Genomes and Genes
Thomas E Lloyd
Affiliation: Johns Hopkins University
- Axonal transport disruption in peripheral nerve disease: From Jack's discoveries as a resident to recent contributionsThomas E Lloyd
Department of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Peripher Nerv Syst 17:46-51. 2012....
- The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic terminiThomas E Lloyd
The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 74:344-60. 2012..Therefore, the p150(Glued) CAP-Gly domain regulates dynein-mediated retrograde transport at synaptic termini, and this function of dynactin is disrupted by a mutation that causes motor neuron disease...
- Flightless flies: Drosophila models of neuromuscular diseaseThomas E Lloyd
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann N Y Acad Sci 1184:e1-20. 2010..This review will summarize recent progress in developing fly models of neuromuscular diseases and will emphasize the contribution that Drosophila has made to our understanding of these diseases...
- Novel therapeutic approaches for inclusion body myositisThomas E Lloyd
Department of Neurology, Johns Hopkins School of Medicine, 600 N Wolfe St Meyer 5 119, Baltimore, MD 21287, USA
Curr Opin Rheumatol 22:658-64. 2010..This review will highlight recent advances in developing strategies to accelerate muscle regeneration and to slow muscle degeneration in myositis, focusing primarily on inclusion body myositis (IBM)...
- WIDE AWAKE mediates the circadian timing of sleep onsetSha Liu
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Neuron 82:151-66. 2014..We propose that WAKE acts as a clock output molecule specifically for sleep, inhibiting LNvs at dusk to promote the transition from wake to sleep...
- Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formationDongyi Xu
Genome Instability and Chromatin Remodeling Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Nat Neurosci 16:1238-47. 2013..Our findings suggest that Top3β acts as an RNA topoisomerase and works with FMRP to promote the expression of mRNAs that are crucial for neurodevelopment and mental health. ..
- Peripheral neuropathy: clinical and electrophysiological considerationsTae Chung
Department of Neurology, The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
Neuroimaging Clin N Am 24:49-65. 2014....
- Cbl-associated protein regulates assembly and function of two tension-sensing structures in DrosophilaRajnish Bharadwaj
Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Development 140:627-38. 2013....