggest candidate genes and pathways, which may contribute to the development or progression of pancreatic cancer...
  86. ncbi request reprint Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
    ..Our results identify a group of common lethal malignancies in which Hh pathway activity, essential for tumour growth, is activated not by mutation but by ligand expression...
  87. ncbi request reprint Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    Yoshiharu Miyamoto
    Departments of Surgery, Oncology, and Pathology, The Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer Cell 3:565-76. 2003
    ..These findings suggest that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells...
  88. ncbi request reprint Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    Sunil S Karhadkar
    Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 431:707-12. 2004
    ..Monitoring and manipulating Hh pathway activity may thus offer significant improvements in diagnosis and treatment of prostate cancers with metastatic potential...
  89. pmc In vivo and in vitro propagation of intraductal papillary mucinous neoplasms
    Hirohiko Kamiyama
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lab Invest 90:665-73. 2010
    ..Patient origin was confirmed using DNA fingerprinting. Most non-invasive IPMNs grow in NOG mice. We successfully established one IPMN cell line, and plan to use it to clarify the molecular pathogenesis of IPMNs...
  90. ncbi request reprint Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms
    Fikret Sahin
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:686-91. 2003
    ..Immunohistochemical analysis for Stk11 expression may be a valid surrogate for genetic analysis of STK11 gene mutations in cancers...
  91. pmc The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection
    Anirban Maitra
    Department of Pathology, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 14:812-9. 2004
    ..The MitoChip is a high-throughput sequencing tool for the reliable identification of mitochondrial DNA mutations from primary tumors in clinical samples...
  92. pmc Discovery of novel tumor markers of pancreatic cancer using global gene expression technology
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins MedicalInstitutions, Baltimore, Maryland 21231 2410, USA
    Am J Pathol 160:1239-49. 2002
    ..The remaining 69 genes have not been implicated in pancreatic cancer before, and have immediate potential as novel therapeutic targets and tumor markers of pancreatic cancer...
  93. pmc HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma
    Alexandra C Hristov
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mod Pathol 22:43-9. 2009
    ..Our results support a role for HMGA2 in the progression of pancreatic ductal adenocarcinoma and suggest that it could be a useful biomarker and rational therapeutic target in more advanced disease...
  94. pmc Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
    Collins A Karikari
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, CRB2 Room 345, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 6:957-66. 2007
    ..These preclinical results suggest that targeting of the apoptotic machinery in pancreatic cancers with XAntags is a promising therapeutic option that warrants further evaluation...
  95. ncbi request reprint Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis
    Feng Wu
    Department of Medicine Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Inflamm Bowel Dis 13:807-21. 2007
    ..Ulcerative colitis (UC) and Crohn's disease (CD) are inflammatory bowel diseases (IBD) with variable, overlapping clinical features and complex pathophysiologies...
  96. ncbi request reprint Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers
    Paula M Hempen
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 63:994-9. 2003
    ..This evidence is compatible with a high degree of selection for inactivation of the ACVR2 gene in tumorigenesis, supporting ACVR2 as a candidate tumor suppressor gene in gastrointestinal cancers...
  97. ncbi request reprint Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: initial imaging in experimental models of pancreatic cancer
    Catherine A Foss
    Department of Radiology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Univeristy, Baltimore, MD 21287 2182, USA
    Mol Imaging 6:131-9. 2007
    ..6PL orthotopic xenograft model showed strong tumor and spleen uptake at 5 days postinjection. Both anti-claudin 4 and anti-PSCA demonstrate promise as radiodiagnostic and possibly radiotherapeutic agents for human pancreatic cancers...
  98. ncbi request reprint Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expression
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:652-9. 2003
    ..We postulate that the upregulation of VEGF-C may be involved in PEN progression and metastases, although not via a direct proangiogenic mechanism...
  99. ncbi request reprint Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays
    Norihiro Sato
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Res 63:3735-42. 2003
    ..Thus, a substantial number of genes are induced by 5Aza-dC treatment of pancreatic cancer cells, and many of them may represent novel targets for aberrant methylation in pancreatic carcinoma...
  100. pmc Molecular genetics of pancreatic intraepithelial neoplasia
    Georg Feldmann
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Ross Bldg 632, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Hepatobiliary Pancreat Surg 14:224-32. 2007
    ..Recent evidence suggests that noninvasive precursor lesions, classified as pancreatic intraepithelial neoplasia (PanIN), can progress to invasive pancreatic cancer. This review will discuss the major genetic alterations in PanIN lesions...
  101. pmc Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice
    Dipankar Pramanik
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mol Cancer Ther 10:1470-80. 2011
    ..The nanovector is a platform with potential broad applicability in systemic miRNA delivery to cancer cells...

Research Grants9

  1. A Sequencing Microarray for Mitochondrial Mutations
    Anirban Maitra; Fiscal Year: 2004
    ..This study will serve as a model for array-based diagnosis of cancer in clinical samples. ..
  2. Hedgehog Inhibitors in Pancreas Cancer
    Anirban Maitra; Fiscal Year: 2005
    ..abstract_text> ..
  3. Hedgehog Inhibitors in Pancreas Cancer
    Anirban Maitra; Fiscal Year: 2006
    ..abstract_text> ..
  4. Hedgehog signaling in pancreatic neoplasia
    Anirban Maitra; Fiscal Year: 2006
    ..Specifically, it will be determined whether Hh misexpression can generate a phenotype of multistep progression of pancreatic cancer that resembles the cognate human condition. ..
  5. Hedgehog Inhibitors in Pancreas Cancer
    Anirban Maitra; Fiscal Year: 2007
    ..abstract_text> ..
  6. Hedgehog Inhibitors in Pancreas Cancer
    Anirban Maitra; Fiscal Year: 2009
    ..abstract_text> ..
  7. Developmental Signaling Pathways in Pancreatic Cancer
    Anirban Maitra; Fiscal Year: 2010
    ....