D MacGlashan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody
    D W MacGlashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Immunol 158:1438-45. 1997
  2. ncbi request reprint Desensitization of IgE-mediated IL-4 release from human basophils
    D MacGlashan
    Johns Hopkins Allergy and Asthma Center, Baltimore, Maryland 21224, USA
    J Leukoc Biol 63:59-67. 1998
  3. ncbi request reprint IgE-mediated desensitization in human basophils and mast cells
    D MacGlashan
    Johns Hopkins University, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Front Biosci 3:d746-56. 1998
  4. ncbi request reprint Pharmacology of IgE-mediated desensitization of human basophils: effects of protein kinase C and src-family kinase inhibitors
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, 21224, USA, Baltimore, MD, USA
    Biochem Pharmacol 60:1717-27. 2000
  5. ncbi request reprint Characteristics of the free cytosolic calcium timelag following IgE-mediated stimulation of human basophils: significance for the nonreleasing basophil phenotype
    D MacGlashan
    Johns Hopkins University, Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Leukoc Biol 69:224-32. 2001
  6. ncbi request reprint Functional consequences of FcepsilonRIalpha up-regulation by IgE in human basophils
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Leukoc Biol 68:479-86. 2000
  7. pmc Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Clin Exp Allergy 40:1365-77. 2010
  8. pmc Subthreshold desensitization of human basophils re-capitulates the loss of Syk and FcεRI expression characterized by other methods of desensitization
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Clin Exp Allergy 42:1060-70. 2012
  9. ncbi request reprint IgE-regulated loss, not IgE-regulated synthesis, controls expression of FcepsilonRI in human basophils
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Leukoc Biol 70:207-18. 2001
  10. pmc Signaling cascades: escape from kinetic proofreading
    D MacGlashan
    Johns Hopkins University Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA dmacglas mail jhmi edu
    Proc Natl Acad Sci U S A 98:6989-90. 2001

Detail Information

Publications10

  1. ncbi request reprint Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody
    D W MacGlashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Immunol 158:1438-45. 1997
    ..One possible explanation for these results is that Fc(epsilon)RI density is directly or indirectly regulated by plasma-free IgE levels...
  2. ncbi request reprint Desensitization of IgE-mediated IL-4 release from human basophils
    D MacGlashan
    Johns Hopkins Allergy and Asthma Center, Baltimore, Maryland 21224, USA
    J Leukoc Biol 63:59-67. 1998
    ..e., stimulation in the presence of Ca(e), these results also indicate that down-regulatory processes differ depending on the presence or absence of Ca(e)...
  3. ncbi request reprint IgE-mediated desensitization in human basophils and mast cells
    D MacGlashan
    Johns Hopkins University, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Front Biosci 3:d746-56. 1998
    ..A variety of processes are discussed and potential mechanisms based on most recent studies using cell lines are explored...
  4. ncbi request reprint Pharmacology of IgE-mediated desensitization of human basophils: effects of protein kinase C and src-family kinase inhibitors
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, 21224, USA, Baltimore, MD, USA
    Biochem Pharmacol 60:1717-27. 2000
    ..These data suggest that PKC has little role in down-regulating the IgE-mediated basophil response. However, like the activation signaling cascade, the desensitization process is dependent on the activation of src family kinases...
  5. ncbi request reprint Characteristics of the free cytosolic calcium timelag following IgE-mediated stimulation of human basophils: significance for the nonreleasing basophil phenotype
    D MacGlashan
    Johns Hopkins University, Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Leukoc Biol 69:224-32. 2001
    ..However, only one characteristic of the [Ca++]i response phenotype of nonreleasing basophils--the [Ca++]i timelag but not the absence of a sustained [Ca++]i elevation--could be mimicked by inhibition of lyn kinase with PP1...
  6. ncbi request reprint Functional consequences of FcepsilonRIalpha up-regulation by IgE in human basophils
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Leukoc Biol 68:479-86. 2000
    ..These results indicate that functional up-regulation does occur but that its magnitude may be modulated because not all components of the signaling pathway are up-regulated in a balanced manner...
  7. pmc Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Clin Exp Allergy 40:1365-77. 2010
    ..The markers CD63 and CD203c have been used in recent years to assess basophil activation but there have been many studies that demonstrate that expression of these markers can be dissociated from histamine release...
  8. pmc Subthreshold desensitization of human basophils re-capitulates the loss of Syk and FcεRI expression characterized by other methods of desensitization
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Clin Exp Allergy 42:1060-70. 2012
    ..However, most signalling studies of human basophils have identified changes in signalling by using other methods of inducing cellular desensitization...
  9. ncbi request reprint IgE-regulated loss, not IgE-regulated synthesis, controls expression of FcepsilonRI in human basophils
    D MacGlashan
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Leukoc Biol 70:207-18. 2001
    ..Taken together, these results suggest that IgE regulates cell surface expression of FcepsilonRI only by regulating the rate that receptor is lost from the cell surface...
  10. pmc Signaling cascades: escape from kinetic proofreading
    D MacGlashan
    Johns Hopkins University Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA dmacglas mail jhmi edu
    Proc Natl Acad Sci U S A 98:6989-90. 2001