Dengke K Ma

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Cycle 8:1526-31. 2009
  2. pmc Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Brain 2:16. 2009
  3. pmc Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Science 323:1074-7. 2009
  4. pmc Adult neural stem cells in the mammalian central nervous system
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Res 19:672-82. 2009
  5. pmc Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain
    Xin Duan
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    Cell 130:1146-58. 2007
  6. ncbi request reprint G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells
    Dengke K Ma
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB735, Baltimore, Maryland 21205, USA
    Stem Cells 26:2131-41. 2008
  7. pmc Neuronal activity modifies the DNA methylation landscape in the adult brain
    Junjie U Guo
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 14:1345-51. 2011
  8. ncbi request reprint Glial influences on neural stem cell development: cellular niches for adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 15:514-20. 2005
  9. ncbi request reprint Cellular niches for endogenous neural stem cells in the adult brain
    J Dedrick Jordan
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    CNS Neurol Disord Drug Targets 6:336-41. 2007
  10. pmc Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis
    Dengke K Ma
    The Solomon Snyder Department of Neuroscience, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 1170:664-73. 2009

Collaborators

Detail Information

Publications11

  1. pmc DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Cycle 8:1526-31. 2009
    ..In this article, we review recent findings and discuss functional and evolutionary implications of such mechanisms underlying active DNA demethylation...
  2. pmc Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Brain 2:16. 2009
    ..In culture, fibroblast growth factor-2 (FGF-2) is sufficient to maintain the self-renewal of adult NSCs derived from the adult rat hippocampus. The underlying signalling mechanism is not fully understood...
  3. pmc Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Science 323:1074-7. 2009
    ..Thus, Gadd45b links neuronal circuit activity to epigenetic DNA modification and expression of secreted factors in mature neurons for extrinsic modulation of neurogenesis in the adult brain...
  4. pmc Adult neural stem cells in the mammalian central nervous system
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Res 19:672-82. 2009
    ..Here, we review recent progress on adult NSCs of the mammalian central nervous system, including topics on their identity, niche, function, plasticity, and emerging roles in cancer and regenerative medicine...
  5. pmc Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain
    Xin Duan
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    Cell 130:1146-58. 2007
    ....
  6. ncbi request reprint G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells
    Dengke K Ma
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB735, Baltimore, Maryland 21205, USA
    Stem Cells 26:2131-41. 2008
    ..These mechanistic findings may guide more efficient reprogramming for future therapeutic applications of stem cells. Disclosure of potential conflicts of interest is found at the end of this article...
  7. pmc Neuronal activity modifies the DNA methylation landscape in the adult brain
    Junjie U Guo
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 14:1345-51. 2011
    ..Our study implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system...
  8. ncbi request reprint Glial influences on neural stem cell development: cellular niches for adult neurogenesis
    Dengke K Ma
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 15:514-20. 2005
    ..Identification of specific niche signals that regulate these sequential steps during adult neurogenesis might lead to strategies to induce functional neurogenesis in other brain regions after injury or degenerative neurological diseases...
  9. ncbi request reprint Cellular niches for endogenous neural stem cells in the adult brain
    J Dedrick Jordan
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    CNS Neurol Disord Drug Targets 6:336-41. 2007
    ..We also highlight some of the potential therapeutic targets to be manipulated within neurogenic niche for repair of the adult central nervous system...
  10. pmc Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis
    Dengke K Ma
    The Solomon Snyder Department of Neuroscience, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 1170:664-73. 2009
    ..Here we review extrinsic mechanisms through which adult neurogenesis is regulated by environmental cues, physiological learning-related stimuli, and neuronal activities...
  11. doi request reprint Oxysterols drive dopaminergic neurogenesis from stem cells
    Dengke K Ma
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21209, USA
    Cell Stem Cell 5:343-4. 2009
    ..In this issue of Cell Stem Cell, Sacchetti et al. (2009) report an unexpected role of liver X receptors and their ligand, oxysterols, in regulating dopaminergic neurogenesis...