Constantine G Lyketsos

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Cognitive decline in adulthood: an 11.5-year follow-up of the Baltimore Epidemiologic Catchment Area study
    C G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 156:58-65. 1999
  2. ncbi A follow-up study of change in quality of life among persons with dementia residing in a long-term care facility
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 18:275-81. 2003
  3. ncbi Effect of dementia and treatment of dementia on time to discharge from assisted living facilities: the Maryland assisted living study
    Constantine G Lyketsos
    Department of Psychiatry Johns Hopkins Bayview, Johns Hopkins Medicine, Maryland 21224, USA
    J Am Geriatr Soc 55:1031-7. 2007
  4. ncbi Should pregnant women avoid eating fish? Lessons from the Seychelles
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Lancet 361:1667-8. 2003
  5. ncbi Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 60:737-46. 2003
  6. ncbi Neuropsychiatric symptoms (behavioral and psychological symptoms of dementia) and the development of dementia treatments
    Constantine G Lyketsos
    Department of Psychiatry, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Int Psychogeriatr 19:409-20. 2007
  7. ncbi Lessons from neuropsychiatry
    Constantine G Lyketsos
    4940 Eastern Avenue, A4 Center, Room 458, Baltimore, MD 21224, USA
    J Neuropsychiatry Clin Neurosci 18:445-9. 2006
  8. ncbi Are old-old patients with major depression more likely to relapse than young-old patients during continuation treatment with escitalopram?
    Constantine G Lyketsos
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    BMC Geriatr 11:2. 2011
  9. ncbi Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": association with functional and cognitive impairment: The Cache County Study
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Dept of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 13:656-64. 2005
  10. ncbi Long-term outcomes of galantamine treatment in patients with Alzheimer disease
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Osler 320, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 12:473-82. 2004

Research Grants

  1. Citalopram Treatment for Agitation in Alzheimer Dementia
    Constantine Lyketsos; Fiscal Year: 2009
  2. Development of blood lipid biomarkers for Alzheimer's disease progression
    Michelle Mielke; Fiscal Year: 2007
  3. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Constantine Lyketsos; Fiscal Year: 2007
  4. DEMENTIA AND PSYCHIATRIC DISORDERS IN ASSISTED LIVING
    Constantine Lyketsos; Fiscal Year: 2005
  5. DEMENTIA AND PSYCHIATRIC DISORDERS IN ASSISTED LIVING
    Constantine Lyketsos; Fiscal Year: 2001
  6. TREATMENT OF DEPRESSION IN ALZHEIMERS DISEASE
    Constantine Lyketsos; Fiscal Year: 2001
  7. Citalopram Treatment for Agitation in Alzheimer Dementia
    Constantine G Lyketsos; Fiscal Year: 2010

Detail Information

Publications103 found, 100 shown here

  1. ncbi Cognitive decline in adulthood: an 11.5-year follow-up of the Baltimore Epidemiologic Catchment Area study
    C G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 156:58-65. 1999
    ..The epidemiology of cognitive decline over 11.5 years was investigated in a large community-residing population, with a special emphasis on the relationship between education and cognitive decline...
  2. ncbi A follow-up study of change in quality of life among persons with dementia residing in a long-term care facility
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 18:275-81. 2003
    ..Dementia is a major public health problem. Increased attention is being paid to the quality of life (QOL) of people with this chronic disease. There have been no longitudinal studies of QOL change in dementia...
  3. ncbi Effect of dementia and treatment of dementia on time to discharge from assisted living facilities: the Maryland assisted living study
    Constantine G Lyketsos
    Department of Psychiatry Johns Hopkins Bayview, Johns Hopkins Medicine, Maryland 21224, USA
    J Am Geriatr Soc 55:1031-7. 2007
    ..To estimate the association between dementia and time to discharge from individual assisted living (AL) facilities and examine, in residents with dementia, factors associated with shorter duration of residence in individual AL facilities...
  4. ncbi Should pregnant women avoid eating fish? Lessons from the Seychelles
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Lancet 361:1667-8. 2003
  5. ncbi Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 60:737-46. 2003
    ..Results of prior antidepressant treatment studies have produced contradictory findings and have not fully assessed the benefits of depression reduction...
  6. ncbi Neuropsychiatric symptoms (behavioral and psychological symptoms of dementia) and the development of dementia treatments
    Constantine G Lyketsos
    Department of Psychiatry, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Int Psychogeriatr 19:409-20. 2007
    ..Empirical characterization of clinically meaningful change in NPS--by examining their relationship with dementia care burden, disability, quality of life, caregiver distress, and resource utilization--would be an important advance...
  7. ncbi Lessons from neuropsychiatry
    Constantine G Lyketsos
    4940 Eastern Avenue, A4 Center, Room 458, Baltimore, MD 21224, USA
    J Neuropsychiatry Clin Neurosci 18:445-9. 2006
  8. ncbi Are old-old patients with major depression more likely to relapse than young-old patients during continuation treatment with escitalopram?
    Constantine G Lyketsos
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    BMC Geriatr 11:2. 2011
    ..This post-hoc analysis compared time to relapse for young-old patients (n = 197) to that for old-old patients (n = 108)...
  9. ncbi Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": association with functional and cognitive impairment: The Cache County Study
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Dept of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 13:656-64. 2005
    ..Authors investigated medical comorbidity in persons with dementia and "Cognitive Impairment, No Dementia" (CIND)...
  10. ncbi Long-term outcomes of galantamine treatment in patients with Alzheimer disease
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Osler 320, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 12:473-82. 2004
    ....
  11. ncbi Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:1475-83. 2002
    ..Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2 population-based studies exist of the prevalence of these symptoms in dementia, and none exist for MCI...
  12. ncbi Randomized, placebo-controlled, double-blind clinical trial of sertraline in the treatment of depression complicating Alzheimer's disease: initial results from the Depression in Alzheimer's Disease study
    C G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, USA
    Am J Psychiatry 157:1686-9. 2000
    ..This study evaluated the efficacy and safety of sertraline in the treatment of major depression in 22 outpatients with Alzheimer's disease...
  13. ncbi Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging
    C G Lyketsos
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Psychiatry 157:708-14. 2000
    ..The authors report findings from a study of 5,092 community residents who constituted 90% of the elderly resident population of Cache County, Utah...
  14. ncbi Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study
    C G Lyketsos
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, USA
    Int J Geriatr Psychiatry 16:1043-53. 2001
    ..We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of persons suffering from Alzheimer's disease (AD)...
  15. ncbi Dementia in elderly persons in a general hospital
    C G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Psychiatry 157:704-7. 2000
    ..This study investigated the prevalence of dementia in a general hospital, reasons for which patients with dementia were admitted, and the relationship between dementia and length of stay, cost, and in-hospital mortality rate...
  16. ncbi Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, U S A
    Int Psychogeriatr 20:871-89. 2008
    ..Several examples are used to illustrate each biomarker utility in the AD context...
  17. ncbi A randomized, controlled trial of bright light therapy for agitated behaviors in dementia patients residing in long-term care
    C G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Int J Geriatr Psychiatry 14:520-5. 1999
    ..Agitated behaviors are common in dementia patients residing in chronic care settings. Their occurrence may be associated with lack of adequate exposure to sunlight and with circadian rhythm disturbances...
  18. ncbi Psychiatric manifestations of neurologic disease: where are we headed?
    Constantin G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins Bayview, Baltimore, MD 21224, USA
    Dialogues Clin Neurosci 9:111-24. 2007
    ....
  19. ncbi Physical aggression in dementia patients and its relationship to depression
    C G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 156:66-71. 1999
    ..The goal of this study was to determine the frequency of physically aggressive behavior in community-residing patients with dementia and its relationship to depression...
  20. ncbi Medical comorbidity in psychiatric inpatients: relation to clinical outcomes and hospital length of stay
    Constantine G Lyketsos
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, 600 North Wolfe Street, Osler 320, Baltimore, MD 21287, USA
    Psychosomatics 43:24-30. 2002
    ..Psychiatrists should redouble their efforts to detect and treat this comorbidity and should consider whether special inpatient units might be needed to care for psychiatric patients with complex medical comorbidity...
  21. ncbi Correlates of caregiver-rated quality of life in assisted living: the Maryland Assisted Living study
    Quincy M Samus
    The Johns Hopkins School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
    J Gerontol B Psychol Sci Soc Sci 61:P311-4. 2006
    ..Because of the strong association of neuropsychiatric symptoms with QOL, special attention should be given to their recognition and amelioration...
  22. ncbi Transition to nursing home from assisted living is not associated with dementia or dementia-related problem behaviors
    Paul B Rosenberg
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD, USA
    J Am Med Dir Assoc 7:73-8. 2006
    ..To examine risk factors for transition from assisted living (AL) care to skilled nursing facility (SNF) care in a random sample of adults residing in AL...
  23. ncbi Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 8:105-13. 2012
    ....
  24. ncbi The incidence of mental and behavioral disturbances in dementia: the cache county study
    Martin Steinberg
    Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Neuropsychiatry Clin Neurosci 15:340-5. 2003
    ..These results argue for a routine assessment of psychiatric disturbances in all patients with dementia, even among those who have never experienced symptoms of mental or behavioral disturbances...
  25. ncbi Cognitive response to pharmacological treatment for depression in Alzheimer disease: secondary outcomes from the depression in Alzheimer's disease study (DIADS)
    Cynthia A Munro
    Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Am J Geriatr Psychiatry 12:491-8. 2004
    ..The authors assessed the cognitive effects of depression treatment with sertraline in patients with Alzheimer disease (AD) and major depression...
  26. ncbi Acetylcholinesterase inhibitors in assisted living: patterns of use and association with retention
    Adam Rosenblatt
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 23:178-84. 2008
    ..To describe patterns of Acetylcholinesterase inhibitor (ACI) use in an Assisted Living (AL) population, and the association of ACIs with retention in AL...
  27. ncbi Design of Depression in Alzheimer's Disease Study-2
    Barbara K Martin
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Geriatr Psychiatry 14:920-30. 2006
    ....
  28. ncbi Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Geriatr Psychiatry 23:170-7. 2008
    ..Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community...
  29. ncbi Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 8:180-7. 2012
    ..Given this response and existence of side effects, we sought to quantify medication use and benefits in a population-based study of incident AD cases...
  30. ncbi Apolipoprotein E genotype and lifetime cognitive decline
    Nicholas A Kozauer
    Division of Geriatric and Neuropsychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Int Psychogeriatr 20:109-23. 2008
    ..The relationship of apolipoprotein E (APOE) genotype to lifetime cognitive decline was examined over 22 years in a large community-based population study...
  31. ncbi Insomnia and daytime sleepiness in people with dementia residing in assisted living: findings from the Maryland Assisted Living Study
    Vani Rao
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Int J Geriatr Psychiatry 23:199-206. 2008
    ..To estimate the frequency and correlates of insomnia and daytime sleepiness among people with dementia in AL facilities...
  32. ncbi Cognitive outcomes after sertaline treatment in patients with depression of Alzheimer disease
    Cynthia A Munro
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Geriatr Psychiatry 20:1036-44. 2012
    ..The authors report cognitive outcomes in patients with depression of AD (dAD) after a 24-week trial of sertraline or placebo...
  33. ncbi Prevalence of neuropsychiatric symptoms in CIND and its subtypes: the Cache County Study
    Matthew E Peters
    The Johns Hopkins University, Baltimore, MD, USA
    Am J Geriatr Psychiatry 20:416-24. 2012
    ..2) To compare the 30-day prevalence of NPS in CIND with that in dementia and cognitively normal individuals. 3) To compare the prevalence of NPS in amnestic MCI (aMCI) with other predementia syndromes...
  34. ncbi Sleep disturbances in the elderly residing in assisted living: findings from the Maryland Assisted Living Study
    Vani Rao
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Int J Geriatr Psychiatry 20:956-66. 2005
    ..Common sleep disturbances are insomnia and excessive daytime sleepiness. There are no published studies on the prevalence of sleep disturbance in the assisted living (AL) setting...
  35. ncbi Do treatment effects vary among differing baseline depression criteria in depression in Alzheimer's disease study ± 2 (DIADS-2)?
    Lea T Drye
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Geriatr Psychiatry 26:573-83. 2011
    ..To determine if the effect of sertraline in the depression in Alzheimer's disease study - 2 (DIADS-2) differed in subgroups of patients defined by baseline depression criteria...
  36. ncbi Predictors of functional impairment in residents of assisted-living facilities: the Maryland Assisted Living study
    Daniel J Burdick
    Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Gerontol A Biol Sci Med Sci 60:258-64. 2005
    ..These results may be instrumental in developing a more efficient model of care for residents of assisted living facilities, one based on having accurate predictive models of degree of impairment...
  37. ncbi Epidemiology of apathy in older adults: the Cache County Study
    Chiadi U Onyike
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Geriatr Psychiatry 15:365-75. 2007
    ..The objectives of this study are to describe the distribution of apathy in community-based older adults and to investigate its relationships with cognition and day-to-day functioning...
  38. ncbi Incidence, prevalence, and outcomes of depression in residents of a long-term care facility with dementia
    Jennifer L Payne
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 17:247-53. 2002
    ..Admission to a long-term care facility may actually result in a reduction of depression within the year after admission in part due to rapid recognition, appropriate diagnosis and treatment...
  39. ncbi The association of neuropsychiatric symptoms and environment with quality of life in assisted living residents with dementia
    Quincy M Samus
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Gerontologist 45:19-26. 2005
    ..We conducted this study to determine whether neuropsychiatric symptoms and environmental characteristics are associated with quality of life in assisted living residents with dementia...
  40. ncbi Sertraline for the treatment of depression in Alzheimer disease
    Paul B Rosenberg
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Geriatr Psychiatry 18:136-45. 2010
    ..The authors conducted a multicenter, randomized, placebo-controlled trial titled "Depression in Alzheimer's Disease-2" to assess the efficacy and tolerability of sertraline for depression in AD...
  41. ncbi Correlates of functional dependence among recently admitted assisted living residents with and without dementia
    Quincy M Samus
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
    J Am Med Dir Assoc 10:323-9. 2009
    ....
  42. ncbi The association between activity participation and time to discharge in the assisted living setting
    Sarah K Tighe
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
    Int J Geriatr Psychiatry 23:586-91. 2008
    ..This study examines the relationship between participation in activities and the length of time residents remain in AL...
  43. ncbi Patient predictors of response to treatment of depression in Alzheimer's disease: the DIADS study
    Martin Steinberg
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:144-50. 2004
    ..To investigate patient predictors of response to treatment of Major Depressive Episode (MDE) in Alzheimer's disease (AD)...
  44. ncbi The Maryland Assisted Living Study: prevalence, recognition, and treatment of dementia and other psychiatric disorders in the assisted living population of central Maryland
    Adam Rosenblatt
    Division of Geriatric Psychiatry and Neuropsychiatry, John Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Am Geriatr Soc 52:1618-25. 2004
    ..To obtain a direct estimate of the prevalence of dementia and other psychiatric disorders in residents of assisted living (AL) in Central Maryland, and their rates of recognition and treatment...
  45. ncbi Comparison of three rating scales as outcome measures for treatment trials of depression in Alzheimer disease: findings from DIADS
    Lawrence S Mayer
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 21:930-6. 2006
    ..The pattern for the other subscales was non-monotonic over waves and resembled the pattern for the entire scale. Perhaps combining the CSDD two subscales obscures the treatment effects for the separate subscales...
  46. ncbi Quality of life of community-residing persons with dementia based on self-rated and caregiver-rated measures
    Betty S Black
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer Building 279, Baltimore, MD 21287, USA
    Qual Life Res 21:1379-89. 2012
    ..To identify correlates of self-rated and caregiver-rated quality of life (QOL) in community-residing persons with dementia (PWD) for intervention development...
  47. ncbi Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study
    Jeannie Marie S Leoutsakos
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Int Psychogeriatr 24:1561-70. 2012
    ..We sought to quantify the relationship in a population-based study of incident AD, and to compare global comorbidity ratings to counts of comorbid conditions and medications as predictors of AD progression...
  48. ncbi Citalopram for agitation in Alzheimer's disease: design and methods
    Lea T Drye
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Alzheimers Dement 8:121-30. 2012
    ..Evidence-supported treatment options for agitation are limited. The citalopram for agitation in Alzheimer's disease (CitAD) study was designed to evaluate the potential of citalopram to ameliorate these symptoms...
  49. ncbi Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 26:127-34. 2011
    ..Among individuals with a history of stroke or myocardial infarction at baseline, progression of AD is influenced by APOE ε4 carrier status and varies by time after AD diagnosis...
  50. ncbi Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study
    Majid Fotuhi
    Department of Neurology, Johns Hopkins University School of Medicine, and Center for Memory and Brain Health, LifeBridge Health Brain and Spine Institute, Baltimore, MD, USA
    Alzheimers Dement 4:223-7. 2008
    ..05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time...
  51. ncbi Predictors of caregiver unawareness and nontreatment of dementia among residents of assisted living facilities: the Maryland Assisted Living Study
    Donovan T Maust
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 14:668-75. 2006
    ..These observations suggest that systematic educational interventions for caregivers and families may improve detection and hence treatment in the AL setting...
  52. ncbi Isolated hallucinosis in Alzheimer's disease is associated with African-American race
    Medhat M Bassiony
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Science, School of Medicine, The Johns Hopkins University, USA
    Int J Geriatr Psychiatry 17:205-10. 2002
    ..This finding has implications for our understanding of the etio-pathogenesis of hallucinations in Alzheimer's disease and for meeting health service needs of African-American patients...
  53. ncbi The persistence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:19-26. 2004
    ..To estimate the 18-month persistence of neuropsychiatric symptoms in dementia in a population-based sample, and to compare the severity of neuropsychiatric symptoms at baseline to the severity at 18-month follow-up...
  54. ncbi Sertraline for the treatment of depression in Alzheimer disease: genetic influences
    Matthew E Peters
    The Johns Hopkins University, Baltimore, MD 21224, USA
    J Geriatr Psychiatry Neurol 24:222-8. 2011
    ..Treatment response by genotype was measured by (1) the modified Alzheimer's Disease Cooperative Study Clinical Global Impression of Change, (2) the Cornell scale for Depression in Dementia, and (3) remission of depression...
  55. ncbi Influence of social network characteristics on cognition and functional status with aging
    Ariel Frank Green
    Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Geriatr Psychiatry 23:972-8. 2008
    ..To determine whether more frequent engagement in larger social networks, and more emotional support protect against cognitive and functional decline with aging...
  56. ncbi Predictors of providing informed consent or assent for research participation in assisted living residents
    Betty S Black
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 16:83-91. 2008
    ..This study's goal was to identify factors associated with providing either informed consent or assent for research in individuals at high risk for cognitive impairment...
  57. ncbi Falls and age in patients with Alzheimer's disease
    Medhat M Bassiony
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Science, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Nerv Ment Dis 192:570-2. 2004
    ..The authors conclude that falls in community-residing patients with AD are significantly associated with old age. Population-based prospective studies are needed to investigate further the risk factors for falls in AD...
  58. ncbi Caregiver assessment of patients' depression in Alzheimer disease: longitudinal analysis in a drug treatment study
    Paul B Rosenberg
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, 550 N Broadway 308, Baltimore, MD 21205, USA
    Am J Geriatr Psychiatry 13:822-6. 2005
    ..Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input...
  59. ncbi A randomized, controlled, clinical trial of activity therapy for apathy in patients with dementia residing in long-term care
    Antonios M Politis
    The Johns Hopkins University, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:1087-94. 2004
    ..More research is needed to develop specific behavioral interventions for apathy in patients with dementia...
  60. ncbi Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 6:378-85. 2010
    ..The present objective was to examine whether plasma ceramides varied by AD severity in a well-characterized clinic sample and were associated with cognitive decline and hippocampal volume loss over 1 year...
  61. ncbi Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community
    Hochang B Lee
    Division of Geriatric Psychiatry and Neuropsychiartry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neuropsychiatry Clin Neurosci 20:101-5. 2008
    ..9 [3.6, 46.0]) and comorbidity of major depressive disorder and panic disorder (9.7 [1.4, 69.0]) in the past 12 months suggested a strong association between restless legs syndrome and major depressive disorder and/or panic disorder...
  62. ncbi Depression and HIV risk behaviors among patients in a sexually transmitted disease clinic
    Heidi E Hutton
    Department of Psychiatry, Johns Hopkins School of Medicine, 550 N Broadway, Suite 203, Baltimore, MD 21205, USA
    Am J Psychiatry 161:912-4. 2004
    ..The authors' goal was to investigate the relationship between depression and HIV risk behaviors or sexually transmitted disease (STD) diagnosis at an urban STD clinic...
  63. ncbi Nonpharmacologic management of behavioral symptoms in dementia
    Laura N Gitlin
    Department of Community Public Health, School of Nursing, Johns Hopkins University, 525 Wolfe St, Ste 316, Baltimore, MD 21205, USA
    JAMA 308:2020-9. 2012
    ..Nonpharmacologic management of behavioral symptoms in dementia can significantly improve quality of life and patient-caregiver satisfaction...
  64. ncbi DTI analyses and clinical applications in Alzheimer's disease
    Kenichi Oishi
    The Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Alzheimers Dis 26:287-96. 2011
    ..Application of these findings in clinical practice remains to be demonstrated...
  65. ncbi Predictors of lane-change errors in older drivers
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 218, Baltimore, Maryland 21287, USA
    J Am Geriatr Soc 58:457-64. 2010
    ..To determine the factors that predict errors in executing proper lane changes among older drivers...
  66. ncbi Pharmacological management of the psychiatric aspects of traumatic brain injury
    Hochang B Lee
    Geriatric Psychiatry and Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Int Rev Psychiatry 15:359-70. 2003
    ..There is a dire need for large, randomized, double blind, placebo-controlled trials that include a broad range of cognitive and behavioral outcome measures...
  67. ncbi Serum sphingomyelins and ceramides are early predictors of memory impairment
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
    Neurobiol Aging 31:17-24. 2010
    ..Results suggest serum SM and ceramides vary according to the timing of the onset of memory impairment and may be good pre-clinical predictors, or biomarkers, of memory impairment: a deficit observed early in AD pathogenesis...
  68. ncbi A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: the Cache County study
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Int J Geriatr Psychiatry 21:509-18. 2006
    ..This decline is small and its clinical significance is uncertain. We could not find an association between CABG and decline in the first five post-operative years...
  69. ncbi Relationship of self-perceptions of memory and worry to objective measures of memory and cognition in the general population
    Laura Jean Podewils
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Psychosomatics 44:461-70. 2003
    ....
  70. ncbi Perspectives on depression, mild cognitive impairment, and cognitive decline
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:130-8. 2006
    ....
  71. ncbi The epidemiology of psychosis in dementia
    Iracema Leroi
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 11:83-91. 2003
    ..CONCLUSION: The profile of delusions and hallucinations seen is different from that seen in schizophrenia, further supporting the hypothesis that AD-associated psychosis is a distinct phenomenological syndrome...
  72. ncbi A clinical approach to mild cognitive impairment
    Paul B Rosenberg
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, USA
    Am J Psychiatry 163:1884-90. 2006
  73. ncbi Tricyclic antidepressants and cognitive decline
    Laura Jean Podewils
    Department of Epidemiology and Mental Hygiene, The Johns Hopkins School of Medicine, 600 North Wolfe Street, Osler 320, Baltimore, MD 21287, USA
    Psychosomatics 43:31-5. 2002
    ..5 years). These findings failed to support the concept that TCA use is related to concurrent measurable cognitive deficits, and TCA use does not appear to significantly compromise memory over a substantial time span...
  74. ncbi Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study
    Laura Jean Podewils
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Epidemiol 161:639-51. 2005
    ..A similar pattern was observed for Alzheimer's disease and vascular dementia. Mechanisms to explain the observed relations deserve further study...
  75. ncbi Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA)
    Melissa D Morgan
    Johns Hopkins University, Baltimore, MD 21224, USA
    Alzheimer Dis Assoc Disord 21:199-204. 2007
    ..These findings suggest that depression is a risk factor for AD in the presence of AD pathology, but depression is not a risk factor for AD pathology...
  76. ncbi Metabolic changes associated with second-generation antipsychotic use in Alzheimer's disease patients: the CATIE-AD study
    Ling Zheng
    Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Am J Psychiatry 166:583-90. 2009
    ..Elderly patients with Alzheimer's disease are frequently treated with these antipsychotics, but limited data are available on their metabolic effects...
  77. ncbi Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
    ....
  78. ncbi Psychopathology in patients with degenerative cerebellar diseases: a comparison to Huntington's disease
    Iracema Leroi
    Program in Cellular and Molecular Medicine, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Psychiatry 159:1306-14. 2002
    ..These results also support previous findings that the cerebellum may have a role in modulating emotion and cognition...
  79. ncbi Rapidly progressive dementias and the treatment of human prion diseases
    Brian S Appleby
    Johns Hopkins University School of Medicine, Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Meyer 279, 600 N Wolfe St, Baltimore, MD 21287, USA
    Expert Opin Pharmacother 12:1-12. 2011
    ....
  80. ncbi Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasma
    Esther S Oh
    Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 21:769-73. 2010
    ..However, the advantages of electrochemiluminescence detection technology include short processing time and small sample volume. This comparison demonstrates the need for a further study in optimizing this system...
  81. ncbi Diagnosis and treatment of depression in Alzheimer's disease. A practical update for the clinician
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5371, USA
    Dement Geriatr Cogn Disord 17:55-64. 2004
    ..It is followed by a practical discussion of the detection, evaluation, quantification, differential diagnosis and treatment of depression in AD...
  82. ncbi Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction
    Paul B Rosenberg
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Geriatr Psychiatry 26:364-72. 2011
    ..Since dementia has been associated with a range of neuropsychiatric symptoms (NPS), we sought to examine the prevalence of NPS in MCI and its subtypes...
  83. ncbi Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Bayview, Alpha Commons Building, 4th Floor, Room 454, Baltimore, MD 21224, USA
    Neuromolecular Med 12:331-40. 2010
    ..Lastly, the potential role of peripheral ceramides in AD pathogenesis is discussed, as well as the possible use of sphingolipids as biomarkers for AD...
  84. ncbi The spectrum of medical illness and medication use among residents of assisted living facilities in central Maryland
    Matthew K McNabney
    Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA
    J Am Med Dir Assoc 9:558-64. 2008
    ..To better inform efforts to optimize care in this setting, we sought to quantify chronic medical illnesses and their treatment...
  85. ncbi Cognitive function after 11.5 years of alcohol use: relation to alcohol use
    Iracema Leroi
    Neuropsychiatry Service, Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Epidemiol 156:747-52. 2002
    ..The authors conclude that, over long time periods, alcohol use is not associated with cognitive decline and, in women, may be associated with less decline...
  86. ncbi Nulliparity and late menopause are associated with decreased cognitive decline
    Robert N McLay
    Department of Psychiatry, Naval Medical Center San Diego, California, USA
    J Neuropsychiatry Clin Neurosci 15:161-7. 2003
    ..These results suggest that greater lifetime exposure to endogenous estrogen may be associated with less age-related cognitive decline...
  87. ncbi Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ....
  88. ncbi Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination Survey
    Chiadi U Onyike
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Epidemiol 158:1139-47. 2003
    ..Prospective studies will be necessary to clarify the obesity-depression relation but await the identification of potential risk factors for depression in the obese...
  89. ncbi The prevalence of psychiatric disorders in sexually transmitted disease clinic patients and their association with sexually transmitted disease risk
    Emily J Erbelding
    Baltimore City Health Department, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Sex Transm Dis 31:8-12. 2004
    ..Psychiatric disorders could limit the success of behavioral counseling strategies. We evaluated the prevalence of psychiatric disorders among sexually transmitted disease (STD) clinic patients and their association with STD risk...
  90. ncbi Validity and reliability of the newly translated Hellenic Neuropsychiatric Inventory (H-NPI) applied to Greek outpatients with Alzheimer's disease: a study of disturbing behaviors among referrals to a memory clinic
    Antonis M Politis
    The Johns Hopkins University, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:203-8. 2004
    ..CONCLUSIONS: These results indicate that the H-NPI is a reliable instrument, able to detect differences in clinically referred groups of AD patients...
  91. ncbi Clinical application of operationalized criteria for 'Depression of Alzheimer's Disease'
    Paul B Rosenberg
    Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 20:119-27. 2005
    ..Criteria for the diagnosis of dAD have been proposed previously...
  92. ncbi Psychiatric aspects of traumatic brain injury
    Vani Rao
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Psychiatr Clin North Am 25:43-69. 2002
    ..The goal of treatment should be to stabilize symptoms; maximize potential; minimize disability; and increase productivity socially, occupationally, and interpersonally...
  93. ncbi Cholinesterase inhibitors and memantine have a role in the treatment of Alzheimer's disease
    Peter V Rabins
    Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Nat Clin Pract Neurol 2:578-9. 2006
  94. ncbi Characteristics and outcomes for assisted living residents with dementia: comparing dementia-specific care units with non-dementia-specific care units
    Quincy M Samus
    J Am Geriatr Soc 56:1361-3. 2008
  95. ncbi Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: phase 1 outcomes from the CATIE-AD effectiveness trial
    David L Sultzer
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Am J Psychiatry 165:844-54. 2008
    ..The study measured the effects of atypical antipsychotics on psychiatric and behavioral symptoms in patients with Alzheimer's disease and psychosis or agitated behavior...
  96. ncbi Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib
    Barbara K Martin
    Arch Neurol 65:896-905. 2008
    ..CONCLUSIONS: Use of naproxen or celecoxib did not improve cognitive function. There was weak evidence for a detrimental effect of naproxen...
  97. ncbi Delusions and hallucinations in Alzheimer's disease: review of the brain decade
    Medhat M Bassiony
    Faculty of Medicine, Zagazig University, Sharkia, Zagazig, Egypt
    Psychosomatics 44:388-401. 2003
    ..Psychosocial methods and both typical and atypical antipsychotics are effective in the treatment of delusions and hallucinations in Alzheimer's disease...
  98. ncbi The relationship between delusions and depression in Alzheimer's disease
    Medhat M Bassiony
    Department of Psychiatry, Faculty of Medicine, Zagazig University, Egypt
    Int J Geriatr Psychiatry 17:549-56. 2002
    ..This finding has implications for our understanding of the etio-pathogenesis and management of delusions and depression in AD...
  99. ncbi Vascular factors and risk for neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study
    Katherine A Treiber
    Department of Psychology, Utah State University, Logan, U S A
    Int Psychogeriatr 20:538-53. 2008
    ..To examine, in an exploratory analysis, the association between vascular conditions and the occurrence of neuropsychiatric symptoms (NPS) in a population-based sample of incident Alzheimer's disease (AD)...
  100. ncbi Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease
    Constantine G Lyketsos
    Am J Geriatr Psychiatry 14:561-72. 2006
  101. ncbi Randomized placebo-controlled trial of donepezil in cognitive impairment in Parkinson's disease
    Iracema Leroi
    Department of Psychiatry, North Manchester General Hospital, Manchester, UK
    Int J Geriatr Psychiatry 19:1-8. 2004
    ..To evaluate the efficacy and safety of donepezil, an acetylcholinesterase inhibitor, as a treatment for cognitive impairment and dementia in patients with Parkinson' s disease (PD)...

Research Grants16

  1. Citalopram Treatment for Agitation in Alzheimer Dementia
    Constantine Lyketsos; Fiscal Year: 2009
    ..abstract_text> ..
  2. Development of blood lipid biomarkers for Alzheimer's disease progression
    Michelle Mielke; Fiscal Year: 2007
    ..A major application would be as a surrogate or secondary outcome measure in clinical trials of emerging therapies for AD. ..
  3. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Constantine Lyketsos; Fiscal Year: 2007
    ..The predictive validity of defining depression in AD using a symptom scale or each of these syndromes will be assessed longitudinally against the various study outcomes, and against efficacy of response to antidepressant treatment. ..
  4. DEMENTIA AND PSYCHIATRIC DISORDERS IN ASSISTED LIVING
    Constantine Lyketsos; Fiscal Year: 2005
    ..abstract_text> ..
  5. DEMENTIA AND PSYCHIATRIC DISORDERS IN ASSISTED LIVING
    Constantine Lyketsos; Fiscal Year: 2001
    ....
  6. TREATMENT OF DEPRESSION IN ALZHEIMERS DISEASE
    Constantine Lyketsos; Fiscal Year: 2001
    ....
  7. Citalopram Treatment for Agitation in Alzheimer Dementia
    Constantine G Lyketsos; Fiscal Year: 2010
    ....