Research Topics
Species | Sean X LengSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
An international model for geriatrics program development in China: the Johns Hopkins-Peking Union Medical College experienceSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, School of Medicine, The Johns Hopkins University, John R Burton Pavilion, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Am Geriatr Soc 58:1376-81. 2010..With such unique experiences, it is hoped that this will serve as a useful model for international geriatrics program development for colleagues in the United States and abroad...- Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies ISean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Exp Gerontol 44:511-6. 2009..These findings provide initial insight into potential roles of neutrophils and monocytes in the pathogenesis of frailty and a basis for further investigation into their function and regulation in frail older women... 
White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, 5505 Hopkins Bayview Circle, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 64:499-502. 2009..WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated...- Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65(495-503)-specific CD8+ T cells in older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Age (Dordr) 33:607-14. 2011.... - IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
Age Ageing 40:475-81. 2011..Previous studies have shown significant association between elevated interleukin-6 (IL-6) levels and frailty. The objective of this study was to evaluate IL-6-independent association of serum neopterin levels with prevalent frailty... - Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adultsTao Qu
Johns Hopkins University School of Medicine, Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Baltimore, MD, USA
Mech Ageing Dev 130:161-6. 2009..These findings suggest upregulated expression of specific stress-responsive genes in monocyte-mediated inflammatory pathway in the syndrome of frailty with potential mechanistic and interventional implications... - Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Gerontol 46:679-84. 2011..These findings suggest that detection of CMV viral DNA in monocytes may be an informative tool to evaluate chronic CMV infection and its potential role in monocyte/macrophage-mediated immune activation in the elderly... 
Inflammation and frailty in older womenSean X Leng
Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Am Geriatr Soc 55:864-71. 2007..To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) and prevalent frailty...- Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fatMonique E Spencer
Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 65:858-65. 2010..In addition to age, we assessed gender, race, body mass index (BMI), and percentage of body fat (%fat) as potential covariates... - Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailtyTao Qu
Biology of Frailty Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Cytokine 46:319-24. 2009..Therapeutic implications include potential development of CXCL-10-based interventional strategies for the prevention and treatment of frailty in older adults... - Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Gerontol 40:982-7. 2005..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults... - Inflammation and immune system alterations in frailtyXu Yao
Divisions of Allergy and Clinical Immunology and Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Clin Geriatr Med 27:79-87. 2011.... - Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adultsXu Yao
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Vaccine 29:5015-21. 2011..These findings suggest that assessing frailty status in the elderly may identify those who are less likely to respond to TIV immunization and be at higher risk for seasonal influenza and its complications... - Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailtySean X Leng
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Aging Clin Exp Res 16:153-7. 2004..The trend toward an inverse correlation between IGF-I and IL-6 in the frail, but not the non-frail group, suggests potential interaction between endocrine and immune/cytokine dysregulation that requires further study in larger cohorts... - T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adultsUmberto De Fanis
Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Am Geriatr Soc 56:904-8. 2008..To evaluate the frequencies of T-lymphocytes expressing CC chemokine receptor-5 (CCR5(+) T-cells) and their relationship with frailty in older adults... - Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women's Health and Aging Studies I and IIPaulo H M Chaves
The Johns Hopkins Center on Aging and Health, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 60:729-35. 2005..We examined the cross-sectional relationship between hemoglobin (Hb) and a recently-validated measure of frailty in community-dwelling older women, and whether this relationship was modified by cardiovascular disease (CVD) status... - Decreased cell proliferation and altered cytokine production in frail older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Aging Clin Exp Res 16:249-52. 2004..In order to investigate specific immune system modulations that may contribute to frailty, eleven age- and sex-matched pairs of community-dwelling frail and non-frail older adults were identified... - Inadvertent self-healing in desperate timesSean X Leng
Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Lancet 370:1458. 2007 - Frailty, inflammation, and immunityHuifen Li
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Aging Dis 2:466-73. 2011..Taken together, these findings demonstrate significant inflammatory and immune dysregulation in frail older adults and highlight the need for strategies to improve the immune function for this vulnerable elderly population...