Manchang Liu

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury
    Dolores B Ascon
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 177:3380-7. 2006
  2. pmc Acute kidney injury leads to inflammation and functional changes in the brain
    Manchang Liu
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Am Soc Nephrol 19:1360-70. 2008
  3. doi request reprint Effect of T cells on vascular permeability in early ischemic acute kidney injury in mice
    Manchang Liu
    Division of Nephrology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Microvasc Res 77:340-7. 2009
  4. pmc Transcriptional analysis of infiltrating T cells in kidney ischemia-reperfusion injury reveals a pathophysiological role for CCR5
    Gang Jee Ko
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Ross Bldg, Rm 965, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 302:F762-73. 2012
  5. pmc Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis
    Heitham T Hassoun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Physiol Renal Physiol 297:F125-37. 2009
  6. pmc Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes
    Miguel Ascon
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 75:526-35. 2009
  7. doi request reprint Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice
    Manchang Liu
    Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Kidney Int 76:277-85. 2009
  8. pmc The local and systemic inflammatory transcriptome after acute kidney injury
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
    J Am Soc Nephrol 19:547-58. 2008
  9. pmc Interactive effects of mechanical ventilation and kidney health on lung function in an in vivo mouse model
    Jeffrey M Dodd-o
    Anesthesiology Critical Care Medicine, Johns Hopkins Hospital, Meyer 297A, 600 N Wolfe St, Baltimore, MD 21287 8106, USA
    Am J Physiol Lung Cell Mol Physiol 296:L3-L11. 2009
  10. doi request reprint The role for T cell repertoire/antigen-specific interactions in experimental kidney ischemia reperfusion injury
    Shailesh Ramchandra Satpute
    Department of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 183:984-92. 2009

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury
    Dolores B Ascon
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 177:3380-7. 2006
    ..These quantitative, qualitative, and functional changes in kidney lymphocytes provide mechanistic insight into how lymphocytes modulate IRI, as well as demonstrating that abdominal surgery alone leads to lymphocyte changes in kidney...
  2. pmc Acute kidney injury leads to inflammation and functional changes in the brain
    Manchang Liu
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Am Soc Nephrol 19:1360-70. 2008
    ..These data demonstrate that severe ischemic AKI induces inflammation and functional changes in the brain. Targeting these pathways could reduce morbidity and mortality in critically ill patients with severe AKI...
  3. doi request reprint Effect of T cells on vascular permeability in early ischemic acute kidney injury in mice
    Manchang Liu
    Division of Nephrology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Microvasc Res 77:340-7. 2009
    ..Our data demonstrate that T cells directly contribute to the increased RVP after kidney ischemia-reperfusion, potentially through T cell cytokine production...
  4. pmc Transcriptional analysis of infiltrating T cells in kidney ischemia-reperfusion injury reveals a pathophysiological role for CCR5
    Gang Jee Ko
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Ross Bldg, Rm 965, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 302:F762-73. 2012
    ..Using discovery techniques to identify transcriptional responses in purified kidney-infiltrating cells enabled the elucidation of novel mechanisms and therapeutic targets for IRI...
  5. pmc Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis
    Heitham T Hassoun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Physiol Renal Physiol 297:F125-37. 2009
    ..Using an initial genomic approach to discovery followed by a mechanistic approach to disease targeting, we demonstrate that pulmonary endothelial apoptosis is a direct mediator of the distant organ dysfunction during experimental AKI...
  6. pmc Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes
    Miguel Ascon
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 75:526-35. 2009
    ..Our study demonstrates that moderate or severe kidney ischemia induces long-term T lymphocyte infiltration and cytokine/chemokine upregulation, leading to kidney structural changes...
  7. doi request reprint Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice
    Manchang Liu
    Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Kidney Int 76:277-85. 2009
    ..Our study demonstrates that Nrf2-deficiency enhances susceptibility to both ischemic and nephrotoxic acute kidney injury, and identifies this transcription factor as a potential therapeutic target in these injuries...
  8. pmc The local and systemic inflammatory transcriptome after acute kidney injury
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
    J Am Soc Nephrol 19:547-58. 2008
    ..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development...
  9. pmc Interactive effects of mechanical ventilation and kidney health on lung function in an in vivo mouse model
    Jeffrey M Dodd-o
    Anesthesiology Critical Care Medicine, Johns Hopkins Hospital, Meyer 297A, 600 N Wolfe St, Baltimore, MD 21287 8106, USA
    Am J Physiol Lung Cell Mol Physiol 296:L3-L11. 2009
    ....
  10. doi request reprint The role for T cell repertoire/antigen-specific interactions in experimental kidney ischemia reperfusion injury
    Shailesh Ramchandra Satpute
    Department of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 183:984-92. 2009
    ..10 mice, a restricted TCR repertoire no longer limited the extent of kidney injury. Thus, both TCR repertoire-dependent and -independent factors mediate T cell functions in kidney IRI...
  11. ncbi request reprint Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: a possible mechanism linking early injury and progressive renal disease?
    Melissa J Burne-Taney
    Division of Nephrology, Johns Hopkins Univ School of Medicine, Ross 965, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 291:F981-6. 2006
    ..These data identify a novel mechanism by which initial kidney injury predisposes to long-term dysfunction and identify lymphocytes as potential therapeutic targets for progressive renal diseases...
  12. ncbi request reprint A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity
    Manchang Liu
    Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 965, Baltimore, MD 21205, USA
    J Am Soc Nephrol 17:765-74. 2006
    ..These data demonstrate that T lymphocytes are direct mediators of experimental cisplatin nephrotoxicity. Targeting T lymphocytes could lead to improved ways to administer cisplatin safely to cancer patients...
  13. ncbi request reprint Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy
    Heitham T Hassoun
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Physiol Renal Physiol 293:F30-40. 2007
    ..Further investigation using this lung molecular signature induced by kidney IRI will provide mechanistic insights and new therapies for critically ill patients with AKI...
  14. pmc Acute renal venous obstruction is more detrimental to the kidney than arterial occlusion: implication for murine models of acute kidney injury
    Xiang Li
    Div of Nephrology, Johns Hopkins Univ School of Medicine, MD 21205, USA
    Am J Physiol Renal Physiol 302:F519-25. 2012
    ..Our data demonstrate important differences in ischemic AKI models. Understanding these differences is important in designing future experimental studies in mice as well as clinical trials in humans...
  15. ncbi request reprint Decreased capacity of immune cells to cause tissue injury mediates kidney ischemic preconditioning
    Melissa J Burne-Taney
    Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Immunol 176:7015-20. 2006
    ..This finding may also be relevant for elucidating the mechanisms underlying cross-talk between injured kidney and distant organs...
  16. doi request reprint Uremic lung: new insights into a forgotten condition
    Paul J Scheel
    Nephrology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Kidney Int 74:849-51. 2008
    ..AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes...
  17. ncbi request reprint Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury
    Roshni R Molls
    Johns Hopkins Univ School of Medicine, Ross 965, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 290:F1187-93. 2006
    ..Measurement of KC and its human analog, Gro-alpha, could serve as a useful new biomarker for ischemic ARF...
  18. pmc Blocking Fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury
    Gang Jee Ko
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Am Soc Nephrol 22:732-42. 2011
    ..In contrast, reconstitution of gld mice with wild-type splenocytes enhanced IRI. These data demonstrate that FasL, particularly on leukocytes, mediates ischemic AKI...
  19. doi request reprint Effects of acid aspiration-induced acute lung injury on kidney function
    Jeffrey B Hoag
    Dept of Medicine and Anesthesiology, The Johns Hopkins Univ, 600 North Wolfe St, Tower 711, Baltimore, MD 21287 8711, USA
    Am J Physiol Renal Physiol 294:F900-8. 2008
    ..Kidney injury in large animal models may be more similar to humans and may differ from results seen in small animal models...
  20. doi request reprint The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice
    Manchang Liu
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Kidney Int 85:134-41. 2014
    ..Thus, activation of Nrf2 signaling with CDDO-imidazolide confers protection from AKI, and presents a new therapeutic opportunity for this common and serious condition. ..