D E Levin

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint A pair of putative protein kinase genes (YPK1 and YPK2) is required for cell growth in Saccharomyces cerevisiae
    P Chen
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, MD 21205
    Mol Gen Genet 236:443-7. 1993
  2. pmc Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1
    B Philip
    Department of Biochemistry and Molecular Biology, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 21:271-80. 2001
  3. pmc A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway
    K S Lee
    Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Mol Cell Biol 13:5843-53. 1993
  4. pmc Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae
    M Rajavel
    Department of Biochemistry, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 19:3969-76. 1999
  5. ncbi request reprint Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway
    U S Jung
    Department of Biochemistry and Molecular Biology, School of Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Mol Microbiol 34:1049-57. 1999
  6. pmc A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C
    K S Lee
    Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Mol Cell Biol 13:3067-75. 1993
  7. ncbi request reprint Activation of yeast protein kinase C by Rho1 GTPase
    Y Kamada
    Department of Biochemisty, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 271:9193-6. 1996
  8. ncbi request reprint The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity
    K S Lee
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, Maryland 21205
    J Biol Chem 269:19725-30. 1994
  9. ncbi request reprint Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC
    M Watanabe
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, Maryland 21205
    J Biol Chem 269:16829-36. 1994
  10. pmc Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin
    C Zhao
    Department of Biochemistry, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 18:1013-22. 1998

Collaborators

Detail Information

Publications18

  1. ncbi request reprint A pair of putative protein kinase genes (YPK1 and YPK2) is required for cell growth in Saccharomyces cerevisiae
    P Chen
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, MD 21205
    Mol Gen Genet 236:443-7. 1993
    ..The YPK1 gene was mapped to the left arm of chromosome XI and YPK2 was mapped to the right arm of chromosome XIII...
  2. pmc Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1
    B Philip
    Department of Biochemistry and Molecular Biology, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 21:271-80. 2001
    ..We demonstrate that Mid2 is not mannosylated in a pmt2 mutant and that this modification is important for signaling by Mid2...
  3. pmc A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway
    K S Lee
    Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Mol Cell Biol 13:5843-53. 1993
    ..Genetic interactions between BCK2 and other pathway components suggested that BCK2 functions on a common pathway branch with PPZ1 and PPZ2...
  4. pmc Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae
    M Rajavel
    Department of Biochemistry, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 19:3969-76. 1999
    ..We conclude that Hcs77 is dedicated to signaling cell wall stress during vegetative growth and that Mid2 participates in this signaling, but its primary role is in signaling wall stress during pheromone-induced morphogenesis...
  5. ncbi request reprint Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway
    U S Jung
    Department of Biochemistry and Molecular Biology, School of Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Mol Microbiol 34:1049-57. 1999
    ..A similar pattern of regulation was observed when cell integrity signalling was induced by environmental stress (i.e. temperature upshift)...
  6. pmc A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C
    K S Lee
    Department of Biochemistry, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205
    Mol Cell Biol 13:3067-75. 1993
    ....
  7. ncbi request reprint Activation of yeast protein kinase C by Rho1 GTPase
    Y Kamada
    Department of Biochemisty, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 271:9193-6. 1996
    ..Recombinant Rho1 confers upon Pkc1 the ability to be stimulated by phosphatidylserine, indicating that Rho1 controls signal transmission through Pkc1...
  8. ncbi request reprint The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity
    K S Lee
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, Maryland 21205
    J Biol Chem 269:19725-30. 1994
    ..These results indicate that PLB1 is principally responsible for the production of the deacylation products of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol...
  9. ncbi request reprint Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC
    M Watanabe
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, Maryland 21205
    J Biol Chem 269:16829-36. 1994
    ....
  10. pmc Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin
    C Zhao
    Department of Biochemistry, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 18:1013-22. 1998
    ..Finally, we show that FKS2 expression is induced as cells enter stationary phase through a SNF1-, calcineurin-, and cell integrity signaling-independent pathway...
  11. ncbi request reprint Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae
    D E Levin
    Department of Biochemistry, Johns Hopkins University, School of Public Health, Baltimore, MD 21205
    Cell Mol Biol Res 40:229-39. 1994
    ..Consistent with the proposed model, Pkc1p selectively phosphorylates Bck1p in vitro and Mpk1p protein kinase activity requires a functional BCK1 gene...
  12. pmc Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog
    K S Lee
    Department of Biochemistry, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205
    Mol Cell Biol 12:172-82. 1992
    ..This region may serve as a hinge between domains whose interaction is regulated by PKC1...
  13. ncbi request reprint Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase
    H Qadota
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
    Science 272:279-81. 1996
    ..Both proteins were localized predominantly at sites of cell wall remodeling. Therefore, it appears that Rho1p is a regulatory subunit of beta(1-->3)glucan synthase...
  14. pmc A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator
    J V Gray
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
    EMBO J 16:4924-37. 1997
    ..We propose that the Pkc1 pathway promotes bud emergence and organized surface growth and is activated by Cdc28-Cln1/Cln2 at the G1-S transition and by Hcs77 upon heat shock. Hcs77 may monitor the state of the cell surface...
  15. pmc Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism
    D R Johnson
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:751-62. 1994
    ..cerevisiae contains at least one other FAA which directs fatty acids to beta-oxidation pathways...
  16. pmc MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C
    K Irie
    Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
    Mol Cell Biol 13:3076-83. 1993
    ..Genetic epistasis experiments indicated that the site of action for MKK1 and MKK2 is between BCK1 and MPK1...
  17. pmc A putative protein kinase gene (kin1+) is important for growth polarity in Schizosaccharomyces pombe
    D E Levin
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    Proc Natl Acad Sci U S A 87:8272-6. 1990
    ..Relative to kin1+ cells, kin1-disrupted cells were differentially sensitive to lysis by treatment with alpha- and beta-glucanases, suggesting an alteration in either the composition or the organization of their cell walls...
  18. ncbi request reprint Dynamics and organization of MAP kinase signal pathways
    B Errede
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill 27599 7260, USA
    Mol Reprod Dev 42:477-85. 1995
    ..This behavior suggests that Ste5, which has been proposed to be a tether for the kinases in the mating pathway, contributes to Ste7 specificity and fidelity of signal transmission...