Lindi Luo

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Aging and the brown Norway rat leydig cell antioxidant defense system
    Lindi Luo
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Androl 27:240-7. 2006
  2. ncbi request reprint Vitamin E, aging and Leydig cell steroidogenesis
    Haolin Chen
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Gerontol 40:728-36. 2005
  3. ncbi request reprint Aging and caloric restriction: effects on Leydig cell steroidogenesis
    Haolin Chen
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Exp Gerontol 40:498-505. 2005
  4. ncbi request reprint Cyclooxygenases in rat Leydig cells: effects of luteinizing hormone and aging
    Haolin Chen
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
    Endocrinology 148:735-42. 2007
  5. ncbi request reprint Temporal relationships among testosterone production, steroidogenic acute regulatory protein (StAR), and P450 side-chain cleavage enzyme (P450scc) during Leydig cell aging
    Lindi Luo
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Androl 26:25-31. 2005
  6. ncbi request reprint Dibutyryl cyclic adenosine monophosphate restores the ability of aged Leydig cells to produce testosterone at the high levels characteristic of young cells
    Haolin Chen
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Endocrinology 145:4441-6. 2004
  7. doi request reprint Simultaneous quantification of steroids in rat intratesticular fluid by HPLC-isotope dilution tandem mass spectrometry
    Alissa Renne
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205 2179, USA
    J Androl 33:691-8. 2012
  8. ncbi request reprint Leydig cell gene expression: effects of age and caloric restriction
    Haolin Chen
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Exp Gerontol 39:31-43. 2004
  9. ncbi request reprint Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells
    Martine Culty
    Department of Cell Biology, Georgetown University School of Medicine, Washington, DC, USA
    J Androl 23:439-47. 2002

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Aging and the brown Norway rat leydig cell antioxidant defense system
    Lindi Luo
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Androl 27:240-7. 2006
    ....
  2. ncbi request reprint Vitamin E, aging and Leydig cell steroidogenesis
    Haolin Chen
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Gerontol 40:728-36. 2005
    ..Taken together, the results of the in vitro and in vivo studies reported herein are consistent with the conclusion that vitamin E exerts a protective effect on Leydig cell steroidogenesis...
  3. ncbi request reprint Aging and caloric restriction: effects on Leydig cell steroidogenesis
    Haolin Chen
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Exp Gerontol 40:498-505. 2005
    ....
  4. ncbi request reprint Cyclooxygenases in rat Leydig cells: effects of luteinizing hormone and aging
    Haolin Chen
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
    Endocrinology 148:735-42. 2007
    ....
  5. ncbi request reprint Temporal relationships among testosterone production, steroidogenic acute regulatory protein (StAR), and P450 side-chain cleavage enzyme (P450scc) during Leydig cell aging
    Lindi Luo
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Androl 26:25-31. 2005
    ..This suggestion is supported by recent studies from our lab demonstrating that long-term (3 days) culture of old Leydig cells with dbcAMP restored testosterone production to levels approximating those of young cells...
  6. ncbi request reprint Dibutyryl cyclic adenosine monophosphate restores the ability of aged Leydig cells to produce testosterone at the high levels characteristic of young cells
    Haolin Chen
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Endocrinology 145:4441-6. 2004
    ..These results strongly suggest that signal transduction deficits are responsible for reduced steroidogenesis by aged Leydig cells and that bypassing signal transduction reverses the steroidogenic decline by the aged cells...
  7. doi request reprint Simultaneous quantification of steroids in rat intratesticular fluid by HPLC-isotope dilution tandem mass spectrometry
    Alissa Renne
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205 2179, USA
    J Androl 33:691-8. 2012
    ....
  8. ncbi request reprint Leydig cell gene expression: effects of age and caloric restriction
    Haolin Chen
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Exp Gerontol 39:31-43. 2004
    ..In contrast to the effects of caloric restriction as seen in many other cell types and systems, the vast majority (44/45) of the Leydig cell genes that changed with age were not 'rescued' by this intervention...
  9. ncbi request reprint Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells
    Martine Culty
    Department of Cell Biology, Georgetown University School of Medicine, Washington, DC, USA
    J Androl 23:439-47. 2002
    ..Taken together, these results suggest that alterations in cholesterol transport and in PBR may play critical roles in age-related decreases in testosterone production in Brown Norway rat Leydig cells...