Tong Li

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase
    Tong Li
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 282:32264-73. 2007
  2. pmc Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo
    Tong Li
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e28179. 2011
  3. ncbi request reprint Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities
    Tong Li
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 27:10849-59. 2007
  4. ncbi request reprint APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
    Guojun Ma
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:192-8. 2005
  5. pmc Modeling an anti-amyloid combination therapy for Alzheimer's disease
    Vivian W Chow
    Department of Pathology, Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Sci Transl Med 2:13ra1. 2010
  6. ncbi request reprint Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals
    Tong Li
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neurosci 23:3272-7. 2003
  7. pmc Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin
    Po Min Chiang
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Neurobiol Aging 33:277-85. 2012
  8. pmc Alzheimer's therapeutics: translation of preclinical science to clinical drug development
    Alena V Savonenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 37:261-77. 2012
  9. pmc Papillomavirus infection requires gamma secretase
    Balasubramanyam Karanam
    Department of Pathology, Johns Hopkins University, Room 308, Cancer Research Building 2, 1550 Orleans St, Baltimore, MD 21231, USA
    J Virol 84:10661-70. 2010
  10. doi request reprint Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity
    Lucia Chávez-Gutiérrez
    Center for Human Genetics, KULeuven, and Department for Molecular and Developmental Genetics, VIB4, Herestraat 49, Leuven, Belgium
    J Biol Chem 283:20096-105. 2008

Collaborators

  • Philip Wong
  • Barbara J Crain
  • CHARLES GEORGE EBERHART
  • Patricia M Day
  • Huaibin Cai
  • Pritam Das
  • Paul F Worley
  • T C Wu
  • Virginia M Y Lee
  • Huaxi Xu
  • T E Golde
  • Alena V Savonenko
  • Donald L Price
  • Po Min Chiang
  • Tatiana Melnikova
  • Balasubramanyam Karanam
  • Vivian W Chow
  • Ryan R Fortna
  • Lucia Chávez-Gutiérrez
  • Se Hoon Choi
  • Giovanni Mario Pitari
  • Vanessa A Morais
  • Xin Yuan
  • Guojun Ma
  • Xue En Liu
  • Xiao Xin Yan
  • Kulandaivelu S Vetrivel
  • Dangsheng Li
  • ANDREW HIATT
  • Juan C Troncoso
  • Don L Price
  • Hyunsu Kim
  • Richard B S Roden
  • Shiwen Peng
  • Christopher Buck
  • Alexandra Tolia
  • Elke Maes
  • Bart De Strooper
  • Sangram S Sisodia
  • Maria J Saraiva
  • Susan N Leight
  • Jeffrey A Johnson
  • Donald S Pijak
  • Ronnie I Baksh
  • Glenn J Bubley
  • Robert W Doms
  • Moumita Barua
  • Adam S Crystal
  • Catarina Brito
  • Scott A Waldman
  • Steven P Balk
  • Michael L Lu
  • Robert A Borgesi
  • Tao Zhang
  • Julia Costa
  • Hongyun Wang
  • Gopal Thinakaran
  • Zhen Dong Zhao
  • William Lin
  • Haipeng Cheng
  • Yu Wen Li
  • Richard E Olson
  • Cynthia M Rominger
  • Guang Fa Wang
  • Shimoga R Prakash
  • You Chun Wang
  • Xiao Ming Gao
  • Ling Wang
  • Hai Ying Lu
  • Wan Fu Zhu
  • Jie Li
  • Hui Zhuang
  • Yong Hua Li
  • Takashi Sakurai
  • Xiao Yuan Xu
  • Robert Zaczek
  • Nobuyuki Nukina
  • Heather Tian
  • Herbert H Samuels
  • Fang Wang

Detail Information

Publications18

  1. ncbi request reprint Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase
    Tong Li
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 282:32264-73. 2007
    ....
  2. pmc Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo
    Tong Li
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e28179. 2011
    ..Our data suggest that whereas fAD-linked PS1 mutants cause early onset disease, upregulation of PS1/γ-secretase activity may be a risk factor for late onset sporadic AD...
  3. ncbi request reprint Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities
    Tong Li
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 27:10849-59. 2007
    ..Our findings suggest that moderate inhibition of gamma-secretase represents an attractive anti-amyloid therapy for Alzheimer's disease...
  4. ncbi request reprint APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
    Guojun Ma
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:192-8. 2005
    ....
  5. pmc Modeling an anti-amyloid combination therapy for Alzheimer's disease
    Vivian W Chow
    Department of Pathology, Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Sci Transl Med 2:13ra1. 2010
    ..No evidence of mechanism-based toxicities was associated with such decreases in amounts of both enzymes. Thus, we propose that targeting both gamma-secretase and BACE1 may be an effective and safe treatment strategy for AD...
  6. ncbi request reprint Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals
    Tong Li
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neurosci 23:3272-7. 2003
    ....
  7. pmc Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin
    Po Min Chiang
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Neurobiol Aging 33:277-85. 2012
    ..We propose a model that identifies critical TMDs of Aph-1 for associations with Nct and PS for the stepwise assembly of γ-secretase components...
  8. pmc Alzheimer's therapeutics: translation of preclinical science to clinical drug development
    Alena V Savonenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 37:261-77. 2012
    ..We discuss ways to improve both the predictive validity of mouse models and the translation of knowledge between preclinical and clinical stages of drug development...
  9. pmc Papillomavirus infection requires gamma secretase
    Balasubramanyam Karanam
    Department of Pathology, Johns Hopkins University, Room 308, Cancer Research Building 2, 1550 Orleans St, Baltimore, MD 21231, USA
    J Virol 84:10661-70. 2010
    ....
  10. doi request reprint Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity
    Lucia Chávez-Gutiérrez
    Center for Human Genetics, KULeuven, and Department for Molecular and Developmental Genetics, VIB4, Herestraat 49, Leuven, Belgium
    J Biol Chem 283:20096-105. 2008
    ..Consequently, these studies indicate that the main role of the Glu(332) is in the maturation and assembly of gamma-secretase rather than in the recognition of the substrates...
  11. ncbi request reprint Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin)
    Se Hoon Choi
    Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 27:7006-10. 2007
    ..Moreover, Abeta deposition is significantly accelerated in the hippocampus and cortex of ceAPPswe/PS1deltaE9/TTR+/- mice. Our results strongly suggest that TTR plays a critical role in modulating Abeta deposition in vivo...
  12. pmc Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes
    Kulandaivelu S Vetrivel
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Illinois 60637, USA
    J Biol Chem 279:44945-54. 2004
    ..These findings are consistent with the localization of gamma-secretase in lipid raft microdomains of post-Golgi and endosomes, organelles previously implicated in amyloidogenic processing of APP...
  13. ncbi request reprint N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53
    Vanessa A Morais
    Instituto de Tecnologia Química e Biológica Instituto de Biologia Experimental e Tecnológica, Avenida da República, Apartado 127, 2781 901 Oeiras, Portugal
    Biochim Biophys Acta 1762:802-10. 2006
    ....
  14. pmc Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells
    Xin Yuan
    Hematology Oncology Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Pathol 169:682-96. 2006
    ..These results reveal a potentially critical function of AR in androgen-independent PCa that is distinct from its previously described transcriptional or nontranscriptional functions...
  15. ncbi request reprint Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells
    Giovanni Mario Pitari
    Division of Clinical Pharmacology, Departments of Pharmacology and Experimental Therapeutics and Medicine, Thomas Jefferson University, 1100 Walnut Street MOB 810, Philadelphia, PA 19107, USA
    Mol Cancer Ther 5:1190-6. 2006
    ..Moreover, combination therapies, including exisulind and agents that induce cGMP signaling, may require careful evaluation in patients with colon cancer...
  16. ncbi request reprint [Comparison among four kits in detection of anti-SARS-CoV IgG in sera of SARS patients]
    Xue En Liu
    Department of Microbiology, Peking University Health Science Center, Beijing 100083, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:514-6. 2004
    ..To compare the sensitivity and specificity of four kits for detection of anti-severe acute respiratory syndrome (SARS)-CoV IgG in sera of SARS patients...
  17. ncbi request reprint Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation
    Xiao Xin Yan
    Bristol Myers Squibb Company, Pharmaceutical Research Institute, Neuroscience Drug Discovery, Wallingford, Connecticut 06492, USA
    J Neurosci 24:2942-52. 2004
    ..The findings in this study support a physiological role of PS or gamma-secretase complex in neuronal and synaptic development and plasticity...
  18. pmc Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer
    Dangsheng Li
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 22:5782-92. 2002
    ..Our results argue against the current silent-partner model for RXR in the TR/RXR heterodimer and reveal an unexpected aspect of cross regulation between TR and RXR...