Zhiping Li

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
    Zhiping Li
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 42:880-5. 2005
  2. pmc Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression
    Li Zhao
    Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    PLoS ONE 6:e18909. 2011
  3. pmc The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity
    Jing Hua
    Shanghai Renji Hospital, Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    PLoS ONE 6:e27038. 2011
  4. ncbi request reprint Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis
    Zhiping Li
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 40:434-41. 2004
  5. ncbi request reprint Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury
    Jude A Oben
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 38:664-73. 2003
  6. pmc CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice
    Zhaolian Bian
    Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai, China
    J Lipid Res 54:44-54. 2013
  7. pmc Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease
    Jing Hua
    Shanghai Renji Hospital, Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    J Lipid Res 51:1696-703. 2010
  8. doi request reprint Liver-targeted gene delivery through retrograde intrabiliary infusion
    Xuan Jiang
    Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA
    Methods Mol Biol 948:275-84. 2013
  9. ncbi request reprint A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury
    Xiong Ma
    Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    Hepatology 46:1519-29. 2007
  10. ncbi request reprint Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    Zhiping Li
    The Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 37:343-50. 2003

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
    Zhiping Li
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 42:880-5. 2005
    ..These diet-induced alterations in the hepatic innate immune system may contribute to obesity-related liver disease...
  2. pmc Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression
    Li Zhao
    Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    PLoS ONE 6:e18909. 2011
    ..Blocking the signaling pathway and interrupting the positive feedback loop are potential therapeutic targets for autoimmune hepatitis...
  3. pmc The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity
    Jing Hua
    Shanghai Renji Hospital, Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    PLoS ONE 6:e27038. 2011
    ..In the current study, we examine the interaction between Tregs and NKT cells to understand the mechanisms of cross immune regulation by these cells...
  4. ncbi request reprint Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis
    Zhiping Li
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 40:434-41. 2004
    ..In conclusion, low NE activity increases hepatic NKT cell apoptosis and depletes liver NKT cells, promoting proinflammatory polarization of hepatic cytokine production that sensitizes the liver to LPS toxicity...
  5. ncbi request reprint Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury
    Jude A Oben
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 38:664-73. 2003
    ..In conclusion, stress-related sympathetic activity modulates progenitor cell accumulation in damaged livers and SNS blockade with alpha-adrenoceptor antagonists enhances hepatic progenitor cell accumulation...
  6. pmc CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice
    Zhaolian Bian
    Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University School of Medicine Renji Hospital, Shanghai, China
    J Lipid Res 54:44-54. 2013
    ..7 cells in vitro. Endotoxin and FFA-induced CCN1 expression in hepatocytes is involved in the hepatic proinflammatory response and macrophage infiltration in murine NAFLD...
  7. pmc Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease
    Jing Hua
    Shanghai Renji Hospital, Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    J Lipid Res 51:1696-703. 2010
    ..In conclusion, both dietary SFA and MUFA alter endogenous antigen presentation to hepatic NKT cells and contribute to NKT cell depletion, leading to further activation of inflammatory signaling, insulin resistance, and hepatic steatosis...
  8. doi request reprint Liver-targeted gene delivery through retrograde intrabiliary infusion
    Xuan Jiang
    Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA
    Methods Mol Biol 948:275-84. 2013
    ..Due to these advantages, RII has the potential to be used for delivering various gene vectors in clinical setting through the endoscopic retrograde cholangiopancreatography procedure...
  9. ncbi request reprint A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury
    Xiong Ma
    Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    Hepatology 46:1519-29. 2007
    ..This scenario is likely one of the pathogenetic mechanisms that facilitate the transformation of simple steatosis into steatohepatitis when a fatty liver is exposed to second or third hits...
  10. ncbi request reprint Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    Zhiping Li
    The Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 37:343-50. 2003
    ..In conclusion, these results support the concept that intestinal bacteria induce endogenous signals that play a pathogenic role in hepatic insulin resistance and NAFLD and suggest novel therapies for these common conditions...
  11. pmc String-like micellar nanoparticles formed by complexation of PEG-b-PPA and plasmid DNA and their transfection efficiency
    Xuan Jiang
    Department of Materials Science and Engineering, and Whitaker Biomedical Engineering Institute, Johns Hopkins University, 205 Maryland Hall, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Pharm Res 28:1317-27. 2011
    ..To investigate the gene delivery efficiency of string-like PEG-b-PPA/DNA micellar nanoparticles in the liver after intravenous injection and intrabiliary infusion...
  12. pmc Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    Xiong Ma
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Hepatol 49:821-30. 2008
    ..In the current study, we evaluated the effect of probiotics, and their mechanisms on diet-induced obesity, steatosis and insulin resistance...
  13. ncbi request reprint Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system
    Zhiping Li
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Gastroenterology 123:1304-10. 2002
    ..g., interleukin [IL]-12) or enhance (e.g., IL-15) hepatic CD4-positive natural killer cell viability...
  14. pmc Probiotic antigens stimulate hepatic natural killer T cells
    Shuwen Liang
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Immunology 141:203-10. 2014
    ..Furthermore, these data suggest that probiotics may contain bacterial glycolipid antigens that directly modulate the effector functions of hepatic NKT cells...
  15. ncbi request reprint Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice
    Jude A Oben
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 308:284-92. 2003
    ..Thus, leptin permits injury-related increases in adrenergic activity and requires NE to activate HSC and induce hepatic fibrogenesis...
  16. doi request reprint Endoscopic visceral fat removal as therapy for obesity and metabolic syndrome: a sham-controlled pilot study (with video)
    Lu Xia
    The Johns Hopkins University, Baltimore, Maryland, USA
    Gastrointest Endosc 74:637-44. 2011
    ..Increased visceral adiposity is a key feature of obesity and metabolic syndrome. Previous studies have generated controversial results regarding visceral fat (VF) removal as a therapy for obesity and metabolic syndrome...
  17. pmc In vivo test of the vertical phase separation hypothesis: the display of major histocompatibility complex (MHC) class I molecules on membranes of B cells from mice fed high-fat diets
    Saame Raza Shaikh
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Br J Nutr 101:804-9. 2009
    ..MHC class I surface levels on B cells were not affected by the MUFA-rich diet. This study suggests that the membrane vertical phase separation hypothesis may have limited application in a physiologically relevant setting...
  18. ncbi request reprint Pathogenesis of nonalcoholic steatohepatitis (NASH)
    Xiong Ma
    Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21205, USA
    Chin J Dig Dis 7:7-11. 2006
    ..This review will briefly discuss the epidemiology of NAFLD and focus on current understanding of the pathogenesis of NASH...
  19. pmc Cadmium exposure and liver disease among US adults
    Omar Hyder
    Department of Surgery, Division of Surgical Oncology, Johns Hopkins University School of Medicine, Blalock 688 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 17:1265-73. 2013
    ....
  20. ncbi request reprint The liver in obesity and type 2 diabetes mellitus
    Zhiping Li
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, 912 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Clin Liver Dis 6:867-77. 2002
    ..Preliminary work in animal and human studies suggests that diverse strategies that inhibit production of TNF alpha and improve insulin resistance also ameliorate NAFLD...
  21. pmc PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion
    Xuan Jiang
    Department of Materials Science and Engineering, and Whitaker Biomedical Engineering Institute, Johns Hopkins University, Baltimore, MD 21218, USA
    J Control Release 122:297-304. 2007
    ..This study demonstrated the potential of PEG-b-PPA/DNA micelles as an efficient carrier for liver-targeted gene delivery...
  22. ncbi request reprint Clinical decision-making by gastroenterologists and hepatologists for patients with early hepatocellular carcinoma
    Hari Nathan
    Division of Surgical Oncology, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 21:1844-51. 2014
    ..We have previously reported on decision making in early HCC by liver surgeons. In the present study, we quantified the impact of clinical factors on choice of therapy for early HCC by gastroenterologists and hepatologists...
  23. doi request reprint Trends in pre-liver transplant screening for cholangiocarcinoma among patients with primary sclerosing cholangitis
    Panagiotis Trilianos
    Division of Gastroenterology and Hepatology, Transplant Hepatology Section, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Digestion 89:165-73. 2014
    ..Cholangiocarcinoma (CCA) is the most common hepatobiliary malignancy complicating primary sclerosing cholangitis (PSC). Unfortunately, timely diagnosis of CCA in PSC patients remains challenging...
  24. pmc Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death
    Tongfang Tang
    Division of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, P R China
    PLoS ONE 8:e81949. 2013
    ..Dietary lipids play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) through alternation of liver innate immune response...
  25. doi request reprint Population pharmacokinetics of piperacillin/tazobactam in neonates and young infants
    Zhiping Li
    Department of Pharmacy, Children s Hospital of Fudan University, Shanghai, China
    Eur J Clin Pharmacol 69:1223-33. 2013
    ....
  26. ncbi request reprint Cyclin D1 induction of cellular migration requires p27(KIP1)
    Zhiping Li
    Kimmel Cancer Center, Departments of Cancer Biology and Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 66:9986-94. 2006
    ..Together, these studies show cyclin D1 promotes mammary epithelial cell migration. p27(KIP1) is required for cyclin D1-mediated cellular migration...
  27. pmc A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
    Zuoren Yu
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 182:509-17. 2008
    ..In turn, miR-17/20 limits the proliferative function of cyclin D1, thus linking expression of a specific miRNA cluster to the regulation of oncogenesis...
  28. pmc Short sleep duration and adiposity in Chinese adolescents
    Yunxian Yu
    The Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Northwestern University, Chicago, IL 60614 3394, USA
    Sleep 30:1688-97. 2007
    ..To investigate the relationship between sleep duration and adiposity measurements in rural Chinese adolescents...
  29. pmc Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation
    Chenguang Wang
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, D C 20007, USA
    Mol Cell Biol 23:6159-73. 2003
    ..The inhibition of PPAR gamma function by cyclin D1 is a new mechanism of signal transduction cross talk between PPAR gamma ligands and mitogenic signals that induce cyclin D1...
  30. ncbi request reprint Monozygotic co-twin analyses of body composition measurements and serum lipids
    Binyan Wang
    Mary Ann J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Prev Med 45:358-65. 2007
    ..To evaluate BMI and direct measures of body fat (BF) and lean body mass (LBM) in relation to fasting serum lipid profiles in a large Chinese population based twin sample using a monozygotic (MZ) co-twin analysis...
  31. pmc Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
    Chenguang Wang
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 103:11567-72. 2006
    ..Cyclin D1-dependent kinase phosphorylates NRF-1 at S47. Cyclin D1 abundance thus coordinates nuclear DNA synthesis and mitochondrial function...
  32. pmc Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
    James Hulit
    The Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Research Building Room E501, 3970 Reservoir Rd, N W, Box 571468, Washington, DC 20057 1468, USA
    Mol Cell Biol 24:7598-611. 2004
    ..The protection of mice, genetically predisposed to intestinal tumorigenesis, through cyclin D1 heterozygosity suggests that modalities that reduce cyclin D1 abundance could provide chemoprotection...

Research Grants3

  1. Nutrition and Nonalcoholic Fatty Liver Disease
    Zhiping Li; Fiscal Year: 2009
    ....
  2. Nutrition and Nonalcoholic Fatty Liver Disease
    Zhiping Li; Fiscal Year: 2010
    ....