Dean F MacKinnon

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicity
    Francis M Mondimore
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Affect Disord 100:171-7. 2007
  2. pmc Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
    Arch Womens Ment Health 12:27-34. 2009
  3. ncbi request reprint Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Psychiatry 159:30-5. 2002
  4. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
  5. pmc Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
  6. ncbi request reprint Clinical correlates and familial aggregation of age at onset in bipolar disorder
    Ping I Lin
    Dept of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, 8th Floor, Baltimore, MD 21205, USA
    Am J Psychiatry 163:240-6. 2006
  7. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
  8. ncbi request reprint Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
    Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003
  9. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
  10. ncbi request reprint Genome-wide scan of bipolar II disorder
    Evaristus A Nwulia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 9:580-8. 2007

Detail Information

Publications41

  1. pmc A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicity
    Francis M Mondimore
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Affect Disord 100:171-7. 2007
    ..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness...
  2. pmc Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
    Arch Womens Ment Health 12:27-34. 2009
    ..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use...
  3. ncbi request reprint Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Psychiatry 159:30-5. 2002
    ..This study used diagnostic data from the NIMH Bipolar Disorder Genetics Initiative to assess in a separate, larger family set the familiality of panic combined with bipolar disorder...
  4. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  5. pmc Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
    ....
  6. ncbi request reprint Clinical correlates and familial aggregation of age at onset in bipolar disorder
    Ping I Lin
    Dept of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, 8th Floor, Baltimore, MD 21205, USA
    Am J Psychiatry 163:240-6. 2006
    ....
  7. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
    ..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms...
  8. ncbi request reprint Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
    Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003
    ..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes...
  9. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
    ..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies...
  10. ncbi request reprint Genome-wide scan of bipolar II disorder
    Evaristus A Nwulia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 9:580-8. 2007
    ..We have performed genome-wide non-parametric analysis on 74 bipolar pedigrees using only the BD II phenotype as affection model...
  11. ncbi request reprint SNP fine mapping of chromosome 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007
    ..Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions...
  12. ncbi request reprint Genetics of recurrent early-onset major depression (GenRED): final genome scan report
    Peter Holmans
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
    Am J Psychiatry 164:248-58. 2007
    ....
  13. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  14. ncbi request reprint Psychotic features in bipolar and unipolar depression
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Bipolar Disord 9:901-6. 2007
    ..We examined the relationship of psychotic depression to polarity in several large familial samples of mood disorder...
  15. ncbi request reprint Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12
    Virginia L Willour
    Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 61:725-7. 2007
    ..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide...
  16. pmc Posttraumatic stress disorder increases risk for suicide attempt in adults with recurrent major depression
    Daniel Stevens
    Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Depress Anxiety 30:940-6. 2013
    ..We tested the hypothesis that PTSD resulting from assaultive trauma increases risk for attempted suicide among individuals with recurrent MDD...
  17. ncbi request reprint Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees
    Francis M Mondimore
    Johns Hopkins Hospital, Meyer 3 181, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 163:1554-60. 2006
    ..The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder...
  18. ncbi request reprint Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Bipolar Disord 10:38-44. 2008
    ..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees...
  19. ncbi request reprint Rapid switching of mood in families with multiple cases of bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Gen Psychiatry 60:921-8. 2003
    ..Phenomena in the bipolar spectrum, including rapid cycling, cyclothymia, and affective instability of borderline personality, may be important markers of etiologic heterogeneity. Rapid switching of mood may be central to these phenomena...
  20. doi request reprint Carbon dioxide induces erratic respiratory responses in bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore Maryland, USA
    J Affect Disord 112:193-200. 2009
    ..Moreover, problems in the arousal and modulation of appetites are central to the clinical syndromes of mania and depression; hence CO(2) may arouse an abnormal respiratory response to "air hunger"...
  21. ncbi request reprint Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Psychiatry 160:1696-8. 2003
    ..The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder...
  22. ncbi request reprint Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
    Am J Psychiatry 160:680-6. 2003
    ....
  23. pmc Association study of serotonin pathway genes in attempted suicide
    Jennifer T Judy
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 159:112-9. 2012
    ..Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior...
  24. doi request reprint Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
    ..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses...
  25. ncbi request reprint Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21
    Virginia L Willour
    The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003
    ..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35...
  26. ncbi request reprint Rapid mood switching and suicidality in familial bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 7:441-8. 2005
    ....
  27. ncbi request reprint Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 116:90-7. 2003
    ..Families with this subtype should be used to search for susceptibility genes common to bipolar disorder and schizophrenia, and for biological markers that may be shared with schizophrenia...
  28. pmc Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q
    Ping I Lin
    Department of Mental Health, The Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Hum Genet 77:545-55. 2005
    ..This inconsistency may be due to differences in the AAO characteristics of the samples examined. Future studies to fine map susceptibility genes for BP on chromosomes 21q22.13 and 18p11.2 should take AAO into account...
  29. pmc Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 156:370-8. 2011
    ..8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles...
  30. ncbi request reprint Panic comorbidity with bipolar disorder: what is the manic-panic connection?
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Bipolar Disord 8:648-64. 2006
    ..As both are episodic disorders of affect regulation, the common pathophysiological mechanism is likely to involve deficits in amygdala-mediated, plasticity-dependent emotional conditioning...
  31. pmc Carbon dioxide provocation of anxiety and respiratory response in bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    J Affect Disord 99:45-9. 2007
    ..Frequent bipolar/panic comorbidity implies bipolar individuals may experience CO2-provoked anxiety and changes in respiratory patterns similar to those experienced by individuals with panic disorder...
  32. ncbi request reprint Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder
    Jennifer L Payne
    Department of Psychiatry, Women s Mood Disorders Center, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 3 181, Baltimore, MD 21287 7381, United States
    J Affect Disord 99:221-9. 2007
    ..We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP)...
  33. ncbi request reprint Diagnostic reliability of bipolar II disorder
    Sylvia G Simpson
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 59:736-40. 2002
    ....
  34. pmc Exonic DNA sequencing of ERBB4 in bipolar disorder
    Fernando S Goes
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20242. 2011
    ..However, the modest sample size in this study cannot definitively rule out a role for rare variants in bipolar disorder and studies with larger sample sizes are needed to confirm the observed association...
  35. doi request reprint Bipolar disorder as maladaptive arousal: a behavioral model and evidence
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Ann N Y Acad Sci 1129:185-9. 2008
    ..If confirmed, the unstable respiratory response to CO2 may prove useful as a bipolar-disorder endophenotype...
  36. ncbi request reprint Affective instability as rapid cycling: theoretical and clinical implications for borderline personality and bipolar spectrum disorders
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Bipolar Disord 8:1-14. 2006
    ....
  37. doi request reprint A collaborative approach to teaching medical students how to screen, intervene, and treat substance use disorders
    Karin J Neufeld
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Subst Abus 33:286-91. 2012
    ..The authors' experience demonstrates that collaboration between 2 clinical departments can produce a successful second-year medical student course based in SBIRT principles...
  38. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  39. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  40. doi request reprint Rapid switching of mood in families with familial bipolar disorder
    Evaristus A Nwulia
    Department of Psychiatry, Howard University, Washington, DC, USA
    Bipolar Disord 10:597-606. 2008
    ..This study aims to confirm these associations and investigate other potential correlates of rapid switching of mood using families from a multisite bipolar linkage study...
  41. pmc Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative
    Danielle M Dick
    Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Am J Hum Genet 73:107-14. 2003
    ..10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder...