Zhiping Li

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
    Zhiping Li
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 42:880-5. 2005
  2. ncbi request reprint Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis
    Zhiping Li
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 40:434-41. 2004
  3. ncbi request reprint Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury
    Jude A Oben
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 38:664-73. 2003
  4. doi request reprint Liver-targeted gene delivery through retrograde intrabiliary infusion
    Xuan Jiang
    Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA
    Methods Mol Biol 948:275-84. 2013
  5. pmc Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    Xiong Ma
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Hepatol 49:821-30. 2008
  6. pmc String-like micellar nanoparticles formed by complexation of PEG-b-PPA and plasmid DNA and their transfection efficiency
    Xuan Jiang
    Department of Materials Science and Engineering, and Whitaker Biomedical Engineering Institute, Johns Hopkins University, 205 Maryland Hall, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Pharm Res 28:1317-27. 2011
  7. ncbi request reprint Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    Zhiping Li
    The Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 37:343-50. 2003
  8. ncbi request reprint Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system
    Zhiping Li
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Gastroenterology 123:1304-10. 2002
  9. ncbi request reprint Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice
    Jude A Oben
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 308:284-92. 2003
  10. doi request reprint Cadmium exposure and liver disease among US adults
    Omar Hyder
    Department of Surgery, Division of Surgical Oncology, Johns Hopkins University School of Medicine, Blalock 688 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 17:1265-73. 2013

Research Grants

Collaborators

  • Anna Mae Diehl
  • Jude A Oben
  • Jing Hua
  • Shuwen Liang
  • Mark J Soloski
  • Xiong Ma
  • Timothy M Pawlik
  • Joseph M Herman
  • Saame Raza Shaikh
  • Michael Edidin
  • Xavier Dray
  • Xuan Jiang
  • Chenguang Wang
  • Hai Quan Mao
  • Richard G Pestell
  • Binyan Wang
  • Omar Hyder
  • Yong Ren
  • Lu Xia
  • James Hulit
  • Michael S Torbenson
  • Zuoren Yu
  • Jianhua Yang
  • Yunxian Yu
  • Xiaobin Wang
  • Xiping Xu
  • Houxun Xing
  • Xue Liu
  • Kongming Wu
  • Phyllis M Novikoff
  • Maofu Fu
  • Chris Albanese
  • John Michael Williford
  • David Cosgrove
  • Ahmet Gurakar
  • Michael Chung
  • Ayman Koteish
  • Amin Firoozmand
  • Cristina Jimeno-Ayllon
  • Anthony N Kalloo
  • Derek Leong
  • Mouen A Khashab
  • Yong Sik Kim
  • Mathew C Casimiro
  • Manran Liu
  • James Whittle
  • Peter McCue
  • Xiaoming Ju
  • Min Wang
  • Terry Hyslop
  • Wei Ma
  • Phyllis C Zee
  • Genfu Tang
  • Chyan Ying Ke
  • Xiao Mo
  • Brandon S Lu
  • Hongjian Wang
  • Jonathan Necheles
  • Fengxiu Ouyang
  • Liuliu Wang
  • Hui Dai
  • Runlei Du
  • Yinan Lu
  • Sanjay Katiyar
  • Jianguo Yang
  • Jennifer E Leader
  • Andrew Quong
  • Stephen W Byers
  • Leonard H Augenlicht
  • Dolores Di Vizio
  • Salimuddin Shah
  • Radma Mahmood
  • Mahadev Rao
  • Robert Russell
  • Toshiyuki Sakamaki
  • Peter Neumeister
  • Jian Nian Zhou
  • Emily L Harris
  • Thomas Rohan
  • Philipp E Scherer
  • Joan G Jones
  • Nagarajan Pattabiraman
  • Lawrence A Donehower
  • David C Johns
  • Michael Brownlee
  • Kathleen D Whitney

Detail Information

Publications24

  1. ncbi request reprint Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
    Zhiping Li
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 42:880-5. 2005
    ..These diet-induced alterations in the hepatic innate immune system may contribute to obesity-related liver disease...
  2. ncbi request reprint Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis
    Zhiping Li
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 40:434-41. 2004
    ..In conclusion, low NE activity increases hepatic NKT cell apoptosis and depletes liver NKT cells, promoting proinflammatory polarization of hepatic cytokine production that sensitizes the liver to LPS toxicity...
  3. ncbi request reprint Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury
    Jude A Oben
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 38:664-73. 2003
    ..In conclusion, stress-related sympathetic activity modulates progenitor cell accumulation in damaged livers and SNS blockade with alpha-adrenoceptor antagonists enhances hepatic progenitor cell accumulation...
  4. doi request reprint Liver-targeted gene delivery through retrograde intrabiliary infusion
    Xuan Jiang
    Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA
    Methods Mol Biol 948:275-84. 2013
    ..Due to these advantages, RII has the potential to be used for delivering various gene vectors in clinical setting through the endoscopic retrograde cholangiopancreatography procedure...
  5. pmc Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    Xiong Ma
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Hepatol 49:821-30. 2008
    ..In the current study, we evaluated the effect of probiotics, and their mechanisms on diet-induced obesity, steatosis and insulin resistance...
  6. pmc String-like micellar nanoparticles formed by complexation of PEG-b-PPA and plasmid DNA and their transfection efficiency
    Xuan Jiang
    Department of Materials Science and Engineering, and Whitaker Biomedical Engineering Institute, Johns Hopkins University, 205 Maryland Hall, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Pharm Res 28:1317-27. 2011
    ..To investigate the gene delivery efficiency of string-like PEG-b-PPA/DNA micellar nanoparticles in the liver after intravenous injection and intrabiliary infusion...
  7. ncbi request reprint Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    Zhiping Li
    The Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 37:343-50. 2003
    ..In conclusion, these results support the concept that intestinal bacteria induce endogenous signals that play a pathogenic role in hepatic insulin resistance and NAFLD and suggest novel therapies for these common conditions...
  8. ncbi request reprint Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system
    Zhiping Li
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Gastroenterology 123:1304-10. 2002
    ..g., interleukin [IL]-12) or enhance (e.g., IL-15) hepatic CD4-positive natural killer cell viability...
  9. ncbi request reprint Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice
    Jude A Oben
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 308:284-92. 2003
    ..Thus, leptin permits injury-related increases in adrenergic activity and requires NE to activate HSC and induce hepatic fibrogenesis...
  10. doi request reprint Cadmium exposure and liver disease among US adults
    Omar Hyder
    Department of Surgery, Division of Surgical Oncology, Johns Hopkins University School of Medicine, Blalock 688 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 17:1265-73. 2013
    ....
  11. doi request reprint Endoscopic visceral fat removal as therapy for obesity and metabolic syndrome: a sham-controlled pilot study (with video)
    Lu Xia
    The Johns Hopkins University, Baltimore, Maryland, USA
    Gastrointest Endosc 74:637-44. 2011
    ..Increased visceral adiposity is a key feature of obesity and metabolic syndrome. Previous studies have generated controversial results regarding visceral fat (VF) removal as a therapy for obesity and metabolic syndrome...
  12. pmc PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion
    Xuan Jiang
    Department of Materials Science and Engineering, and Whitaker Biomedical Engineering Institute, Johns Hopkins University, Baltimore, MD 21218, USA
    J Control Release 122:297-304. 2007
    ..This study demonstrated the potential of PEG-b-PPA/DNA micelles as an efficient carrier for liver-targeted gene delivery...
  13. ncbi request reprint The liver in obesity and type 2 diabetes mellitus
    Zhiping Li
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, 912 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Clin Liver Dis 6:867-77. 2002
    ..Preliminary work in animal and human studies suggests that diverse strategies that inhibit production of TNF alpha and improve insulin resistance also ameliorate NAFLD...
  14. pmc In vivo test of the vertical phase separation hypothesis: the display of major histocompatibility complex (MHC) class I molecules on membranes of B cells from mice fed high-fat diets
    Saame Raza Shaikh
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Br J Nutr 101:804-9. 2009
    ..MHC class I surface levels on B cells were not affected by the MUFA-rich diet. This study suggests that the membrane vertical phase separation hypothesis may have limited application in a physiologically relevant setting...
  15. ncbi request reprint Pathogenesis of nonalcoholic steatohepatitis (NASH)
    Xiong Ma
    Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21205, USA
    Chin J Dig Dis 7:7-11. 2006
    ..This review will briefly discuss the epidemiology of NAFLD and focus on current understanding of the pathogenesis of NASH...
  16. doi request reprint Probiotic antigens stimulate hepatic natural killer T cells
    Shuwen Liang
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Immunology 141:203-10. 2014
    ..Furthermore, these data suggest that probiotics may contain bacterial glycolipid antigens that directly modulate the effector functions of hepatic NKT cells. ..
  17. ncbi request reprint A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury
    Xiong Ma
    Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    Hepatology 46:1519-29. 2007
    ..This scenario is likely one of the pathogenetic mechanisms that facilitate the transformation of simple steatosis into steatohepatitis when a fatty liver is exposed to second or third hits...
  18. pmc Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
    Chenguang Wang
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 103:11567-72. 2006
    ..Cyclin D1-dependent kinase phosphorylates NRF-1 at S47. Cyclin D1 abundance thus coordinates nuclear DNA synthesis and mitochondrial function...
  19. pmc A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
    Zuoren Yu
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 182:509-17. 2008
    ..In turn, miR-17/20 limits the proliferative function of cyclin D1, thus linking expression of a specific miRNA cluster to the regulation of oncogenesis...
  20. pmc Short sleep duration and adiposity in Chinese adolescents
    Yunxian Yu
    The Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Northwestern University, Chicago, IL 60614 3394, USA
    Sleep 30:1688-97. 2007
    ..To investigate the relationship between sleep duration and adiposity measurements in rural Chinese adolescents...
  21. ncbi request reprint Monozygotic co-twin analyses of body composition measurements and serum lipids
    Binyan Wang
    Mary Ann J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Prev Med 45:358-65. 2007
    ..To evaluate BMI and direct measures of body fat (BF) and lean body mass (LBM) in relation to fasting serum lipid profiles in a large Chinese population based twin sample using a monozygotic (MZ) co-twin analysis...
  22. pmc Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
    James Hulit
    The Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Research Building Room E501, 3970 Reservoir Rd, N W, Box 571468, Washington, DC 20057 1468, USA
    Mol Cell Biol 24:7598-611. 2004
    ..The protection of mice, genetically predisposed to intestinal tumorigenesis, through cyclin D1 heterozygosity suggests that modalities that reduce cyclin D1 abundance could provide chemoprotection...
  23. pmc Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation
    Chenguang Wang
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, D C 20007, USA
    Mol Cell Biol 23:6159-73. 2003
    ..The inhibition of PPAR gamma function by cyclin D1 is a new mechanism of signal transduction cross talk between PPAR gamma ligands and mitogenic signals that induce cyclin D1...
  24. ncbi request reprint Cyclin D1 induction of cellular migration requires p27(KIP1)
    Zhiping Li
    Kimmel Cancer Center, Departments of Cancer Biology and Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 66:9986-94. 2006
    ..Together, these studies show cyclin D1 promotes mammary epithelial cell migration. p27(KIP1) is required for cyclin D1-mediated cellular migration...

Research Grants3

  1. Nutrition and Nonalcoholic Fatty Liver Disease
    Zhiping Li; Fiscal Year: 2010
    ....