Research Topics
Species | Dean F MacKinnonSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicityFrancis M Mondimore
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
J Affect Disord 100:171-7. 2007..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness...
Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigreesJennifer L Payne
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
Arch Womens Ment Health 12:27-34. 2009..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use...
Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Psychiatry 159:30-5. 2002..This study used diagnostic data from the NIMH Bipolar Disorder Genetics Initiative to assess in a separate, larger family set the familiality of panic combined with bipolar disorder...- Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33Fernando S Goes
Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:236-47. 2007..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features... - Family-based association study of Neuregulin 1 with psychotic bipolar disorderFernando S Goes
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009.... - Clinical correlates and familial aggregation of age at onset in bipolar disorderPing-I Lin
Dept. of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N. Broadway, 8th Floor, Baltimore, MD 21205, USA
Am J Psychiatry 163:240-6. 2006..Thus, age at onset may conceivably be used to identify more homogeneous groups of bipolar disorder families and thereby facilitate the mapping of bipolar disorder susceptibility genes... - Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and XPeter P Zandi
Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes... - The bipolar disorder phenome database: a resource for genetic studiesJames B Potash
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:1229-37. 2007..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies... - Genome-wide linkage and follow-up association study of postpartum mood symptomsPamela Belmonte Mahon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
Am J Psychiatry 166:1229-37. 2009..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms... - Genome-wide scan of bipolar II disorderEvaristus A Nwulia
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Bipolar Disord 9:580-8. 2007..We have performed genome-wide non-parametric analysis on 74 bipolar pedigrees using only the BD II phenotype as affection model... - SNP fine mapping of chromosome 8q24 in bipolar disorderPeter P Zandi
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007..Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions... - Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigreesMelvin G McInnis
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287-7463, USA
Biol Psychiatry 54:1265-73. 2003..Application of conditional analyses is potentially useful in larger sample collections to identify susceptibility genes of modest influence that may not be identified in a genome-wide scan aimed to identify single gene effects... - Psychotic features in bipolar and unipolar depressionFernando S Goes
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
Bipolar Disord 9:901-6. 2007..We examined the relationship of psychotic depression to polarity in several large familial samples of mood disorder... - Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12Virginia L Willour
Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Psychiatry 61:725-7. 2007..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide... - Genetics of recurrent early-onset major depression (GenRED): final genome scan reportPeter Holmans
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
Am J Psychiatry 164:248-58. 2007.... - Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigreesFrancis M Mondimore
Johns Hopkins Hospital, Meyer 3 181, 600 North Wolfe St, Baltimore, MD 21287, USA
Am J Psychiatry 163:1554-60. 2006..The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder... - Rapid switching of mood in families with multiple cases of bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Arch Gen Psychiatry 60:921-8. 2003..Phenomena in the bipolar spectrum, including rapid cycling, cyclothymia, and affective instability of borderline personality, may be important markers of etiologic heterogeneity. Rapid switching of mood may be central to these phenomena... - Familial aggregation of postpartum mood symptoms in bipolar disorder pedigreesJennifer L Payne
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Bipolar Disord 10:38-44. 2008..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees... - Carbon dioxide induces erratic respiratory responses in bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore Maryland, USA
J Affect Disord 112:193-200. 2009..Moreover, problems in the arousal and modulation of appetites are central to the clinical syndromes of mania and depression; hence CO(2) may arouse an abnormal respiratory response to "air hunger"... - Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
Am J Psychiatry 160:1696-8. 2003..The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder... - Association study of serotonin pathway genes in attempted suicideJennifer T Judy
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 159:112-9. 2012..Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior... - Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21Virginia L Willour
The Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35... - Rapid mood switching and suicidality in familial bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Bipolar Disord 7:441-8. 2005.... - Family-based association of FKBP5 in bipolar disorderV L Willour
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Mol Psychiatry 14:261-8. 2009..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses... - Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigreesJames B Potash
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 116:90-7. 2003..Families with this subtype should be used to search for susceptibility genes common to bipolar disorder and schizophrenia, and for biological markers that may be shared with schizophrenia... - Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorderJames B Potash
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
Am J Psychiatry 160:680-6. 2003.... - Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21qPing-I Lin
Department of Mental Health, The Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
Am J Hum Genet 77:545-55. 2005..This inconsistency may be due to differences in the AAO characteristics of the samples examined. Future studies to fine map susceptibility genes for BP on chromosomes 21q22.13 and 18p11.2 should take AAO into account... - Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorderPamela Belmonte Mahon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 156:370-8. 2011..8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles... - Panic comorbidity with bipolar disorder: what is the manic-panic connection?Dean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
Bipolar Disord 8:648-64. 2006..As both are episodic disorders of affect regulation, the common pathophysiological mechanism is likely to involve deficits in amygdala-mediated, plasticity-dependent emotional conditioning... - Carbon dioxide provocation of anxiety and respiratory response in bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
J Affect Disord 99:45-9. 2007..Frequent bipolar/panic comorbidity implies bipolar individuals may experience CO2-provoked anxiety and changes in respiratory patterns similar to those experienced by individuals with panic disorder... - Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorderJennifer L Payne
Department of Psychiatry, Women s Mood Disorders Center, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 3 181, Baltimore, MD 21287 7381, United States
J Affect Disord 99:221-9. 2007..We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP)... - Diagnostic reliability of bipolar II disorderSylvia G Simpson
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
Arch Gen Psychiatry 59:736-40. 2002.... - Exonic DNA sequencing of ERBB4 in bipolar disorderFernando S Goes
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 6:e20242. 2011..However, the modest sample size in this study cannot definitively rule out a role for rare variants in bipolar disorder and studies with larger sample sizes are needed to confirm the observed association... - Affective instability as rapid cycling: theoretical and clinical implications for borderline personality and bipolar spectrum disordersDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Bipolar Disord 8:1-14. 2006.... - Bipolar disorder as maladaptive arousal: a behavioral model and evidenceDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
Ann N Y Acad Sci 1129:185-9. 2008..If confirmed, the unstable respiratory response to CO2 may prove useful as a bipolar-disorder endophenotype... - A collaborative approach to teaching medical students how to screen, intervene, and treat substance use disordersKarin J Neufeld
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Subst Abus 33:286-91. 2012..The authors' experience demonstrates that collaboration between 2 clinical departments can produce a successful second-year medical student course based in SBIRT principles... - Rapid switching of mood in families with familial bipolar disorderEvaristus A Nwulia
Department of Psychiatry, Howard University, Washington, DC, USA
Bipolar Disord 10:597-606. 2008..This study aims to confirm these associations and investigate other potential correlates of rapid switching of mood using families from a multisite bipolar linkage study... - Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigreesThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
Biol Psychiatry 56:18-23. 2004.... - Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection... - Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics InitiativeDanielle M Dick
Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
Am J Hum Genet 73:107-14. 2003..10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder...